TCM Prescription: Zi Bu Shen Rong Pills



Prescription Description
Prescription IDTCMF6700
Pinyin NameZi Bu Shen Rong Wan
Chinese Name滋补参茸丸
English NameZi Bu Shen Rong Pills
Function Description心悸, 健忘, 遗精, 阳痿
IndicationsInvoluntary ejaculation disorder, Impotence disorder, Forgetfulness disorder, Palpitations, Sexual dysfunction
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
MC81.2 [Palpitations, 心悸 ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH746 Carapax et plastrum testudinis 龟甲 TCMH746
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH2488 Alpinia oxyphylla 益智 TCMH2488 ITSAJ4276-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1329 Arillus longan 龙眼肉 TCMH1329
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH916 Succinus 琥珀 TCMH916
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 14.0877
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, KIT, MAOB, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 13.7375
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AB1, IGF1R, MAOB, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2, SRC, TYR 11.701
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.9661
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6023
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GBA2, HMGCR, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR, XDH 10.6023
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MMP2, PIK3CA, PPARA, PPARG, PTGS2, SRC, TYR 10.162
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.0001
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.82413
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2, SRC, TERT, TYR 9.48087
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 9.13547
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.03291
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, NQO2, PPARG, PTGS1, PTGS2, TYR, XDH 9.02539
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.02539
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 8.58773
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRM1, GRM3, GRM5, GRM8 8.49377
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DNMT1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARG, PTGS1, PTGS2, SRC, TERT, XDH 8.49377
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 8.38882
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.17599
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 8.15139
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.9389
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 7.9389
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 7.9389
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.7996
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.68545
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, HSP90AB1, MAOB, PPARG, PTGS2, SRC, TYR 7.68447
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.66622
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, KIT, MAOB, MMP2, PPARA, PPARG, PTGS2, SRC 7.66622
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP2, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 7.50268
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.40205
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MAOB, MMP9, PTGS2, SRC, TERT 7.39376
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARG, SLC1A1 7.08249
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.99872
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, MAOB, PPARG, PTGS2, SRC, TYR 6.97586
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 6.95353
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, PTGS2 6.77235
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, GRM1, HMGCR, HSP90AB1, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.75354
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 6.7217
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 6.67253
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.56914
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.37316
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.31673
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARG, PTGS2, SRC, TERT 6.30359
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 6.30359
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.26591
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.19688
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG, PTGS1, PTGS2 6.1864
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.18159
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, HSP90AB1, KDR, KIT, MAOB, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, SRC, TERT, TNKS2, TYR 6.18159
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, GRM1, HMGCR, HSD11B2, HSP90AA1, HSP90AB1, KIT, MMP2, PPARA, PPARG, PTGS2, SRC, TERT, TYR 6.15157
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.15077
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.15077
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HMGCR, HSD11B2, HSP90AB1, KDR, MAOB, PPARG, PTGS2, SRC 6.15077
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.14645
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.14645
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, MAOB, PPARA, PPARG, PTGS2, SRC 6.11524
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT 6.11524
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARG, PTGS2, SRC 6.08449
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.06154
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.94813
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, HSP90AB1, NQO2, PTGS1 5.93527
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, HSP90AA1, HSP90AB1, KDR, KIT, MET, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.86947
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, PIK3CA, PIK3CB, PPARG, SRC, TERT 5.85622
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTPN1, SRC, TNKS, TNKS2 5.76303
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.73641
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, GRM1, HMGCR, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.71058
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARG, SLC1A1 5.69913
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 5.69913
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 5.6646
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 5.65854
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR 5.65269
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, GRM5 5.64651
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DRD2, ESRRB, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.64054
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, HMGCR, MAOB, TYR 5.5301
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSP90AB1, KDR, KIT, MAOB, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, SRC, TYR 5.52907
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, SRC, TNKS2, TYR 5.49349
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 5.49349
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KIT, PDE5A, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, TNKS 5.47335
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.44021
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.44021
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.4318
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.42353
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.42353
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, TNKS2 5.42353
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 5.39219
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.32713
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.32713
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.32713
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.30304
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 5.26878
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 5.23992
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 5.21357
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 5.18016
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.15346
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 5.12963
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.12963
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, KIT, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, TERT, TNKS, XDH 5.10059
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.09483
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, KIT, PIK3CA, PPARA, PPARG, SRC, TYR 5.07244
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MAOB, MMP9, PTGS2, TERT 5.06499
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.02287
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 5.01899
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KIT, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 5.01114
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 5.00808
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.9795
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.95422
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.9208
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, HSP90AA1, KDR, MAOB, SRC 4.89417
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PPARG, PTGS1, PTGS2 4.8703
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIM1, PPARG, PTGS2, SLC1A1, SRC, TERT, TNKS2, XDH 4.82643
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.7808
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DRD2, DYRK1A, ESR1, F3, FABP4, HMGCR, HSP90AA1, HSP90AB1, IGF1R, MET, MMP12, MMP2, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 4.7808
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, ESR1, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.7808
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, SRC, TYR 4.77158
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC, TERT, TNKS 4.76769
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS 4.74277
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, HMGCR, HSP90AA1, IGF1R, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.7105
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 4.70785
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS 4.70785
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PPARG, PTGS2, SRC 4.70785
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.67542
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.65904
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TYR 4.65904
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.65576
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.65576
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, MAOB, MMP12, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT 4.64028
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS 4.61883
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PPARG, PTGS2, SRC, TERT 4.60613
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR, XDH 4.60586
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.59811
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PTGS2, SLC1A1 4.57697
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 4.56897
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, KIT, PPARA, PPARG, PTGS2, SRC 4.56897
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.49691
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 4.47803
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, KIT, PDE5A, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, TERT, TNKS, XDH 4.46647
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, MAOB 4.4561
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, SRC 4.40028
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, HMGCR, HSP90AA1, IGF1R, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.37923
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, SRC 4.34627
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.27635
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TYR 4.26029
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, GRIK5, HSP90AA1, HSP90AB1, MAOB, PTGS2, SLC1A1 4.24079
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.23067
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARG, PTGS2, PTPN1, SRC, TERT 4.23067
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.23067
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 4.18788
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DYRK1A, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, HSP90AA1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.17889
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.12837
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, PPARG 4.11363
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 4.11084
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC, TERT 4.08735
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 4.08735
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 4.0847
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, KIT, PTGS2 4.07901
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.05159
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 4.04797
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, HCAR2, HSP90AB1, MMP12, PPARG, PTGS2, SRC, TERT 4.00624
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.00427
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 3.99786
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.99344
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, ESRRB, F3, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIM1, PPARG, PTGS2, SLC1A1, SRC, TERT 3.95596
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 3.94505
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, HSP90AB1, PPARG, PTGS2, SRC 3.91006
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, GRM1, HMGCR, KDR, KIT, PDE5A, PIK3CB, PTPN1, SRC, XDH 3.88863
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, KIT, PPARA, PPARG, SRC 3.86855
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AB1, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 3.86438
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC 3.84275
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.81996
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.77071
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.72125
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 3.7154
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, PTGS2 3.67052
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.66613
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.66386
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOB, TYR 3.65645
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PPARG, SRC 3.64473
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PPARG, PTGS2, SRC 3.63234
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.62994
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR 3.59111
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AB1, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 3.59018
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HMGCR, HSD11B2, KIT, PDE5A, PIK3CA, PTGS2, SRC, TYR 3.55577
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, ESR1, ESR2, F3, FLT3, GRM1, HMGCR, HSP90AB1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.53711
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PPARG, PTGS2, TERT 3.52977
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.51598
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, SRC 3.49217
[BP] GO:0008542 None APP, DRD1, DRD2, HMGCR, KIT 3.47916
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, PPARG, SRC 3.47601
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, ESR1, ESRRA, HCAR2, HSP90AA1, HSP90AB1, KIT, MMP12, MMP2, PDE5A, PIK3CA, PIK3CB, PPARG, PTPN1, SRC 3.47331
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.46048
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 3.42955
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.40952
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.40952
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.38501
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, HMGCR, KIT, PTGS2 3.38482
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.34047
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.34047
[BP] GO:0007632 None APP, DRD1, DRD2, HMGCR, KIT 3.28903
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.27827
[BP] GO:0048169 None APP, DRD2, GRM5, KIT 3.27566
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.26791
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, KIT, PDE5A, PIK3CB, PTPN1, SRC 3.26288
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.24418
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2 3.24418
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, KIT, PPARG, SRC 3.23081
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.23081
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSP90AB1, KIT, PPARG, PTGS2, SRC 3.22984
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.22476
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD1, DRD2, GRM5, HMGCR, KIT, PTGS2 3.21293
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.20966
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, HSP90AB1, KIT, MMP2, MMP9, PPARG, PTGS2, SRC 3.19542
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, PPARG, PTGS2, SRC 3.18266
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.17573
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.17511
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CHRM1, DRD1, DRD2, GRM5, MAOB, MMP9, PTGS2 3.17444
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 3.17444
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.17444
[BP] GO:0008217 None ADORA1, DRD2, HSD11B2, PPARA, PPARG, PTGS1, PTGS2 3.17444
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DRD1, DRD2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 3.17253
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, GRM1, HCAR2, KIT, PDE5A, PTGS2, SLC1A1 3.17041
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 3.12572
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, HSP90AA1, HSP90AB1, IGF1R, SRC, TNKS, TNKS2 3.12014
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, HSP90AB1, KDR, PTGS2, SRC 3.11453
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.1121
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, PDE5A, PIK3CB, PTPN1, SRC, XDH 3.09999
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, KIT, PTGS2 3.09598
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, HMGCR, KIT, PTGS2, TYR 3.08943
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, PDE5A, PTGS2, SLC1A1 3.08943
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, MAOB, PTGS2, SRC 3.08773
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, HMGCR, PTGS2, SRC 3.08773
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, MAOB, PTGS2, SRC 3.05125
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.02204
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 3.01997
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 3.00369
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.99302
[BP] GO:0006937 None ADORA1, CHRM1, CHRM2, CHRM3, KIT, PDE5A, PTGS2 2.99302
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.98683
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.97832
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 2.9676
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 2.96623
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, MAOB, PDE5A, XDH 2.92076
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 2.91764
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.90769
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.90769
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.90769
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, SRC 2.90769
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, PIK3CA, TNKS2 2.8848
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.86634
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOB 2.85857
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, HSP90AA1, HSP90AB1, IGF1R, PIK3CA, PPARG, SRC, TNKS, TNKS2 2.8577
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.82297
[BP] GO:0009115 None AOX1, XDH 2.81063
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.80302
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.80302
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, GRM5, IGF1R, MMP2, PPARG, PTGS2, SRC 2.80302
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, PIK3CA 2.78906
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.78513
[BP] GO:0008306 None APP, DRD1, DRD2, HMGCR, KIT 2.78248
[BP] GO:0042391 None ADORA1, APP, BCL2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.7641
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, KIT, SRC 2.75667
[BP] GO:0051973 positive regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, TNKS 2.74752
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PPARG, PTGS2 2.74741
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, DRD1, ESR1, FLT3, GRM5, IGF1R, KIT, MMP2, PPARG, PTGS2, SRC 2.73558
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGS2, SRC 2.73558
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.70733
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, MAOB 2.7032
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, HMGCR, PTGS2 2.68719
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, HMGCR, PTGS2 2.68719
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HMGCR, HSP90AB1, IGF1R, KIT, PDE5A, PIK3CB, PTPN1, SRC 2.65765
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.63359
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HMGCR, HSP90AB1, KDR, KIT, PDE5A, PIM1, PPARG, PTGS2, SRC, TERT 2.62868
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, DRD2, FABP3, PDE5A, PPARG, PTGS2, TERT, XDH 2.62193
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.61866
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PTGS2, SRC, XDH 2.59505
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PTGS2, SRC, XDH 2.55507
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, KIT, PDE5A, PIK3CB, PTPN1, SRC 2.55047
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, HMGCR, PTGS2 2.549
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, GRM5, IGF1R, MMP2, PPARG, PTGS2, SRC 2.54626
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.54626
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, GBA2, HSP90AA1, MAOB, PDE5A, PIK3CB, SRC, XDH 2.54116
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, HMGCR, PTGS2 2.5362
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.5362
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.52168
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARG, PTGS2, TYR 2.52168
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, PPARG, PTGS2, SRC, TYR 2.52168
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP12, PPARA, PPARG, PTGS2, SRC, TERT, TNKS, TNKS2 2.51653
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, DRD2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, PPARG, SRC, TNKS, TNKS2 2.51429
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HSP90AB1, KIT, PDE5A, PIK3CB, PTPN1, SRC 2.48056
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.48039
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.48039
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.48039
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.46122
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.46122
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.46122
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, MAOB, PTGS2 2.44735
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 2.42703
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, HMGCR, PTGS2, SRC 2.41958
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, MAOB, MMP9, PTGS2 2.41657
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PPARG, PTGS2, SRC, XDH 2.41042
[BP] GO:0099566 None GRM1, GRM5 2.41042
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.41042
[BP] GO:0046110 None AOX1, XDH 2.41042
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41042
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.39384
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, IGF1R, MET, MMP12, PPARA, PPARG, PTPN1, SRC, TERT, TNKS, TNKS2 2.37165
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DYRK1A, HMGCR, HSP90AA1, HSP90AB1, IGF1R, MET, PTGS2, PTPN1, TERT, XDH 2.35897
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB 2.33624
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.32546
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.32477
[BP] GO:0007004 None HSP90AA1, HSP90AB1, TERT 2.32477
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KIT, MMP12, MMP9, PPARA, PPARG, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 2.29547
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PTGS2, SRC, XDH 2.29547
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, SRC, TNKS 2.28781
[BP] GO:0030100 regulation of endocytosis APP, AXL, DRD2, PIK3CB, PPARG, PTPN1, SRC 2.26576
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.26319
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.26319
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, GRM1, GRM5, PIK3CB 2.25462
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.24369
[BP] GO:0048168 None APP, DRD2, GRM5, KIT 2.22996
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HMGCR, KIT, PTGS2, TYR 2.22075
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, MET, MMP12, PPARA, PPARG, PTGS2, SRC, TERT, TNKS, TNKS2 2.19338
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, HSP90AB1, MMP12, MMP2, PPARA, PPARG, PTGS2, PTPN1, SRC 2.19287
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.17686
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, CHRM3, KIT, PDE5A, PTGS2 2.17254
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.17248
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, KDR, KIT, MET, MMP2, MMP9, PPARG, PTGS2, SRC, TERT 2.16448
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 2.15799
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KIT, MMP12, MMP9, PPARA, PPARG, SLC1A1, SRC, TERT, TNKS, XDH 2.15698
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.15698
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.15698
[BP] GO:0070213 None TNKS, TNKS2 2.15698
[BP] GO:0006145 None AOX1, XDH 2.15698
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15698
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.15548
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, KIT, PTPN1, SRC 2.15421
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 2.14619
[BP] GO:0051099 positive regulation of binding APP, HSP90AB1, MET, MMP9, PPARG, TERT 2.13056
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.13009
[BP] GO:1900542 None DRD1, DRD2, ESRRB, GRM3, GRM8, PDE5A, PPARA 2.12636
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, IGF1R, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.12496
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, GRM1, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.12179
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HSP90AA1, HSP90AB1, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT 2.12176
[BP] GO:0007611 None APP, DRD1, DRD2, GRM5, HMGCR, KIT, PTGS2 2.11969
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.11167
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PPARG, PTGS2, SRC, XDH 2.11167
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.11167
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.11167
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.11167
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.10561
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, HSP90AA1, HSP90AB1, KIT, MMP9, SLC1A1, XDH 2.09967
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HMGCR, HSD11B2, PPARG, PTGS2, SRC, TYR 2.09967
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, HCAR2, HMGCR, HSP90AB1, MMP12, PTGS2, PTPN1, SRC 2.09967
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, HSP90AA1, HSP90AB1, PTGS2, XDH 2.06358
[BP] GO:0006140 None DRD1, DRD2, ESRRB, GRM3, GRM8, PDE5A, PPARA 2.06358
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.0599
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0599
[BP] GO:0032409 None ABCB1, APP, BCL2, DRD2, GRM5, MMP9, PPARG 2.0553
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.05495
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.05495
[BP] GO:0030258 lipid modification CYP1A1, CYP3A4, KIT, MET, PIK3CA, PIK3CB, PPARG 2.04706
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, PPARG 2.04259
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KIT, MMP12, MMP9, PPARA, PPARG, SLC1A1, SRC, TNKS, XDH 2.04219
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.0373
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 2.02686
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, HSP90AA1, HSP90AB1, TERT, TNKS 2.02338
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, KIT, PTPN1, SRC 2.02065
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.01433
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.01433
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.00979
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, DRD2, HCAR2, HSP90AB1, MMP12, PTGS2, SRC 2.0077
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MET, PTGS2, SLC1A1, SRC 7.68447
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR 6.14645
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 5.54478
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.65576
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SRC, TERT 4.59853
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, PTGS2, SLC1A1, SRC 4.56897
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 4.55505
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 4.49195
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 4.2646
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.24599
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 3.81996
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1, SRC 3.50387
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1, SRC 3.50387
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 3.47916
[CC] GO:0120025 None ADORA1, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 3.38761
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.29881
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.29881
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, KIT, MAOB, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.23078
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.14703
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 3.09478
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.09085
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.02296
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2, GRIK5 2.91651
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.78906
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.75529
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.60484
[CC] GO:0031090 None ALOX5, APP, BACE1, BCL2, CA4, CHRM2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, FUT7, GBA2, GRIA2, GRIA4, HMGCR, HSP90AB1, MAOB, PTGS1, PTGS2, SRC, TNKS, TNKS2, TYR 2.33834
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.26319
[CC] GO:0097458 None ADORA1, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, SRC 2.14964
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.14524
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.13009
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, HSP90AA1, HSP90AB1, SRC 2.11548
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, GRIK5, HMGCR, KDR, PTGS2, PTPN1, XDH 2.03438
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTPN1, TNKS, TYR, XDH 17.2442
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.7881
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK1A, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 14.1107
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR, XDH 13.4891
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 9.88857
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.74429
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.32653
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DYRK1A, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, SRC 8.55547
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.53086
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 8.34559
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARG, PTPN1, TNKS 8.33511
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG 8.19222
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, TERT, TNKS, TNKS2, TYR, XDH 8.15139
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.08699
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD11B2, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, SRC, XDH 7.9389
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.73132
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.66622
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG 7.50268
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.46321
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG 7.15924
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 6.97586
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 6.84309
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 6.4909
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, TERT, TNKS, TNKS2, TYR, XDH 6.37316
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.37316
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG 6.29866
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.19549
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.14645
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARG 5.86947
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARG 5.86947
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.5301
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.35816
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, FLT3, GRIK5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP9, NQO2, PPARG, PTGS2, TERT, TYR, XDH 5.10059
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.74212
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 4.70785
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 4.70785
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.56897
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, SRC 4.48856
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARG, SLC1A1, SRC, XDH 4.4458
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 4.29221
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.18494
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.97533
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.80798
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.62994
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 3.48343
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.46048
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, XDH 3.27566
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.27541
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, XDH 3.27518
[MF] GO:0042803 protein homodimerization activity ACHE, AOX1, BCL2, DRD2, FLT3, HMGCR, HSP90AA1, HSP90AB1, KIT, MAOB, NQO2, PTGS2, TERT, TYR, XDH 3.23066
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.17444
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.17444
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.14933
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARG, SLC1A1, SRC, XDH 3.09457
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.07344
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.01997
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.90769
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.90769
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.81063
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81063
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81063
[MF] GO:0008389 None CYP2A13, CYP2A6 2.81063
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PPARG 2.77429
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, XDH 2.7032
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.69974
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.66506
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, AOX1, AXL, BCL2, DRD2, FLT3, HMGCR, HSP90AA1, HSP90AB1, KIT, MAOB, NQO2, PPARG, PTGS2, TERT, TYR, XDH 2.65335
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSP90AA1, HSP90AB1, KIT, MET, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS2 2.5362
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NQO2 2.45812
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.44735
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41042
[MF] GO:0099583 None GRM1, GRM5 2.41042
[MF] GO:0008081 None ADORA1, CHRM1, CHRM3, CHRM5, PDE5A 2.33624
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.32034
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 2.32033
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.30678
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.26319
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.26319
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.2003
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MAOB, MET, MMP12, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT, XDH 2.17686
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.16528
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15698
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.15698
[MF] GO:0004971 None GRIA2, GRIA4 2.15698
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.15698
[MF] GO:0043621 protein self-association ACHE, DYRK1A, FLT3, PPARG 2.15548
[MF] GO:0019902 phosphatase binding BCL2, HMGCR, MET, PPARA, PPARG, PTPN1 2.12179


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.9223
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4 9.4859
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 8.7587
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.3655
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.5907
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, IGF1R, CDK6, PIK3CA, KIT, BCL2, PPARG, MET 7.8897
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.6529
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA, GRIA4 7.2768
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 8.3343
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, MAOB, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.6811
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PIK3CB 6.0416
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, CDK6, HSP90AB1, CHRM1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 5.9842
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.9889
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 5.6799
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.2347
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.5114
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP2D6, CYP1A2, AOX1, CYP3A4 5.0201
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, PIK3CA, BCL2, PIK3CB, IGF1R 4.4594
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, KIT, GRM8, PIK3CB, GRM1 4.3453
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KIT, KDR, PIK3CB, DRD2, MET, IGF1R 4.278
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.2334
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, CDC25B, IGF1R 4.278
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9348
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, DRD1, DRD2 4.5096
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.278
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, CYP2D6, ALOX5, PTGS2, PTGS1 4.0231
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, DRD1, GRM1 3.9031
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.1654
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.6203
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.0105
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 3.9154
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.0452
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9031
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.5141
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB 3.507
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 3.9622
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8665
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.587
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.2979
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD1, DRD2, GRM1 3.5504
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 2.9772
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PPARG, PIK3CB, HMGCR, IGF1R 2.9303
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 2.5953
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, DRD1, DRD2, GRIA4 2.8693
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.5117
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 2.9846
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PDE5A, PIK3CB 2.4202
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, DRD1, GRIA4 2.9531
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.2991
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PPARG, PIK3CB, IGF1R 2.4733
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.3492
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.0539
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.7368
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2662
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.2735
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 2.8748
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6847
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.1369
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.1826
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.1826
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.1826
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.035
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.7552
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.0175
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 1.9566
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.8114
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.5016
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1516
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.4853
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2287
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3025
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.2858
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.6267
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.4224
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PPARG, PIK3CB 1.3296
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.2004
Axon guidance_Homo sapiens_hsa04360 MET 0.3347
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.7418
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3424
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.2893
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.3296
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.224
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.2418
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2 1.1229
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.678
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.0776
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4048
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 1.9296
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.6256
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.5795
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.0395
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4232
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6402
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6232
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.6256
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 0.7959
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.1826
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7445
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.0483
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4394
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7562
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4394
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.035
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4394
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.7703
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1151
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.035
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4394
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4394
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4464
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8147
Peroxisome_Homo sapiens_hsa04146 XDH 0.4521
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.081
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.035
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9151
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4671
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.9435
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.9743
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9259
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9872
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9435
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9618
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9259
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 0.9408
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9578
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9872
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9492
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.493
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0395
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0051
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5056
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5081
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.122
Shigellosis_Homo sapiens_hsa05131 SRC 0.5274
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5303
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.1153
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.0884
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.1655
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1357
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.5555
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1655
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2437
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.3771
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.2761
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.3296
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2528
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6183
Malaria_Homo sapiens_hsa05144 MET 0.6232
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6256
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3341
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6256
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6256
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.3787
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6402
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.6778
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6362
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4224
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6735
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.504
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7867
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.766
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7185
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7867
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5864
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6747
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7418
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8153
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8063
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8447
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9172
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8771
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9535
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9435
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9965
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0094
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2915


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)