| GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
|
[BP] GO:0065008 |
regulation of biological quality
|
ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MIF, MTNR1B, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH |
15.3067 |
|
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
14.4358 |
|
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
14.4358 |
|
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
13.2747 |
|
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
12.607 |
|
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
12.4445 |
|
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
11.7159 |
|
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
11.7159 |
|
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH |
11.1125 |
|
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
11.0497 |
|
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH |
11.0184 |
|
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.9858 |
|
[BP] GO:0042221 |
response to chemical
|
ABCG2, ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TYR |
10.7548 |
|
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, DRD1, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.7548 |
|
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, DRD1, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.7548 |
|
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
10.6508 |
|
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH |
10.5623 |
|
[BP] GO:0042592 |
homeostatic process
|
ABCG2, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, PIK3CA, PIK3CB, SMAD3, SRC |
10.1764 |
|
[BP] GO:1901700 |
response to oxygen-containing compound
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR |
10.0606 |
|
[BP] GO:0032879 |
regulation of localization
|
ACHE, ADORA1, ADORA3, ADRB2, APEX1, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK |
10.0144 |
|
[BP] GO:0007187 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, DRD1, GRM1, GRM3, GRM5, GRM8, HTR6, MTNR1A, MTNR1B |
9.85191 |
|
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH |
9.69862 |
|
[BP] GO:0048518 |
positive regulation of biological process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH |
9.66929 |
|
[BP] GO:0010033 |
response to organic substance
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
9.51705 |
|
[BP] GO:0050896 |
response to stimulus
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR |
9.40324 |
|
[BP] GO:0044281 |
small molecule metabolic process
|
ABCG2, AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH |
9.17551 |
|
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
9.17551 |
|
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 |
9.16854 |
|
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK |
9.01638 |
|
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK |
9.00149 |
|
[BP] GO:0051966 |
regulation of synaptic transmission, glutamatergic
|
ADORA1, DRD1, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 |
8.36784 |
|
[BP] GO:0003018 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, DRD1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2, SRC, TEK |
8.32325 |
|
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK |
8.32325 |
|
[BP] GO:0048878 |
chemical homeostasis
|
ABCG2, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, PIK3CA, PIK3CB, SMAD3 |
8.29913 |
|
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
8.28825 |
|
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, DRD1, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 |
8.24528 |
|
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, DRD1, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 |
8.24528 |
|
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CYP19A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TYR |
8.18681 |
|
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK |
8.07055 |
|
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, APEX1, BCL2, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
8.01934 |
|
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
7.93435 |
|
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
7.93339 |
|
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
7.93339 |
|
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.93305 |
|
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ADRB2, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH |
7.91941 |
|
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
7.83205 |
|
[BP] GO:0051049 |
regulation of transport
|
ACHE, ADORA1, ADRB2, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, MIF, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
7.72476 |
|
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
7.57333 |
|
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, AURKB, BCL2, CA2, CA7, DRD1, EGFR, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PTGS2, SRC |
7.50355 |
|
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR |
7.46188 |
|
[BP] GO:0007268 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, MTNR1B, SLC1A1 |
7.44704 |
|
[BP] GO:0098916 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, MTNR1B, SLC1A1 |
7.44704 |
|
[BP] GO:0099536 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, MTNR1B, SLC1A1 |
7.32856 |
|
[BP] GO:0099537 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, MTNR1B, SLC1A1 |
7.32856 |
|
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ADRB2, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH |
7.32856 |
|
[BP] GO:0009719 |
response to endogenous stimulus
|
ADRB2, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK |
7.29302 |
|
[BP] GO:0007186 |
G-protein coupled receptor signaling pathway
|
ADORA1, ADORA3, ADRB1, ADRB2, CA2, CHRM1, CHRM2, CHRM4, DRD1, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, INSR, MTNR1A, MTNR1B, PIK3CA, PIK3CB, SRC |
7.20931 |
|
[BP] GO:0007188 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, DRD1, GRM1, GRM3, GRM5, GRM8 |
7.20763 |
|
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.1649 |
|
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP1B1, DRD1, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK |
7.15791 |
|
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
7.15101 |
|
[BP] GO:0003013 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, DRD1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2, SRC, TEK |
7.12879 |
|
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR2A, HTR2C, MTNR1B, PRKCA |
7.12387 |
|
[BP] GO:0007200 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, ESR1, GRM5, HTR2A, HTR2B, HTR2C |
7.05613 |
|
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA6, CA7, CA9 |
7.05613 |
|
[BP] GO:0032270 |
positive regulation of cellular protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.05215 |
|
[BP] GO:0097746 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, DRD1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
6.99347 |
|
[BP] GO:0035296 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, DRD1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
6.99347 |
|
[BP] GO:0031399 |
regulation of protein modification process
|
ADORA1, ADRB2, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
6.9902 |
|
[BP] GO:0065009 |
regulation of molecular function
|
ADORA1, ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.96088 |
|
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
6.95426 |
|
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.90555 |
|
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, ADRB2, AXL, BCL2, CA1, CHRM4, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK |
6.85941 |
|
[BP] GO:0007154 |
None
|
ADORA1, ADRB1, ADRB2, AXL, BCL2, CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, MTNR1B, PTGS2, SLC1A1, TEK |
6.79972 |
|
[BP] GO:0050880 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, DRD1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
6.77467 |
|
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 |
6.77467 |
|
[BP] GO:0035150 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, DRD1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
6.74708 |
|
[BP] GO:0043405 |
regulation of MAP kinase activity
|
ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, PTPN1, SRC |
6.73034 |
|
[BP] GO:0070887 |
cellular response to chemical stimulus
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC |
6.71541 |
|
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGS1, PTGS2, TBXAS1 |
6.71541 |
|
[BP] GO:0007267 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, MTNR1B, SLC1A1, TEK |
6.71541 |
|
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TEK, TOP1, XDH |
6.66224 |
|
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
6.62222 |
|
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK |
6.58611 |
|
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, DRD1, EGFR, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
6.55111 |
|
[BP] GO:0007215 |
None
|
GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
6.52404 |
|
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, EGFR, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR |
6.5109 |
|
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGS1, PTGS2, TBXAS1 |
6.48279 |
|
[BP] GO:0042493 |
response to drug
|
ABCG2, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, EGFR, FABP3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC, TOP1 |
6.47801 |
|
[BP] GO:0031401 |
positive regulation of protein modification process
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
6.47366 |
|
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC, TEK |
6.42556 |
|
[BP] GO:0071310 |
cellular response to organic substance
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC |
6.42426 |
|
[BP] GO:0009987 |
cellular process
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
6.4136 |
|
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, HMGCR, HSD17B1, HSD17B2 |
6.36799 |
|
[BP] GO:0030335 |
positive regulation of cell migration
|
BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
6.28447 |
|
[BP] GO:0007193 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, GRM1, GRM3, GRM5, GRM8 |
6.27718 |
|
[BP] GO:0043549 |
regulation of kinase activity
|
ADORA1, ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
6.27718 |
|
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK |
6.27467 |
|
[BP] GO:0044057 |
None
|
ADORA1, ADORA3, ADRB1, ADRB2, CHRM1, CHRM2, EGFR, GPR35, GRM1, HCAR2, HTR2A, HTR2C, PRKCA, PTGS2, SLC1A1, SMAD3 |
6.25495 |
|
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TEK, TOP1, XDH |
6.25495 |
|
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HTR2A, HTR2B, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR |
6.24352 |
|
[BP] GO:0008152 |
metabolic process
|
ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
6.23048 |
|
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
6.2122 |
|
[BP] GO:0048583 |
regulation of response to stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.15177 |
|
[BP] GO:2000147 |
positive regulation of cell motility
|
BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
6.11885 |
|
[BP] GO:0023052 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, MTNR1B, SLC1A1, TEK |
6.08634 |
|
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH |
6.05449 |
|
[BP] GO:0045859 |
regulation of protein kinase activity
|
ADORA1, ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC |
6.05301 |
|
[BP] GO:0051716 |
cellular response to stimulus
|
ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A |
6.02745 |
|
[BP] GO:0051272 |
positive regulation of cellular component movement
|
BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
5.97386 |
|
[BP] GO:0019369 |
arachidonic acid metabolic process
|
CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 |
5.97386 |
|
[BP] GO:0033674 |
positive regulation of kinase activity
|
ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
5.96749 |
|
[BP] GO:0070372 |
regulation of ERK1 and ERK2 cascade
|
DUSP3, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, PTPN1, SRC, TEK |
5.93401 |
|
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC, TEK |
5.93401 |
|
[BP] GO:0065007 |
biological regulation
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP1, TOP2A, XDH |
5.88862 |
|
[BP] GO:0014070 |
response to organic cyclic compound
|
ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TEK, TYR |
5.85471 |
|
[BP] GO:0040017 |
positive regulation of locomotion
|
BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK |
5.78858 |
|
[BP] GO:0051338 |
regulation of transferase activity
|
ADORA1, ADRB2, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
5.78059 |
|
[BP] GO:0048511 |
rhythmic process
|
AXL, BCL2, CSNK2A1, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, RORC, SRC, TOP1, TOP2A |
5.77896 |
|
[BP] GO:0044237 |
cellular metabolic process
|
ABCG2, ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
5.71644 |
|
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, BCL2, CA2, CHRM1, CHRM2, CYP1B1, EGFR, ESR1, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH |
5.68681 |
|
[BP] GO:0009725 |
response to hormone
|
AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK |
5.68681 |
|
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK |
5.6766 |
|
[BP] GO:0006468 |
protein phosphorylation
|
AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK, TOP1 |
5.65373 |
|
[BP] GO:0071900 |
regulation of protein serine/threonine kinase activity
|
ADORA1, ADRB2, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, PTPN1, SRC |
5.63877 |
|
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
ADRB2, AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC |
5.63267 |
|
[BP] GO:0050801 |
ion homeostasis
|
ABCG2, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
5.61006 |
|
[BP] GO:0045860 |
positive regulation of protein kinase activity
|
ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC |
5.52765 |
|
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
5.49863 |
|
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ABCG2, ACHE, ADRB2, AKR1B1, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH |
5.47873 |
|
[BP] GO:0051347 |
positive regulation of transferase activity
|
ADORA1, ADRB2, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
5.47337 |
|
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK |
5.33623 |
|
[BP] GO:0070374 |
positive regulation of ERK1 and ERK2 cascade
|
EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, SRC, TEK |
5.31787 |
|
[BP] GO:0032268 |
regulation of cellular protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.28913 |
|
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, F3, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PTGS2, SLC1A1, SMAD3, SRC, TEK |
5.28027 |
|
[BP] GO:0043085 |
positive regulation of catalytic activity
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH |
5.27053 |
|
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC |
5.26372 |
|
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
5.26372 |
|
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 |
5.20449 |
|
[BP] GO:1903725 |
regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK |
5.1762 |
|
[BP] GO:0033993 |
response to lipid
|
ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR |
5.1762 |
|
[BP] GO:0043406 |
positive regulation of MAP kinase activity
|
ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MIF, PIK3CB, PTPN1, SRC |
5.15742 |
|
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGS1, PTGS2, TBXAS1 |
5.14531 |
|
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
5.14063 |
|
[BP] GO:0009894 |
regulation of catabolic process
|
ADORA1, ADRB2, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1, SMAD3 |
5.13743 |
|
[BP] GO:0007196 |
None
|
GRM1, GRM3, GRM5, GRM8 |
5.13249 |
|
[BP] GO:0071073 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
5.13249 |
|
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, DRD1, HTR2A, HTR2B, HTR2C, KDR, SRC |
5.13196 |
|
[BP] GO:0098771 |
inorganic ion homeostasis
|
ABCG2, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
5.10876 |
|
[BP] GO:0006805 |
xenobiotic metabolic process
|
CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NQO2, PTGS1, RORC |
5.0516 |
|
[BP] GO:0055082 |
cellular chemical homeostasis
|
ABCG2, BCL2, CA2, CA7, DRD1, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 |
5.02166 |
|
[BP] GO:0008283 |
cell proliferation
|
ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, SRC, TEK, TYR |
5.01485 |
|
[BP] GO:0048871 |
multicellular organismal homeostasis
|
ADORA1, ADRB1, ADRB2, AKR1B1, DRD1, HTR2A, MET, PIK3CA |
4.94615 |
|
[BP] GO:0016310 |
phosphorylation
|
AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1 |
4.942 |
|
[BP] GO:0071902 |
positive regulation of protein serine/threonine kinase activity
|
ADORA1, ADRB2, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MIF, PIK3CB, PTPN1, SRC |
4.87662 |
|
[BP] GO:0044093 |
positive regulation of molecular function
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH |
4.86878 |
|
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, ADRB2, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC |
4.86063 |
|
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK |
4.85015 |
|
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, ADRB2, BCL2, DRD1, DUSP3, EGFR, ESR1, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH |
4.82311 |
|
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, ADRB2, BCL2, DRD1, DUSP3, EGFR, ESR1, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH |
4.80185 |
|
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, HMGCR |
4.76937 |
|
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
4.75273 |
|
[BP] GO:0032101 |
regulation of response to external stimulus
|
ADORA1, CYP19A1, DRD1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MIF, MMP12, PPARA, PRKCA, PTGS2, SMAD3, TEK |
4.72001 |
|
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 |
4.71842 |
|
[BP] GO:0019725 |
cellular homeostasis
|
ABCG2, APEX1, BCL2, CA2, CA7, DRD1, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 |
4.70282 |
|
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 |
4.55699 |
|
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH |
4.54594 |
|
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK |
4.54125 |
|
[BP] GO:0051246 |
regulation of protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.51807 |
|
[BP] GO:0090087 |
None
|
ACHE, ADORA1, CA2, CHRM1, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
4.51628 |
|
[BP] GO:0055080 |
cation homeostasis
|
ABCG2, BCL2, CA2, CA7, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
4.50576 |
|
[BP] GO:0080134 |
regulation of response to stress
|
ADORA1, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.50335 |
|
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK |
4.49253 |
|
[BP] GO:0001659 |
None
|
ADORA1, ADRB1, ADRB2, DRD1, HTR2A |
4.45159 |
|
[BP] GO:0014065 |
phosphatidylinositol 3-kinase signaling
|
HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB |
4.45159 |
|
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
4.43419 |
|
[BP] GO:0050789 |
regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP1, TOP2A, XDH |
4.43091 |
|
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 |
4.41699 |
|
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.38006 |
|
[BP] GO:0032845 |
None
|
ADORA1, BCL2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, SRC |
4.3455 |
|
[BP] GO:0007216 |
None
|
GRM1, GRM3, GRM5, GRM8 |
4.33165 |
|
[BP] GO:0030003 |
cellular cation homeostasis
|
ABCG2, BCL2, CA2, CA7, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
4.29714 |
|
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 |
4.29714 |
|
[BP] GO:0010243 |
response to organonitrogen compound
|
ADRB2, AKR1B1, APEX1, DRD1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR |
4.20909 |
|
[BP] GO:0035556 |
intracellular signal transduction
|
ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, DRD1, EGFR, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK |
4.20058 |
|
[BP] GO:0051050 |
positive regulation of transport
|
ACHE, ADORA1, ADRB2, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, EGFR, HCAR2, HTR2B, INSR, MIF, MMP12, PTGS2, SMAD3, SRC |
4.19597 |
|
[BP] GO:0006873 |
cellular ion homeostasis
|
ABCG2, BCL2, CA2, CA7, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
4.18137 |
|
[BP] GO:0048513 |
animal organ development
|
ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR |
4.15724 |
|
[BP] GO:0072507 |
divalent inorganic cation homeostasis
|
BCL2, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
4.14735 |
|
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC |
4.14193 |
|
[BP] GO:0006721 |
terpenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR |
4.11381 |
|
[BP] GO:0050794 |
regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
4.10505 |
|
[BP] GO:1903530 |
regulation of secretion by cell
|
ACHE, ADORA1, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, SRC |
4.1012 |
|
[BP] GO:0071071 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
4.1012 |
|
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK, TOP1, TOP2A |
4.09721 |
|
[BP] GO:0007190 |
None
|
ADORA3, ADRB1, ADRB2, DRD1, PRKCA |
4.09721 |
|
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC |
4.09721 |
|
[BP] GO:1901652 |
response to peptide
|
ADRB2, AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK |
4.08251 |
|
[BP] GO:0051701 |
interaction with host
|
AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC |
4.07605 |
|
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
4.07192 |
|
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC |
4.06525 |
|
[BP] GO:0007197 |
None
|
CHRM1, CHRM2, CHRM4 |
4.03286 |
|
[BP] GO:0010513 |
None
|
HTR2A, HTR2B, HTR2C |
4.03286 |
|
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH |
4.00814 |
|
[BP] GO:0097756 |
None
|
ADORA1, HMGCR, HTR2A, HTR2B, PTGS2 |
3.99888 |
|
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
3.98693 |
|
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ADRB2, BCL2, CYP19A1, DRD1, DUSP3, EGFR, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
3.85451 |
|
[BP] GO:0002791 |
None
|
ACHE, ADORA1, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, SRC |
3.83444 |
|
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 |
3.83221 |
|
[BP] GO:1901698 |
response to nitrogen compound
|
ADRB2, AKR1B1, APEX1, DRD1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR |
3.8258 |
|
[BP] GO:0007610 |
None
|
BCL2, DRD1, EGFR, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, MTNR1A, PPARA, PTGS2 |
3.81371 |
|
[BP] GO:1900542 |
None
|
ADRB1, DRD1, GRM3, GRM8, HTR2A, INSR, MTNR1A, PPARA, PRKCA |
3.80128 |
|
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, ADRB2, CA2, CA7, DRD1, EGFR, PTGS2 |
3.80011 |
|
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC |
3.79478 |
|
[BP] GO:0055065 |
metal ion homeostasis
|
ABCG2, BCL2, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
3.77613 |
|
[BP] GO:0003008 |
None
|
ADORA1, ADRB1, ADRB2, AKR1B1, BCL2, CHRM1, CYP1B1, DRD1, EGFR, GRM1, GRM5, GRM8, HMGCR, HTR2A, HTR2B, INSR, PIK3CA, PTGS2, SRC, TEK, TYR |
3.76718 |
|
[BP] GO:0007207 |
None
|
CHRM1, CHRM2, CHRM4 |
3.76331 |
|
[BP] GO:0016098 |
monoterpenoid metabolic process
|
CYP1A2, CYP2D6, CYP3A4 |
3.76331 |
|
[BP] GO:0051046 |
None
|
ACHE, ADORA1, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, SRC |
3.75754 |
|
[BP] GO:0006874 |
cellular calcium ion homeostasis
|
BCL2, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
3.7575 |
|
[BP] GO:0016477 |
cell migration
|
AXL, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK |
3.74888 |
|
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK |
3.72001 |
|
[BP] GO:0006140 |
None
|
ADRB1, DRD1, GRM3, GRM8, HTR2A, INSR, MTNR1A, PPARA, PRKCA |
3.71375 |
|
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
3.65064 |
|
[BP] GO:0055074 |
calcium ion homeostasis
|
BCL2, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
3.63734 |
|
[BP] GO:0038083 |
peptidyl-tyrosine autophosphorylation
|
EGFR, IGF1R, INSR, KDR, SRC |
3.62556 |
|
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
ADRB2, AKR1B1, APEX1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC |
3.6193 |
|
[BP] GO:0032787 |
None
|
ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, MIF, PPARA, PTGS1, PTGS2, TBXAS1 |
3.60813 |
|
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
3.60757 |
|
[BP] GO:0072503 |
cellular divalent inorganic cation homeostasis
|
BCL2, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
3.59244 |
|
[BP] GO:0042391 |
None
|
ADORA1, ADRB2, BCL2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC |
3.57465 |
|
[BP] GO:0006875 |
cellular metal ion homeostasis
|
ABCG2, BCL2, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 |
3.56038 |
|
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, HMGCR, KDR, SRC |
3.55697 |
|
[BP] GO:0040016 |
embryonic cleavage
|
PIK3CB, TOP1, TOP2A |
3.55282 |
|
[BP] GO:0009820 |
alkaloid metabolic process
|
CYP1A2, CYP2D6, CYP3A4 |
3.55282 |
|
[BP] GO:0010511 |
None
|
HTR2A, HTR2B, HTR2C |
3.55282 |
|
[BP] GO:0001505 |
regulation of neurotransmitter levels
|
ACHE, CYP1B1, DRD1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3 |
3.53783 |
|
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, HSPA1A, HTR2C, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A |
3.49394 |
|
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK |
3.48684 |
|
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC |
3.48684 |
|
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
ADRB2, AKR1B1, APEX1, DRD1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC |
3.4535 |
|
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.44494 |
|
[BP] GO:0007210 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.44494 |
|
[BP] GO:0098664 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.44494 |
|
[BP] GO:0009895 |
negative regulation of catabolic process
|
ADORA1, BCL2, EGFR, HCAR2, HTR2B, MET, PIK3CA, PPARA, SMAD3 |
3.44494 |
|
[BP] GO:0046883 |
regulation of hormone secretion
|
ADORA1, CYP19A1, EGFR, HCAR2, HMGCR, HTR2A, HTR2C, MTNR1B, PRKCA |
3.44494 |
|
[BP] GO:0015711 |
organic anion transport
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 |
3.41906 |
|
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK |
3.39472 |
|
[BP] GO:0050890 |
None
|
ADORA1, CHRM1, DRD1, EGFR, GRM5, HMGCR, HTR2A, INSR, PTGS2 |
3.33389 |
|
[BP] GO:1901699 |
cellular response to nitrogen compound
|
ADRB2, AKR1B1, APEX1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC |
3.32892 |
|
[BP] GO:0043065 |
positive regulation of apoptotic process
|
BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH |
3.32245 |
|
[BP] GO:0043269 |
regulation of ion transport
|
ADORA1, ADRB2, BCL2, CA2, CA7, CHRM1, DRD1, GPR35, GRM5, HTR2A, MIF, MMP9, PTGS2 |
3.31618 |
|
[BP] GO:0040011 |
locomotion
|
AXL, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK |
3.3011 |
|
[BP] GO:0048870 |
cell motility
|
AXL, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK |
3.28372 |
|
[BP] GO:0043068 |
positive regulation of programmed cell death
|
BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH |
3.28224 |
|
[BP] GO:0008217 |
None
|
ADORA1, ADRB1, ADRB2, PPARA, PTGS1, PTGS2, SMAD3 |
3.27371 |
|
[BP] GO:0032103 |
positive regulation of response to external stimulus
|
EGFR, F3, FABP4, KDR, MET, MIF, PRKCA, PTGS2, SMAD3 |
3.25877 |
|
[BP] GO:0009266 |
None
|
ADORA1, ADRB1, ADRB2, HSPA1A, HTR2A, HTR2B, PTGS2 |
3.25877 |
|
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC |
3.22439 |
|
[BP] GO:0070201 |
None
|
ACHE, BCL2, CHRM1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
3.21871 |
|
[BP] GO:0071704 |
organic substance metabolic process
|
ABCG2, ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
3.21243 |
|
[BP] GO:0051828 |
entry into other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
3.20879 |
|
[BP] GO:0051806 |
entry into cell of other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
3.20879 |
|
[BP] GO:0030260 |
entry into host cell
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
3.20879 |
|
[BP] GO:0044409 |
entry into host
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
3.20879 |
|
[BP] GO:0051482 |
None
|
DRD1, GPR35, GRM1, HTR2C |
3.20621 |
|
[BP] GO:0033032 |
regulation of myeloid cell apoptotic process
|
BCL2, HCAR2, MIF, PIK3CB |
3.20621 |
|
[BP] GO:0050873 |
None
|
ADRB1, ADRB2, FABP4, PTGS2 |
3.20621 |
|
[BP] GO:0070988 |
demethylation
|
APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 |
3.20621 |
|
[BP] GO:0051480 |
regulation of cytosolic calcium ion concentration
|
DRD1, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, SMAD3 |
3.20621 |
|
[BP] GO:1903522 |
None
|
ADORA1, ADORA3, ADRB1, CHRM1, CHRM2, EGFR, HTR2A, PTGS2, SLC1A1 |
3.20621 |
|
[BP] GO:0001952 |
regulation of cell-matrix adhesion
|
BCL2, KDR, PIK3CB, SMAD3, SRC, TEK |
3.17153 |
|
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 |
3.14457 |
|
[BP] GO:0048015 |
phosphatidylinositol-mediated signaling
|
HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB |
3.14457 |
|
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK |
3.14289 |
|
[BP] GO:2001242 |
regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
3.14287 |
|
[BP] GO:0090066 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, DRD1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
3.14186 |
|
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, PRKCA, SRC |
3.12278 |
|
[BP] GO:0044236 |
multicellular organism metabolic process
|
ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9 |
3.11137 |
|
[BP] GO:2001225 |
regulation of chloride transport
|
CA2, CA7, GRM5 |
3.1002 |
|
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
3.1002 |
|
[BP] GO:0032846 |
positive regulation of homeostatic process
|
AURKB, CA2, CA7, DRD1, EGFR, HCAR2, PIK3CB, PTGS2 |
3.07494 |
|
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH |
3.07351 |
|
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC |
3.07108 |
|
[BP] GO:0050805 |
negative regulation of synaptic transmission
|
ACHE, ADORA1, DRD1, HTR2A, PTGS2 |
3.06055 |
|
[BP] GO:0046889 |
None
|
FABP3, HTR2A, HTR2B, HTR2C, PTGS2 |
3.06055 |
|
[BP] GO:0048017 |
inositol lipid-mediated signaling
|
HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB |
3.06055 |
|
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH |
3.05134 |
|
[BP] GO:0006940 |
None
|
ADORA1, ADRB2, CHRM1, CHRM2, PTGS2 |
3.0311 |
|
[BP] GO:0050730 |
None
|
ADORA1, EGFR, FLT3, GRM5, HTR2A, MIF, PTPN1, SRC |
3.01974 |
|
[BP] GO:0007568 |
aging
|
APEX1, AURKB, BCL2, CYP1A1, HMGCR, HTR2A, MIF, PTGS2 |
3.01974 |
|
[BP] GO:0007346 |
regulation of mitotic cell cycle
|
APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TOP2A |
3.00944 |
|
[BP] GO:0042596 |
None
|
ADRB1, BCL2, DRD1, HTR2C |
3.00656 |
|
[BP] GO:0010942 |
positive regulation of cell death
|
BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH |
2.99801 |
|
[BP] GO:0019371 |
None
|
PTGS1, PTGS2, TBXAS1 |
2.98538 |
|
[BP] GO:2000377 |
regulation of reactive oxygen species metabolic process
|
BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH |
2.98372 |
|
[BP] GO:0010863 |
positive regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B |
2.9592 |
|
[BP] GO:0001503 |
ossification
|
ALPL, BCL2, EGFR, MMP2, MMP9, TEK |
2.95873 |
|
[BP] GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation
|
ADORA1, FLT3, GRM5, HTR2A, MIF, PTPN1, SRC |
2.9228 |
|
[BP] GO:0042180 |
None
|
AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR |
2.92065 |
|
[BP] GO:0032147 |
activation of protein kinase activity
|
ADORA1, ADRB2, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC |
2.91983 |
|
[BP] GO:0050679 |
None
|
EGFR, F3, HTR2B, KDR, MMP12, PRKCA, TEK |
2.89529 |
|
[BP] GO:1903524 |
None
|
ADRB1, EGFR, HTR2A, PTGS2, SLC1A1 |
2.89477 |
|
[BP] GO:0048732 |
gland development
|
BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR |
2.89446 |
|
[BP] GO:0051223 |
None
|
ACHE, CHRM1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
2.8925 |
|
[BP] GO:0031329 |
regulation of cellular catabolic process
|
ADRB2, APEX1, BCL2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1 |
2.88753 |
|
[BP] GO:0007208 |
None
|
HTR2A, HTR2C |
2.88365 |
|
[BP] GO:0070989 |
oxidative demethylation
|
CYP1A2, CYP2D6, CYP3A4 |
2.88286 |
|
[BP] GO:0021885 |
forebrain cell migration
|
AXL, DRD1, EGFR, HTR6 |
2.875 |
|
[BP] GO:0030802 |
None
|
ADRB1, DRD1, GRM3, GRM8, MTNR1A, PRKCA |
2.87238 |
|
[BP] GO:0031347 |
regulation of defense response
|
ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK |
2.87226 |
|
[BP] GO:0048010 |
vascular endothelial growth factor receptor signaling pathway
|
AXL, KDR, PIK3CA, PIK3CB, SRC |
2.84989 |
|
[BP] GO:0009611 |
response to wounding
|
ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 |
2.84923 |
|
[BP] GO:1900274 |
regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B |
2.83218 |
|
[BP] GO:0046456 |
icosanoid biosynthetic process
|
ALOX5, MIF, PTGS1, PTGS2 |
2.78962 |
|
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.78712 |
|
[BP] GO:0001516 |
None
|
MIF, PTGS1, PTGS2 |
2.78712 |
|
[BP] GO:0046457 |
None
|
MIF, PTGS1, PTGS2 |
2.78712 |
|
[BP] GO:0050678 |
None
|
EGFR, F3, HTR2B, KDR, MMP12, PRKCA, SMAD3, TEK, XDH |
2.78321 |
|
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, HMGCR, TYR |
2.78321 |
|
[BP] GO:0032880 |
regulation of protein localization
|
ACHE, BCL2, CHRM1, CSNK2A1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
2.78321 |
|
[BP] GO:0002793 |
None
|
ACHE, ADORA1, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC |
2.76515 |
|
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
2.76515 |
|
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 |
2.75629 |
|
[BP] GO:0001525 |
angiogenesis
|
CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK |
2.75629 |
|
[BP] GO:0060078 |
None
|
ADORA1, GRIA2, GRIA4, GRIK5, GRM5 |
2.73219 |
|
[BP] GO:0048660 |
regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 |
2.72186 |
|
[BP] GO:0038128 |
None
|
EGFR, PIK3CA, PRKCA, SRC |
2.71581 |
|
[BP] GO:1904951 |
positive regulation of establishment of protein localization
|
ACHE, BCL2, CHRM1, EGFR, HCAR2, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC |
2.71124 |
|
[BP] GO:0050708 |
None
|
ACHE, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, SRC |
2.70836 |
|
[BP] GO:1900371 |
None
|
ADRB1, DRD1, GRM3, GRM8, MTNR1A, PRKCA |
2.70706 |
|
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
ADRB1, ADRB2, AURKB, DRD1, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PPARA, PTGS2, RORC, SMAD3, SRC, TOP2A |
2.70653 |
|
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.70416 |
|
[BP] GO:0019538 |
protein metabolic process
|
ACHE, ADRB2, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
2.70346 |
|
[BP] GO:0051726 |
regulation of cell cycle
|
APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PRKCA, PTGS2, SMAD3, SRC, TOP2A |
2.70121 |
|
[BP] GO:0030808 |
None
|
ADRB1, DRD1, GRM3, GRM8, MTNR1A, PRKCA |
2.69341 |
|
[BP] GO:0051098 |
regulation of binding
|
ADRB2, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC |
2.67448 |
|
[BP] GO:0006811 |
None
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD1, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, PPARA, SLC1A1 |
2.64783 |
|
[BP] GO:0001936 |
None
|
F3, HTR2B, KDR, PRKCA, TEK, XDH |
2.6442 |
|
[BP] GO:1904407 |
positive regulation of nitric oxide metabolic process
|
EGFR, INSR, PTGS2, SMAD3 |
2.6442 |
|
[BP] GO:0045429 |
positive regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3 |
2.6442 |
|
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, HSPA1A |
2.62868 |
|
[BP] GO:0009968 |
negative regulation of signal transduction
|
ADRB2, BCL2, DUSP3, EGFR, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH |
2.62827 |
|
[BP] GO:2000106 |
regulation of leukocyte apoptotic process
|
AURKB, AXL, HCAR2, MIF, PIK3CB |
2.62292 |
|
[BP] GO:0044070 |
regulation of anion transport
|
ADORA1, CA2, CA7, GRM5, MIF |
2.62292 |
|
[BP] GO:0033273 |
response to vitamin
|
ALPL, CYP1A1, EGFR, PTGS2, TYR |
2.62292 |
|
[BP] GO:0048869 |
cellular developmental process
|
ACHE, ADRB1, ADRB2, ALPL, AXL, BCL2, CDC25B, CYP1A1, DRD1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HTR2B, KDR, MET, MIF, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A |
2.62071 |
|
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 |
2.61918 |
|
[BP] GO:0045776 |
None
|
ADORA1, ADRB1, ADRB2, PPARA |
2.61239 |
|
[BP] GO:0007623 |
circadian rhythm
|
EGFR, MTNR1A, MTNR1B, PPARA, RORC, TOP1 |
2.60281 |
|
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH |
2.60134 |
|
[BP] GO:0001775 |
cell activation
|
ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, RORC, SMAD3, SRC |
2.58469 |
|
[BP] GO:0044267 |
cellular protein metabolic process
|
ADRB2, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
2.57351 |
|
[BP] GO:0010595 |
positive regulation of endothelial cell migration
|
KDR, MET, PRKCA, PTGS2, TEK |
2.55881 |
|
[BP] GO:0006082 |
organic acid metabolic process
|
ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
2.55701 |
|
[BP] GO:2000811 |
negative regulation of anoikis
|
BCL2, PIK3CA, SRC |
2.55125 |
|
[BP] GO:0007213 |
None
|
CHRM1, CHRM2, CHRM4 |
2.55125 |
|
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.55125 |
|
[BP] GO:0045986 |
None
|
ADORA1, ADRB2, PTGS2 |
2.55125 |
|
[BP] GO:0001938 |
None
|
F3, HTR2B, KDR, PRKCA, TEK |
2.54028 |
|
[BP] GO:0043393 |
regulation of protein binding
|
ADRB2, AURKB, BCL2, MET, MMP9, PPARA, SRC |
2.53749 |
|
[BP] GO:0032102 |
negative regulation of response to external stimulus
|
ADORA1, CYP19A1, DRD1, HMGCR, MIF, PPARA, SMAD3, TEK |
2.53522 |
|
[BP] GO:0006820 |
anion transport
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 |
2.52987 |
|
[BP] GO:0043271 |
negative regulation of ion transport
|
ADORA1, BCL2, GPR35, HTR2A, MMP9, PTGS2 |
2.52987 |
|
[BP] GO:0019752 |
carboxylic acid metabolic process
|
ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
2.52987 |
|
[BP] GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH |
2.52897 |
|
[BP] GO:0030799 |
None
|
ADRB1, DRD1, GRM3, GRM8, MTNR1A, PRKCA |
2.51666 |
|
[BP] GO:0002009 |
morphogenesis of an epithelium
|
BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC |
2.51032 |
|
[BP] GO:0050793 |
regulation of developmental process
|
ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, F3, HMGCR, HTR2A, HTR2C, INSR, KDR, MIF, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, XDH |
2.50823 |
|
[BP] GO:1901653 |
cellular response to peptide
|
ADRB2, AKR1B1, APEX1, GRM5, IGF1R, INSR, SRC |
2.50823 |
|
[BP] GO:0099566 |
None
|
GRM1, GRM5 |
2.497 |
|
[BP] GO:0009822 |
alkaloid catabolic process
|
CYP2D6, CYP3A4 |
2.497 |
|
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.497 |
|
[BP] GO:0002025 |
None
|
ADRB1, ADRB2 |
2.497 |
|
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, CDC25B, CYP1A1, DUSP3, INSR, PRKCA |
2.49414 |
|
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
2.47936 |
|
[BP] GO:2000379 |
positive regulation of reactive oxygen species metabolic process
|
EGFR, INSR, PTGS2, SMAD3, XDH |
2.46842 |
|
[BP] GO:0022414 |
reproductive process
|
AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, MTNR1A, PTGS2, SRC, TOP2A |
2.46817 |
|
[BP] GO:0071248 |
cellular response to metal ion
|
CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.43277 |
|
[BP] GO:0010632 |
regulation of epithelial cell migration
|
KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK |
2.43187 |
|
[BP] GO:0030155 |
regulation of cell adhesion
|
BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, SMAD3, SRC, TEK |
2.40014 |
|
[BP] GO:0010518 |
positive regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B |
2.38899 |
|
[BP] GO:0048545 |
response to steroid hormone
|
ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC |
2.38813 |
|
[BP] GO:0031328 |
positive regulation of cellular biosynthetic process
|
ADRB1, ADRB2, AURKB, DRD1, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PTGS2, RORC, SMAD3, SRC, TOP2A |
2.38719 |
|
[BP] GO:0051047 |
None
|
ACHE, ADORA1, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC |
2.37575 |
|
[BP] GO:0006928 |
movement of cell or subcellular component
|
AXL, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, TEK |
2.36979 |
|
[BP] GO:0097755 |
None
|
ADRB1, ADRB2, DRD1, EGFR |
2.35886 |
|
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.35658 |
|
[BP] GO:0045766 |
positive regulation of angiogenesis
|
CYP1B1, F3, KDR, PRKCA, PTGS2, TEK |
2.35187 |
|
[BP] GO:0006464 |
cellular protein modification process
|
ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
2.34871 |
|
[BP] GO:0036211 |
protein modification process
|
ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
2.34871 |
|
[BP] GO:0051094 |
positive regulation of developmental process
|
ADRB2, AXL, BCL2, CA2, CYP1B1, F3, HMGCR, HTR2A, HTR2C, INSR, KDR, PIM1, PRKCA, PTGS2, SMAD3, SRC, TEK |
2.34848 |
|
[BP] GO:0031960 |
response to corticosteroid
|
ALPL, BCL2, EGFR, FLT3, PTGS2, SRC |
2.33992 |
|
[BP] GO:0050727 |
regulation of inflammatory response
|
ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK |
2.33416 |
|
[BP] GO:0051222 |
positive regulation of protein transport
|
ACHE, CHRM1, EGFR, HCAR2, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC |
2.33172 |
|
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, ESR1, FABP4, GRM3, GRM8, HMGCR, HSPA1A, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH |
2.32056 |
|
[BP] GO:0030817 |
None
|
ADRB1, DRD1, GRM3, GRM8, PRKCA |
2.31581 |
|
[BP] GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3 |
2.30412 |
|
[BP] GO:0033138 |
positive regulation of peptidyl-serine phosphorylation
|
BCL2, EGFR, MIF, PIK3CA, PTGS2 |
2.29927 |
|
[BP] GO:0090257 |
None
|
ADORA1, ADRB2, CHRM1, CHRM2, PRKCA, PTGS2, SMAD3 |
2.29855 |
|
[BP] GO:0051893 |
regulation of focal adhesion assembly
|
KDR, SMAD3, SRC, TEK |
2.24584 |
|
[BP] GO:0033555 |
multicellular organismal response to stress
|
ADRB1, BCL2, DRD1, HTR2C |
2.24584 |
|
[BP] GO:0090109 |
regulation of cell-substrate junction assembly
|
KDR, SMAD3, SRC, TEK |
2.24584 |
|
[BP] GO:0072593 |
reactive oxygen species metabolic process
|
BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR |
2.24233 |
|
[BP] GO:0071498 |
cellular response to fluid shear stress
|
CA2, PTGS2, SRC |
2.24116 |
|
[BP] GO:0051968 |
None
|
DRD1, EGFR, PTGS2 |
2.24116 |
|
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
2.24116 |
|
[BP] GO:0033031 |
positive regulation of neutrophil apoptotic process
|
HCAR2, PIK3CB |
2.23965 |
|
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.23965 |
|
[BP] GO:0019932 |
second-messenger-mediated signaling
|
ADRB1, ADRB2, DRD1, EGFR, GRM5, HTR2B, KDR |
2.22993 |
|
[BP] GO:0050714 |
None
|
ACHE, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC |
2.22993 |
|
[BP] GO:0007611 |
None
|
DRD1, EGFR, GRM5, HMGCR, HTR2A, INSR, PTGS2 |
2.22993 |
|
[BP] GO:0003006 |
developmental process involved in reproduction
|
ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC |
2.22089 |
|
[BP] GO:2000116 |
regulation of cysteine-type endopeptidase activity
|
CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH |
2.22088 |
|
[BP] GO:0008150 |
biological_process
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
2.22088 |
|
[BP] GO:0018105 |
peptidyl-serine phosphorylation
|
AURKB, BCL2, DRD1, PRKCA, SRC, TOP1 |
2.21582 |
|
[BP] GO:0010038 |
response to metal ion
|
BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.19809 |
|
[BP] GO:0046890 |
None
|
FABP3, HMGCR, HTR2A, HTR2B, HTR2C, PTGS2 |
2.19058 |
|
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC |
2.1736 |
|
[BP] GO:1903391 |
regulation of adherens junction organization
|
KDR, SMAD3, SRC, TEK |
2.17327 |
|
[BP] GO:0045428 |
regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3 |
2.17327 |
|
[BP] GO:0043436 |
oxoacid metabolic process
|
ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
2.14386 |
|
[BP] GO:0031348 |
negative regulation of defense response
|
ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK |
2.14133 |
|
[BP] GO:2000209 |
regulation of anoikis
|
BCL2, PIK3CA, SRC |
2.14133 |
|
[BP] GO:0095500 |
None
|
CHRM1, CHRM2, CHRM4 |
2.14133 |
|
[BP] GO:0009404 |
toxin metabolic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.14133 |
|
[BP] GO:1903831 |
None
|
CHRM1, CHRM2, CHRM4 |
2.14133 |
|
[BP] GO:0010638 |
positive regulation of organelle organization
|
ADRB2, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK |
2.13621 |
|
[BP] GO:0071241 |
cellular response to inorganic substance
|
CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.13065 |
|
[BP] GO:0010517 |
regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B |
2.12304 |
|
[BP] GO:0030168 |
platelet activation
|
AXL, PIK3CA, PIK3CB, PRKCA, SRC |
2.11559 |
|
[BP] GO:0007204 |
positive regulation of cytosolic calcium ion concentration
|
DRD1, ESR1, GPR35, GRM1, HTR2A, HTR2B, HTR2C |
2.10489 |
|
[BP] GO:0019229 |
None
|
CHRM1, EGFR, HTR2A, PTGS2 |
2.09707 |
|
[BP] GO:1904018 |
positive regulation of vasculature development
|
CYP1B1, F3, KDR, PRKCA, PTGS2, TEK |
2.09394 |
|
[BP] GO:0051894 |
None
|
KDR, SMAD3, TEK |
2.09285 |
|
[BP] GO:0007202 |
None
|
EGFR, HTR2A, HTR2B |
2.09285 |
|
[BP] GO:1903409 |
reactive oxygen species biosynthetic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.09285 |
|
[BP] GO:0070301 |
cellular response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1 |
2.07319 |
|
[BP] GO:0060193 |
positive regulation of lipase activity
|
EGFR, ESR1, HTR2A, HTR2B |
2.05076 |
|
[BP] GO:0010641 |
None
|
F3, SRC |
2.05076 |
|
[BP] GO:0007598 |
None
|
F10, F3 |
2.05076 |
|
[BP] GO:0050927 |
None
|
F3, KDR, SMAD3 |
2.04748 |
|
[BP] GO:0045932 |
None
|
ADORA1, ADRB2, PTGS2 |
2.04748 |
|
[BP] GO:0042311 |
None
|
ADRB1, ADRB2, DRD1 |
2.04748 |
|
[BP] GO:1900544 |
None
|
ADRB1, DRD1, HTR2A, INSR, MTNR1A |
2.04124 |
|
[BP] GO:0045981 |
None
|
ADRB1, DRD1, HTR2A, INSR, MTNR1A |
2.04124 |
|
[BP] GO:0050728 |
negative regulation of inflammatory response
|
ADORA1, CYP19A1, PPARA, SMAD3, TEK |
2.04124 |
|
[BP] GO:0009991 |
response to extracellular stimulus
|
ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, PTGS2, SRC, TYR |
2.04015 |
|
[BP] GO:0030814 |
None
|
ADRB1, DRD1, GRM3, GRM8, PRKCA |
2.02605 |
|
[BP] GO:0050920 |
regulation of chemotaxis
|
CYP19A1, F3, KDR, MET, MIF, SMAD3 |
2.01914 |
|
[BP] GO:0006706 |
steroid catabolic process
|
CYP19A1, CYP1A2, CYP3A4 |
2.00649 |
|
[BP] GO:0050926 |
None
|
F3, KDR, SMAD3 |
2.00649 |
|
[BP] GO:0035235 |
None
|
GRIA2, GRIA4, GRIK5 |
2.00649 |
|
[BP] GO:1903393 |
None
|
KDR, SMAD3, TEK |
2.00649 |
|
[BP] GO:0006693 |
None
|
MIF, PTGS1, PTGS2 |
2.00649 |
|
[BP] GO:0006692 |
None
|
MIF, PTGS1, PTGS2 |
2.00649 |
|
[CC] GO:0031226 |
intrinsic component of plasma membrane
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM4, DRD1, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TEK |
10.126 |
|
[CC] GO:0005886 |
plasma membrane
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, DRD1, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, SLC1A1, SMAD3, SRC, TEK |
9.84618 |
|
[CC] GO:0044459 |
plasma membrane part
|
ABCG2, ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PTGS2, SLC1A1, SRC, TEK |
9.18414 |
|
[CC] GO:0098590 |
plasma membrane region
|
ABCG2, ADORA1, ADRB2, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, PTGS2, SLC1A1, SRC, TEK |
8.77038 |
|
[CC] GO:0005887 |
integral component of plasma membrane
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CHRM1, CHRM2, CHRM4, DRD1, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TEK |
8.4095 |
|
[CC] GO:0016020 |
membrane
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX5, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR |
7.90589 |
|
[CC] GO:0044425 |
membrane part
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TEK, TYR |
7.58945 |
|
[CC] GO:0043235 |
receptor complex
|
ABCG2, ADRB2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, MTNR1A, SMAD3 |
4.38811 |
|
[CC] GO:0097060 |
None
|
CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
3.98471 |
|
[CC] GO:0031224 |
None
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TBXAS1, TEK, TYR |
3.89093 |
|
[CC] GO:0120025 |
None
|
ADORA1, AKR1B1, BACE1, CA2, CHRM1, CHRM2, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR6, PIK3CA, PTGS2, SRC, TEK |
3.58605 |
|
[CC] GO:0043005 |
None
|
ADORA1, BACE1, CA2, CHRM1, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, PTGS2, SRC |
3.39416 |
|
[CC] GO:0042995 |
cell projection
|
ADORA1, AKR1B1, BACE1, CA2, CHRM1, CHRM2, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR6, PIK3CA, PTGS2, SRC, TEK |
3.264 |
|
[CC] GO:0044432 |
endoplasmic reticulum part
|
BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, F10, FLT3, GRIA2, HMGCR, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 |
3.16238 |
|
[CC] GO:0042734 |
None
|
GRIK5, GRM1, GRM3, GRM5, GRM8 |
3.11605 |
|
[CC] GO:0016021 |
None
|
ABCG2, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CYP3A4, DRD1, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TBXAS1, TEK, TYR |
3.06206 |
|
[CC] GO:0009330 |
None
|
TOP1, TOP2A |
2.88365 |
|
[CC] GO:0044456 |
None
|
ACHE, ADORA1, CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC |
2.80626 |
|
[CC] GO:0005789 |
endoplasmic reticulum membrane
|
BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, GRIA2, HMGCR, HSD17B2, PTGS1, PTGS2, TBXAS1 |
2.76515 |
|
[CC] GO:0097458 |
None
|
ADORA1, BACE1, CA2, CHRM1, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, INSR, PTGS1, PTGS2, SRC, TOP1 |
2.75629 |
|
[CC] GO:0005783 |
None
|
ADORA1, APEX1, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, HSPA1A, KDR, PRKCA, PTGS2, PTPN1, XDH |
2.66004 |
|
[CC] GO:0014069 |
None
|
ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC |
2.61918 |
|
[CC] GO:0099572 |
None
|
ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC |
2.61918 |
|
[CC] GO:0045211 |
None
|
CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM3 |
2.47936 |
|
[CC] GO:0045121 |
membrane raft
|
BACE1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK |
2.41203 |
|
[CC] GO:0098857 |
membrane microdomain
|
BACE1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK |
2.39422 |
|
[CC] GO:0031233 |
None
|
CA4, F10, F3 |
2.29927 |
|
[CC] GO:0044463 |
None
|
ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, DRD1, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SRC |
2.19653 |
|
[CC] GO:0120038 |
None
|
ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, DRD1, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SRC |
2.19653 |
|
[CC] GO:0044464 |
cell part
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
2.05205 |
|
[CC] GO:0044444 |
cytoplasmic part
|
ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, INSR, KDR, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TOP1, TOP2A, TYR, XDH |
2.0235 |
|
[CC] GO:0045202 |
None
|
ACHE, CHRM1, CHRM2, CHRM4, EGFR, GRIA2, HTR2B |
2.00386 |
|
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK |
12.7678 |
|
[MF] GO:0046914 |
transition metal ion binding
|
ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH |
11.6526 |
|
[MF] GO:0099600 |
transmembrane receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK |
11.6526 |
|
[MF] GO:0004888 |
transmembrane signaling receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK |
11.6526 |
|
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
11.6526 |
|
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK |
11.5883 |
|
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK |
11.2006 |
|
[MF] GO:0004871 |
signal transducer activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SMAD3, TEK |
11.1912 |
|
[MF] GO:0030594 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, HTR6 |
11.1912 |
|
[MF] GO:0008144 |
drug binding
|
ABCG2, ACHE, AURKB, AXL, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SRC, TEK, TOP1, TOP2A |
10.4979 |
|
[MF] GO:0003824 |
catalytic activity
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
10.4979 |
|
[MF] GO:0043167 |
ion binding
|
ABCG2, ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
10.3257 |
|
[MF] GO:0008227 |
None
|
ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 |
8.49145 |
|
[MF] GO:0008066 |
None
|
GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
7.88244 |
|
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
7.55023 |
|
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
7.22747 |
|
[MF] GO:0099528 |
None
|
CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 |
6.91326 |
|
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK |
6.8894 |
|
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 |
6.8894 |
|
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 |
6.69567 |
|
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 |
6.62222 |
|
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
6.53136 |
|
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 |
6.39912 |
|
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR |
6.2122 |
|
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK |
6.17007 |
|
[MF] GO:0004930 |
None
|
ADORA1, ADORA3, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, DRD1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MTNR1A, MTNR1B |
6.1216 |
|
[MF] GO:0008270 |
zinc ion binding
|
CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PTPN1, RORC, SMAD3 |
5.88399 |
|
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, ESR1, F10, GLO1, HTR2A, HTR2B, HTR2C, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TOP2A, TYR, XDH |
5.65949 |
|
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, TYR |
5.61006 |
|
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 |
5.58384 |
|
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 |
5.06422 |
|
[MF] GO:0048037 |
cofactor binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, TBXAS1, XDH |
5.0582 |
|
[MF] GO:0005506 |
iron ion binding
|
ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, XDH |
5.04996 |
|
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK, TOP1 |
5.02166 |
|
[MF] GO:0043560 |
insulin receptor substrate binding
|
IGF1R, INSR, PIK3CA, PIK3CB |
4.76023 |
|
[MF] GO:0042562 |
hormone binding
|
ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2 |
4.73462 |
|
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1 |
4.71637 |
|
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK |
4.63547 |
|
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1 |
4.21942 |
|
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, ADRB2, APEX1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC |
4.06937 |
|
[MF] GO:0016907 |
None
|
CHRM1, CHRM2, CHRM4 |
4.03286 |
|
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, ADRB2, APEX1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC |
4.00814 |
|
[MF] GO:0046872 |
metal ion binding
|
ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TOP2A, TYR, XDH |
3.68118 |
|
[MF] GO:0004993 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.44494 |
|
[MF] GO:0099589 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.44494 |
|
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1 |
3.36708 |
|
[MF] GO:0019899 |
enzyme binding
|
ADRB1, ADRB2, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, F3, GRM5, HMGCR, HSPA1A, MET, MIF, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A |
3.22792 |
|
[MF] GO:0016725 |
oxidoreductase activity, acting on CH or CH2 groups
|
CYP1A2, CYP3A4, XDH |
3.21976 |
|
[MF] GO:0004716 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity
|
EGFR, INSR, KDR |
3.21976 |
|
[MF] GO:0036094 |
small molecule binding
|
ABCG2, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SLC1A1, SRC, TEK, TOP1, TOP2A, XDH |
3.18369 |
|
[MF] GO:0001540 |
amyloid-beta binding
|
ACHE, ADRB2, BACE1, GRIA2, INSR |
3.17491 |
|
[MF] GO:0019902 |
phosphatase binding
|
BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 |
3.05501 |
|
[MF] GO:0043176 |
None
|
HTR2A, HTR2B, HTR2C |
2.98538 |
|
[MF] GO:0051378 |
None
|
HTR2A, HTR2B, HTR2C |
2.98538 |
|
[MF] GO:0005524 |
ATP binding
|
ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A |
2.93674 |
|
[MF] GO:0008395 |
steroid hydroxylase activity
|
CYP19A1, CYP1A1, CYP2D6, CYP3A4 |
2.91348 |
|
[MF] GO:0004666 |
prostaglandin-endoperoxide synthase activity
|
PTGS1, PTGS2 |
2.88365 |
|
[MF] GO:0071886 |
None
|
HTR2A, HTR2C |
2.88365 |
|
[MF] GO:0042802 |
identical protein binding
|
ABCG2, ACHE, ADRB2, BCL2, CSNK2A1, EGFR, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, SMAD3, TOP2A, TYR, XDH |
2.85944 |
|
[MF] GO:0070405 |
ammonium ion binding
|
ACHE, DRD1, HTR2A, HTR2B, HTR2C |
2.82406 |
|
[MF] GO:0032559 |
adenyl ribonucleotide binding
|
ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A |
2.81639 |
|
[MF] GO:0097159 |
organic cyclic compound binding
|
ABCG2, ADORA1, ADRB1, ADRB2, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, ESR1, FLT3, HMGCR, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, XDH |
2.79861 |
|
[MF] GO:0030554 |
adenyl nucleotide binding
|
ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A |
2.78321 |
|
[MF] GO:0043168 |
anion binding
|
ABCG2, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SLC1A1, SRC, TEK, TOP1, TOP2A, XDH |
2.7823 |
|
[MF] GO:0140096 |
catalytic activity, acting on a protein
|
AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TEK, TOP1 |
2.69261 |
|
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, XDH |
2.60281 |
|
[MF] GO:0000166 |
nucleotide binding
|
ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A, XDH |
2.52122 |
|
[MF] GO:1901265 |
nucleoside phosphate binding
|
ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A, XDH |
2.52077 |
|
[MF] GO:0008502 |
None
|
MTNR1A, MTNR1B |
2.497 |
|
[MF] GO:0070576 |
vitamin D 24-hydroxylase activity
|
CYP1A1, CYP3A4 |
2.497 |
|
[MF] GO:0004939 |
None
|
ADRB1, ADRB2 |
2.497 |
|
[MF] GO:0099583 |
None
|
GRM1, GRM5 |
2.497 |
|
[MF] GO:0015464 |
None
|
CHRM1, CHRM2, CHRM4 |
2.41802 |
|
[MF] GO:0003674 |
molecular_function
|
ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
2.40427 |
|
[MF] GO:0004970 |
None
|
GRIA2, GRIA4, GRIK5 |
2.35658 |
|
[MF] GO:0005234 |
None
|
GRIA2, GRIA4, GRIK5 |
2.35658 |
|
[MF] GO:0042165 |
neurotransmitter binding
|
ACHE, HTR2A, HTR2B, HTR2C |
2.30412 |
|
[MF] GO:1901338 |
None
|
ADRB1, ADRB2, DRD1 |
2.29927 |
|
[MF] GO:0034875 |
caffeine oxidase activity
|
CYP1A2, CYP3A4 |
2.23965 |
|
[MF] GO:0004971 |
None
|
GRIA2, GRIA4 |
2.23965 |
|
[MF] GO:0033695 |
oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
|
CYP1A2, CYP3A4 |
2.23965 |
|
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, CYP19A1, CYP1A2, NQO2, XDH |
2.14482 |
|
[MF] GO:0101020 |
estrogen 16-alpha-hydroxylase activity
|
CYP1A1, CYP3A4 |
2.05076 |
|
[MF] GO:0043559 |
insulin binding
|
IGF1R, INSR |
2.05076 |
|
[MF] GO:0051380 |
None
|
ADRB1, ADRB2 |
2.05076 |
|
[MF] GO:0005518 |
collagen binding
|
ACHE, MMP12, MMP9, SMAD3 |
2.03063 |
