TCM Prescription: Yan Ke Ning Tablets



Prescription Description
Prescription IDTCMF6664
Pinyin NameYan Ke Ning Pian
Chinese Name炎可宁片
English NameYan Ke Ning Tablets
Function Description疮痈, 瘰疬, 痢疾, 热淋
IndicationsDysentery disorder, Heat stranguria disorder, Acute tonsillitis, Bacterial pneumonia, Acute conjunctivitis, Otitis media
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ];
CA03 [Acute tonsillitis, 急性扁桃体炎 ];
CA40.0 [Bacterial pneumonia, 细菌性肺炎 ];
9A60.Z [Conjunctivitis, unspecified, 结膜炎,未特指的 ];
AB0Z [Otitis media, unspecified, 中耳炎,未特指的 ];
Human Tissues Associated with IndicationIntestine, Bladder
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.8017
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.8017
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA12, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, ESR1, F3, FABP3, FABP4, GSK3B, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TNKS, TNKS2, XDH 13.7335
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.9626
[BP] GO:0007187 None ADORA1, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 10.6848
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, ESR1, FABP3, GSK3B, HSD11B2, HTR1B, HTR5A, IDO1, MMP2, MMP9, PIK3CA, PPARA, PTGS2 10.4633
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, ESR1, FABP3, FABP4, GSK3B, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, MMP2, MMP9, PIK3CA, PPARA, PTGS2 9.78922
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.3733
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2C 8.47682
[BP] GO:0042493 response to drug ABCB1, AKR1B1, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 8.15602
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, XDH 7.73705
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 7.66779
[BP] GO:0050795 None ADORA1, CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 7.66779
[BP] GO:0007188 None ADORA1, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 7.31245
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, ESR1, FABP3, FABP4, GSK3B, HSD11B2, HTR1B, HTR5A, IDO1, MMP2, PIK3CA, PPARA, PTGS2 7.25209
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.15497
[BP] GO:0007193 None ADORA1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 7.1333
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, CA12, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, FABP3, FUT7, HTR2B, HTR2C, IDO1, PIK3CA, PPARA, PTGS1, PTGS2, XDH 7.05732
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 6.92776
[BP] GO:0097746 None ADORA1, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.92355
[BP] GO:0035296 None ADORA1, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.92355
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1 6.71553
[BP] GO:0050880 None ADORA1, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.70518
[BP] GO:0035150 None ADORA1, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.70238
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.70238
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.70238
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, BCL2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 6.70139
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, BCL2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 6.68674
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.53642
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, ESR1, HSD11B2, HTR1B, HTR5A, PTGS2 6.53642
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA7, CNR1, CNR2, DRD2, HTR1B 6.49641
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, HTR1B, HTR2A, PTGS2 6.49641
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.47149
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, MMP1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, TNKS2 6.33721
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.26416
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.24687
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PTGS1, PTGS2 6.2384
[BP] GO:0099536 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.06409
[BP] GO:0099537 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.06409
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA7, CNR1, DRD1, DRD2, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2, TNKS, TNKS2 6.04289
[BP] GO:0033993 response to lipid ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, IDO1, PTGS2 5.74547
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1 5.73741
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, ESR1, F3, FABP3, FABP4, GSK3B, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.64712
[BP] GO:0006939 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7 5.53588
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.42549
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, F3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, TNKS, TNKS2, XDH 5.35385
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, HTR1B, HTR2A, MMP9, PTGS2 5.35385
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DRD2, ESR1, F3, FABP4, GSK3B, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, TNKS, TNKS2, XDH 5.3491
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, F3, FABP4, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 5.3491
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.33131
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, HTR2C, TNKS, TNKS2 5.31097
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, F3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, TNKS, TNKS2, XDH 5.26591
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD2, F3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 5.25459
[BP] GO:0007268 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.16661
[BP] GO:0098916 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.16661
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 5.12395
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.12395
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.112
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA7, CNR1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.0846
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA7, CNR1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.0846
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1 5.03964
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, GSK3B, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2 4.98119
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HTR1B, HTR1D 4.9679
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.95145
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, HTR1A 4.8521
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FABP3, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, MMP2, MMP9, PTGS1, PTGS2, XDH 4.80447
[BP] GO:0051967 None ADORA1, DRD2, HTR1B, HTR2A 4.70442
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, DRD2, PPARA 4.69865
[BP] GO:0006730 one-carbon metabolic process CA12, CA4, CA7, CA9, DHFR 4.68963
[BP] GO:0007610 None BCL2, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, PPARA, PTGS2 4.6579
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2 4.6232
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, HTR1B, HTR2A 4.52283
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.48125
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA7, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 4.4507
[BP] GO:0090066 None ADORA1, ALOX15, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.35834
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA4, CA7, CA9 4.28954
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CYP1B1, DRD2, F3, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PTGS2, XDH 4.28954
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS1, PTGS2 4.28954
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 4.28954
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA7, DRD1, DRD2, HTR2A, HTR2B, HTR2C 4.26378
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, GSK3B, HSD11B2, HTR1A, HTR2C, IDO1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 4.25554
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.25554
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 4.22996
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, BCL2, CA7, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 4.17227
[BP] GO:0007154 None ADORA1, BCL2, CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 4.13558
[BP] GO:0008217 None ADORA1, CNR1, DRD2, HSD11B2, PPARA, PTGS1, PTGS2 4.10699
[BP] GO:0007267 None ADORA1, CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.04862
[BP] GO:0032846 positive regulation of homeostatic process CA7, CNR1, DRD1, DRD2, PIK3CB, PTGS2, TNKS, TNKS2 4.0228
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, ESR1, F3, FABP3, FABP4, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, TNKS, TNKS2, XDH 4.01727
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, BCL2, CA7, CNR1, CYP19A1, DRD1, DRD2, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 4.01655
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1 4.01555
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 4.01535
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DHFR, DRD1, DRD2, FABP3, GSK3B, HSD11B2, HTR1B, MMP2, PPARA, PTGS2 4.01185
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 4.00124
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, IDO1 3.93633
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C, IDO1 3.91304
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, IDO1, PPARA, PTGS2, PTPRS 3.88287
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2 3.85794
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, TNKS, TNKS2, XDH 3.8252
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.78512
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, IDO1, PTGS1, PTGS2 3.77881
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DHFR, DRD1, DRD2, FABP3, GSK3B, HSD11B2, HTR1B, MMP2, PPARA, PTGS2 3.67837
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA9, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, ESR1, FABP4, FUT7, GSK3B, HSD11B1, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, TNKS2 3.6485
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 3.6485
[BP] GO:0023052 None ADORA1, CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.6313
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 3.6313
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, MMP9, PTGS2 3.60632
[BP] GO:0003012 None ADORA1, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 3.59866
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A 3.59731
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.59648
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CNR1, CNR2, CYP19A1, DHFR, DRD2, ESR1, F3, FABP4, GSK3B, IDO1, MMP2, PPARA, PTGS2, PTPRS, XDH 3.58648
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 3.57358
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, PIK3CA 3.56449
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.56449
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.49256
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.49256
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.46987
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.44451
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.44451
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1 3.41981
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 3.39291
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, ESR1, F3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS2 3.38129
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2 3.35505
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, BCL2, CA12, CA7, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.35049
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.33687
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 3.33687
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, BCL2, CNR1, CNR2, CSNK2A1, DHFR, DRD1, DRD2, ESR1, F3, FABP4, GSK3B, HTR2A, HTR2B, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, XDH 3.30855
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.27872
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, DRD1, DRD2, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 3.26821
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A 3.23044
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, DRD1, DRD2, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 3.22665
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 3.2242
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.2242
[BP] GO:0006936 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 3.2242
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DRD2, ESR1, FABP3, FABP4, GSK3B, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, MMP9, PIK3CA, PPARA, PTGS2, PTPRS, TNKS, TNKS2, XDH 3.20197
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, ESR1, FABP4, IDO1, MMP2, PPARA, PTGS2, PTPRS 3.1795
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.1795
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.13547
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, DRD1, DRD2, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 3.10442
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, DRD1, DRD2, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 3.10442
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA7, DRD1, DRD2, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 3.08799
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 3.08799
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.07823
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 3.02984
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, BCL2, CA12, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FUT7, GSK3B, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, XDH 3.0255
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, GSK3B, HTR2B, IDO1, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 3.01416
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR1B, HTR2A 2.98947
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP2, MMP9, PIK3CB, XDH 2.98947
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA 2.9834
[BP] GO:0051588 None DRD1, DRD2, HTR1A, HTR1B, HTR2C 2.97407
[BP] GO:0007208 None HTR2A, HTR2C 2.96923
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, HTR2C 2.95749
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, GSK3B, HTR1B, MMP2, MMP9, PIK3CA, PTGS2 2.9473
[BP] GO:0050999 None CNR1, CNR2, DHFR, HTR2B 2.92144
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.88931
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.88844
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.88844
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CYP1A1, DRD1, DRD2, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2 2.88838
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, GSK3B, HTR2B, IDO1, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.88731
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DRD2, ESR1, FABP3, FABP4, GSK3B, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, MMP9, PIK3CA, PPARA, PTGS2, PTPRS, TNKS, TNKS2, XDH 2.87601
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.86928
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PPARA, PTGS1, PTGS2 2.86524
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, GSK3B, HTR2B, IDO1, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.84364
[BP] GO:0050433 None CNR1, DRD2, HTR1B, HTR2A 2.82898
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, DRD1, DRD2, HTR1A, PTGS2 2.80799
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.78438
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.78438
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.7704
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, F3, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, TNKS, TNKS2 2.74892
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, HTR1A, HTR2A, HTR2C 2.73153
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, XDH 2.73005
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 2.70426
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, PTGS2 2.70426
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, GSK3B, HTR1B, MMP2, PIK3CA, PTGS2 2.70127
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, XDH 2.70127
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 2.70111
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.67188
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, CSNK2A1, DHFR, HTR2B, HTR2C, PIK3CA, PIK3CB, PTGS2 2.65346
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, HTR1A 2.6531
[BP] GO:0051051 negative regulation of transport ADORA1, BCL2, CNR1, DRD2, GSK3B, HTR1B, HTR2A, MMP9, PTGS2 2.64347
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.62292
[BP] GO:0032496 response to lipopolysaccharide ALPL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2 2.61016
[BP] GO:0031623 None ACHE, DRD2, HTR1B, HTR2B 2.59578
[BP] GO:0032768 None CNR1, CNR2, DHFR, HTR2B 2.59578
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, PPARA, PTPRS 2.59578
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, HTR2C 2.5749
[BP] GO:0033602 None CNR1, DRD2 2.57253
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA12, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, ESR1, F3, FABP3, FABP4, GSK3B, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, XDH 2.56867
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.56742
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.5647
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CSNK2A1, DRD2, ESR1, F3, GSK3B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.5647
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD2, ESR1, GSK3B, HTR7, PPARA 2.5647
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.55619
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.55619
[BP] GO:0048148 None DRD1, DRD2, HTR2A 2.53782
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.52072
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, DRD2, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.51911
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.51531
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PPARA, PTGS1, PTGS2 2.51365
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, ESR1, GSK3B, HTR1B, HTR2A, MMP9, PTGS2, PTPRS, XDH 2.49839
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, ESR1, GSK3B, HTR1B, HTR2A, MMP9, PTGS2, PTPRS, XDH 2.48739
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, PIK3CA, PIK3CB 2.48739
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.48739
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, XDH 2.48262
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, CNR1, CNR2, CYP19A1, DRD2, IDO1, PTPRS 2.47666
[BP] GO:0002237 response to molecule of bacterial origin ALPL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2 2.47626
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA7, DRD1, DRD2, PTGS2 2.47604
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.46533
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PPARA, PTGS1, PTGS2 2.4589
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.43806
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, GSK3B, MMP9, PPARA, PTGS2, PTPRS, XDH 2.43107
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.40228
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C 2.39606
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.39606
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.39606
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DHFR, DRD1, DRD2, ESR1, F3, FABP4, GSK3B, HTR2A, HTR2B, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, TNKS, XDH 2.39449
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C 2.39449
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.39449
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.39449
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, DRD1, DRD2, FABP4, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 2.38707
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.38518
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, DRD2, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.37827
[BP] GO:0016477 cell migration CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, MMP1, MMP9, PIK3CA, PIK3CB 2.37041
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.35338
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.35338
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.35338
[BP] GO:0070213 None TNKS, TNKS2 2.35338
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA7 2.35338
[BP] GO:0038171 None CNR1, CNR2 2.35338
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.35338
[BP] GO:0014827 None HTR1D, HTR2B 2.35338
[BP] GO:0044092 negative regulation of molecular function ADORA3, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, GSK3B, MMP9, PPARA, PTGS2, TNKS 2.35028
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, PIK3CA, TNKS2 2.35028
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, DRD2, ESR1, F3, GSK3B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.32327
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.31963
[BP] GO:0030003 cellular cation homeostasis BCL2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.29919
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.26274
[BP] GO:0001975 None CNR2, DRD1, DRD2 2.26274
[BP] GO:1900543 None DRD2, HTR1B, HTR1E, PPARA 2.26026
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, HTR2C 2.23938
[BP] GO:0045980 None DRD2, HTR1B, HTR1E, PPARA 2.23938
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, ESR1, GSK3B, HSD11B1, HTR5A, MMP9, PIK3CA, PPARA, PTGS2, PTPRS 2.23451
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, DRD1, DRD2, FABP4, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.23236
[BP] GO:0006873 cellular ion homeostasis BCL2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.22979
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, BCL2, CSNK2A1, DHFR, DRD1, DRD2, GSK3B, HTR2B, HTR2C, PIK3CA, PIK3CB, PTGS2, PTPRS, TNKS, XDH 2.21847
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, CYP19A1, CYP1A2, GSK3B, IDO1, NQO2, XDH 2.20081
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.18305
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.18305
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.18305
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C 2.1829
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, DHFR, DRD2, HTR2B, HTR2C, PIK3CA, PIK3CB, PTGS2, XDH 2.18006
[BP] GO:1900542 None DRD1, DRD2, HTR1B, HTR1E, HTR2A, PPARA 2.18006
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, HTR1D, MMP9, PTGS2 2.17818
[BP] GO:0060401 None DRD2, HTR2A, HTR2B, HTR2C 2.17818
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, HTR1B 2.17818
[BP] GO:0021853 None DRD1, DRD2 2.17818
[BP] GO:0099565 chemical synaptic transmission, postsynaptic DRD2, GSK3B 2.17818
[BP] GO:0071502 None HTR1B, HTR2B 2.17818
[BP] GO:1904936 None DRD1, DRD2 2.17818
[BP] GO:0042321 None ADORA1, DRD2 2.17818
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.15591
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, IDO1, PTGS1, PTGS2 2.15446
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, GSK3B, TNKS 2.13993
[BP] GO:0009266 None ADORA1, HTR1B, HTR2A, HTR2B, PTGS2 2.1303
[BP] GO:0006140 None DRD1, DRD2, HTR1B, HTR1E, HTR2A, PPARA 2.1303
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.11782
[BP] GO:1901570 None ALOX15, ALOX5, PTGS1, PTGS2 2.10246
[BP] GO:0042220 None CNR1, DRD2, HTR1B 2.08101
[BP] GO:0045777 None ADORA1, CNR1, HSD11B2 2.08101
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.08101
[BP] GO:0048870 cell motility CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, MMP1, MMP9, PIK3CA, PIK3CB 2.08101
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, HSD11B2, HTR1B, PTGS2 2.07463
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 2.07416
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, TNKS, TNKS2, XDH 2.06932
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.05428
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.04718
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, MMP9, PTGS2 2.0394
[BP] GO:0019217 None CNR1, FABP3, PPARA, PTGS2 2.0394
[BP] GO:0021843 None DRD1, DRD2 2.0394
[BP] GO:0021830 None DRD1, DRD2 2.0394
[BP] GO:0014831 None HTR1D, HTR2B 2.0394
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.0394
[BP] GO:0021826 None DRD1, DRD2 2.0394
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.0394
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.0394
[BP] GO:0055080 cation homeostasis BCL2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.03385
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, BCL2, CSNK2A1, DHFR, DRD1, DRD2, GSK3B, HTR2B, HTR2C, PIK3CA, PIK3CB, PTGS2, PTPRS, TNKS, XDH 2.03385
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, GSK3B, TNKS 2.02983
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, BCL2, CA12, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, ESR1, FABP3, FABP4, FUT7, GSK3B, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, XDH 2.02983
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.02685
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B 2.02685
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, DHFR 2.0125
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, BCL2, CA12, CA14, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FUT7, GSK3B, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, TNKS, TNKS2 5.56255
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, CNR1, CNR2, DRD1, DRD2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTPRS 5.42405
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, CA12, CA14, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F3, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTPRS 4.62806
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTPRS 4.39925
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS 4.34592
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, CA4, CA9, CNR1, CNR2, DRD1, DRD2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2, PTPRS 3.91969
[CC] GO:0120025 None ADORA1, AKR1B1, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, TUBB3 2.42847
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, TUBB3 2.21982
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, HSD11B1, HSD11B2, PTGS1, PTGS2 2.07816
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.8017
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.8017
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.4755
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.4755
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.3761
[MF] GO:0008227 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.2695
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 13.9221
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.5347
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.9292
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, CA12, CA14, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, ESR1, F3, FABP3, FABP4, GSK3B, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, TUBB3, XDH 10.9443
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HSD11B1, HSD11B2, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, XDH 8.20369
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, CA12, CA14, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2, TNKS, TNKS2, XDH 7.28669
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA12, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, TNKS, XDH 6.69173
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA4, CA7, CA9 6.44282
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.35785
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HSD11B2, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, XDH 5.96339
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 5.8497
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS1, PTGS2 5.63169
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.53588
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS1, PTGS2 5.41455
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.31097
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, CA12, CA14, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, F3, FUT7, GSK3B, HSD11B1, HSD11B2, HSD17B1, IDO1, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, TUBB3, XDH 5.15085
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 5.112
[MF] GO:0008144 drug binding ABCB1, ACHE, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, GSK3B, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PPARA 5.08815
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.0754
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.0754
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.03964
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 4.94194
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 4.51097
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.25554
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2 4.01535
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA4, CA7, CA9 3.87918
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.74791
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.70497
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.6485
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.46838
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA4, CA7, CA9 3.30468
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1, XDH 3.25603
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.97407
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.96923
[MF] GO:0003845 None HSD11B1, HSD11B2 2.96923
[MF] GO:0071886 None HTR2A, HTR2C 2.96923
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.88731
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.57253
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.57253
[MF] GO:0004949 None CNR1, CNR2 2.57253
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1 2.49839
[MF] GO:0008270 zinc ion binding CA12, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, TNKS 2.45915
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.35338
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.35338
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1 2.22275
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.17818
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1 2.15591
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, ESR1, GSK3B, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TUBB3, XDH 2.0394
[MF] GO:0005496 steroid binding CYP3A4, ESR1, HSD11B2, HSD17B1 2.01497


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 18.2793
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2 15.4531
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, DRD1, DRD2, PPARA, HTR4 10.4278
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.5394
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1 6.7286
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.4825
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.8755
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, DRD1, HTR5A, HTR4 5.9311
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, CYP3A4, CYP19A1, PTGS1, DHFR, HSD11B1, FUT7, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.8601
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.8775
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA4, CA7, CA9, CA14 7.4065
Gap junction_Homo sapiens_hsa04540 TUBB3, HTR2B, HTR2C, HTR2A, DRD1, DRD2 5.4689
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.8477
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, HTR2A 3.9318
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB, F3 3.9158
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.6696
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 3.9318
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1628
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.6022
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, PIK3CA, BCL2, PIK3CB 3.5538
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, PIK3CA, PIK3CB, ESR1 3.3392
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.1537
Prostate cancer_Homo sapiens_hsa05215 GSK3B, PIK3CA, BCL2, PIK3CB 3.0697
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3917
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, CYP1B1, PTGS2, MMP9 2.8576
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1109
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.7948
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, BCL2, PIK3CB 2.7948
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.7948
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7948
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PIK3CA, PIK3CB, PPARA 2.7948
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.7493
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, PIK3CA, PIK3CB, ESR1 2.7493
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, PIK3CA, BCL2, PIK3CB 2.7331
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.7493
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, PIK3CA, PIK3CB 2.5608
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, PPARA 2.5867
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, BCL2, PIK3CB, MMP9 2.4853
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, PIK3CB, PPARA 2.4408
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.298
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.8748
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.9245
Focal adhesion_Homo sapiens_hsa04510 GSK3B, PIK3CA, BCL2, PIK3CB 2.0248
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB, DRD2 1.9792
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, PIK3CA, PIK3CB 2.3577
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, PIK3CA, PIK3CB 2.1571
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.5462
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, PIK3CA, PIK3CB 2.7082
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 1.9792
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.7943
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, PIK3CA, PIK3CB 1.9792
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.2463
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0834
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6674
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, DRD1, DRD2 1.7352
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B, PIK3CA, PIK3CB 1.6688
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, PIK3CA, PIK3CB 1.6603
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4853
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIK3CB 1.5662
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6295
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.5662
Influenza A_Homo sapiens_hsa05164 GSK3B, PIK3CA, PIK3CB 1.4793
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, PIK3CA, BCL2, PIK3CB 1.4486
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, PIK3CA, PIK3CB 1.4512
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.2689
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3706
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.381
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3633
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.3693
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, PIK3CA, PIK3CB 1.1772
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3699
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.381
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4062
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4062
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4353
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 1.0128
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, PIK3CB 0.7617
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.7844
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB 1.2375
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.4694
Axon guidance_Homo sapiens_hsa04360 GSK3B 0.4639
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.047
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0385
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.0456
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8706
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.0861
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 1.0128
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0064
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2645
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2718
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.2609
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1989
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2278
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2375
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2278
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2094
Melanogenesis_Homo sapiens_hsa04916 GSK3B 0.5415
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.2278
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5411
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4592
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5574
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.4793
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.5704
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.473
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5206
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5712
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4722
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.4656
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.4722
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.572
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4391
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.4512
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.3905
Peroxisome_Homo sapiens_hsa04146 XDH 0.5953
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.5567
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4512
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5651
Bile secretion_Homo sapiens_hsa04976 ABCB1, CYP3A4 1.4512
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.4528
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6108
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6345
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.6326
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6474
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6611
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6786
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6755
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6603
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.6499
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6688
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7042
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.7286
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.7286
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7515
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7557
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7734
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7926
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8745
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9263
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9169
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9076
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8706
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9821
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA4 1.0167
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 1.0583
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.5589
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2463


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)