TCM Prescription: Xiao Chuan Pills



Prescription Description
Prescription IDTCMF6651
Pinyin NameXiao Chuan Wan
Chinese Name哮喘丸
English NameXiao Chuan Pills
Function Description咳嗽, 喘病
IndicationsDyspnea
Disease ICD-11 Category MD11.5 [Dyspnoea, 呼吸困难 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH60 Ginkgo biloba 白果 TCMH60 ITSAJ4779-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH705 Trichosanthes kirilowii 瓜蒌 TCMH705 ITSAO4359-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2025 Pollen pini 松花粉 TCMH2025
TCMH2681 Caulis bambusae in taeniam 竹茹 TCMH2681
TCMH1179 Citri exocarpium rubrum 橘红 TCMH1179
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH777 Pumex 海浮石 TCMH777
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT340 GLRA1 Glycine receptor subunit alpha-1 Ion channel P23415
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT578 GLRA2 Glycine receptor subunit alpha-2 Ion channel P23416
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, GLRA1, HSD17B2, IGF1R, INSR, MAOB, MMP2, MMP9, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, PPARD, RORC, SRC, TEK, TRPV1, TYR 13.1808
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GLRA1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, PPARD, RORC, SMAD3, SRC, TEK, TRPV1, TYR 13.1808
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, INSR, KDR, MAOB, MET, MIF, OPRD1, OPRK1, OPRM1, PDE3A, POLA1, POLB, PPARA, PPARD, SMAD3, SRC, TEK, TERT, TRPV1, XDH 13.1808
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GLRA1, HSD17B2, HSPA1A, HTR2A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, PPARD, RORC, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, TYR 13.1808
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PDE3A, PPARA, PPARD, TBXAS1, TRPV1 11.759
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, MIF, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PPARD, TBXAS1, TYR, XDH 10.7707
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, TBXAS1 10.1383
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, GLRA1, HTR2A, KDR, MAOB, NR3C1, OPRK1, OPRM1, PDE3A, POLB, SRC, TOP1, TRPV1 9.97155
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, TBXAS1 9.85579
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, MAOB, NR3C1, OPRK1, OPRM1, PDE3A, RORC, SRC, TEK, TRPV1, TYR 9.22782
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE5A, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.18147
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE5A, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.15259
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, GLRA1, IGF1R, INSR, MAOB, MMP2, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, TRPV1 9.14737
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 8.97045
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GLRA1, HSD17B2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TRPV1, TYR 8.9614
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GLRA1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARD, RORC, SMAD3, SRC, TERT, TRPV1 8.9614
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARD, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.74459
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 8.71426
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, EGFR, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, OPRM1, PDE5A, PIM1, PPARD, SMAD3, SRC, TEK, TERT, XDH 8.71208
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARA, PPARD, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.7038
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 8.67472
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, MIF, PDE3A, PPARA, PPARD, TBXAS1 8.67472
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 8.55607
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 8.53306
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, PIM1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.50073
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GLRA1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, PPARD, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 8.50073
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, GLRA1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, PIM1, PPARA, PPARD, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 8.48324
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, GLRA1, KDR, MAOB, OPRD1, OPRK1, POLB, SRC 8.32184
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, GLRA1, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK, TRPV1, TYR 8.26909
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PPARD, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.25959
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BACE1, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, GLRA1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.24165
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, TBXAS1 8.22542
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PPARD, TBXAS1 8.21092
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 8.21085
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, GLRA1, IGF1R, INSR, KDR, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARD, RORC, SMAD3, SRC, TRPV1 8.2077
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BACE1, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, GLRA1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.10488
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 8.00034
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, MAOB, NR3C1, OPRK1, OPRM1, PPARD, RORC, SRC, TYR 7.93222
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, OPRK1, PPARD, SMAD3, SRC, TEK, TERT 7.89425
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.87358
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, OPRK1, PPARD 7.8371
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, GLRA1, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK, TRPV1, TYR 7.77615
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLRA1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, PIM1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.65919
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, GLRA1, KDR, MAOB, MMP9, SRC, TERT 7.55902
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, INSR, MAOB, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PPARD, PTPN1, SMAD3, SRC, TERT, TRPV1 7.55902
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP2, NR3C1, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TYR, XDH 7.39747
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARA, PPARD, PTPN1, SMAD3, SRC, TEK, TERT 7.39538
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARD, PTPN1, SMAD3, SRC, TEK, TERT 7.35284
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GLRA1, GPR35, HSPA1A, HTR2A, IGF1R, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.28028
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, EGFR, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MIF, OPRK1, OPRM1, PDE5A, PPARD, PTPN1, SRC, TEK, XDH 7.2123
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PPARD 7.18815
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PPARD, PTPN1, SRC, TEK, XDH 7.16311
[BP] GO:0003018 None ADORA1, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PDE3A, PPARD, SRC, TEK 7.15587
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOB, PPARD, TBXAS1, TYR, XDH 7.15587
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, POLB, PPARA, PPARD, SMAD3, SRC, TEK, TERT, TRPV1, TYR 7.01593
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, MAOB, NR3C1, OPRK1, PDE3B, PPARA, SRC, TEK, TRPV1 7.01121
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE5A, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.99661
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 6.98709
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1 6.9862
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PPARD, PTPN1, SMAD3, SRC, TEK, TERT 6.76974
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GLRA1, GPR35, HCAR2, HSPA1A, HTR2A, IGF1R, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 6.74201
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARD, SMAD3, SRC, TEK, TERT 6.73931
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HTR2A, INSR, KDR, MAOB, MET, MIF, MMP2, MMP9, PDE3A, PDE3B, PIM1, POLB, PPARA, PPARD, RORC, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.61907
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PPARA, PPARD, TBXAS1 6.52566
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, DRD2, EGFR, FLT3, HTR1A, HTR2A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD, TEK, TERT 6.52566
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOB, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PDE5A, PPARD, SRC, XDH 6.50028
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 6.49872
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLB, PPARD, PTPN1, SRC, TEK, TOP1, XDH 6.47288
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, GLRA1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 6.44806
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARD, SMAD3, SRC, TEK, TERT 6.31313
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, PDE3A, PPARD 6.26239
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, MIF, OPRK1, OPRM1, PDE5A, PTPN1, SRC, TEK, XDH 6.17124
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, GLRA1, IGF1R, INSR, MMP2, MMP9, NR3C1, OPRK1, PDE3A, PDE3B, PPARD, RORC, SRC, TRPV1 6.16043
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, DRD2, EGFR, GLRA1, GPR35, HCAR2, HTR2A, OPRD1, OPRK1, OPRM1, PDE5A, SMAD3, TRPV1 6.08367
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLB, PPARD, PTPN1, SRC, TEK, TOP1, XDH 6.03472
[BP] GO:0003013 None ADORA1, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PDE3A, PPARD, SRC, TEK 6.01875
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, AXL, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GPR35, HTR2A, INSR, MET, POLA1, POLB, SMAD3, SRC, TERT, TRPV1 6.01472
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GLRA1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLB, PPARA, PPARD, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK, TRPV1 5.98288
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CNR2, DRD1, DRD2, DUSP3, EGFR, GLRA1, GPR35, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SMAD3, SRC, TERT, XDH 5.83002
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CNR2, DRD1, DRD2, DUSP3, EGFR, GLRA1, GPR35, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SMAD3, SRC, TERT, XDH 5.80769
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARD, SMAD3, SRC, TEK, TERT 5.76215
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, DRD1, DRD2, EGFR, HCAR2, HTR2A, KDR, MIF, OPRK1, SRC, TRPV1 5.75753
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2 5.75679
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DRD2, DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MIF, OPRK1, OPRM1, PDE5A, PTPN1, SRC, TEK, XDH 5.74027
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, PDE3A, PPARD 5.73176
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2A, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 5.68978
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2A, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 5.68978
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, GLRA1, KDR, NR3C1, OPRM1, SRC, TRPV1 5.66112
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HTR1A, MAOB, PPARD, TYR 5.64737
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, HTR7, OPRK1, OPRM1, PPARA, RORC, SRC, TOP1, TOP2A 5.63405
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, NR3C1, OPRM1, PDE3A, RORC, SRC, TRPV1 5.58309
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, OPRM1, PPARA, PPARD, SMAD3 5.54162
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, POLB, PPARA, PPARD, SMAD3, SRC, TEK, TERT 5.53046
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CNR1, CSNK2A1, CYP1B1, DRD2, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PDE5A, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.52579
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GLRA1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 5.52579
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CDC25B, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 5.52579
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.52579
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.52579
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CNR1, CNR2, CYP19A1, DRD2, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, OPRK1, PPARA, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.48108
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CHRM1, CHRM2, CNR1, CYP1B1, DRD2, EGFR, GLRA1, GPR35, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PDE5A, PIM1, PPARD, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.48088
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, GLRA1, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 5.42967
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, GLRA1, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 5.42967
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CNR1, CNR2, CYP19A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PDE3B, PPARA, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.35441
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CDC25B, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 5.34067
[BP] GO:0003008 None ADORA1, AKR1B1, CHRM1, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, GLRA1, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE3A, PDE5A, PPARD, SRC, TEK, TRPV1, TYR 5.28674
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.27075
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.25786
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CHRM1, CNR1, DRD1, DRD2, GPR35, HTR1A, HTR2A, MAOB, MIF, MMP9, OPRD1, OPRK1, OPRM1 5.25464
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, DRD1, DRD2, EGFR, FABP4, KDR, MET, MIF, MMP12, OPRM1, PPARA, PPARD, SMAD3, TEK 5.25288
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.22766
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.2163
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.16409
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MIF, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, POLA1, POLB, PPARA, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 5.14986
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, PPARD, SMAD3, SRC, TEK, TERT 5.11925
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, EGFR, GLRA1, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 5.06211
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, PPARD, SMAD3, SRC, TEK, TERT 4.99058
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, MAOB, MIF, MMP12, OPRK1, OPRM1, PPARD, SRC, TRPV1 4.93046
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, RORC 4.92896
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, HTR2A, KDR, MIF, OPRM1, PTPN1, SRC, TEK 4.89063
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM4, CYP1A1, EGFR, FLT3, HTR1A, MET, MIF, PIM1, POLA1, PPARD, SRC, TEK, TYR 4.86332
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, OPRK1, OPRM1, PPARD, SRC 4.84827
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, HTR2A, MET, TRPV1 4.82874
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD1, DRD2, MIF, PPARA, PPARD, SMAD3, TEK 4.82211
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARD, TRPV1 4.8075
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, TEK, XDH 4.78109
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.74863
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, TEK, XDH 4.74863
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TRPV1, XDH 4.71979
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 4.71396
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA, PPARD, SMAD3, TEK 4.71102
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, EGFR, GLRA1, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 4.70785
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PTPN1, SRC, TEK, XDH 4.70785
[BP] GO:0097746 None ADORA1, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PPARD 4.69277
[BP] GO:0035296 None ADORA1, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PPARD 4.69277
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, EGFR, HCAR2, INSR, MIF, MMP12, OPRK1, PPARD, SMAD3, SRC, TERT, TRPV1 4.68721
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, MAOB, MIF, MMP12, OPRK1, OPRM1, PPARD, SRC 4.6615
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, GLRA1, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 4.6615
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, GLRA1, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 4.6615
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, DRD1, EGFR, FLT3, GLRA1, IGF1R, INSR, MMP2, NR3C1, OPRM1, PDE3A, PDE3B, SMAD3, SRC, TRPV1 4.65694
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, PDE3B, PPARA, RORC, SRC, TEK 4.63006
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, OPRK1, OPRM1, PPARD, SRC 4.61197
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CNR1, CYP1B1, DRD2, EGFR, HCAR2, HSPA1A, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRM1, PDE3A, PDE5A, PIM1, SMAD3, SRC, TEK, TERT, TRPV1 4.57896
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BACE1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, HTR2A 4.54868
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BACE1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, HTR2A 4.54868
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, TEK, XDH 4.54064
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, HSPA1A, MAOB 4.52619
[BP] GO:0050880 None ADORA1, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PPARD 4.52156
[BP] GO:0035150 None ADORA1, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PPARD 4.49863
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.4736
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PPARA, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.46887
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BACE1, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FLT3, FUT7, GLO1, HSPA1A, HTR1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLB, PPARA, PPARD, PTPN1, SENP6, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 4.46726
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.46279
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRK1, PPARD, SRC, TRPV1 4.42983
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.40848
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, GLRA1, PPARA, PPARD, TRPV1 4.38477
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.38477
[BP] GO:0030534 None DRD1, DRD2, GLRA1, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 4.35
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, HTR2A 4.34856
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, GLRA1, MAOB, MMP9, TERT 4.33585
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.3297
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, HTR1A, INSR, MAOB, SMAD3, TRPV1 4.30815
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, HTR2A, KDR, MIF, OPRM1, SRC, TEK 4.27407
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.27289
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, EGFR, NR3C1, OPRK1, OPRM1 4.22787
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, OPRK1, PPARD 4.19593
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 4.17726
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A 4.15904
[BP] GO:0040017 positive regulation of locomotion ALOX12, DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, OPRK1, SMAD3, SRC, TEK, TERT 4.15772
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC, TRPV1 4.09512
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, TEK, XDH 4.09512
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC 4.09186
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 4.08032
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, POLB, PPARA, PPARD, SMAD3, SRC, TEK, TYR 4.04633
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.02063
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.02063
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.99584
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, OPRK1, PDE3B, PPARA, SRC, TEK, TRPV1 3.99458
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, NR3C1, OPRD1, OPRM1, PDE3A, SMAD3, SRC, TRPV1 3.99281
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.97151
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOB, PDE10A, PDE3A, PDE3B, PDE5A, PPARD, XDH 3.97108
[BP] GO:0031644 None ADORA1, GLRA1, GPR35, OPRD1, OPRK1, OPRM1 3.95807
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FABP3, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.94924
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PDE5A, PIM1, POLA1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TRPV1, XDH 3.94924
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B, PDE5A 3.94924
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PPARD, PTPN1, SMAD3, SRC, TEK 3.9474
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD, SMAD3, TEK 3.86314
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, OPRD1, OPRM1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.85284
[BP] GO:0030335 positive regulation of cell migration ALOX12, DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 3.8449
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PDE5A, PPARD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.83907
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GLRA1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.80167
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, HTR2A, OPRK1 3.77722
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, MIF, SRC, TERT 3.77722
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, GLRA1, KDR, OPRD1 3.7606
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MAOB, MMP9, PIM1, POLB, PPARA, PPARD, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 3.75894
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, GLRA1, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, TEK 3.75894
[BP] GO:0042060 None ALOX15, EGFR, OPRM1, PPARA, PPARD, SMAD3 3.75238
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.75238
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 3.75238
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, HSPA1A, MAOB, PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.75087
[BP] GO:0007610 None CNR1, DRD1, DRD2, EGFR, GLRA1, HTR1A, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PPARA, TRPV1 3.74329
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, MAOB, TYR 3.72784
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.72784
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.72784
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.72784
[BP] GO:2000147 positive regulation of cell motility ALOX12, DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 3.7217
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.69507
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GLRA1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TRPV1, XDH 3.65267
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MIF, PPARD 3.645
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, MIF, MMP9, NUAK1, OPRM1, PDE5A, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.64318
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, FABP3, FABP4, GPR35, HTR2A, INSR, MET, SMAD3, TRPV1 3.63307
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PTPN1, SRC 3.61653
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A, MAOB 3.6139
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 3.61137
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, OPRD1, PDE3A, SMAD3, SRC, TRPV1 3.60501
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, OPRD1, OPRM1, POLA1, POLB, PPARD, PTPN1, SRC, TERT, TOP2A, TRPV1 3.60046
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.58997
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7, TRPV1 3.54706
[BP] GO:0042698 ovulation cycle AXL, EGFR, OPRK1, OPRM1 3.54543
[BP] GO:0050995 None ADORA1, CNR1, HCAR2, PDE3B 3.54543
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.51889
[BP] GO:0042391 None ADORA1, CNR1, CNR2, DRD1, GLRA1, GPR35, KDR, OPRD1, OPRM1, SRC, TRPV1 3.51784
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MIF, MMP12, PPARD, SRC 3.48236
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, GLRA1, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, TEK, TRPV1 3.47667
[BP] GO:0072523 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.47198
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, DUSP3, EGFR, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRM1, PDE3B, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.46988
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, DRD2, DUSP3, MIF, MMP12, PDE5A 3.46544
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR2A, MET, OPRK1 3.44058
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.43994
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SRC, TEK, XDH 3.42847
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.41107
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.41107
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PDE3B, PPARA 3.40321
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE5A, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.4001
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.3985
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, INSR, MIF, PDE5A, PTPN1, SRC 3.38431
[BP] GO:0043271 negative regulation of ion transport ADORA1, CNR1, DRD2, GPR35, HTR2A, MAOB, MMP9 3.37638
[BP] GO:0019233 None CNR1, CNR2, OPRD1, OPRK1, OPRM1 3.36919
[BP] GO:0050877 None ADORA1, CHRM1, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, GLRA1, HTR2A, INSR, OPRD1, OPRK1, OPRM1, TRPV1, TYR 3.354
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.35164
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, PPARD 3.31707
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, GLRA1, HSD17B2, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PPARD, SRC, TOP2A 3.30741
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, GLRA1, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, TEK 3.3061
[BP] GO:0050890 None ADORA1, CHRM1, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, OPRK1 3.29832
[BP] GO:2000243 None GLRA1, INSR, PDE3A, PDE5A, SRC 3.26713
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR, PDE3A, PPARD 3.26147
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, GLRA1, MMP9 3.2593
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, DRD2, EGFR, FLT3, HSPA1A, HTR2A, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.25112
[BP] GO:0043434 None APEX1, FABP3, INSR, OPRK1, PDE3B, PPARA, SRC, TEK, TRPV1 3.22909
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRM1, PPARD, PTPN1, SMAD3, SRC 3.22654
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, INSR, MET, SRC, TEK, XDH 3.21686
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRK1, PPARD, SRC 3.20442
[BP] GO:0014059 None CNR1, DRD2, HTR2A, OPRK1 3.17931
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17931
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17931
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17931
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17931
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 3.1765
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 3.15734
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PDE5A, PIM1, POLA1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.13559
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, GLRA1, HTR2A, MAOB, MMP12, OPRK1, OPRM1, PPARD, SMAD3, SRC, TRPV1, TYR 3.13559
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.13559
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, MIF, PDE3A, PIM1, SENP6, SMAD3, SRC, TERT, TOP2A 3.11086
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, CDC25B, DRD2, EGFR, FLT3, HSPA1A, HTR2A, INSR, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.1108
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PPARD, SRC, TEK 3.10696
[BP] GO:0002791 None ACHE, ADORA1, CNR1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRM1, PPARD, SRC 3.09646
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, HSPA1A, MAOB, PDE10A, PDE3A, PDE3B, PDE5A, PPARD, SRC, XDH 3.09579
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.0769
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B, PDE5A 3.0769
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.0769
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 3.05533
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, MIF, PDE5A, PTPN1, SRC, TEK 3.05383
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC, TEK 3.03564
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, EGFR, HCAR2 3.03564
[BP] GO:0050795 None ADORA1, CNR1, DRD2, HTR1A, HTR2A 3.02673
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B, PDE5A 3.02612
[BP] GO:0043278 None CNR1, DRD2, OPRK1, OPRM1 2.97328
[BP] GO:0014072 None CNR1, DRD2, OPRK1, OPRM1 2.97328
[BP] GO:0007568 aging APEX1, AURKB, CNR1, CYP1A1, HTR2A, MIF, POLB, TERT 2.97328
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, FABP4, PPARA, PPARD, SMAD3, TEK 2.92517
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, MIF, MMP12, PPARD, SRC 2.92517
[BP] GO:1902893 None PPARA, PPARD, SMAD3, TERT 2.92517
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOB 2.91776
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 2.91776
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, GLRA1, MMP9 2.89315
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SENP6, SRC, TEK, TOP1, TOP2A 2.88383
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 2.88383
[BP] GO:0051930 None ADORA1, OPRD1, OPRK1, OPRM1 2.88093
[BP] GO:0051931 None ADORA1, OPRD1, OPRK1, OPRM1 2.88093
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 2.86684
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.86395
[BP] GO:0031635 None OPRK1, OPRM1 2.86395
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.86395
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.86395
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.86395
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.86395
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.86092
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.86092
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.86092
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.84868
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, NR3C1, SRC 2.8233
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 2.81836
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, MIF, PDE5A, PTPN1, SRC, TEK 2.80767
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC 2.80266
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR 2.80266
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC, TEK 2.77175
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, PPARA, SRC, TEK 2.76581
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF 2.76244
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76215
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC 2.7346
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, PPARD, SRC, TEK 2.73112
[BP] GO:0051094 positive regulation of developmental process ALOX12, AXL, CA2, CNR1, CYP1B1, DRD2, HTR2A, INSR, KDR, OPRM1, PDE3A, PDE5A, PIM1, PPARD, SMAD3, SRC, TEK, TERT 2.72512
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.7178
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CNR1, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, PDE3B, PPARA, PTPN1, SMAD3 2.71651
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 2.7157
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, MMP12, OPRK1, OPRM1, PPARD, SMAD3, SRC 2.7057
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE5A, PIM1, POLA1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.7057
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PPARD, SRC, TEK 2.7057
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7 2.68378
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PPARD, TERT 2.68378
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.6765
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.6765
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, MIF, PDE5A, PTPN1, SRC 2.66673
[BP] GO:0050708 None ACHE, CNR1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRM1, PPARD, SRC 2.65949
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, HSPA1A, IGF1R, MET, MIF, MMP9, PDE3B, PTPN1, SRC, XDH 2.64598
[BP] GO:0009895 negative regulation of catabolic process ADORA1, CNR1, EGFR, HCAR2, MET, PDE3B, PPARA, SMAD3 2.63885
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PPARD, TRPV1, TYR 2.63198
[BP] GO:0003012 None ADORA1, DRD1, DRD2, GLRA1, HTR2A, HTR7, PDE5A, TRPV1 2.62933
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, EGFR, HSPA1A, INSR, MIF, PDE3A, SENP6, TERT 2.62371
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, PPARD 2.6209
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.6136
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.6136
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, CNR1, CYP1A1, EGFR, OPRM1, PPARD, SRC, TRPV1, TYR 2.60183
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.598
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.598
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARD, TYR 2.59045
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA 2.58004
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, INSR, MIF, PDE5A, PTPN1, SRC 2.5636
[BP] GO:0007623 circadian rhythm DRD2, EGFR, HTR7, PPARA, RORC, TOP1 2.5636
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.54436
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.54436
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, MMP12, OPRK1, OPRM1, PPARD, SMAD3, SRC 2.54051
[BP] GO:2000241 regulation of reproductive process CNR1, GLRA1, INSR, PDE3A, PDE5A, SRC 2.53229
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.52159
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.52159
[BP] GO:0032868 None FABP3, INSR, OPRK1, PDE3B, PPARA, SRC 2.51784
[BP] GO:0050999 None CNR1, CNR2, EGFR, TERT 2.51062
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, KDR, MET, MIF, OPRM1, SMAD3 2.4863
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, PPARD 2.47642
[BP] GO:0060359 None CNR1, DRD1, DRD2, OPRK1, OPRM1 2.46778
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.46778
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.46778
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46778
[BP] GO:0033602 None CNR1, DRD2 2.46778
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.44926
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, MIF, SRC, TRPV1 2.44926
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, DRD2, EGFR, HTR2A, PDE5A 2.43744
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.42846
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PPARD 2.42621
[BP] GO:0050433 None CNR1, DRD2, HTR2A, OPRK1 2.41933
[BP] GO:0043279 None CNR1, DRD2, OPRK1, OPRM1, TRPV1 2.40939
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 2.39682
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 2.38424
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, MAOB, NR3C1, SRC 2.34217
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PDE3B, PDE5A, PPARA, SMAD3, SRC, TEK 2.34164
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, PPARD 2.33829
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.33648
[BP] GO:0007631 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.33178
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.33178
[BP] GO:0042053 None DRD1, HTR1A, MAOB 2.32743
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.32743
[BP] GO:0042069 None DRD1, HTR1A, MAOB 2.32743
[BP] GO:0051223 None ACHE, CHRM1, CNR1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRM1, PPARD, PTPN1, SMAD3, SRC 2.3123
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, MAOB, NR3C1, SRC 2.29713
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, PPARD, TEK 2.29531
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, DRD2, EGFR, HCAR2, MIF, MMP12, PPARD, SMAD3, SRC 2.27785
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.27785
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.27785
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, CA2, CNR1, CYP1B1, DRD2, EGFR, HTR2A, INSR, KDR, MIF, NUAK1, OPRM1, PDE3A, PDE3B, PDE5A, PIM1, PPARA, PPARD, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.27383
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.27021
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, EGFR, HTR2A, IGF1R, INSR, KDR, MET, MIF, NUAK1, OPRM1, PDE3A, POLB, PTPN1, SRC, TEK 2.25365
[BP] GO:0032880 regulation of protein localization ACHE, CHRM1, CNR1, CSNK2A1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRM1, PPARD, PTPN1, SMAD3, SRC, TERT 2.23474
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.22059
[BP] GO:0050730 None ADORA1, EGFR, FLT3, HTR2A, MIF, PTPN1, SRC 2.21989
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, PPARD 2.21989
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.21582
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.21582
[BP] GO:0007198 None HTR1A, HTR7 2.21582
[BP] GO:0060282 None PDE3A, PDE5A 2.21582
[BP] GO:0051970 None GLRA1, GPR35 2.21582
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.21582
[BP] GO:0038171 None CNR1, CNR2 2.21582
[BP] GO:1905881 None PDE3A, PDE5A 2.21582
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21582
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.21422
[BP] GO:1900542 None DRD1, DRD2, HTR2A, INSR, OPRM1, PDE5A, PPARA 2.19777
[BP] GO:0032922 None DRD2, PPARA, RORC, TOP1 2.19581
[BP] GO:0009187 None PDE10A, PDE3A, PDE3B, PDE5A 2.19581
[BP] GO:0032768 None CNR1, CNR2, EGFR, TERT 2.19581
[BP] GO:0051051 negative regulation of transport ADORA1, CNR1, DRD2, GPR35, HSPA1A, HTR2A, MAOB, MMP9, OPRK1, OPRM1 2.19328
[BP] GO:0007611 None CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, OPRK1 2.19149
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, CYP1B1, DRD2, FABP3, HSPA1A, OPRM1, PDE5A, PPARD, SMAD3, TERT, XDH 2.17952
[BP] GO:0031667 response to nutrient levels ALPL, CNR1, CYP1A1, EGFR, OPRM1, PPARD, SRC, TRPV1, TYR 2.17102
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.1695
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.16795
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR 2.16795
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.14947
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD1, DRD2, FABP3, GLRA1, HTR2A, OPRM1, PPARA, PPARD, TRPV1 2.14792
[BP] GO:0072347 None CNR1, DRD2, OPRK1, OPRM1 2.14792
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.14792
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.14792
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, GLRA1, HSD17B2, KDR, MMP2, SRC 2.13671
[BP] GO:0006140 None DRD1, DRD2, HTR2A, INSR, OPRM1, PDE5A, PPARA 2.13671
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.13443
[BP] GO:0070201 None ACHE, CHRM1, CNR1, DRD2, EGFR, HCAR2, MIF, MMP12, OPRM1, PPARD, PTPN1, SMAD3, SRC 2.13225
[BP] GO:0050866 negative regulation of cell activation ALOX12, AXL, CNR1, CNR2, DUSP3, PDE5A 2.12434
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.12434
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.12434
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.12434
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12434
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.12434
[BP] GO:0007162 negative regulation of cell adhesion ALOX12, CYP1B1, DUSP3, PDE3B, PDE5A, PPARA, SRC 2.10273
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE5A, PIM1, POLA1, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.10273
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, MIF, PTPN1, SRC 2.09074
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, CHRM1, DRD2, EGFR, HCAR2, MIF, MMP12, PPARD, SMAD3, SRC 2.08792
[BP] GO:0051894 None KDR, SMAD3, TEK 2.07674
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.07674
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.07674
[BP] GO:0030522 intracellular receptor signaling pathway NR3C1, PIM1, PPARA, PPARD, RORC, SRC 2.06933
[BP] GO:0019439 None CYP1A1, CYP2A6, HSPA1A, MAOB, PDE10A, PDE3A, PDE3B, PDE5A, XDH 2.05999
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.05453
[BP] GO:0021853 None DRD1, DRD2 2.04146
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.04146
[BP] GO:1904936 None DRD1, DRD2 2.04146
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.04146
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.04146
[BP] GO:0042321 None ADORA1, DRD2 2.04146
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.0335
[BP] GO:0007626 None DRD1, DRD2, GLRA1, OPRD1, OPRK1, OPRM1 2.02578
[BP] GO:0046434 None PDE10A, PDE3A, PDE3B, PDE5A, XDH 2.01722
[BP] GO:0045927 positive regulation of growth ALOX12, CSNK2A1, DRD2, EGFR, INSR, PIM1, PPARD 2.01567
[BP] GO:0045471 None CNR1, GLRA1, MAOB, OPRK1, POLB 2.00207
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, FLT3, GLRA1, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK, TRPV1 7.24599
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, FLT3, GLRA1, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK, TRPV1 7.00148
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, EGFR, GLRA1, HTR2A, INSR, MET, OPRD1, OPRM1, SIGMAR1, SRC, TEK, TRPV1 5.83273
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DUSP3, EGFR, FLT3, GLRA1, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TEK, TRPV1 5.17011
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD1, DRD2, EGFR, FLT3, GLO1, GLRA1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 4.90842
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FLT3, FUT7, GLO1, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR 4.58626
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FLT3, FUT7, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SIGMAR1, SRC, TBXAS1, TEK, TRPV1, TYR 4.01753
[CC] GO:0043204 None CNR2, DRD2, GLRA1, OPRK1, OPRM1, PDE10A, TOP1 3.86314
[CC] GO:0032589 None ADORA1, INSR, OPRD1, OPRM1, TRPV1 3.8365
[CC] GO:0045121 membrane raft BACE1, CNR1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.83088
[CC] GO:0098857 membrane microdomain BACE1, CNR1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.80793
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, OPRD1, OPRM1, SRC, TRPV1 3.60046
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, BACE1, CA1, CA2, CA4, CA7, CDC25B, CES2, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GLRA1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR2A, INSR, KDR, MAOB, MIF, MMP2, MMP9, NR3C1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 3.51439
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD2, GLRA1, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 3.32307
[CC] GO:0043679 None CHRM1, CHRM2, DRD2, OPRD1, OPRK1 3.30327
[CC] GO:0098589 membrane region BACE1, CNR1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.22262
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CNR1, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 3.09587
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CNR1, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 3.09587
[CC] GO:0044306 None CHRM1, CHRM2, DRD2, OPRD1, OPRK1 2.86395
[CC] GO:0009330 None TOP1, TOP2A 2.86395
[CC] GO:0043005 None ADORA1, BACE1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD2, GLRA1, HTR2A, OPRD1, OPRK1, OPRM1, SRC 2.78021
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, FLT3, FUT7, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, TBXAS1, TEK, TRPV1, TYR 2.70747
[CC] GO:0097458 None ADORA1, BACE1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD2, GLRA1, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PDE10A, SIGMAR1, SRC, TOP1, TRPV1 2.67985
[CC] GO:0032590 None INSR, OPRD1, OPRM1 2.6765
[CC] GO:0044432 endoplasmic reticulum part BACE1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, FLT3, HSD11B1, HSD17B2, PTPN1, SIGMAR1, TBXAS1 2.62324
[CC] GO:0005783 None ADORA1, APEX1, CA4, CES2, CYP19A1, CYP2D6, FLT3, GLRA1, HSPA1A, KDR, OPRM1, PDE3B, PTPN1, SIGMAR1, XDH 2.59809
[CC] GO:0045211 None CHRM1, CHRM2, CHRM4, GLRA1, OPRD1, SIGMAR1, TRPV1 2.4319
[CC] GO:0097060 None CHRM1, CHRM2, CHRM4, CNR1, GLRA1, OPRD1, SIGMAR1, TRPV1 2.42106
[CC] GO:0031256 None ADORA1, INSR, OPRD1, OPRM1, SRC, TRPV1 2.34855
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, FLT3, FUT7, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, TBXAS1, TEK, TRPV1, TYR 2.22924
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, HSD11B1, HSD17B2, SIGMAR1, TBXAS1 2.21212
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 2.19581
[CC] GO:0098793 None ADORA1, CHRM1, CHRM2, DRD2, OPRD1, OPRK1 2.16795
[CC] GO:0120025 None ADORA1, AKR1B1, BACE1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD1, DRD2, GLRA1, HTR2A, OPRD1, OPRK1, OPRM1, SRC, TEK 2.13041
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 14.3399
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PTPN1, SENP6, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TYR, XDH 13.1808
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GLO1, GLRA1, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 13.1808
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.4544
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FLT3, GLRA1, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PIM1, PPARA, PPARD, SIGMAR1, SRC, TEK, TOP1, TOP2A, TRPV1 10.7343
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GLRA1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PPARD, RORC, SIGMAR1, TEK, TRPV1 10.3571
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, GLO1, GLRA1, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SMAD3, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 10.004
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.36438
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GLRA1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PPARD, RORC, SIGMAR1, TEK, TRPV1 9.15128
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, XDH 9.0737
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GLRA1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PPARD, RORC, SIGMAR1, TEK, TRPV1 8.88932
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GLRA1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PPARD, RORC, SIGMAR1, SMAD3, TEK, TRPV1 8.8849
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, POLB 8.7038
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.24165
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK, TRPV1 7.9605
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK, TRPV1 7.9605
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 7.89425
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOB, TBXAS1, TYR, XDH 7.87358
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, GLRA1, HTR1A, HTR2A, HTR7, OPRM1 7.36451
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SMAD3, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 7.22925
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.16138
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR2A, HTR7, OPRM1 6.82161
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.78492
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.78116
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.49915
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1, POLB 6.46559
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.34997
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 6.05625
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.02783
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARD, PTPN1, RORC, SMAD3 5.70184
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, DRD2, HTR1A, HTR2A, HTR7 5.68978
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.62492
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.25786
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, MAOB, POLA1, SRC, TBXAS1, XDH 4.91704
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, GPR35, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 4.65233
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.54254
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, PDE10A, PDE3A, PDE3B, PDE5A 4.46957
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B, PDE5A 4.27289
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CES2, CHRM1, DUSP3, PDE10A, PDE3A, PDE3B, PDE5A, POLA1, PTPN1 4.15904
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.97151
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 3.86291
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, DUSP3, PDE10A, PDE3A, PDE3B, PDE5A, PTPN1 3.82716
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, GLRA1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE10A, PDE3A, PDE5A, PIM1, POLA1, PPARD, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 3.6573
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.58632
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NR3C1 3.54329
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.41315
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B, PDE5A 3.41107
[MF] GO:0042165 neurotransmitter binding ACHE, GLRA1, HTR1A, HTR2A, HTR7 3.40321
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B, PDE5A 3.35164
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.33096
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK, TERT, TOP1 3.30333
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.20442
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.20442
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 2.95444
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 2.95444
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.86395
[MF] GO:0004119 None PDE3A, PDE3B 2.86395
[MF] GO:0008389 None CYP2A13, CYP2A6 2.86395
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.8277
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.598
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP12, NR3C1, NUAK1, PDE10A, PDE3A, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, XDH 2.59497
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.5636
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.47195
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE10A, PDE3A, PDE5A, PIM1, POLA1, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 2.46778
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE10A, PDE3A, PDE5A, PIM1, POLA1, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 2.46778
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.46778
[MF] GO:0004949 None CNR1, CNR2 2.46778
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.46778
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.46778
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, GLRA1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE10A, PDE3A, PDE5A, PIM1, PPARD, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 2.43338
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.38843
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GLRA1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TYR, XDH 2.38392
[MF] GO:0016853 None ALOX12, ALOX15, MIF, TBXAS1, TOP1, TOP2A 2.34855
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1 2.31598
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1 2.28189
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21582
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21582
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.16795
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.16795
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.12434
[MF] GO:1901363 heterocyclic compound binding ADORA1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EGFR, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP12, NR3C1, NUAK1, PDE10A, PDE3A, PDE5A, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, XDH 2.10273
[MF] GO:0003707 steroid hormone receptor activity NR3C1, PPARA, PPARD, RORC 2.10273
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.07674
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.07674
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.04146
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04146
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.01048


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, CHRM2, CHRM1, GPR35, CHRM4, HTR1A, OPRK1, OPRM1, TRPV1, HTR2A, NR3C1, GLRA1, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2 14.2554
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.5126
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.3995
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.9851
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.2922
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.2922
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2, PPARA 6.1508
Serotonergic synapse_Homo sapiens_hsa04726 HTR7, MAOB, CYP2D6, ALOX5, ALOX15, HTR1A, ALOX12, HTR2A 5.9813
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.0016
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.9066
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.7194
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 4.3262
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, EGFR, HSPA1A 4.1436
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.8102
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, INSR, PDE3B, ADORA1, PDE3A, PDE5A 3.8884
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 3.4415
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP2D6, CYP1A2, CYP3A4 3.8207
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R, PPARD 3.1857
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.1972
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 3.8207
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 2.9727
Gap junction_Homo sapiens_hsa04540 SRC, HTR2A, DRD1, DRD2, EGFR 3.3758
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR7, CHRM1, HTR2A, DRD1, EGFR 2.9727
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9594
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE10A, PDE3B, PDE3A, PDE5A, XDH 2.9792
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 3.5405
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, PDE3B, ADORA1 3.0805
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 3.3617
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1, HTR2A 2.2865
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, ALOX12 2.9727
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.1238
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 2.9223
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.2191
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 1.994
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 1.9863
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 1.9382
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.9248
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.0177
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9382
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5382
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5771
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.495
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8489
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, CDC25B, IGF1R 1.5224
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9014
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 2.1834
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 1.9382
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4216
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8925
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1308
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1, DRD2 1.2439
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PPARD 1.1509
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.134
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, ADORA1 1.3186
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR, PDE3B 1.1676
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0919
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 0.9772
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, TERT 0.6957
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7038
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, MIF, TYR 2.5745
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.7167
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7167
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 0.8167
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9024
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.7038
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8649
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 0.8952
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6674
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2311
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7038
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6735
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2474
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6556
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2388
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2311
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2406
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.2474
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6613
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.2609
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.6556
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2673
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.6503
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.488
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.631
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8925
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6128
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.4845
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3047
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9772
Axon guidance_Homo sapiens_hsa04360 MET 0.3185
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3256
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3358
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.0911
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3558
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1222
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3682
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3749
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3749
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.0853
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3682
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.3749
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.0796
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3827
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3824
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.3867
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.0402
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3991
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.134
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3991
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4095
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4087
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3986
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0911
Peroxisome_Homo sapiens_hsa04146 XDH 0.4095
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4414
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8052
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4429
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4401
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4292
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4495
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4675
Shigellosis_Homo sapiens_hsa05131 SRC 0.4694
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.488
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.4833
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5064
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5092
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5268
Malaria_Homo sapiens_hsa05144 MET 0.5415
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.5378
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5455
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5849
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6128
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6402
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5476
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6128
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6128
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.5382
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6988
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4889
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6666
DNA replication_Homo sapiens_hsa03030 POLA1 0.6334
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7038
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6704
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8022
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6988
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.7167
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MIF 1.9863
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9066
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9024


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)