TCM Prescription: Yin Lian Qing Gan Recipe



Prescription Description
Prescription IDTCMF6825
Pinyin NameYin Lian Qing Gan He Ji
Chinese Name茵莲清肝合剂
English NameYin Lian Qing Gan Recipe
Function Description胁痛
IndicationsHypochondrium pain disorder
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1496 Rhizoma dryopteris crassirhizomae 绵马贯众 TCMH1496 GBVM2585-11
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH916 Succinus 琥珀 TCMH916
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH71 Oldenlandia diffusa 白花蛇舌草 TCMH71 ITSAI3173-14
TCMH132 Scutellaria barbata 半枝莲 TCMH132 ITSAN1801-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1609 Eupatorium fortunei 佩兰 TCMH1609 ITSAP481-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2578 Lycopi Herba 泽兰 TCMH2578
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2646 Rhizoma paridis 重楼 TCMH2646
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, FUT7, HMGCR, HSD17B3, IDO1, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR, XDH 14.2963
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 13.8221
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 13.8021
[BP] GO:0042221 response to chemical ABCG2, ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP1, TYR 13.7251
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 13.0157
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, HCAR2, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 12.5321
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, HCAR2, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 12.5139
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 12.4139
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DHFR 11.8808
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 11.8808
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS1, PTGS2 11.8808
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS1, PTGS2 11.7694
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 11.6967
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS1, PTGS2 11.5525
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AR, BCHE, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, RELA, SLC6A4, SRC, TERT, XDH 11.2268
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0872
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 10.5785
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, IDO1, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 10.5785
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 10.4451
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, HMGCR, HSD17B1, HSD17B2, HSD17B3 10.4397
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 10.3988
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, HMGCR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 9.70193
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FLT3, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 9.66405
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 9.60777
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP1, TYR 9.54416
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS1, PTGS2 9.53252
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC, TERT 9.49632
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PTGES, PTGS1, PTGS2 9.37169
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, GSK3B, HMGCR, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 9.29117
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 9.25242
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, XDH 9.1556
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 9.09552
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, XDH 9.09552
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS1, PTGS2 9.09552
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APP, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GSK3B, IGF1R, KIT, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC 8.82735
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AKR1C3, ALPL, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, KIT, PPARA, PTGS2, RELA, SLC6A4, SRC 8.78649
[BP] GO:0006805 xenobiotic metabolic process BCHE, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, NQO2, PTGS1, RORC 8.51047
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 8.4773
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD17B2, IDO1, IGF1R, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TOP1, TYR 8.33367
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RELA, RORC, SLC6A4, SRC, TERT 7.99071
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PIK3CA, PPARA, PTPRS, RELA, SRC, TYR 7.92823
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, XDH 7.86692
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT 7.53993
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 7.53993
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 7.49278
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CACNA1C, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SLC6A4, SRC, TERT, TNKS2, TYR 7.49278
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, IDO1, PPARA, PTGES, PTGS1, PTGS2 7.45181
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.35346
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 7.21623
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RELA, RORC, SLC6A4, SRC 7.0061
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.77669
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.673
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 6.64947
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA, TERT 6.5948
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 6.56778
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DHFR, HMGCR, HSD17B3, MAOA, TYR 6.49949
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT 6.49496
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 6.43314
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, DHFR, FABP3, HMGCR, KCNH2, KDR, PTGS2, RELA, SLC6A2, SLC6A4, SRC, TOP1 6.36488
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 6.19672
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 6.1004
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 6.08026
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 6.0769
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.03953
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 6.02503
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, PTGS2, TERT 6.02426
[BP] GO:0006082 organic acid metabolic process ABCG2, AKR1C3, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 6.00701
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 6.00607
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, BCHE, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SLC6A4, SRC 5.99537
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, GSK3B, HCAR2, HMGCR, IGF1R, KCNH2, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 5.96502
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 5.96086
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.90084
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.86613
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.85813
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.81069
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.77912
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.77912
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AR, AXL, BCL2, CA2, CACNA1C, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, HCAR2, HMGCR, IDO1, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, RELA, SLC6A4, SRC, TERT, TNKS2, XDH 5.63687
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 5.63687
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DHFR, ESR1, F3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 5.57601
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 5.57601
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TNKS, TOP1 5.55863
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.48585
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 5.47466
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3 5.46647
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, KIT, PPARA, PTGS2, RORC, SRC 5.46647
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, FLT3, HMGCR, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 5.45887
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FLT3, GSK3B, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SRC, TYR 5.44929
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.44929
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, DHFR, HMGCR, HSD17B3, IDO1, PTGES, PTGS1, PTGS2 5.42164
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 5.28521
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HMGCR, HSD17B3, IDO1 5.16446
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC 5.08387
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 4.94153
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.94153
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 4.94153
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CES1, CYP19A1, DHFR, HMGCR, HSD17B3, TYR 4.86971
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS, TOP1 4.84541
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, ESR1, GSK3B, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RELA, RORC, SLC6A4, SRC 4.82937
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCHE, BCL2, CA2, FLT3, PTGS2, RELA, SRC 4.81394
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 4.80805
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, DHFR, ESR1, ESR2, F3, FLT3, GSK3B, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, TERT, TNKS, XDH 4.79856
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.79351
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.79351
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 4.76763
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, GSK3B, KIT, PPARA, RORC, SLC6A4, SRC, TOP1 4.76578
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, BCHE, BCL2, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SRC, TERT, XDH 4.74812
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, BCHE, BCL2, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SRC, TERT, XDH 4.72775
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.70752
[BP] GO:0006693 None AKR1C3, CES2, PTGES, PTGS1, PTGS2 4.68587
[BP] GO:0006692 None AKR1C3, CES2, PTGES, PTGS1, PTGS2 4.68587
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTGS2, RELA, SRC, TERT 4.65898
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, KIT, MAP2K1, PTGS2, SRC 4.65293
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, HMGCR, HSD17B1, HSD17B2, HSD17B3 4.63378
[BP] GO:0019371 None AKR1C3, PTGES, PTGS1, PTGS2 4.63378
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.59611
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, ESR1, F10, F3, FLT3, FUT7, GSK3B, HMGCR, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TOP1, TYR, XDH 4.55602
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.55371
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, BCHE, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, DHFR, IDO1, MAOA 4.54796
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.54796
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.43391
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, FLT3, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 4.4329
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, HSD17B3, IDO1, KIT, MAP2K1, MMP2, MMP9, PTGS2, SLC6A4, SRC 4.384
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.36269
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, BCHE, CYP1A1, HMGCR, PTGS2, RELA, SLC6A4, TYR 4.31087
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.30962
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.30657
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.27316
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 4.26536
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.25161
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.25161
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2, HSD17B3 4.22571
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CYP1A1, CYP1B1, HMGCR, KDR, RELA, SLC6A4, SRC 4.22013
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 4.18561
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, IDO1, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SLC6A2, SLC6A4, SRC, TERT 4.16755
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.16732
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.14564
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.14036
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.09805
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.07639
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 4.06784
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APP, AR, ESR1, FLT3, GSK3B, IGF1R, KIT, MMP2, PTGS2, RELA, SLC6A4, SRC 4.02925
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 4.00346
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.00346
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 3.99811
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.96115
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCHE, BCL2, CYP1A1, HMGCR, PTGS2, RELA, SLC6A4, SRC, TYR 3.94505
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 3.91982
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.91916
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCHE, BCL2, CYP1B1, FABP3, IDO1, MAP2K1, PTGES, PTGS2, SLC6A4, TERT, XDH 3.89631
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 3.85661
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, GSK3B, HCAR2, HMGCR, KCNH2, MAP2K1, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 3.85367
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, SRC, TERT 3.83933
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.82959
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, AR, BCL2, CYP19A1, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 3.81821
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 3.73985
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.7045
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.64795
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HMGCR 3.62568
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, XDH 3.5843
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MAP2K1, MET, PIK3CB, PIM1, SRC, TYR 3.57595
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, PTGS2, RELA, TYR 3.57045
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 3.57045
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, BCHE, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TYR 3.51764
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.51581
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.46827
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCHE, BCL2, CYP1A1, HMGCR, PTGS2, RELA, SLC6A4, SRC, TYR 3.44721
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.44106
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.44106
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP1 3.43572
[BP] GO:0042133 neurotransmitter metabolic process ACHE, BCHE, CYP1B1, DHFR, MAOA, SLC6A4 3.40925
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.40052
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, PTPRS, RELA 3.38058
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.37407
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.34444
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, KIT, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TERT, TYR 3.34351
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.3428
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.33854
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.30686
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT, TNKS 3.2854
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, HMGCR, SRC, TNKS, TNKS2 3.26747
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.26747
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.26747
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.26747
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 3.25276
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 3.21224
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 3.20689
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.20378
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 3.20184
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9, TERT 3.20184
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, KIT, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA 3.20184
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, BCHE, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TYR 3.1727
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.171
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, ESR1, ESRRA, HCAR2, IDO1, KIT, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, RELA, SRC 3.14786
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.12184
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.10519
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, ESR1, GSK3B, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.09942
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCHE, BCL2, FLT3, PTGS2, SRC 3.09585
[BP] GO:0048878 chemical homeostasis ABCG2, ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB 3.09585
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCHE, BCL2, CDC25B, CES1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SRC, TERT 3.09077
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, HMGCR, IDO1, KDR, KIT, MAP2K1, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SLC6A4, SRC, TERT, TNKS2, XDH 3.09077
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.05645
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.05395
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.05395
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.05395
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 3.05125
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.03247
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.02379
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 3.01078
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, GSK3B, HCAR2, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT 3.00853
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.00735
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3, HMGCR 3.00735
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.00369
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, GSK3B, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, PTGS2, PTPN1, PTPRS, TERT, XDH 3.00329
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.0001
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 2.99944
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 2.98698
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, PTGS2, SLC6A4 2.97063
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BCHE, CA2, CA7, KIT, PTGS2, SLC6A4 2.97063
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BCHE, CA2, CA7, KIT, PTGS2, SLC6A4 2.97063
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, HMGCR, MAP2K1, PTGS2, RELA, TERT 2.94017
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.93356
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, MAP3K7, PIM1, RELA 2.90531
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.88744
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.88744
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HCAR2, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 2.88581
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.85644
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.85644
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.8437
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, TYR 2.81155
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MAP3K7, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC 2.79954
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, FLT3, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.79103
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CYP1B1, ESR1, ESRRA, F3, GSK3B, HMGCR, IDO1, KDR, KIT, MAP2K1, PIM1, PTGS2, PTPRS, RELA, SLC6A4, SRC, TERT, XDH 2.79103
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.79103
[BP] GO:0016488 None AKR1B10, AKR1C3 2.79103
[BP] GO:0016487 None AKR1B10, AKR1C3 2.79103
[BP] GO:0016107 None AKR1B10, AKR1C3 2.79103
[BP] GO:0009115 None AOX1, XDH 2.79103
[BP] GO:0006714 None AKR1B10, AKR1C3 2.79103
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, PPARA 2.77277
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.7681
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, IDO1, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SRC, TERT 2.75025
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, BCHE, CSNK2A1, MAOA 2.73065
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, BCL2, CSNK2A1, ESRRB, GSK3B, HCAR2, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PTPN1, RELA 2.72417
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.7237
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 2.7237
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.69686
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.69686
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.69686
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, DHFR, MAOA, PTGS2, SLC6A2, SLC6A4 2.68803
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.66311
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, FLT3, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.64695
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 2.6357
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.62667
[BP] GO:0097756 None ADORA1, HMGCR, PTGS2, SLC6A4 2.62317
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, GSK3B, MAP2K1, TNKS 2.62142
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.60593
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, HCAR2, MET, PIK3CA, PPARA, RELA 2.60493
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 2.57949
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.5767
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGES, PTGS1, PTGS2 2.5767
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGES, PTGS1, PTGS2 2.5665
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, RELA, SRC 2.54668
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.53614
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.53269
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.53269
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.52771
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.51098
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.49164
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, ESR1, FLT3, RELA, RORC, SLC6A4, SRC 2.49164
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.48224
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP1B1, DHFR, HMGCR 2.48175
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, GSK3B, MAP2K1, TNKS 2.4702
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.45557
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.45557
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.45557
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.45557
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.45557
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.45334
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, KCNH2, MMP9, PTGS2 2.44332
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, FLT3, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.44102
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KCNH2, KDR, PTGS2, RELA, SRC 2.42989
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.42358
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.40138
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, HMGCR, KIT, PTGS2, RELA, TYR 2.40138
[BP] GO:0046110 None AOX1, XDH 2.39937
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39937
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.39937
[BP] GO:0016095 None AKR1B10, AKR1C3 2.39937
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, DHFR, SLC6A4 2.39937
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.39937
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, TNKS, TNKS2 2.36997
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.35588
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, IDO1, PTGES, PTGS1, PTGS2 2.35519
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.34557
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.32868
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 2.31171
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.2827
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTPN1, RELA, SRC 2.27985
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GSK3B, PTGES, PTGS2, RELA, SRC 2.27845
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AR, AXL, BCHE, BCL2, CES1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, KIT, MAP2K1, MMP2, MMP9, PTGS2, RORC 2.26992
[BP] GO:0010906 None ESRRB, GSK3B, PPARA, RORC, SRC 2.26565
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.26472
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCHE, BCL2, CYP1A1, CYP1A2, HMGCR, IDO1, KIT, MMP12, PTGES, PTGS2, RELA, SLC6A4, SRC, TYR 2.26472
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, RORC, SRC, TERT, TNKS, TNKS2 2.26074
[BP] GO:0003018 None ADORA1, ADRA2A, HMGCR, PTGS2, SLC6A4, SRC 2.25913
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, GSK3B, IDO1, MAOA, PIK3CB, SRC, XDH 2.25514
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, AR, BCL2, CACNA1C, CSNK2A1, GSK3B, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC, TERT 2.24761
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.21358
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GSK3B, IGF1R, MMP2, PTGS2, RELA, SLC6A4, SRC 2.2086
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.18954
[BP] GO:0050730 None ADORA1, ADRA2A, APP, FLT3, KIT, PTPN1, SRC 2.18954
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, PIK3CA, PIM1, PTPRS, SLC6A4, TNKS2 2.1876
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CACNA1C, GSK3B, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.17231
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.15153
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.15153
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, GSK3B, KDR, PIK3CB, SRC 2.15153
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.15153
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.15153
[BP] GO:0070213 None TNKS, TNKS2 2.15153
[BP] GO:0006145 None AOX1, XDH 2.15153
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15153
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, GSK3B, SRC, TNKS, TOP1 2.1394
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TYR 2.11292
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CACNA1C, KCNH2, MMP9, PTGS2, SLC6A4 2.1102
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.1069
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1069
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.1069
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.10442
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, DHFR, PTGS2, XDH 2.09197
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, KIT, MAP3K7, RELA 2.08109
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.06937
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.0559
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0559
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, KIT, PTPN1, SRC 2.04282
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.0371
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, ESR1, F10, F3, FLT3, FUT7, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TOP1 2.03037
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.02947
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.0211
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.02076
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.01805
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.00933
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.00844
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 5.6125
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, BCHE, PTGES 5.21224
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, F10, F3, FLT3, FUT7, GSK3B, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR 4.16084
[CC] GO:0044432 endoplasmic reticulum part APP, BCHE, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, F10, FLT3, HMGCR, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1 4.16084
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, ESR1, F10, F3, FLT3, GSK3B, HCAR2, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SLC6A2, SLC6A4, SRC, TERT 2.9448
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.62287
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, HMGCR, HSD17B3, KDR, MAP2K1, PTGS2, PTPN1, XDH 2.60086
[CC] GO:0043226 organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.50274
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HMGCR, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2 2.20838
[CC] GO:0031233 None CA4, F10, F3 2.20838
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 18.0299
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 18.0299
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, F10, F3, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 17.3028
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.2354
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 11.3779
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1434
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 10.1423
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 9.29117
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.92668
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, TNKS 8.82976
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, HMGCR, HSD17B1, IDO1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 8.30502
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, IDO1, PTGS1, PTGS2, SRC 7.99173
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, IDO1, PTGS1, PTGS2, SRC 7.66766
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2, TYR 7.18024
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, XDH 7.03876
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 6.64947
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.21861
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.06822
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.06822
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TOP1 6.00101
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC, SHBG 5.77206
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.5808
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HMGCR, HSD17B1, HSD17B2, HSD17B3, XDH 5.46647
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.46016
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADRA2A, AOX1, APP, BCHE, BCL2, CSNK2A1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KCNH2, KDR, KIT, MAP3K7, MET, MMP9, NQO2, PTGS2, RELA, SLC6A4, TERT, TYR, XDH 5.35511
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.9175
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 4.9175
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TOP1 4.90708
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 4.63378
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.18846
[MF] GO:0043168 anion binding ABCG2, ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, DHFR, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTPRS, RELA, SRC, TOP1, XDH 4.18561
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 4.16084
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 4.16084
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, PPARA, RORC, SHBG 4.07803
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 4.00346
[MF] GO:0042803 protein homodimerization activity ABCG2, ACHE, ADRA2A, AOX1, BCL2, FLT3, HMGCR, KCNH2, KIT, NQO2, PTGS2, RELA, SLC6A4, TERT, TYR, XDH 3.94048
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT, TOP1 3.87881
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.75171
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.64933
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.64933
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.64921
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BCHE, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, ESR1, ESR2, ESRRB, F3, GSK3B, HMGCR, KCNH2, KIT, MET, PPARA, PTGS2, PTPN1, RELA, SLC6A4, SRC, TNKS2 3.64699
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.59147
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, SHBG 3.48533
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADRA2A, AOX1, AR, AXL, BCL2, FLT3, HMGCR, KCNH2, KIT, NQO2, PTGS2, RELA, SLC6A4, TERT, TYR, XDH 3.24091
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.21224
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2, HSD17B3 3.16044
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.16044
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADORA1, ADRA2A, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SLC6A4, SRC, TERT, TOP1, XDH 3.13882
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2, HSD17B3 3.05395
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SRC 2.90062
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.88744
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 2.79103
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.79103
[MF] GO:0045550 None AKR1B10, AKR1C3 2.79103
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.79103
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.79103
[MF] GO:0008389 None CYP2A13, CYP2A6 2.79103
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SRC 2.78521
[MF] GO:1901363 heterocyclic compound binding ABCG2, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TOP1, XDH 2.59556
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA, RORC 2.53964
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AOX1, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, XDH 2.48662
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, BCHE, CA1, CA2, CES1, CES2 2.42989
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.39937
[MF] GO:0047718 None AKR1B10, AKR1C3 2.39937
[MF] GO:0005330 None SLC6A2, SLC6A4 2.39937
[MF] GO:0047045 None AKR1C3, HSD17B3 2.39937
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.39937
[MF] GO:0047374 None CES1, CES2 2.39937
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.39937
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.39937
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.38535
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, F10, F3, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TOP1 2.30678
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.20838
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 2.20838
[MF] GO:0008134 transcription factor binding AR, BCL2, ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, RELA, SRC, TERT 2.20838
[MF] GO:0000166 nucleotide binding ABCG2, AOX1, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, XDH 2.16785
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AOX1, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, XDH 2.16684
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15153
[MF] GO:0032795 None ADORA1, ADRA2A 2.15153
[MF] GO:0005497 None AR, SHBG 2.15153
[MF] GO:0003674 molecular_function ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.12714
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, RELA, TOP1 2.10442
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 2.06031


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.0446
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 9.909
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1B1, HMGCR, PTGS2, CYP2C19, CYP19A1, PTGS1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, AKR1C3, TYR, DHFR, CYP2A6, AKR1B10, CYP1A2, CYP1A1, ALPL, PTGES, IDO1, CES1 8.6936
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET 7.9439
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, CACNA1C, PTGS2, CYP2C19, PTGS1, SLC6A4 8.337
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, ESR2, RELA 7.4347
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 8.0614
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA 6.8005
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 6.8005
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, PTGS2, CYP2C19, PTGES, PTGS1 6.5896
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.3322
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.5194
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.3754
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.3641
Focal adhesion_Homo sapiens_hsa04510 GSK3B, MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 5.3748
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.5706
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.3748
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 5.8798
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.1571
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET 5.2033
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, MAP2K1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 4.5653
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, PIK3CA, ADORA1, CACNA1C, PIK3CB, PPARA, RELA 4.5653
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB, RELA 4.9809
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.0095
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 4.4637
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, KIT, KDR, PIK3CB, MET, IGF1R 4.4103
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.2584
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, PIK3CA, KIT, KDR, PIK3CB, MET, RELA, IGF1R 4.2494
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.2884
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 4.2788
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 4.1954
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, ADORA1, CACNA1C, PIK3CB, ADRA2A 4.1954
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PIK3CA, PIK3CB, PPARA, RELA 4.2159
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.0082
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.0784
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 4.0784
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1, PIK3CA, BCL2, PIK3CB 4.2494
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 4.0585
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 3.7711
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.782
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 4.0585
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, PIK3CA, ESRRB, PIK3CB, IGF1R 3.7071
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, PIK3CA, PIK3CB, RELA 4.0283
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP2C19 4.0828
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.4921
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.4921
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, MAP2K1, PIK3CA, SRC, PIK3CB 3.7071
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.7129
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.0283
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, PIK3CA, SRC, PIK3CB, RELA 3.1264
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.3499
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.5862
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, MAP3K7, IGF1R 3.0772
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 2.9796
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 2.8891
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, PPARA, RELA 2.9714
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, MAP2K1, PIK3CA, PIK3CB 2.8928
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, PIK3CB, PPARA, RELA 2.752
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.671
Influenza A_Homo sapiens_hsa05164 GSK3B, MAP2K1, PIK3CA, PIK3CB, RELA 2.4953
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, IGF1R 3.1264
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.4526
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 2.9796
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.1158
Melanogenesis_Homo sapiens_hsa04916 GSK3B, MAP2K1, KIT, TYR 2.53
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.671
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2524
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.6243
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.1158
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.1278
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.8598
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.8781
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2515
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.2476
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2607
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, KIT, PIK3CB 2.0253
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, PIK3CA, TERT, PIK3CB, RELA 1.862
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2941
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1264
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.2875
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 1.9931
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1, PIK3CA, PIK3CB 3.4731
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8928
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB 1.5136
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.5712
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0558
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3781
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.2632
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4165
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6243
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4327
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1, MAP3K7 1.3314
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4314
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.38
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRA2A 0.7719
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4327
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4429
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4442
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4731
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7726
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.6979
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4442
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.107
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOA, CACNA1C 1.4271
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.6712
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.1409
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4604
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4442
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4528
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.7506
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4544
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.6786
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 0.8262
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.6457
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.8173
Peroxisome_Homo sapiens_hsa04146 XDH 0.4604
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP, CACNA1C 1.1991
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4614
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8468
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4604
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4724
Pertussis_Homo sapiens_hsa05133 RELA 0.484
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4862
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4862
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 0.9606
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9767
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.0797
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.0082
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.6498
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0546
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0546
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.0546
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5346
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.032
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1386
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.0797
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.124
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2044
Legionellosis_Homo sapiens_hsa05134 RELA 0.5892
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1991
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5892
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2044
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.24
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB 2.2933
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2318
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2534
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6128
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2974
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2974
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2485
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6178
Malaria_Homo sapiens_hsa05144 MET 0.6202
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.2485
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6178
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6278
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6243
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.327
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3032
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6509
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.4643
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4296
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6855
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4909
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7359
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7359
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7943
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.5965
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7731
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8173
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7943
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.8256
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7807
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 3.0237
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8233
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7833
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7354
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6544
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8173
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8468
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.988
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8794
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9158
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9767
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0816
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.3584
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3359


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)