TCM Prescription: Xie Li Xiao Capsule



Prescription Description
Prescription IDTCMF681
Pinyin NameXie Li Xiao Jiao Nang 
Chinese Name泻痢消胶囊
English NameXie Li Xiao Capsule
Function Description腹泻, 痢疾
IndicationsDysentery disorder, Diarrhea, Dysentery
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
ME05.1 [Diarrhoea, 腹泻 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1161 Coptis chinensis 酒黄连 TCMH1161 ITSAO4469-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR2B, HTR2C, KDR, MET, MTNR1B, POLA1, POLB, PPARA, SRC, TNKS, TNKS2, XDH 10.2524
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.88446
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 7.88377
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 7.59169
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR2C, MTNR1B 7.45317
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, POLB, PPARA, SRC, TYR 7.26416
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.16451
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, FABP3, HSD11B2, HTR2A, HTR2B, HTR2C, KDR, POLB, SRC 7.1318
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD1, HTR2A, HTR2B, HTR2C, KDR, SRC, TNKS, TNKS2 6.99795
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 6.85223
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 6.83646
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.73612
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, POLB, PPARA, SRC, TYR 6.68957
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, POLB, PPARA, SRC, TYR 6.68957
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, HTR2B, HTR2C, PIM1, PPARA, TBXAS1, TYR, XDH 6.6165
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.37829
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, ESR1, HTR2A, HTR2B, HTR2C 6.23411
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, HTR6, MTNR1A, MTNR1B 6.19392
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.89825
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 5.7635
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.7635
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, HTR2A, HTR2B, HTR2C, KDR, SRC 5.7635
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR 5.71785
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MTNR1A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 5.70966
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.66018
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MTNR1B, PTPN1, SRC, TNKS, TNKS2, XDH 5.66018
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, MTNR1B, POLA1, POLB, SRC 5.65964
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MTNR1B, PTPN1, SRC, TNKS, TNKS2, XDH 5.57412
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.43004
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, KDR, POLB, SRC 5.21371
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, KDR, MET, PIM1, POLB, PPARA, SRC, TNKS2, TYR 5.21371
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, SRC, TYR 5.17685
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.15232
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP12, PIM1, SRC, XDH 5.09389
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MTNR1A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 5.02008
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 4.97906
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, PIM1, PPARA, SRC, TNKS2, TYR 4.94146
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PTPN1, SRC, XDH 4.94146
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 4.86188
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2 4.72046
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 4.72046
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.68858
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP12, POLA1, POLB, PPARA, PTPN1, SRC, TYR 4.60254
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.56093
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MTNR1B, PPARA, PTPN1, SRC 4.55095
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 4.4411
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31201
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 4.31201
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.24663
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC 4.19477
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.16592
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, SRC 4.16517
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.10441
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP12, PIM1 4.05098
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, SRC 4.01879
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, PIM1, POLB, PPARA, SRC, TYR 4.00785
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, MET, PIM1, POLA1, SRC, TYR 4.00785
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.99804
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.99804
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.99001
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.94185
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.91928
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, SRC 3.91928
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, XDH 3.91928
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, PTPN1, SRC, XDH 3.86339
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.81721
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 3.79115
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, MTNR1B 3.79115
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.77324
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR2A, HTR2C, HTR6, MTNR1B 3.69875
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR2A, HTR2C, HTR6, MTNR1B 3.69875
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MET, PPARA, TBXAS1 3.6939
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.57939
[BP] GO:0007210 None HTR2A, HTR2B, HTR2C, HTR6 3.57939
[BP] GO:0098664 None HTR2A, HTR2B, HTR2C, HTR6 3.57939
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.5738
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, HTR2A, HTR2B, HTR2C, HTR6, MTNR1A, MTNR1B, SRC 3.51713
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, GBA2, TYR 3.49912
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH 3.42836
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.42577
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.39888
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.34389
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MTNR1A, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.30223
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, HTR2A 3.30223
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, PIM1, PTPN1, SRC, XDH 3.29476
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH 3.15026
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, SRC 3.13237
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC 3.1285
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11623
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, SRC 3.10432
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD1, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MTNR1A, PTPN1, SRC, XDH 3.09331
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD1, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MTNR1A, PTPN1, SRC, XDH 3.09331
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.06331
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MTNR1A, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.04069
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.02075
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, MTNR1A, MTNR1B, PPARA, SRC 3.00475
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, GBA2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.97847
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, DRD1, HTR2A, HTR2C, HTR6, MTNR1B 2.92527
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, DRD1, HTR2A, HTR2C, HTR6, MTNR1B 2.92527
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, HSD11B2, HTR2A, HTR2B, POLB, PPARA, SRC, TYR 2.91203
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.89961
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR2A, HTR2C, HTR6, MTNR1B 2.89961
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC 2.89961
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MTNR1A, PPARA, SRC, TNKS, TNKS2 2.85803
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, HTR2A 2.85151
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, HTR2A 2.85151
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 2.84866
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MTNR1A, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.8409
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR2A, HTR2C, HTR6, MTNR1B 2.83466
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81369
[BP] GO:0007208 None HTR2A, HTR2C 2.80572
[BP] GO:0009115 None AOX1, XDH 2.80572
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, SRC 2.80267
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, TNKS, TNKS2 2.73738
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, SRC 2.73738
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73311
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.72284
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA 2.68388
[BP] GO:0003018 None ADORA1, CHRM1, DRD1, HTR2A, HTR2B, SRC 2.66709
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1 2.65368
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.57012
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MTNR1A, PPARA, PTPN1, SRC, XDH 2.57012
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.57012
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57012
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2B, HTR2C, KDR, MET, MMP12, PIM1, SRC, TNKS2, XDH 2.56846
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.56076
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MTNR1A, PPARA, PTPN1, SRC, XDH 2.53587
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.50776
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50091
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.46375
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR2A, HTR2C, HTR6, MTNR1B 2.46375
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, MTNR1A, PPARA, SRC, TNKS, TNKS2 2.45512
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.43861
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 2.43861
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.43861
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.41089
[BP] GO:0046110 None AOX1, XDH 2.41089
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41089
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.40186
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.39555
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.39287
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.39287
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.39287
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, PIM1, PTPN1, SRC 2.39012
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MTNR1A, MTNR1B, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.34043
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, ESR1, ESR2, IGF1R, MET, MMP12, PPARA, PTPN1, SRC, XDH 2.33779
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP12, SRC, XDH 2.33599
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.30989
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.29278
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD1, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 2.2835
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28321
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.28321
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.28105
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD1, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, PPARA, PTPN1, SRC 2.27547
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.2738
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, HTR2A 2.2738
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.24691
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC 2.24582
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, HTR2A, MET 2.2444
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MTNR1A, SRC 2.2404
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MTNR1A, MTNR1B, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.2404
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.2404
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC, TYR 2.21235
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.19005
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19005
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.19005
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, POLB, PPARA, SRC 2.19003
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, FLT3, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC, XDH 2.19003
[BP] GO:0070213 None TNKS, TNKS2 2.19003
[BP] GO:0006145 None AOX1, XDH 2.19003
[BP] GO:0038171 None CNR1, CNR2 2.19003
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.19003
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, SRC 2.18715
[BP] GO:0097746 None ADORA1, CHRM1, DRD1, HTR2A, HTR2B 2.18194
[BP] GO:0035296 None ADORA1, CHRM1, DRD1, HTR2A, HTR2B 2.18194
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C 2.18194
[BP] GO:0050795 None ADORA1, CNR1, HTR2A, HTR2B 2.18194
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.18194
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.16868
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.16578
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 2.16578
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.16578
[BP] GO:0003013 None ADORA1, CHRM1, DRD1, HTR2A, HTR2B, SRC 2.14897
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS, XDH 2.14147
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, MMP12, SRC, TYR 2.13425
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1 2.10961
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.09893
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, SRC, XDH 2.09166
[BP] GO:0050880 None ADORA1, CHRM1, DRD1, HTR2A, HTR2B 2.07997
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.07997
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.07997
[BP] GO:0035150 None ADORA1, CHRM1, DRD1, HTR2A, HTR2B 2.06787
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, HTR2A, HTR2B, HTR2C 2.04622
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, SRC 2.04
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.03794
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.03794
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, HTR2B, HTR2C, MMP12, MTNR1B, PTPN1, SRC 2.02849
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.02849
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.02849
[BP] GO:0043696 None CDK6, ESRRB 2.02849
[BP] GO:0043697 None CDK6, ESRRB 2.02849
[BP] GO:0010641 None F3, SRC 2.02849
[BP] GO:0007598 None F10, F3 2.02849
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.00697
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.00697
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, PTPN1, SRC, XDH 2.00399
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SRC 2.00399
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC, TYR 2.00399
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 5.7635
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PIM1, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR 4.35978
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 4.18369
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PTPN1, SRC, TBXAS1, TYR 3.92634
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD1, ESR1, F10, F3, FLT3, GBA2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PIM1, PTPN1, SRC 3.59682
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, SRC 3.46843
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, TBXAS1, TYR 2.55224
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 2.42096
[CC] GO:0031233 None CA4, F10, F3 2.33779
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MTNR1A, MTNR1B, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.23213
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, TBXAS1 2.16737
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 10.0586
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.65223
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 7.90547
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 7.59169
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 7.47617
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 7.47617
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 7.26416
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 7.11436
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.68957
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA 6.62021
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.1868
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 6.08903
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, SRC 5.89825
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.70966
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, HTR2A, HTR2B, HTR2C, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 5.65964
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, HTR2A, HTR2B, HTR2C, HTR6 5.65964
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 5.6383
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 5.54364
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B 5.54364
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.20449
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 5.08697
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.02008
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.97906
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.84265
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, POLA1, SRC, TBXAS1, XDH 4.48554
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.14856
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.06303
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.99804
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.92634
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.91318
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.90161
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PTPN1, TNKS 3.80869
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.79115
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.79115
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 3.62708
[MF] GO:0004993 None HTR2A, HTR2B, HTR2C, HTR6 3.57939
[MF] GO:0099589 None HTR2A, HTR2B, HTR2C, HTR6 3.57939
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, HTR2A, HTR2B, HTR2C, HTR6, MTNR1A, MTNR1B 3.51311
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.44835
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 3.42836
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.40056
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.36113
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.29476
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.25424
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.20898
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, HTR2A, HTR2B, HTR2C 3.05917
[MF] GO:0043176 None HTR2A, HTR2B, HTR2C 3.00608
[MF] GO:0051378 None HTR2A, HTR2B, HTR2C 3.00608
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.91618
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.80572
[MF] GO:0003845 None HSD11B1, HSD11B2 2.80572
[MF] GO:0071886 None HTR2A, HTR2C 2.80572
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.67582
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.43861
[MF] GO:0042165 neurotransmitter binding ACHE, HTR2A, HTR2B, HTR2C 2.43172
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, PIM1, PPARA, PTPN1, SRC 2.41309
[MF] GO:0008502 None MTNR1A, MTNR1B 2.41089
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41089
[MF] GO:0004949 None CNR1, CNR2 2.41089
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.39287
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.36583
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.19003
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.19003
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.19003
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.11793
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, PPARA, PTPN1, SRC 2.09893
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.02849
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.02849


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CHRM4, HTR2B, HTR2C, HTR2A, HTR6, MTNR1A, CNR2, CNR1, MTNR1B, ADORA3, ADORA1, DRD1 10.699
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 10.699
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0007
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9303
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.5382
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, CHRM1, HTR2B, HTR2C, HTR2A, DRD1 4.2237
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.0425
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0425
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 3.3761
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8523
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A, DRD1 3.8108
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.8739
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, HTR2B, HTR2C, HTR2A 3.3761
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, CHRM1, ADORA1, DRD1, PPARA 3.2356
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, MET, IGF1R 2.8962
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.1864
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, HTR2A 2.575
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MET, CDC25B 2.4267
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 2.3786
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.3786
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.3231
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9978
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9974
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.0156
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3 1.6578
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.0156
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 1.6678
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4 1.5945
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, BCL2, MET, IGF1R 1.388
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3826
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.516
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2 1.3313
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2716
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.1977
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 1.086
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2802
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2761
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0201
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2504
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2266
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.049
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2109
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2679
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0097
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.039
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.0201
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9101
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0684
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1223
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2076
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9477
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9846
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.2466
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0293
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1203
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8938
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9101
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3987
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1897
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9101
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8242
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6678
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8069
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8139
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8874
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7194
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.668
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6927
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6321
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6899
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2314
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2314
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5919
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3193
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3415
Alcoholism_Homo sapiens_hsa05034 DRD1 0.3264
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3191
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3858
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3858
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3752
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3858
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3718
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3601
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3945
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3858
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3945
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4047
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4089
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4047
Axon guidance_Homo sapiens_hsa04360 MET 0.3999
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.398
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4634
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4634
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6419
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5807
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.453
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4708
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4835
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.4789
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4707
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4634
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4707
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4835
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4835
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4832
Peroxisome_Homo sapiens_hsa04146 XDH 0.4934
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8517
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5337
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5327
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5458
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5556
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5556
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5556
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5541
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.547
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5659
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5556
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5577
Shigellosis_Homo sapiens_hsa05131 SRC 0.5556
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5884
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6209
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6321
Malaria_Homo sapiens_hsa05144 MET 0.6321
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.6321
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6321
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6321
Bladder cancer_Homo sapiens_hsa05219 SRC 0.6741
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6893
DNA replication_Homo sapiens_hsa03030 POLA1 0.706
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.751
Base excision repair_Homo sapiens_hsa03410 POLB 0.731
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7729
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8069
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.797
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9101
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0106
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9914
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2266


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)