TCM Prescription: Xiao Er Zhi Xie Ling Capsules



Prescription Description
Prescription IDTCMF6571
Pinyin NameXiao Er Zhi Xie Ling Jiao Nang
Chinese Name小儿止泻灵胶囊
English NameXiao Er Zhi Xie Ling Capsules
Function Description腹泻
IndicationsDiarrhea
Disease ICD-11 Category ME05.1 [Diarrhoea, 腹泻 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH1663 Semen euryales 芡实 TCMH1663
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1196 Salmonella
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1281 Clostridium difficile
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1326 Shigella
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 11.3101
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 11.3101
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TYR 11.2297
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.5592
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.5592
[BP] GO:0065008 regulation of biological quality ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.56371
[BP] GO:0006629 lipid metabolic process ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B2, MET, PDE3A, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 9.56371
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 9.56371
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRM1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.09753
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PTGS2, SMAD3, SRC, TEK 8.79974
[BP] GO:0010646 regulation of cell communication ADORA1, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.78514
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HSPA1A, PDE10A, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.66571
[BP] GO:0023051 regulation of signaling ADORA1, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.66571
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, FLT3, OPRK1, OPRM1, PDE3A, PTGS2, RORC, SRC, TEK, TYR 8.60073
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PTGS2, RORC, SMAD3, SRC 8.59874
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TYR 8.59874
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.30654
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, DRD2, EGFR, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.14885
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PTGS2, RORC, SMAD3, SRC 8.01092
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 7.68942
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.67468
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 7.66526
[BP] GO:0050896 response to stimulus ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TYR 7.66526
[BP] GO:0048522 positive regulation of cellular process ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 7.43809
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.31348
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.28492
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.28492
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.25147
[BP] GO:0008152 metabolic process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 7.20446
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.20446
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PDE3A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 7.10113
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, OPRK1, OPRM1, PTGS2, RORC, SRC, TYR 7.03898
[BP] GO:0006796 phosphate-containing compound metabolic process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 6.88515
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.83012
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, OPRK1, PDE3B, PPARA, PTGS2, SRC, TEK 6.75703
[BP] GO:0044255 cellular lipid metabolic process AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PDE3A, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 6.75703
[BP] GO:0003018 None ADORA1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PDE3A, PTGS2, SRC, TEK 6.74238
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PTGS2, SRC, TEK, TYR 6.73186
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC 6.71336
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.71336
[BP] GO:0032879 regulation of localization ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.71336
[BP] GO:0006793 phosphorus metabolic process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 6.53766
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 6.53656
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, ESR1, HTR7, OPRK1, OPRM1, PPARA, RORC, SRC, TOP1 6.50526
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 6.4825
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.4633
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.4633
[BP] GO:0044237 cellular metabolic process AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 6.4178
[BP] GO:0048518 positive regulation of biological process ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.37914
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PTGS2, SRC, TEK, TYR 6.31181
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 6.31162
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, DRD1, DRD2, ESR1, GPR35, HCAR2, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, SIGMAR1, SRC 6.2865
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.20703
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HTR2A, KDR, OPRK1, OPRM1, PDE3A, PTGS2, SRC, TOP1 6.20485
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PDE3A, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.08766
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP2, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.08378
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, OPRK1, PDE3A, PDE3B, PIK3CA, PTGS2, RORC, SRC 6.07533
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, EGFR, HCAR2, HTR2A, KDR, OPRK1, PIK3CB, PTGS2, SRC 6.06388
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 5.99787
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.96774
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.95759
[BP] GO:0031399 regulation of protein modification process ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.93622
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, FLT3, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 5.91196
[BP] GO:0032502 developmental process ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, INSR, KDR, MET, MMP2, MMP9, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 5.85193
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.84664
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.82869
[BP] GO:0003013 None ADORA1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PDE3A, PTGS2, SRC, TEK 5.82869
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 5.81559
[BP] GO:0010817 regulation of hormone levels ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, OPRK1 5.75769
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, OPRK1, OPRM1, PIK3CB, PTPN1, SRC, TEK, XDH 5.74107
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.72848
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.70613
[BP] GO:0010648 negative regulation of cell communication ADORA1, DRD1, DRD2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTGS2, PTPN1, SMAD3, SRC, XDH 5.70447
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, OPRM1, PDE3A, PTGS2, RORC, SRC 5.70158
[BP] GO:0023057 negative regulation of signaling ADORA1, DRD1, DRD2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTGS2, PTPN1, SMAD3, SRC, XDH 5.69001
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DRD2, DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, OPRK1, OPRM1, PIK3CB, PTPN1, SRC, TEK, XDH 5.63043
[BP] GO:0051049 regulation of transport ADORA1, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, INSR, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 5.60816
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP9, NUAK1, OPRD1, OPRM1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.57096
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, PDE3B, PPARA, PTGS2, RORC, SRC, TEK 5.56176
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.53298
[BP] GO:0007193 None ADORA1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.46965
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.3923
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 5.3895
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 5.32985
[BP] GO:1901564 organonitrogen compound metabolic process AKR1B1, ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SENP6, SMAD3, SRC, TEK, TOP1, TYR, XDH 5.32985
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.2417
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.19777
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, OPRK1, PTGS2, SMAD3, SRC, TEK 5.19546
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD11B1, HSD17B2 5.18536
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, CDC25B, DRD2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.17202
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK 5.16873
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.15625
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, MMP9, NUAK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.12715
[BP] GO:0009056 catabolic process ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIK3CB, SRC, XDH 5.12715
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, OPRD1, OPRK1, OPRM1 5.12715
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.11077
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, PTGS2, SMAD3, SRC, TEK 5.0279
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PTGS2, PTPN1, SRC 5.01385
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 4.92989
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.92452
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, PTGS2, SMAD3, SRC, TEK 4.92118
[BP] GO:0048513 animal organ development AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 4.91467
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, INSR, MET, PIK3CA, PIK3CB, SMAD3 4.89355
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, OPRK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.88009
[BP] GO:0031401 positive regulation of protein modification process ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.80598
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A, PTGS2 4.80144
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 4.76058
[BP] GO:0048523 negative regulation of cellular process ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.75969
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.73724
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.73682
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1 4.6774
[BP] GO:0007188 None ADORA1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.65889
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, PTGS2, SMAD3, SRC, TEK 4.62359
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.62225
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, PDE3A 4.59145
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 4.57264
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, HCAR2, PIK3CB, PTGS2 4.54526
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.51909
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 4.5088
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, EGFR, ESR1, FABP4, KDR, MET, MMP12, OPRM1, PPARA, PTGS2, SMAD3, TEK 4.49206
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.46653
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.46275
[BP] GO:0048856 anatomical structure development ADORA1, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 4.46275
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CYP1B1, DRD2, EGFR, ESR1, GPR35, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 4.4459
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, RORC 4.4459
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.4459
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PTGS2, SMAD3, SRC 4.4459
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, DRD1, DRD2, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.4459
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PTGS2, SRC 4.40798
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.40045
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, OPRK1, PTGS2, SMAD3, SRC, TEK 4.39435
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA 4.3604
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, SRC 4.34246
[BP] GO:0048519 negative regulation of biological process ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.33364
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7, PTGS2 4.32697
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 4.29615
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.27629
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, PPARA, PTGS2, SRC, TEK 4.25264
[BP] GO:0097746 None ADORA1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PTGS2 4.23423
[BP] GO:0035296 None ADORA1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PTGS2 4.23423
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, DRD1, DRD2, GPR35, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1, PTGS2 4.23423
[BP] GO:0007187 None ADORA1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.22506
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, PDE3A 4.21718
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DRD1, DRD2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.21701
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, PPARA 4.20654
[BP] GO:0006950 response to stress ADORA1, ADORA3, AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 4.19453
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PDE3B, PTGS2, PTPN1, SRC, XDH 4.1697
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, EGFR, GPR35, HCAR2, HTR2A, OPRD1, OPRK1, OPRM1, PTGS2, SMAD3 4.15431
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 4.14505
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.12683
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, PIK3CB, PTPN1, SRC 4.1216
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PTGS2, SRC 4.1216
[BP] GO:0050880 None ADORA1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PTGS2 4.08465
[BP] GO:0035150 None ADORA1, DRD1, EGFR, HTR1A, HTR2A, HTR7, PTGS2 4.06473
[BP] GO:0003008 None ADORA1, AKR1B1, CYP1B1, DRD1, DRD2, EGFR, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PTGS2, SRC, TEK, TYR 4.05041
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, OPRK1, PDE3B, PPARA, PTGS2, SRC, TEK 4.03248
[BP] GO:0044238 primary metabolic process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 4.01131
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.00444
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 4.0025
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.98119
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, HTR2A, KDR, OPRM1, PTPN1, SRC, TEK 3.96849
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.94796
[BP] GO:0030534 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 3.94266
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.9103
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, OPRM1, PTGS2, SRC 3.87752
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.87694
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC 3.8761
[BP] GO:0042698 ovulation cycle AXL, EGFR, OPRK1, OPRM1 3.85128
[BP] GO:0051246 regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.82717
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.8057
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, INSR, KDR, MET, PDE3B, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.77918
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.77105
[BP] GO:0071704 organic substance metabolic process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 3.7568
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.74354
[BP] GO:0009987 cellular process ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 3.6724
[BP] GO:0050804 modulation of chemical synaptic transmission ADORA1, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HTR2A, PTGS2 3.67032
[BP] GO:0099177 regulation of trans-synaptic signaling ADORA1, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HTR2A, PTGS2 3.67032
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.62986
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.62986
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.62986
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.62986
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PTGS2, SRC 3.59639
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.54815
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, EGFR, HTR2A, IGF1R, INSR, KDR, MET, NUAK1, OPRM1, PDE3A, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.49963
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.4761
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.4761
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, DRD2, EGFR, HCAR2, HSPA1A, HTR2A, KDR, MET, MMP12, MMP9, OPRM1, PDE3A, PIM1, PTGS2, SMAD3, SRC, TEK 3.4761
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.4461
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.42577
[BP] GO:0050805 negative regulation of synaptic transmission ADORA1, DRD1, DRD2, HTR2A, PTGS2 3.38487
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SENP6, SRC, TEK, TOP1 3.32376
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CSNK2A1, CYP2D6, DRD2, DUSP3, EGFR, ESR1, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRM1, PDE3B, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 3.32376
[BP] GO:0009611 response to wounding ADORA3, CYP1A1, DRD2, EGFR, OPRM1, PPARA, SMAD3 3.30742
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.29507
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, IGF1R, PIK3CA, PIK3CB 3.29507
[BP] GO:0065007 biological regulation ADORA1, ADORA3, AKR1B1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP1, XDH 3.29107
[BP] GO:0001505 regulation of neurotransmitter levels CYP1B1, DRD1, DRD2, EGFR, HTR1A, INSR, PTGS2, SMAD3 3.29107
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, DRD2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, INSR, MET, MMP9, OPRD1, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 3.28206
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PDE3B, PIK3CA, PIK3CB, PTGS2, TEK 3.28206
[BP] GO:0007610 None DRD1, DRD2, EGFR, HTR1A, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PPARA, PTGS2 3.26889
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 3.26559
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26559
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.2531
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.2531
[BP] GO:0008283 cell proliferation AURKB, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.24778
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, PPARA 3.24121
[BP] GO:0019222 regulation of metabolic process ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 3.23912
[BP] GO:0042445 hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B2 3.23912
[BP] GO:0031644 None ADORA1, GPR35, OPRD1, OPRK1, OPRM1 3.22463
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MET, PDE3B, PIK3CA, PPARA, SMAD3 3.21816
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, OPRK1 3.21816
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, INSR, PIK3CB, PTPN1, SRC 3.20775
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 3.17408
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.17408
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.1705
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, GPR35, HTR2A, PIK3CB, SMAD3 3.1705
[BP] GO:0051930 None ADORA1, OPRD1, OPRK1, OPRM1 3.1705
[BP] GO:0051931 None ADORA1, OPRD1, OPRK1, OPRM1 3.1705
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 3.16128
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.1575
[BP] GO:0050890 None ADORA1, DRD1, DRD2, EGFR, HTR2A, INSR, OPRK1, PTGS2 3.13476
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.13476
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.13319
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, HTR2A, KDR, OPRM1, SRC, TEK 3.09442
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, PTGS2, SRC 3.08524
[BP] GO:0051952 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 3.08524
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.08524
[BP] GO:0043434 None FABP3, INSR, OPRK1, PDE3B, PPARA, PTGS2, SRC, TEK 3.07587
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, OPRD1, OPRM1, PDE3A, SMAD3, SRC 3.06608
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, TYR 3.03444
[BP] GO:0007623 circadian rhythm DRD2, EGFR, HTR7, PPARA, RORC, TOP1 2.98963
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 2.9831
[BP] GO:0031635 None OPRK1, OPRM1 2.96965
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.964
[BP] GO:0051050 positive regulation of transport ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, EGFR, HCAR2, INSR, MMP12, OPRK1, PTGS2, SMAD3, SRC 2.94745
[BP] GO:0032868 None FABP3, INSR, OPRK1, PDE3B, PPARA, SRC 2.94599
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.94301
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, GPR35, HTR2A, MMP9, PTGS2 2.91418
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PDE3A, PTGS2, SRC 2.91418
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.91151
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, PTGS2, SRC 2.90265
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.88985
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.88985
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.87328
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.87328
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.87328
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, DRD2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 2.83466
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.83081
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.81774
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.81554
[BP] GO:0008217 None ADORA1, DRD2, PPARA, PTGS1, PTGS2, SMAD3 2.80038
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.79531
[BP] GO:0050789 regulation of biological process ADORA1, ADORA3, AKR1B1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP1, XDH 2.77886
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.77724
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.74683
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A, TYR 2.72452
[BP] GO:0050794 regulation of cellular process ADORA1, ADORA3, AKR1B1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, XDH 2.72192
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.71442
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.71442
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2 2.7086
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PDE3A, PIM1, PTGS2, SENP6, SMAD3, SRC 2.69344
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.68356
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, PIK3CB, SMAD3 2.68356
[BP] GO:0007631 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.68356
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.68356
[BP] GO:0017144 drug metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, HSPA1A 2.68355
[BP] GO:0007611 None DRD1, DRD2, EGFR, HTR2A, INSR, OPRK1, PTGS2 2.67807
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.66093
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR, PDE3A 2.64686
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.64686
[BP] GO:0009968 negative regulation of signal transduction DRD2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, PTGS2, PTPN1, SMAD3, SRC, XDH 2.63094
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.62872
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.60585
[BP] GO:0072523 None PDE10A, PDE3A, PDE3B, XDH 2.59787
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.57852
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, OPRD1, PDE3A, SMAD3, SRC 2.5785
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57057
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AXL, CYP1A1, DRD1, EGFR, ESR1, OPRK1, OPRM1, PTGS2, SRC 2.55408
[BP] GO:0030155 regulation of cell adhesion CYP1B1, DUSP3, KDR, NUAK1, PDE3B, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.54588
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 2.54378
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.54378
[BP] GO:0050994 None ADORA1, HCAR2, PDE3B, PPARA 2.54378
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, PIK3CB, SMAD3, SRC, TEK 2.54227
[BP] GO:0008610 lipid biosynthetic process AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.54157
[BP] GO:0019233 None OPRD1, OPRK1, OPRM1, PTGS2 2.5146
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.50843
[BP] GO:0007613 None DRD1, DRD2, HTR2A, INSR, PTGS2 2.5071
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.48844
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.48844
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.48766
[BP] GO:1903530 regulation of secretion by cell ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC 2.48745
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, INSR, PIK3CB, PTPN1, SRC 2.46517
[BP] GO:0032922 None DRD2, PPARA, RORC, TOP1 2.46517
[BP] GO:0010959 None ADORA1, DRD1, DRD2, GPR35, HTR2A, OPRD1, OPRK1, PTGS2 2.43401
[BP] GO:1901575 None ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.42317
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41087
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.41087
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.40733
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.40733
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.40733
[BP] GO:0097164 None AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 2.39675
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.36132
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.35373
[BP] GO:0050995 None ADORA1, HCAR2, PDE3B 2.35166
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.35119
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC 2.32081
[BP] GO:0007198 None HTR1A, HTR7 2.32081
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.32081
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32081
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32081
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B2 2.3163
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, IGF1R, PIK3CA, PIK3CB 2.3163
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30436
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, PPARA, SMAD3, TEK 2.28253
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, OPRM1, PTGS2, SMAD3 2.28253
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, OPRD1 2.27679
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.27569
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.26897
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.26367
[BP] GO:0051894 None KDR, SMAD3, TEK 2.26367
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.26367
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.26367
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.26367
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26367
[BP] GO:0051047 None ADORA1, CYP19A1, DRD2, EGFR, HCAR2, MMP12, OPRK1, SRC 2.25703
[BP] GO:0043467 regulation of generation of precursor metabolites and energy HTR2A, INSR, OPRK1, PIK3CA, PPARA 2.25703
[BP] GO:0051046 None ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC 2.25703
[BP] GO:0050795 None ADORA1, DRD2, HTR1A, HTR2A 2.25703
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, IGF1R, PIK3CA, PIK3CB 2.25703
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.23174
[BP] GO:0051051 negative regulation of transport ADORA1, DRD2, GPR35, HSPA1A, HTR2A, MMP9, OPRK1, OPRM1, PTGS2 2.2295
[BP] GO:0050793 regulation of developmental process AXL, CA2, CYP1B1, DRD2, EGFR, ESR1, HTR2A, INSR, KDR, NUAK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.18756
[BP] GO:0007268 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.18504
[BP] GO:0098916 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.18504
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.1793
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17231
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.17231
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.17231
[BP] GO:0019637 organophosphate metabolic process CSNK2A1, DRD2, EGFR, HSPA1A, MET, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PTGS2, XDH 2.16844
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.16758
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, PIK3CB, SMAD3 2.16053
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.16053
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.15867
[BP] GO:0050877 None ADORA1, CYP1B1, DRD1, DRD2, EGFR, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PTGS2, TYR 2.15268
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.1519
[BP] GO:0021853 None DRD1, DRD2 2.15094
[BP] GO:1904936 None DRD1, DRD2 2.15094
[BP] GO:0042321 None ADORA1, DRD2 2.15094
[BP] GO:0099536 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.14347
[BP] GO:0099537 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.14347
[BP] GO:0031323 regulation of cellular metabolic process ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.13063
[BP] GO:0046486 glycerolipid metabolic process CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.12596
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.10148
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.10148
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SENP6, SMAD3, SRC, TEK, TOP1 2.07992
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.07992
[BP] GO:0032872 regulation of stress-activated MAPK cascade DUSP3, EGFR, IGF1R, OPRK1, PTPN1, XDH 2.07992
[BP] GO:0007612 None DRD1, DRD2, INSR, OPRK1, PTGS2 2.07992
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.07811
[BP] GO:0043627 response to estrogen CA2, ESR1, OPRK1, TEK 2.07811
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, OPRK1, PTGS2, PTPN1, XDH 2.07382
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade DUSP3, EGFR, IGF1R, OPRK1, PTPN1, XDH 2.07382
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.06658
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.06658
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, CA2, CYP19A1, DRD2, DUSP3, ESR1, HCAR2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.06431
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, ESR1, GPR35, HTR2A, PIK3CA, PIK3CB, SMAD3 2.05953
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, PTGS2, SRC 2.04881
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, CSNK2A1, DRD2, EGFR, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, OPRD1, PDE3A, PIK3CB, PTPN1, SENP6, SMAD3, SRC, TEK 2.04772
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, PIK3CB, SMAD3 2.04772
[BP] GO:0044248 cellular catabolic process AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, HSPA1A, PDE10A, PDE3A, PDE3B, PIK3CB, SRC, XDH 2.0448
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B 2.03215
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.03215
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.03215
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.028
[BP] GO:0009314 response to radiation AURKB, DRD1, DRD2, EGFR, OPRK1, OPRM1, PTGS2, TYR 2.02693
[BP] GO:0006928 movement of cell or subcellular component AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.02468
[BP] GO:0033029 regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.01884
[BP] GO:0021843 None DRD1, DRD2 2.01884
[BP] GO:0021830 None DRD1, DRD2 2.01884
[BP] GO:0021826 None DRD1, DRD2 2.01884
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.01884
[BP] GO:0042060 None EGFR, OPRM1, PPARA, SMAD3 2.01504
[BP] GO:1901890 None KDR, SMAD3, TEK 2.00522
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.00522
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B 2.00522
[BP] GO:0043114 None PDE3A, SRC, TEK 2.00522
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CA4, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 4.85816
[CC] GO:0044425 membrane part ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SIGMAR1, SRC, TBXAS1, TEK, TYR 4.7489
[CC] GO:0045121 membrane raft BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, PTGS2, SRC, TEK 4.60196
[CC] GO:0098857 membrane microdomain BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, PTGS2, SRC, TEK 4.58337
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, BACE1, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 4.53334
[CC] GO:0016020 membrane ADORA1, ADORA3, ALOX5, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TYR 4.4459
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, OPRD1, OPRM1, PTGS2, SIGMAR1, SRC, TEK 4.08544
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, BACE1, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PTGS2, SIGMAR1, SRC, TEK 4.01114
[CC] GO:0098589 membrane region BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, PTGS2, SRC, TEK 3.98738
[CC] GO:0005886 plasma membrane ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK 3.95607
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, OPRD1, OPRM1, SRC 3.52598
[CC] GO:0032589 None ADORA1, INSR, OPRD1, OPRM1 2.88985
[CC] GO:0032590 None INSR, OPRD1, OPRM1 2.87328
[CC] GO:0044432 endoplasmic reticulum part BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1, SIGMAR1, TBXAS1 2.77288
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PTGS1, SIGMAR1, SRC 2.5785
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PTGS1, SIGMAR1, SRC 2.5785
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, HSD11B1, HSD17B2, PTGS1, PTGS2, SIGMAR1, TBXAS1 2.5785
[CC] GO:0005783 None ADORA1, CA4, CYP19A1, CYP2D6, FLT3, HSPA1A, KDR, OPRM1, PDE3B, PTGS2, PTPN1, SIGMAR1, XDH 2.48766
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.35133
[CC] GO:0043204 None DRD2, OPRK1, OPRM1, PDE10A, TOP1 2.35119
[CC] GO:0044444 cytoplasmic part ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, BACE1, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, HTR2A, INSR, KDR, MMP2, MMP9, NQO2, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TOP1, TYR, XDH 2.28912
[CC] GO:0005901 caveola HTR2A, INSR, PTGS2, SRC 2.11538
[CC] GO:0031224 None ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA4, CA9, DRD1, DRD2, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, TBXAS1, TEK, TYR 2.06247
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01884
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.3658
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 11.3101
[MF] GO:0043167 ion binding ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 11.2297
[MF] GO:0003824 catalytic activity ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SENP6, SRC, TBXAS1, TEK, TOP1, TYR, XDH 11.2297
[MF] GO:0008144 drug binding AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PDE10A, PIK3CA, PIK3CB, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP1 8.64896
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.60411
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.25147
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TEK 7.11758
[MF] GO:0043169 cation binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 6.81065
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.71336
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.55848
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 6.3074
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TEK 6.27944
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, SMAD3, TEK 6.17848
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 6.07533
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TEK 6.06161
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 5.84664
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 5.84664
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TBXAS1, TYR 5.72768
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 5.70539
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.55545
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.53298
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 5.35515
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.33087
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.23199
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 5.17202
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.10416
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.95511
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 4.89549
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.7296
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 4.58903
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 4.56938
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 4.21425
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.05997
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.93067
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, PTGS2, SRC, TBXAS1, XDH 3.6724
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.57195
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.53354
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRM1 3.45552
[MF] GO:0044877 macromolecular complex binding ADORA1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.4169
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SENP6, SRC, TEK, TOP1 3.4169
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.39657
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 3.22439
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.16128
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.16128
[MF] GO:0070405 ammonium ion binding DRD1, DRD2, HTR1A, HTR2A, HTR7 3.1575
[MF] GO:0032403 protein complex binding ADORA1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.15
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 3.00001
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.96965
[MF] GO:0004119 None PDE3A, PDE3B 2.96965
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.87328
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.78726
[MF] GO:0004930 None ADORA1, ADORA3, DRD1, DRD2, GPR35, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 2.77886
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 2.74346
[MF] GO:0097159 organic cyclic compound binding ADORA1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, ESR1, FLT3, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 2.74303
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 2.74303
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.67139
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.50416
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.47311
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.46517
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.46165
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.41087
[MF] GO:0042578 None ADORA1, ALPL, CDC25B, DUSP3, PDE10A, PDE3A, PDE3B, PTPN1 2.35373
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.35166
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.26367
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.26367
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.26367
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.2177
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.20895
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.16053
[MF] GO:1901363 heterocyclic compound binding ADORA1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, FLT3, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 2.16053
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.1519
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.1519
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15094
[MF] GO:0008528 None GPR35, OPRD1, OPRK1, OPRM1, SIGMAR1 2.14347
[MF] GO:0001653 None GPR35, OPRD1, OPRK1, OPRM1, SIGMAR1 2.13005
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 2.12273
[MF] GO:0033218 amide binding BACE1, IGF1R, INSR, NQO2, OPRD1, OPRK1, OPRM1 2.10494
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B2, XDH 2.07992
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.06658
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.06247
[MF] GO:0104005 hijacked molecular function AXL, EGFR, HSPA1A, HTR2A 2.028
[MF] GO:0001618 virus receptor activity AXL, EGFR, HSPA1A, HTR2A 2.028
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01884
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.00522


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.051
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.0501
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PDE3B, ADORA1, PIK3CB, PTGS2, PTGS1 8.8114
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, OPRM1, MMP9, ESR1, EGFR, HSPA1A 8.385
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.0304
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.067
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, PDE3B, ADORA1, PDE3A, HTR1A, PIK3CB, DRD1, DRD2, PPARA 7.0834
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 7
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR7, GPR35, ADORA3, ADORA1, HTR1A, OPRK1, OPRM1, HTR2A, DRD1, DRD2 7
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.6511
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 5.5977
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, PIK3CA, ADORA3, INSR, PDE3B, ADORA1, PDE3A, PIK3CB 5.6392
Serotonergic synapse_Homo sapiens_hsa04726 HTR7, CYP2D6, ALOX5, HTR1A, HTR2A, PTGS2, PTGS1 5.6392
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9408
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 4.9702
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 4.6801
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3664
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.5707
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.4903
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.187
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.3101
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.4136
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.0742
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.187
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 3.7073
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.2707
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB 3.7073
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.6908
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PDE3B, PIK3CB, CDC25B, IGF1R 3.7513
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6216
Gap junction_Homo sapiens_hsa04540 SRC, HTR2A, DRD1, DRD2, EGFR 3.9622
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.0782
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.6008
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.4176
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, PIK3CA, ADORA3, ADORA1, PIK3CB 3.4397
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, PIK3CB, MMP9 3.1366
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.5635
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.9897
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PDE3B, PIK3CB 3.2163
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.3874
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.3728
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGS1 3.4397
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.2577
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, EGFR, IGF1R 2.961
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.9897
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB, HTR2A 2.8365
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.8881
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1433
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6609
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3085
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5809
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, HSPA1A 2.5809
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5809
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.511
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.4104
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.3888
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.3249
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.3405
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.2627
Calcium signaling pathway_Homo sapiens_hsa04020 HTR7, HTR2A, DRD1, EGFR 2.0258
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 2.0486
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0258
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.8788
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.8077
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5656
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5153
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.4366
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.9031
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3029
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0121
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3252
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3118
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.3252
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3512
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1898
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.3454
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.8788
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.0573
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3922
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.2465
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2856
Axon guidance_Homo sapiens_hsa04360 MET 0.4075
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.994
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4156
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.5809
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3405
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.9014
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9014
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9115
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7595
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, PIK3CB 2.3972
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9241
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4827
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 0.9838
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.9374
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.482
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.8771
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.963
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4944
Cholinergic synapse_Homo sapiens_hsa04725 PIK3CA, PIK3CB 1.0347
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.511
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0658
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 2.3712
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 1.0948
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.142
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0764
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0984
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5203
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5203
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1098
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.533
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5315
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3219
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.159
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5191
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.142
Peroxisome_Homo sapiens_hsa04146 XDH 0.533
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5549
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5688
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5667
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5784
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.6609
Bile secretion_Homo sapiens_hsa04976 CA2 0.5763
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3114
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3501
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5919
Shigellosis_Homo sapiens_hsa05131 SRC 0.6003
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3291
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.8881
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6282
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.3454
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4366
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3817
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3817
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6588
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4411
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.87
Malaria_Homo sapiens_hsa05144 MET 0.7011
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7144
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5786
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7196
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6442
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.823
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9014
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.823
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8658
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8827
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9481
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9024
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9031
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8207
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8758
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9014
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1408
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1101
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2868


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)