TCM Prescription: Yi Shen Ling Infusion



Prescription Description
Prescription IDTCMF6630
Pinyin NameYi Shen Ling Chong Ji
Chinese Name益肾灵冲剂
English NameYi Shen Ling Infusion
Function Description阳痿, 早泄, 遗精
IndicationsPremature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Sexual dysfunction, Premature ejaculation
Disease ICD-11 Category SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1) ];
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
HA03.0Z [Male early ejaculation, unspecified, 男性早泄，未特指的 ];
Human Tissues Associated with IndicationKidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH1663 Semen euryales 芡实 TCMH1663
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH611 Rubus idaeus 覆盆子 TCMH611 ITSAE336-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
TCMH1156 Semen allii tuberosi 韭菜子 TCMH1156
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK, TRPV1 10.1013
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PPARG, PRKCA, SMAD3, SRC, TEK, TRPV1, XDH 9.40015
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, MET, PPARA, PPARG, TRPV1 9.40015
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK, TRPV1 8.64923
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 8.17502
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PPARG, RORC, SRC, TEK, TRPV1 8.14377
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, XDH 7.84956
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 7.8112
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.66386
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.56997
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, RORC, SRC, TEK, TRPV1 7.30804
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PPARA, PPARG, SRC, TEK, TRPV1 7.03799
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARG, RORC, SMAD3, SRC, TRPV1 7.03799
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1 7.02742
[BP] GO:0042127 regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK, XDH 7.02644
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.99397
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.99397
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.97268
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.90679
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.89748
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HSPA1A, PIM1, PPARA, PPARG, XDH 6.70993
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 6.55164
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.4948
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PPARG 6.47865
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP2, NR3C1, PPARG, RORC, SMAD3, SRC, TRPV1 6.45147
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.3965
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 6.3951
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.3951
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.33703
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD11B1, HSD17B1 6.33703
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.2824
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.13813
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK 6.1244
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.12048
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.04832
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.94301
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.90322
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, RORC, SRC, TRPV1 5.89746
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.78776
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARG, PTPN1, RORC, SMAD3, SRC, TRPV1 5.7866
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, AXL, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, INSR, MET, PPARG, SMAD3, SRC, TRPV1 5.7866
[BP] GO:0032879 regulation of localization ACHE, ALOX12, ALOX15, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 5.7866
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 5.77389
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 5.72495
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.70375
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.67584
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.67584
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 5.67413
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, DRD3, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, TEK 5.60643
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.55581
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 5.53543
[BP] GO:0080134 regulation of response to stress ALOX12, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.34624
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK 5.33907
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.32605
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA, PPARG, TRPV1 5.2233
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, NR3C1, PPARG, RORC, SRC 5.19761
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, XDH 5.19349
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.15012
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.14149
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 5.13994
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, XDH 5.12777
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, FABP4, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SLC5A1, SMAD3, SRC, TEK, TRPV1 5.10309
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK 4.95558
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.95038
[BP] GO:0019216 regulation of lipid metabolic process CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PPARG, RORC, SRC, TEK 4.91729
[BP] GO:0040012 regulation of locomotion ALOX12, CHRM1, CYP19A1, CYP1B1, DRD3, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK 4.87365
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.86867
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, CDC25B, CHRM5, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.86867
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, PPARG, XDH 4.85814
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.84389
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, CDC25B, CHRM5, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.82241
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.82241
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSP90AB1, INSR, KDR, MMP9, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK 4.69014
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.67543
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 4.64562
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.63398
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.63398
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PPARG, SMAD3, TRPV1 4.5916
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 4.57273
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1, RORC 4.54142
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD3, EGFR, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.49385
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, PPARG, RORC, SRC 4.46768
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, PRKCA 4.45315
[BP] GO:0051049 regulation of transport ACHE, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, DRD3, EGFR, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, MMP9, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TRPV1 4.43414
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK, XDH 4.42204
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.41724
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, HSP90AB1, KDR, NR3C1, PPARG, SRC, TRPV1 4.39242
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.35465
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 4.34444
[BP] GO:0065009 regulation of molecular function AURKB, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 4.33679
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.33676
[BP] GO:0007165 signal transduction AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 4.32272
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1 4.2944
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARG, RORC, SRC, TRPV1 4.29342
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK, TRPV1 4.24836
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, RORC, SRC 4.21204
[BP] GO:0030335 positive regulation of cell migration ALOX12, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 4.20276
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA, PPARG, TRPV1 4.19218
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK 4.19218
[BP] GO:0030334 regulation of cell migration ALOX12, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK 4.18305
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PRKCA, PTPN1, SRC 4.17318
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.16401
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, CDC25B, DRD3, EGFR, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.13739
[BP] GO:2000147 positive regulation of cell motility ALOX12, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 4.07888
[BP] GO:0048585 negative regulation of response to stimulus ALOX12, ALOX15, CYP19A1, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.06704
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.03427
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, SRC, TRPV1 4.03427
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.02531
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.02531
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD3, EGFR, ESR1, PPARA, PPARG, RORC, SRC 4.01984
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSP90AB1, INSR, PRKCA, SRC 4.01984
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 3.98916
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, INSR, MET, SRC, TEK, XDH 3.96715
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.95336
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.93718
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 3.93718
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK, TRPV1 3.9355
[BP] GO:2000145 regulation of cell motility ALOX12, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK 3.92571
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CHRM3, CYP1B1, DRD3, EGFR, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK, TRPV1 3.91242
[BP] GO:0040017 positive regulation of locomotion ALOX12, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 3.86898
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 3.86724
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.80935
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.80935
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.75541
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.73745
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.73745
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.63101
[BP] GO:0050790 regulation of catalytic activity AURKB, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.62848
[BP] GO:0051239 regulation of multicellular organismal process ALOX12, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD3, EGFR, ESR1, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK, TRPV1, XDH 3.62848
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.62701
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, RORC, SRC 3.61556
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.59728
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD3, EGFR, HSPA1A 3.58517
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.58087
[BP] GO:0051270 regulation of cellular component movement ALOX12, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK 3.56639
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK 3.56627
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.56627
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.56352
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.56003
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.52739
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, PRKCA, SMAD3 3.48165
[BP] GO:0032101 regulation of response to external stimulus ALOX12, CYP19A1, DRD3, EGFR, ESR1, FABP4, KDR, MET, PPARA, PPARG, PRKCA, SMAD3, TEK 3.47389
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.46936
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC 3.46878
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 3.46331
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD3, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.46306
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 3.46306
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3, SLC5A1 3.4491
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, PPARG, SRC, TEK, TRPV1 3.42118
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARG, SMAD3, SRC, TRPV1 3.3595
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC, TEK 3.31239
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29438
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.28214
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC, TEK 3.28214
[BP] GO:0001775 cell activation ALOX5, AXL, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PRKCA, RORC, SMAD3, SRC, TRPV1 3.2772
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 3.2772
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, CDC25B, EGFR, FABP3, FLT3, HSP90AB1, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.27643
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, CDC25B, EGFR, FABP3, FLT3, HSP90AB1, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.27643
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.27465
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 3.27183
[BP] GO:0051050 positive regulation of transport ACHE, AXL, CA2, CHRM1, CYP19A1, DRD3, EGFR, HCAR2, HSP90AB1, INSR, PPARG, SMAD3, SRC, TRPV1 3.2694
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 3.17114
[BP] GO:0007193 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3 3.16555
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 3.16555
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, SMAD3, SRC, TEK 3.15526
[BP] GO:0010648 negative regulation of cell communication ACHE, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 3.14924
[BP] GO:0031399 regulation of protein modification process ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 3.14924
[BP] GO:0023057 negative regulation of signaling ACHE, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 3.13592
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.09101
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, AURKB, AXL, CSNK2A1, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK 3.08452
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD3, FABP3, PPARA, PPARG, SLC5A1, SLC5A2, SLC5A4, TRPV1 3.07827
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.07827
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.06297
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, PPARG, SRC 3.05006
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC 3.04712
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, PTPN1, SRC, TEK 3.04345
[BP] GO:0009892 negative regulation of metabolic process AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 3.04044
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC, TRPV1 3.04044
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK 3.03877
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PPARG, PRKCA, SRC, TEK 3.03008
[BP] GO:0038128 None EGFR, HSP90AA1, PRKCA, SRC 3.03008
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PRKCA, SMAD3, SRC 3.03008
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD3, HSP90AA1, KDR, SRC 3.0073
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, EGFR, FLT3, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 3.00385
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA 2.99484
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.98181
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.98181
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.98181
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.9737
[BP] GO:0044057 None CHRM1, CHRM2, CHRM3, DRD3, EGFR, GPR35, HCAR2, PRKCA, SMAD3, TRPV1 2.96088
[BP] GO:0042325 regulation of phosphorylation ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, TEK, XDH 2.95307
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.94513
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD3, HSP90AA1, HSP90AB1, HSPA1A, MMP9, TRPV1, XDH 2.94513
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.94002
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3 2.93123
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.91417
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.89134
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.88975
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, CDC25B, EGFR, ESR1, FLT3, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.86736
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 2.82965
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC 2.79645
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PRKCA, SMAD3, SRC, TEK 2.78488
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, NR3C1, PPARA, PPARG, RORC 2.77313
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1 2.75003
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.74858
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.74858
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.74858
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, CDC25B, EGFR, FLT3, HSP90AB1, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 2.74836
[BP] GO:0044093 positive regulation of molecular function AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 2.73455
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.72622
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.69127
[BP] GO:0051172 None AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HSP90AB1, HSPA1A, IGF1R, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.69127
[BP] GO:0051098 regulation of binding AURKB, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC 2.69127
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.66962
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.66962
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.66962
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.66962
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.65047
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC, TRPV1 2.63571
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.62692
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.6017
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.5987
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, NR3C1, PPARG, RORC, SRC 2.59428
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, CDC25B, EGFR, FLT3, HSP90AB1, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 2.58073
[BP] GO:0007166 cell surface receptor signaling pathway AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.58073
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58058
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.55919
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.55919
[BP] GO:0009611 response to wounding ACHE, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 2.55298
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, DRD3, EGFR, HCAR2, KDR, SRC, TRPV1 2.53689
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.53689
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK 2.53064
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSP90AB1, INSR, PPARG, SRC 2.50885
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSP90AB1, INSR, PPARG, SRC 2.50543
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.50543
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC 2.4876
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.48135
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, PPARA, PPARG, SMAD3, TEK 2.44399
[BP] GO:0043434 None FABP3, INSR, PPARA, PPARG, SRC, TEK, TRPV1 2.43483
[BP] GO:0009968 negative regulation of signal transduction DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 2.42903
[BP] GO:0032102 negative regulation of response to external stimulus ALOX12, CYP19A1, DRD3, PPARA, PPARG, SMAD3, TEK 2.42903
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.42903
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.40376
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.39735
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.39735
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.39735
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.39735
[BP] GO:0019222 regulation of metabolic process ACHE, ALOX15, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.39294
[BP] GO:0002682 regulation of immune system process ALOX15, AXL, CA2, CYP19A1, DUSP3, ESR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARG, PRKCA, PTPN1, SMAD3, SRC 2.3858
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC 2.3858
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, SMAD3, TEK 2.3858
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, CA2, CYP1B1, DRD3, EGFR, ESR1, HSP90AB1, INSR, KDR, NUAK1, PIM1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.38173
[BP] GO:0080090 regulation of primary metabolic process ALOX15, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.36432
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, KDR, PRKCA, SRC, TEK 2.36432
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34806
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, IGF1R, INSR, MMP2, PPARG, SRC, TRPV1 2.34192
[BP] GO:0070482 response to oxygen levels CYP1A1, MMP2, PPARA, PPARG, SMAD3, SRC, TEK 2.34192
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.34192
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.34192
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34192
[BP] GO:0009894 regulation of catabolic process CSNK2A1, EGFR, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PTPN1, SMAD3 2.32708
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.32708
[BP] GO:0051894 None KDR, SMAD3, TEK 2.31108
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.31108
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.31108
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31108
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.3067
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 2.30424
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, NR3C1, PPARA, PPARG, RORC 2.29485
[BP] GO:0043393 regulation of protein binding AURKB, HSP90AB1, MET, MMP9, PPARA, SRC 2.29485
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PPARG, SMAD3, SRC, XDH 2.28441
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.28392
[BP] GO:0000122 None AURKB, DRD3, ESR1, ESR2, HSPA1A, NR3C1, PPARA, PPARG, RORC, SMAD3, TRPV1 2.28392
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PPARG 2.27905
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD3, KDR, SRC, TRPV1 2.26718
[BP] GO:0015908 None DRD3, FABP3, PPARA, PPARG 2.26718
[BP] GO:0040008 regulation of growth ALOX12, CSNK2A1, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, PPARG, SMAD3 2.26713
[BP] GO:0051179 None ACHE, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, EGFR, ESR1, FABP3, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PPARA, PPARG, SLC5A1, SLC5A2, SLC5A4, SRC, TRPV1, XDH 2.25311
[BP] GO:0051234 None ACHE, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, EGFR, FABP3, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PPARA, PPARG, SLC5A1, SLC5A2, SLC5A4, SRC, TRPV1, XDH 2.24976
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.24955
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.24955
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.22702
[BP] GO:1903393 None KDR, SMAD3, TEK 2.22702
[BP] GO:0043085 positive regulation of catalytic activity AURKB, CDC25B, EGFR, ESR1, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 2.22315
[BP] GO:0001936 None KDR, PPARG, PRKCA, TEK, XDH 2.21561
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.209
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, CSNK2A1, DRD3, DUSP3, ESR1, ESR2, FABP4, HSP90AB1, HSPA1A, IGF1R, MET, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.19692
[BP] GO:0051246 regulation of protein metabolic process ALOX15, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.19692
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, GPR35, SMAD3, TRPV1 2.19692
[BP] GO:0031099 regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.1803
[BP] GO:0090087 None ACHE, CA2, CHRM1, DRD3, EGFR, HCAR2, HSP90AB1, PRKCA, PTPN1, SMAD3, SRC 2.1803
[BP] GO:0010605 negative regulation of macromolecule metabolic process AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.1803
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.1803
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, NR3C1, SRC 2.1803
[BP] GO:0046541 None CHRM1, CHRM3 2.1803
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.1803
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.1803
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.1803
[BP] GO:0010891 None PPARA, PPARG 2.1803
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, IGF1R, INSR, MMP2, PPARG, SRC, TRPV1 2.16565
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.16325
[BP] GO:0043627 response to estrogen CA2, ESR1, PPARG, TEK 2.16325
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.16325
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.16325
[BP] GO:0034219 None SLC5A1, SLC5A2, SLC5A4 2.16325
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.16325
[BP] GO:0032868 None FABP3, INSR, PPARA, PPARG, SRC 2.15858
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TRPV1 2.15212
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.14795
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, EGFR, FLT3, HSP90AA1, HSP90AB1, INSR, PTPN1, SRC, TEK 2.14584
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, PPARG, SRC 2.14456
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.13276
[BP] GO:0065007 biological regulation ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.12814
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD3, EGFR, HCAR2 2.1254
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.1103
[BP] GO:0045892 None AURKB, DRD3, ESR1, ESR2, FABP4, HSPA1A, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC, TRPV1 2.09872
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.09035
[BP] GO:0050678 None EGFR, KDR, PPARG, PRKCA, SMAD3, TEK, XDH 2.09002
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09002
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09002
[BP] GO:0006810 None ACHE, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, FABP3, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PPARA, PPARG, SLC5A1, SLC5A2, SLC5A4, SRC, TRPV1, XDH 2.08961
[BP] GO:0043412 macromolecule modification ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.08825
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, KDR, PPARG, PRKCA, TEK, XDH 2.08618
[BP] GO:0045321 leukocyte activation ALOX5, AXL, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, RORC, SMAD3, TRPV1 2.08618
[BP] GO:0009410 None DRD3, EGFR, HSP90AB1, NR3C1, PPARG 2.08039
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.07885
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05944
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.05944
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.05944
[BP] GO:0043549 regulation of kinase activity CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, PTPN1, SRC, TEK 2.05944
[BP] GO:0010887 None PPARA, PPARG 2.05148
[BP] GO:0010871 None PPARA, PPARG 2.05148
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.05148
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.05148
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PPARG, SMAD3, SRC, XDH 2.05148
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.03268
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG 2.01515
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.01515
[BP] GO:0010564 regulation of cell cycle process AURKB, CDC25B, CSNK2A1, CYP1A1, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR 2.01515
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.01515
[BP] GO:0032870 cellular response to hormone stimulus EGFR, ESR1, FLT3, INSR, NR3C1, PPARG, SRC 2.01515
[CC] GO:0005886 plasma membrane ACHE, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD3, EGFR, ESR1, FLT3, GPR35, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1 4.7578
[CC] GO:0044459 plasma membrane part ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, DUSP3, EGFR, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1 4.11235
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, HSP90AA1, HSP90AB1, INSR, MET, SRC, TEK, TRPV1 3.79975
[CC] GO:0031226 intrinsic component of plasma membrane AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 3.58517
[CC] GO:0016020 membrane ACHE, ALOX12, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1 3.55482
[CC] GO:0016323 basolateral plasma membrane CA2, CA4, CA9, CHRM3, EGFR, HSP90AB1, TEK 3.37066
[CC] GO:0044425 membrane part ACHE, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PTPN1, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1 3.29504
[CC] GO:0005887 integral component of plasma membrane AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 3.27414
[CC] GO:1904813 None ALOX5, HSP90AA1, HSP90AB1, HSPA1A, MMP9 2.32708
[CC] GO:0031253 None CA4, CA9, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 2.1803
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.05148
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, XDH 15.1471
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 11.0762
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD3, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, SRC, TEK, TRPV1 10.8286
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.87408
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 8.94456
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.17878
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.84956
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.28905
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.92826
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3 6.7408
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.64849
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.3965
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.3951
[MF] GO:0038023 signaling receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 6.36983
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.35787
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, TRPV1, XDH 6.33703
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.75208
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 5.67501
[MF] GO:0004872 receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 5.59771
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.59691
[MF] GO:0004871 signal transducer activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, SMAD3, TEK, TRPV1 5.56031
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.47974
[MF] GO:0060089 molecular transducer activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 5.38327
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.34429
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.27208
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, XDH 5.15012
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.14149
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, TRPV1, XDH 5.00188
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.99551
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA, PPARG, RORC 4.87256
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.81714
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.6254
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.38777
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.17528
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PPARG, RORC, TRPV1 4.05944
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, NR3C1, RORC 4.05944
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 3.95336
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.95336
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.93718
[MF] GO:0099600 transmembrane receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 3.83006
[MF] GO:0004888 transmembrane signaling receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 3.83006
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 3.80447
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.75541
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.63374
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 3.56639
[MF] GO:0019899 enzyme binding AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, MET, NR3C1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK 3.46306
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 3.45673
[MF] GO:0032403 protein complex binding ACHE, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 3.43357
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.4314
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.4314
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 3.42705
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.39956
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, PRKCA, SRC, TEK, TRPV1, XDH 3.28813
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 3.17114
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.05846
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, PRKCA, SRC, TEK, TRPV1, XDH 3.04959
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.98181
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.98181
[MF] GO:0008389 None CYP2A13, CYP2A6 2.98181
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 2.91911
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC 2.84046
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH 2.73848
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH 2.73701
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 2.72669
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC 2.61721
[MF] GO:0031072 heat shock protein binding CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 2.5987
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.58058
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.58058
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.58058
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK 2.56373
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.55952
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3 2.53933
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.48135
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.44438
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.44399
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.41701
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.4092
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.39735
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.34192
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.34192
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.34192
[MF] GO:0015145 None SLC5A1, SLC5A2, SLC5A4 2.31108
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.25311
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.22702
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.18724
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.18724
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.18724
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, XDH 2.1803
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.1803
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.1803
[MF] GO:0043559 insulin binding IGF1R, INSR 2.1803
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, SMAD3, TRPV1, XDH 2.15233
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.12642
[MF] GO:0004629 None CHRM1, CHRM3, CHRM5 2.09002
[MF] GO:0035257 None ESR1, FLT3, PPARG, SMAD3, SRC 2.05944
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05944
[MF] GO:0097718 None HSP90AA1, HSP90AB1, HSPA1A 2.05944
[MF] GO:0050543 None FABP3, PPARG 2.05148
[MF] GO:0004064 arylesterase activity CA1, CA2 2.05148
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.0282


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9363
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.4187
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8661
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.1048
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, SMAD3, HSP90AB1, FLT3, MMP1, MMP2, PPARG, PRKCA, MMP9, MET, EGFR, IGF1R 6.7126
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.4938
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 6.4619
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.8564
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, EGFR, IGF1R 6.3468
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.6238
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.1485
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, PRKCA 4.6176
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4114
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, CHRM5, TRPV1, NR3C1, DRD3 4.3559
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 3.9504
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 3.9112
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6521
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.402
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, PRKCA, EGFR 3.5906
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, PRKCA, TEK, EGFR, IGF1R 3.6521
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, PRKCA, MET, EGFR, IGF1R 3.3361
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B 3.3361
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 3.2487
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, EGFR, IGF1R 2.8468
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.3262
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA, EGFR 2.8256
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA, ALOX12, TRPV1 2.7467
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, PRKCA 2.724
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.7467
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.7352
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, PRKCA, ALOX12 2.5795
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3127
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, PRKCA, MMP9 2.2302
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, PRKCA, EGFR, CDC25B, HSPA1A 2.2076
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.2941
Glioma_Homo sapiens_hsa05214 PRKCA, EGFR, IGF1R 2.248
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2565
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2302
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7467
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.2852
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PPARA 1.8784
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2229
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2076
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1993
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 2.1742
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA, EGFR 2.0001
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.2146
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.9219
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7812
Bile secretion_Homo sapiens_hsa04976 CA2, SLC5A1, CYP3A4 2.2076
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6164
Gap junction_Homo sapiens_hsa04540 SRC, PRKCA, EGFR 1.9944
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 1.9041
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 2.1336
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5264
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA, ESR1 1.7077
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.7077
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PRKCA 1.5264
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, IGF1R 1.6627
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1005
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, PRKCA, EGFR 1.5198
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.5418
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA, EGFR 1.4431
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, HSPA1A 1.3836
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8617
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2314
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8735
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8407
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8502
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6423
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA, DRD3 0.8914
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8136
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9165
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9492
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA, EGFR 1.0622
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2946
Influenza A_Homo sapiens_hsa05164 PRKCA, HSPA1A 0.7317
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.3102
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3179
Purine metabolism_Homo sapiens_hsa00230 XDH 0.328
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3272
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3172
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3571
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.342
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3649
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PRKCA 0.3731
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4014
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4014
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA 1.1479
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.4033
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.1516
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA 1.1737
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1443
Platelet activation_Homo sapiens_hsa04611 SRC 0.4218
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCA 0.4245
Axon guidance_Homo sapiens_hsa04360 MET 0.4136
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4218
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4462
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4365
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4245
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4633
Melanogenesis_Homo sapiens_hsa04916 PRKCA 0.4708
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4708
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.4786
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4708
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2369
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.4708
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4773
Morphine addiction_Homo sapiens_hsa05032 PRKCA 0.4799
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.4773
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA 0.4708
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4786
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4856
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5007
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4996
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4848
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5028
Peroxisome_Homo sapiens_hsa04146 XDH 0.5007
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.539
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.4544
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3663
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5553
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5478
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5596
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCA, EGFR 1.4544
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5596
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5459
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4519
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.5574
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.4272
Shigellosis_Homo sapiens_hsa05131 SRC 0.5596
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5817
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3731
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5727
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.4519
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4353
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6121
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6264
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6121
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.5613
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6302
Malaria_Homo sapiens_hsa05144 MET 0.6381
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.6302
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6423
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 SLC5A1 0.66
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, PRKCA 1.704
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8784
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7535
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7535
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.8136
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7506
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8342
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7948
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8359
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8407
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0638
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8038
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8342
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3021
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0622


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)