TCM Prescription: Jin Hua Ming Mu Pills



Prescription Description
Prescription IDTCMF648
Pinyin NameJin Hua Ming Mu Wan 
Chinese Name金花明目丸
English NameJin Hua Ming Mu Pills
Function Description头痛, 齿痛, 口舌生疮
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationHeart, Brain
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH1487 Buddleja officinalis 密蒙花 TCMH1487 ITSAM868-14
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
TCMH1117 Rhizoma fagopyri cymosi 金荞麦 TCMH1117
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MET, POLA1, POLB, PPARA, PRKCA, SRC, TNKS, TNKS2, TRPV1, XDH 10.0023
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.48431
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 9.40015
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, POLB, PPARA, RORC, SRC, TRPV1, TYR 8.06459
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, POLB, PPARA, PRKCA, RORC, SRC, TRPV1, TYR 8.00286
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIM1, POLB, PPARA, PRKCA, RORC, SRC, TNKS2, TOP2A, TYR 7.42701
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 7.42701
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, POLB, PPARA, PRKCA, RORC, SRC, TRPV1, TYR 7.29129
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, FABP3, FUT7, GLO1, PIM1, PPARA, TYR, XDH 7.2508
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EPHX2, F10, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.16609
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.96101
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.8342
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.75731
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.34353
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 6.26495
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TOP2A, TRPV1, XDH 6.26495
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.26495
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 6.26495
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 6.25944
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 6.25667
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SRC, TOP2A, TRPV1, XDH 6.23427
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.22155
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.17491
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PHF8, TYR, XDH 6.14068
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 6.00129
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.93181
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.82906
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 5.80522
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 5.8022
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NR3C1, RORC, SRC, TRPV1, TYR 5.78312
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SRC, TOP2A, TRPV1, XDH 5.64867
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, EPHX2, F10, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TRPV1, TYR 5.44042
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 5.39964
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.12415
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 5.08411
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, POLA1, POLB, PTPN1, RORC, SRC, TOP2A, TRPV1 5.08411
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, SRC, XDH 5.08411
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 5.08411
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, F10, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, SRC, TRPV1 5.08411
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC 5.05381
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC, TRPV1 5.02689
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, F10, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TOP2A, TRPV1, TYR 5.01908
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, FABP3, FABP4, FUT7, MET, PPARA 4.99076
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 4.88208
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SRC 4.83099
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 4.69331
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 4.69095
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 4.68876
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 4.68876
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 4.63336
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.62803
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PPARA 4.58385
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, SRC, TNKS, TNKS2, TRPV1 4.55174
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PHF8, PIM1, POLB, PPARA, RORC, SRC, TYR 4.51405
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.50138
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, POLB, PRKCA, PTPN1, SRC, TNKS, XDH 4.47357
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EPHX2, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC, TRPV1 4.37445
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EPHX2, KDR, POLB, SRC 4.36574
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 4.36114
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.32145
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA 4.27518
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 4.26061
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SRC 4.21633
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, POLB, SRC, TRPV1 4.21633
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.17678
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, POLB, PRKCA, PTPN1, SRC, TNKS, XDH 4.16834
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA 4.04578
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, FLT3, MET, PIM1, POLA1, SRC, TYR 3.99585
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, FLT3, NR3C1, RORC, SRC, TRPV1 3.99585
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, PHF8, POLB, PPARA, SRC, TYR 3.88717
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, EPHX2, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 3.88717
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, NR3C1, SRC, TRPV1 3.83195
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, F10, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, POLB, PPARA, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.78137
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC, TNKS 3.78137
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.73019
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.72356
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PPARA 3.72356
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.72175
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.64985
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.59459
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.59459
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, F10, FLT3, KDR, MET, PRKCA, PTPN1, SRC, XDH 3.59459
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.52824
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.48744
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.41036
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 3.41036
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 3.39587
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.36613
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.36613
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.34597
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.30338
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 3.25705
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, RORC 3.24826
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.24146
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 3.23453
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.21206
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, GLO1, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.20666
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 3.12275
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.09006
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.0739
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.04232
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 3.03263
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.02221
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.93529
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PRKCA, SRC 2.91073
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.90752
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.90261
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PIM1, PPARA, TYR 2.8915
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.87585
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC, TNKS 2.85447
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 2.85447
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, MET, PRKCA, SRC, TNKS, TOP2A 2.81453
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.80646
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS 2.80646
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, F10, MET, PRKCA, XDH 2.80215
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EPHX2, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.8019
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, IGF1R, KDR, MET, MMP9, PRKCA, PTPN1, SRC, XDH 2.79841
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, F10, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, POLB, PPARA, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.78089
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2, TRPV1 2.78089
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78089
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.77414
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.77414
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.77414
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.77414
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 2.69006
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9 2.66908
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, F10, FLT3, FUT7, IGF1R, KDR, MET, NR3C1, PHF8, PIM1, POLB, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.66153
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, PRKCA, TNKS, TOP2A 2.63244
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 2.63167
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.59595
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, F10, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIM1, POLB, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.58726
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.54571
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.54571
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PIM1, PPARA, TYR 2.53684
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.48194
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.48194
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.47242
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PIM1, PPARA, TYR 2.46621
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.45853
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 2.44542
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.44542
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, SRC, TRPV1 2.44542
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, POLA1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.44542
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, F10, FLT3, FUT7, IGF1R, KDR, MET, PHF8, PIM1, POLB, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.39361
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, F10, FLT3, FUT7, IGF1R, KDR, MET, PHF8, PIM1, POLB, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.39361
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.39361
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.39361
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.39361
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.39361
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.39361
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39361
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.38466
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37167
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.36546
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, MMP2, POLB, PPARA, SRC, TRPV1, TYR 2.34536
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.32113
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.28949
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.27622
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EPHX2, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TOP2A, TRPV1 2.27215
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.25703
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, HCAR2, MMP12, MMP9, PPARA, PRKCA, PTPN1, SRC, TRPV1 2.25155
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.21926
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.21498
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.20503
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, PPARA, RORC, SRC, TOP2A 2.20503
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, EPHX2, POLB, PTPN1 2.20503
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.20103
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.19024
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 2.18555
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, HCAR2, KDR, MET, MMP12, MMP9, PIM1, PRKCA, SRC, TRPV1 2.18295
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, EPHX2, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, POLA1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.17925
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16361
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, EPHX2, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, POLA1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.16271
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, SRC 2.16271
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, KDR, PRKCA, PTPN1, SRC, XDH 2.16271
[BP] GO:0070213 None TNKS, TNKS2 2.16271
[BP] GO:0097176 epoxide metabolic process ALOX12, EPHX2 2.16271
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.16271
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.14789
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.13662
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC 2.13662
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.13132
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.13068
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.13068
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 2.12341
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, HCAR2, KDR, MET, MMP12, MMP9, PIM1, PRKCA, SRC, TNKS2, TRPV1, XDH 2.09043
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 2.0857
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2 2.07691
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.04629
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.04629
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.04629
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.04561
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, EPHX2, FABP3, FABP4, MET, TRPV1 2.04561
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.04213
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.04213
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.03346
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.03346
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.01508
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.01408
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 2.00799
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, TRPV1 2.00799
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.00799
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, NR3C1, SRC 2.00799
[BP] GO:0046541 None CHRM1, CHRM3 2.00799
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.00799
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.00799
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.00799
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FLT3, FUT7, GLO1, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PHF8, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR 2.63167
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, F10, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SRC, TRPV1 2.42229
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NR3C1, PIM1, POLA1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.32221
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, BCL2, CA1, CA2, CA7, CBR1, CDC25B, CDK6, CSNK2A1, EPHX2, FABP3, FABP4, FLT3, GLO1, HSD17B1, NR3C1, PIM1, POLA1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.04213
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, FLT3, IGF1R, KDR, MET, TRPV1 1.93397
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, TNKS, TYR, XDH 15.1471
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, POLA1, POLB, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 14.7968
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.2523
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.87408
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.22448
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.06869
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 8.00346
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PHF8, TYR, XDH 7.2508
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, XDH 6.66102
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PPARA, PRKCA, PTPN1, RORC, TNKS 6.62541
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.26495
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.2422
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 6.2422
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PRKCA, SRC, TOP2A, TRPV1 5.32031
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.16973
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.97176
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.97945
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.90446
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.89894
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.64367
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, TYR 3.59459
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, POLA1, PTPN1 3.41036
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.30362
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.20669
[MF] GO:0016803 ether hydrolase activity ALOX12, ALOX15, EPHX2 3.20669
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.19656
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.16887
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1 3.04908
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.01283
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.87167
[MF] GO:0016801 None ALOX12, ALOX15, EPHX2 2.85518
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.85447
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.84391
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.77414
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 2.77414
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.6613
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.64306
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.64079
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 2.54571
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.44603
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.39361
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.39361
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.39361
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.39361
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.34281
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLA1, POLB, PRKCA, SRC 2.31843
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, POLA1, SRC, XDH 2.30191
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.29489
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.16271
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.16271
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.14789
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.10303
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.06627
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.04629
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.01508
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.01508
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.01508
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.00799


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9446
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.8139
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7493
Metabolic pathways_Homo sapiens_hsa01100 CBR1, EPHX2, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 6.1565
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2, PRKCA 5.5106
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.3379
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.102
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, ALOX15, ALOX12 4.369
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, IGF1R 4.0862
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, PRKCA, MMP9, MET, IGF1R 4.034
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, TRPV1, NR3C1 4.1142
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, CDC25B 4.034
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0862
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, PRKCA, MET, IGF1R 3.6799
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PRKCA, ALOX12 3.4103
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, PRKCA, MET, IGF1R 3.2278
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8989
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, PRKCA, MMP9 2.9821
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA, ALOX12, TRPV1 2.6253
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, PRKCA 2.6183
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, PRKCA 2.6117
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1078
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 2.4544
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, PRKCA, MET, IGF1R 2.3718
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.3595
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1, PRKCA 2.3718
Glioma_Homo sapiens_hsa05214 CDK6, PRKCA, IGF1R 2.1593
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6253
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.2112
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 2.0237
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0622
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8419
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.8055
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.1593
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7368
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9948
Ras signaling pathway_Homo sapiens_hsa04014 KDR, PRKCA, MET, IGF1R 1.5864
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, PRKCA, IGF1R 1.704
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 1.7518
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4207
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.5864
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.4207
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 1.0749
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9017
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.205
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA 1.0696
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PRKCA 1.3189
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA 1.0696
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3189
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0126
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1129
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0696
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0696
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.0029
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9481
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3128
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.0696
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8085
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.0749
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2008
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.7841
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.2871
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 0.9017
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.0584
Gap junction_Homo sapiens_hsa04540 SRC, PRKCA 1.0696
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9017
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.7673
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA 1.0696
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.1967
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7399
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1811
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8722
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0475
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA 0.7399
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7073
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2928
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6868
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6133
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6834
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2314
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.5358
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3232
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3463
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3227
Influenza A_Homo sapiens_hsa05164 PRKCA 0.338
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3463
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3776
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3943
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3943
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3923
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PRKCA 0.3905
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.403
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4008
Platelet activation_Homo sapiens_hsa04611 SRC 0.4151
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.403
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4173
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4151
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4151
Axon guidance_Homo sapiens_hsa04360 MET 0.4098
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.4074
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4387
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4291
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4173
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4466
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA 0.4631
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.4689
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4631
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4631
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4522
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4689
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.4631
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.4689
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4689
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA 0.4631
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4751
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4764
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.4947
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4757
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5003
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5327
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5061
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5373
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5342
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5411
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5358
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5411
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7368
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5453
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5411
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5411
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5411
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.5391
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5358
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5358
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5411
Shigellosis_Homo sapiens_hsa05131 SRC 0.5411
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5411
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5753
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.601
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.601
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6242
Malaria_Homo sapiens_hsa05144 MET 0.6082
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.704
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.6158
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.688
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9087
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCA 0.6821
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7073
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6763
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7399
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7073
DNA replication_Homo sapiens_hsa03030 POLA1 0.7007
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7841
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7406
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7739
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9991
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0292


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)