TCM Prescription: Xiao Er Bai Ri Ke Powder



Prescription Description
Prescription IDTCMF6556
Pinyin NameXiao Er Bai Ri Ke San
Chinese Name小儿百日咳散
English NameXiao Er Bai Ri Ke Powder
Function Description咳嗽, 百日咳
IndicationsPertussis
Disease ICD-11 Category 1C12.Z [Whooping cough, unspecified, 百日咳，未特指的 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH2337 Flos inulae 旋覆花 TCMH2337
TCMH2725 Fructus perillae 紫苏子 TCMH2725
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2117 Lepidium apetalum 葶苈子 TCMH2117 ITSAB3973-14
TCMH46 Stemona tuberosa 百部 TCMH46 GBVC4204-11, GBVC4202-11
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH552 Rhizoma pinelliae preparata 法半夏 TCMH552
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.385
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.385
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.66138
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 8.57053
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, POLA1, POLB, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.57053
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 8.08201
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, POLB, RORC, SMAD3, SRC, TEK, TYR 7.90525
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 7.84662
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 7.77367
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, RORC, SRC, TEK, TYR 7.6969
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, MIF, TBXAS1 7.32576
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 7.32493
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 7.32493
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.27344
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.23174
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 7.23174
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 7.23174
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.19068
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.15987
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, POLB, RORC, SMAD3, SRC, TEK, TYR 6.89588
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.80324
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.79869
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 6.60217
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.51771
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HMGCR, HSPA1A, MIF, PIM1, TBXAS1, TYR, XDH 6.44572
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.15675
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, TNKS, XDH 6.11838
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.11838
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 6.06072
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HMGCR, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, RORC, SMAD3, SRC, TEK, TNKS2, TYR 6.04929
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TEK, TYR 5.99063
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 5.96142
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.83957
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.81435
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, TNKS, XDH 5.80242
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC 5.76265
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.74273
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, HSD17B2 5.70511
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 5.70511
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.66035
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.60677
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.55457
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 5.49467
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.46962
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.45698
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, SMAD3, SRC, TEK, TYR 5.36121
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, HMGCR, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SMAD3, SRC, TEK, TNKS2, TYR 5.24933
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.24933
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 5.20798
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK 5.19349
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HMGCR, KDR, MIF, SRC, TNKS, TNKS2 5.15117
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, MIF, TBXAS1 5.07072
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 5.03818
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 5.03818
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC, TEK 4.97845
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.97316
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK, TYR 4.97316
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.95317
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.90897
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC 4.76455
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, MIF, PIM1, POLA1, SRC, TEK, TYR 4.64098
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC 4.62852
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, SRC, TEK 4.61757
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 4.61757
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.58899
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.58392
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.5407
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 4.53659
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.53659
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.47579
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.47457
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.47457
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.43773
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.4339
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.4339
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.37425
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 4.30103
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 4.30103
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 4.2937
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.28963
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, POLB, RORC, SMAD3, SRC, TEK, TYR 4.2642
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.25904
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.25904
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.24987
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSPA1A, MMP2, POLB, SMAD3, SRC, TEK, TYR 4.22719
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.22719
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, MIF, SRC, TNKS, TNKS2 4.2204
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.19522
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.18933
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.18818
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC, TEK, TNKS 4.18818
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 4.1656
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC 4.12752
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HMGCR, HSD17B1, HSD17B2 4.12752
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, HMGCR, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.11429
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 4.09842
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.07774
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 4.07486
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 4.06744
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 4.02071
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.00568
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC 3.97882
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.97766
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.97334
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.90634
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.86522
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.85817
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.8345
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.82709
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.80529
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.78467
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.76292
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.70433
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.65609
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.63134
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.60951
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.57908
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.57336
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PTPN1, SRC, TNKS 3.53416
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, HMGCR, KDR, MIF, PTPN1, SRC, TEK 3.53416
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.52219
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.51797
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KDR, POLB, SRC 3.48928
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.4892
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 3.44608
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.40679
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC 3.37293
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, SMAD3, SRC, TEK 3.36836
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.33897
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 3.28836
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.27258
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.25088
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC 3.21158
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, TYR 3.1944
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS 3.18328
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.17875
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.15304
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HMGCR, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.14853
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.11777
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.11402
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 3.06856
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CHRM2, CYP1B1, EGFR, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TNKS2, XDH 3.06785
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, HSD17B2, MIF 3.06387
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK, TNKS 3.05151
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.01823
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.01808
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.01808
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HMGCR, HSPA1A, INSR, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC 3.00408
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.00062
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.95706
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.95706
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.95151
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.94954
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TNKS 2.92471
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.92471
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, EGFR, FLT3, HMGCR, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.86306
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PTPN1, SMAD3, SRC, TEK 2.86306
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.86042
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, HMGCR, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 2.85897
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.84301
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.8158
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.78472
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, SMAD3, SRC, TEK 2.78472
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.78472
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.78472
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.78472
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.78472
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.78412
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, RORC, SRC, TEK 2.77958
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.77026
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.75177
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.74851
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC 2.72104
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, SMAD3, SRC, TEK 2.72104
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.71459
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, SMAD3 2.70592
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.66635
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.6597
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.65648
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.63002
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.63002
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.63002
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, HMGCR, KDR, MET, MIF, MMP12, SMAD3, TEK 2.59644
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.59274
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.5866
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PTPN1, SMAD3, SRC, TEK 2.58197
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.57462
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56724
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.56724
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTPN1, XDH 2.56632
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.55766
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIM1, POLB, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 2.51428
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.51428
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade EGFR, HMGCR, KDR, MIF, SRC, TEK 2.51428
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC 2.51337
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A 2.50678
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, MIF, MMP12, SMAD3, SRC 2.50122
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.49224
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, TBXAS1 2.49224
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.48939
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.48636
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.42543
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.4193
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.4193
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.41255
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.41255
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 2.40865
[BP] GO:0043412 macromolecule modification ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.40865
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.4029
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.4029
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.38994
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38994
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.38994
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.38305
[BP] GO:0033554 cellular response to stress AKR1B1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PTPN1, SRC 2.38212
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, NUAK1, POLB, PTPN1, SRC, TEK 2.38051
[BP] GO:0032872 regulation of stress-activated MAPK cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.35453
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, SRC, TYR 2.35276
[BP] GO:0051894 None KDR, SMAD3, TEK 2.34984
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.34984
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.34984
[BP] GO:0070213 None TNKS, TNKS2 2.3446
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3446
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.34228
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.32618
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.31985
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.30878
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.30878
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.29926
[BP] GO:0010564 regulation of cell cycle process AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, TNKS 2.27747
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, POLA1, SMAD3, SRC 2.26775
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.26775
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.26775
[BP] GO:1903393 None KDR, SMAD3, TEK 2.26775
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, TNKS, TNKS2 2.26606
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.24977
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.22782
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.22363
[BP] GO:0050730 None ADORA1, EGFR, FLT3, MIF, PTPN1, SRC 2.22116
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, HMGCR, MIF, POLB 2.22116
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, HMGCR, KDR, MET, MIF, MMP2, MMP9, RORC, SMAD3, SRC, TEK 2.20473
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, SMAD3, SRC, TNKS 2.17394
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, SRC 2.17135
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.17135
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.15395
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.14124
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, RORC, SRC 2.13794
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.13752
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.12903
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.12903
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 2.12903
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.12167
[BP] GO:0051248 None CSNK2A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MIF, MMP9, PTPN1, SMAD3, SRC, XDH 2.11887
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.11887
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, SRC, TEK, TYR 2.11887
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.11887
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.11887
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.11887
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.10972
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 2.09584
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.092
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, SRC 2.08662
[BP] GO:0003018 None ADORA1, EGFR, HMGCR, SRC, TEK 2.08662
[BP] GO:1901890 None KDR, SMAD3, TEK 2.08662
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.08662
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.08217
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.08217
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.08217
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.05465
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.0529
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.04761
[BP] GO:0002793 None ACHE, ADORA1, EGFR, MIF, MMP12, SRC 2.04162
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.03858
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.03858
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.03858
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.03858
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.03513
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.02816
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, TYR 2.02547
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.02421
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, RORC 2.00125
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.62787
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, PIM1, POLA1, PTPN1, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.41452
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, FUT7, GPR35, HMGCR, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR 2.36693
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, HMGCR, HSD17B2, PTPN1, TBXAS1 2.04162
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.03858
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 14.2296
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 10.4957
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2725
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 10.1706
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.63849
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.15987
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.00769
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.60217
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.69276
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.49078
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.24933
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 5.20763
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 5.1488
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 5.12198
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 4.98226
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.95686
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 4.82721
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.64314
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.59174
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.47579
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PTPN1, RORC, SMAD3, TNKS 4.47483
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.30103
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, POLA1, SRC, TBXAS1, XDH 4.28963
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.25857
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 4.19522
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.05507
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.95459
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PTPN1, SMAD3, SRC 3.63864
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.57336
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.47912
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.47912
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, XDH 3.27258
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.24742
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PTPN1, SMAD3, SRC 3.1944
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.08453
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 3.06785
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1, SMAD3 2.87669
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, HMGCR, HSPA1A, MET, MIF, POLA1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS2 2.6844
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.56724
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.51428
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.50678
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.41452
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.41452
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.41351
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.36693
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3446
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3446
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.18136
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.16022
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16022
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.14519
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.08662
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.05436
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.04782
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03858


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.8551
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.3865
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.6071
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.8407
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, CYP3A4, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.9469
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3963
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 4.329
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.329
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3015
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.9566
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8435
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8435
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.8055
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.5281
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.5277
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2732
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.7889
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.2441
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.0952
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3749
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.2704
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3871
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2704
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7889
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2486
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2457
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.2704
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0338
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2356
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.994
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9792
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.2356
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.7833
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.2425
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6436
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7414
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5957
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7314
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GPR35, ADORA3, ADORA1 1.5482
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.702
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4148
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.2647
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.2105
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.191
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1298
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4339
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4066
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR 1.0587
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3835
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9897
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1563
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.919
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1776
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0031
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1888
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1582
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.919
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2647
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3786
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.914
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4148
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.983
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.914
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.919
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9087
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4066
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8655
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8655
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8309
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3835
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3498
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.8119
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.4066
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, EGFR 0.8097
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8119
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.734
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1 0.7506
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.6229
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3656
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3808
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3652
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4281
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.423
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR 0.4244
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4443
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4564
Hepatitis C_Homo sapiens_hsa05160 EGFR 0.4564
Axon guidance_Homo sapiens_hsa04360 MET 0.469
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4773
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4829
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5046
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4856
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5013
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5184
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5261
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5258
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.53
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5183
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5346
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5947
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5343
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5473
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5592
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5527
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5527
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5539
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5521
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8539
Peroxisome_Homo sapiens_hsa04146 XDH 0.56
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5941
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5955
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5751
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5928
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5812
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.756
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6229
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8713
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6254
Shigellosis_Homo sapiens_hsa05131 SRC 0.6234
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6469
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8102
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7426
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.67
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6731
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6912
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6946
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0338
Malaria_Homo sapiens_hsa05144 MET 0.7064
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7104
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7815
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8119
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8748
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8377
Base excision repair_Homo sapiens_hsa03410 POLB 0.8219
DNA replication_Homo sapiens_hsa03030 POLA1 0.8097
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8801
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8465
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8748
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.919
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0016
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0653
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1585


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)