TCM Prescription: Yi Shen Wu Fa Oral Liquid



Prescription Description
Prescription IDTCMF6658
Pinyin NameYi Shen Wu Fa Kou Fu Ye
Chinese Name益肾乌发口服液
English NameYi Shen Wu Fa Oral Liquid
Function Description脱发症, 白发症
IndicationsAlopecia
Disease ICD-11 Category ED70 [Alopecia or hair loss, 脱发 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 10.6074
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9 9.56988
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.70152
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, HSD17B1, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 8.10441
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.20457
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, SLC1A1, XDH 7.18864
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIK3CA, PPARA, PPARG, PTGS1, PTGS2, XDH 7.1782
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.94437
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 6.94437
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.78641
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.54948
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 6.36875
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.13125
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.79044
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 5.72853
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.68075
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 5.48408
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.35422
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.35422
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.35422
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 5.32198
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.3077
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.3077
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.3077
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.3077
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.3077
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.23763
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 5.15634
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.13774
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1 4.93745
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, NQO2, PTGS1 4.88734
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, GRIK5, GRM5, HSP90AB1, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2 4.77089
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 4.68002
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.65818
[BP] GO:0007154 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PTGS2, SLC1A1 4.53327
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.44692
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PPARG, PTGS1, PTGS2, XDH 4.39167
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.37723
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 4.28574
[BP] GO:1901568 fatty acid derivative metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.11179
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, PPARG 4.0714
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.92826
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.8701
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.8701
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.80126
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PPARG 3.79512
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.7128
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.7128
[BP] GO:0032787 None CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 3.7128
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.67852
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.63151
[BP] GO:0010033 response to organic substance AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, GRIK5, GRM5, HSP90AA1, HSP90AB1, MMP2, PIK3CA, PPARA, PPARG, PTGS2 3.63151
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 3.58986
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SLC1A1, XDH 3.52344
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PPARG 3.45478
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTPN1 3.38925
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.26512
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.26512
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26512
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, PIK3CA, PIK3CB, PTGS1, PTGS2 3.23815
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, CHRM5, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, XDH 3.19999
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, CHRM5, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, XDH 3.15675
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, XDH 3.0933
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, XDH 3.00708
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, XDH 2.98089
[BP] GO:0042221 response to chemical AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, GRIK5, GRM5, HSP90AA1, HSP90AB1, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2 2.945
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, HSP90AA1, MMP1, MMP2, MMP9, PIK3CB, XDH 2.92454
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, CSNK2A1, CYP1B1, ESR1, GRIK5, HCAR2, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, XDH 2.89743
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, HSP90AA1, HSP90AB1, PTGS2, SLC1A1 2.88808
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRM1, HCAR2, HSP90AB1, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.88148
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, HCAR2, PPARA, PPARG, PTGS2 2.87462
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRM1, HCAR2, HSP90AB1, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.86552
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.75233
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1 2.73136
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, CSNK2A1, CYP1B1, ESR1, GRIK5, HCAR2, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, XDH 2.7267
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, CSNK2A1, CYP1B1, ESR1, GRIK5, HCAR2, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, XDH 2.68199
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, PTGS2, SLC1A1 2.67773
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, PPARA, PPARG, PTGS2 2.67713
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, CA1, CSNK2A1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1 2.65662
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, GRM5, MMP2, PPARA, PPARG, PTGS2 2.64475
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, PTGS2, SLC1A1 2.64475
[BP] GO:0099566 None GRM1, GRM5 2.46221
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46221
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, XDH 2.42223
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, MMP2, MMP9, PPARG, PTGS1, PTGS2, XDH 2.37579
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSP90AB1, PPARG, PTGS2 2.37579
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PPARG, PTGS2 2.37579
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, CDC25B, CSNK2A1, ESR1, FABP4, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, XDH 2.3529
[BP] GO:0051049 regulation of transport ACHE, ADORA1, CA2, CA7, CHRM1, CYP19A1, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1 2.3466
[BP] GO:0006810 None ACHE, ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, XDH 2.31479
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30073
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, CYP1B1, ESR1, GRIK5, GRM5, MMP2, MMP9, PIK3CA, PPARG, PTGS2 2.25756
[BP] GO:0010035 response to inorganic substance AKR1B1, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PTGS2 2.25756
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.25756
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.25756
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25756
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.24841
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, FABP3, GRM1, GRM5, HSP90AB1, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.24385
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, FABP3, GRM1, GRM5, HSP90AB1, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.24385
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, GRIK5, GRM5, HSP90AB1, MMP2, MMP9, PIK3CA, PPARG, PTGS2 2.24385
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.2259
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.2259
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.2259
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2259
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.17975
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, GRM1, GRM5, HSP90AB1, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.17587
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1 2.16721
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1 2.16679
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, HSP90AB1, MMP2, PPARA, PPARG, PTGS2, PTPN1 2.14651
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.14651
[BP] GO:0008217 None ADORA1, PPARA, PPARG, PTGS1, PTGS2 2.13507
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.13227
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.10768
[BP] GO:0046541 None CHRM1, CHRM3 2.04434
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.04434
[BP] GO:0010891 None PPARA, PPARG 2.04434
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, GRM1, GRM5, HSP90AB1, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.03912
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSP90AA1, HSP90AB1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1 2.03717
[BP] GO:0051234 None ACHE, ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, XDH 2.03717
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, HSP90AA1, PPARA, PPARG, SLC1A1 2.03717
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.0291
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, GRM1, GRM5, HSP90AB1, PIK3CA, PIK3CB, PTPN1 2.01661
[BP] GO:0006937 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 2.01098
[BP] GO:0045923 None PPARA, PPARG, PTGS2 2.00527
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, CA2, CYP1A1, GRM1, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, PTGS2 2.00527
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.00502
[BP] GO:0019217 None FABP3, PPARA, PPARG, PTGS2 2.00405
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, PTGS2, SLC1A1 6.96872
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.46097
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.72843
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 4.37723
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.67787
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2 3.44972
[CC] GO:0044463 None ADORA1, AKR1B1, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1 2.98911
[CC] GO:0120038 None ADORA1, AKR1B1, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1 2.98911
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2 2.73315
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, CA12, CA14, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, MMP2, PIK3CA, PIK3CB, PTPN1, SLC1A1 2.68747
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5 2.52652
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5 2.52652
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2 2.51664
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, CA12, CA14, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1 2.47338
[CC] GO:0097458 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2 2.47049
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, PTGS2, SLC1A1 2.10768
[CC] GO:0045202 None ACHE, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.01661
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 15.255
[MF] GO:0046914 transition metal ion binding CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PPARG, PTPN1, XDH 11.7664
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 9.78967
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 8.70152
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.68552
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 7.41054
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PPARG, PTPN1 7.18864
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.96828
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.54948
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 5.78661
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.72853
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.49921
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.49312
[MF] GO:0043167 ion binding ACHE, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, HSD17B1, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, XDH 5.33557
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.25762
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG 5.11467
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSP90AA1, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, XDH 4.63758
[MF] GO:0043169 cation binding ACHE, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, XDH 4.57516
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, XDH 4.53327
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, XDH 4.53327
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG 4.41069
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.27488
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.27176
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG 4.25106
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.09002
[MF] GO:0005506 iron ion binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.03677
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG 3.8701
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.7128
[MF] GO:0046872 metal ion binding CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, XDH 3.69718
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 3.56492
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 3.56492
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.46994
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.26512
[MF] GO:0008144 drug binding ACHE, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AA1, HSP90AB1, NQO2, PIK3CA, PIK3CB, PPARA, PPARG 3.2368
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.10062
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 3.08148
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85273
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85273
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85273
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG 2.73136
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG 2.73136
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.67358
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.51664
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.51664
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.51664
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, PPARG 2.46896
[MF] GO:0099583 None GRM1, GRM5 2.46221
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2259
[MF] GO:0004971 None GRIA2, GRIA4 2.2259
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.14651
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.14651
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04434


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA7, CA6, CA9, CA14 16.8857
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 10.6014
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, PIK3CA, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 9.5829
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.5824
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 7.0811
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, PIK3CB 6.4048
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.6895
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, PIK3CA, MMP1, MMP2, PPARG, PIK3CB, PTGS2, MMP9 4.8976
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1 5.4812
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.8049
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.1947
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 4.6306
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.7972
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, CDC25B 4.2221
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.8874
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 4.1513
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 4.1842
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, CHRM5, PIK3CB 3.7484
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1, ESR2 3.5131
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, PIK3CA, PIK3CB 3.1737
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.9108
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, PIK3CA, PIK3CB 2.8139
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.9108
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.9108
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.8139
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.8139
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.3302
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, AKR1B10, HSD17B1, CYP1A2, CYP1A1, AKR1B1, PTGS2, CYP19A1, XDH, PTGS1 2.1878
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, CYP1B1, PTGS2, MMP9, CDC25B 2.2874
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9504
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.9374
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.5411
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIK3CB 2.0111
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.4689
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PPARG, PIK3CB 2.0883
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4744
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.187
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.8336
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.8536
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PPARG, PIK3CB 1.8239
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PPARG, PIK3CB 1.7862
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1 1.7862
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.768
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7862
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, PIK3CB, MMP9 1.7165
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.7506
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.7001
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.6613
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.5183
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3007
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4004
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4142
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4907
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4861
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6182
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.6176
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.1227
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5955
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1 1.5955
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6653
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.7481
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIK3CB 1.0468
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5289
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1 1.0118
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3731
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.555
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, PIK3CB 0.8752
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB 1.116
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5481
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.5615
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 1.0924
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7981
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.9289
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.1466
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.8921
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, PIK3CB 1.3503
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 PPARG, MMP9 0.9727
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.5547
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, PIK3CB 0.8993
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, PIK3CB 0.8303
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.4121
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.9897
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.3609
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.5183
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB 1.3255
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.4451
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.5547
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.3354
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.5183
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 1.1776
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.5544
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.2299
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.9481
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.5544
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.3148
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3388
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.5299
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.5814
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.3731
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.3255
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5959
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3503
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.3573
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, PIK3CB 1.2387
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.6022
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.3255
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5299
Serotonergic synapse_Homo sapiens_hsa04726 PTGS2, PTGS1 1.2756
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.6176
Gap junction_Homo sapiens_hsa04540 GRM5, GRM1 1.4078
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.5183
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6223
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7095
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.6356
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7862
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7397
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6356
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6356
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.6356
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.5183
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.7001
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.4907
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6356
Arachidonic acid metabolism_Homo sapiens_hsa00590 PTGS2, PTGS1 1.5814
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.542
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.6423
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.6356
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9606
Peroxisome_Homo sapiens_hsa04146 XDH 0.6482
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.4959
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.7293
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6951
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7047
Bile secretion_Homo sapiens_hsa04976 CA2 0.7025
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8365
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9161
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7368
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.5278
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.821
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8471
Thyroid cancer_Homo sapiens_hsa05216 PPARG 1.0131
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 1.0131
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2 1.0924
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0352


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)