TCM Prescription: Xiao Er Xie Xie Ting Granules



Prescription Description
Prescription IDTCMF6469
Pinyin NameXiao Er Xie Xie Ting Ke Li
Chinese Name小儿泄泻停颗粒
English NameXiao Er Xie Xie Ting Granules
Function Description腹泻
IndicationsDiarrhea
Disease ICD-11 Category ME05.1 [Diarrhoea, 腹泻 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH296 Radix aconiti 川乌 TCMH296
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, TNKS, TNKS2, XDH 10.7476
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, RORC, TYR 10.4654
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, RORC, TYR 9.97065
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, TYR 9.42708
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.09863
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.09863
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, MMP2, PIK3CA, PPARA, PRKCA, PTGS2, RORC, TYR 8.48184
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PRKCA 7.89795
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, TYR 7.5689
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.55746
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.4203
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 7.20663
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 7.19718
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.03223
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.98669
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HTR2B, HTR2C, PIK3CA, PPARA, PTGS1, PTGS2, TYR, XDH 6.89799
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, MMP12, MMP2, MMP9, PRKCA, PTGS1, PTGS2, XDH 6.57783
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.57783
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.45091
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2 6.44677
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.37902
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TYR 6.35698
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP12, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, TNKS2, TYR 6.3082
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 6.2675
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.25691
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.96747
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.94778
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.78424
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.66185
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.66185
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, MMP12, MMP2, MMP9, PRKCA, PTGS2 5.61078
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.55209
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, CNR1, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2, TNKS, TNKS2 5.5297
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.52655
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.40234
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.40234
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.38382
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 5.27771
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.26702
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.25235
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.23633
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.22325
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.13609
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 5.12127
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 5.11652
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2 5.07714
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, RORC, TNKS2, TYR 5.06218
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.04601
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1, RORC, TNKS, TNKS2 5.00045
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC 4.9056
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 4.89381
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.77372
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.76009
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.76009
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.6384
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.62473
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 4.45332
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 4.43666
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 4.43666
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4096
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 4.32241
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, XDH 4.27336
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 4.27336
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.26753
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, XDH 4.2332
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C 4.07036
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.05013
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 4.04444
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.93333
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.9076
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 3.85426
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, TNKS, TNKS2 3.85426
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.7846
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.7507
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.7507
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.73838
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.73838
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.68779
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1 3.68779
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.62328
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60907
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.60063
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HTR1A, TYR 3.55992
[BP] GO:0006690 icosanoid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.54136
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.48751
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 3.44319
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 3.43326
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, PIK3CA, PPARA, TYR 3.43206
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, XDH 3.393
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.34569
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.34082
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1 3.32743
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.30408
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.25702
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, MMP9, PIK3CA, PPARA, PTGS2, RORC, TYR 3.25702
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.23201
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PTGS2 3.21368
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.20317
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 3.18274
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15984
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 3.14656
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.14656
[BP] GO:0090066 None ADORA1, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.14656
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C 3.1412
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.07869
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.03361
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 3.01886
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.98792
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.98792
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C 2.98183
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 2.98183
[BP] GO:0007154 None ADORA1, BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 2.98183
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, XDH 2.96138
[BP] GO:0006631 fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 2.95835
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, MMP2, MMP9, PIK3CA, PTGS2, RORC 2.92405
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 2.91858
[BP] GO:0007267 None ADORA1, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.90641
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, XDH 2.89875
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D 2.89867
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCA, PTPN1, XDH 2.89867
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2 2.86629
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 2.86564
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85368
[BP] GO:0007208 None HTR2A, HTR2C 2.84109
[BP] GO:0009115 None AOX1, XDH 2.84109
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 2.82893
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.82583
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.82191
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.81393
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 2.80942
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 2.80685
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.80456
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 2.80456
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.78686
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.78686
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, MMP2, PIK3CA, PTGS2, RORC 2.78451
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, XDH 2.76787
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, TYR 2.74349
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2 2.74349
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.74349
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 2.70592
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.67675
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 2.66866
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, XDH 2.66866
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.65482
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA 2.64946
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.6155
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.58659
[BP] GO:0023052 None ADORA1, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.56318
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.51861
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.48833
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2 2.48833
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.4826
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, HTR1A, HTR2A, HTR2C, PRKCA 2.45055
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2, TYR 2.45055
[BP] GO:0046110 None AOX1, XDH 2.45055
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45055
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.44167
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2 2.42237
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 2.42117
[BP] GO:0032787 None ALOX15, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, PTGS1, PTGS2 2.41451
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA 2.39421
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.36604
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.33939
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 2.33431
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.3128
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PTPN1 2.30045
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2 2.26595
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2, TYR 2.26595
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.2578
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.25524
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, ESRRB, HTR2A, HTR2B, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1 2.21519
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2 2.21485
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20748
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 2.2038
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.2012
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2 2.2012
[BP] GO:0070213 None TNKS, TNKS2 2.2012
[BP] GO:0006145 None AOX1, XDH 2.2012
[BP] GO:0038171 None CNR1, CNR2 2.2012
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2012
[BP] GO:0014827 None HTR1D, HTR2B 2.2012
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.19673
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, MMP12, PPARA, PRKCA, PTGS2 2.18105
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.17559
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.17559
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17559
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.17332
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1 2.17004
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.15075
[BP] GO:0009892 negative regulation of metabolic process ADORA1, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, TNKS, TNKS2, XDH 2.09046
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 2.08439
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.07867
[BP] GO:0007610 None BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 2.07813
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.04945
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1 2.04444
[BP] GO:1900543 None HTR1B, HTR1E, PPARA, PRKCA 2.0442
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2, TYR 2.02384
[BP] GO:0045980 None HTR1B, HTR1E, PPARA, PRKCA 2.02384
[BP] GO:0043696 None CDK6, ESRRB 2.01604
[BP] GO:0043697 None CDK6, ESRRB 2.01604
[BP] GO:0071502 None HTR1B, HTR2B 2.01604
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, MMP12, MMP2, PPARA, PRKCA, PTGS2, PTPN1, XDH 2.01301
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.01032
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.00835
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.0058
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.0058
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR 3.70042
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.51913
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, GBA2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PRKCA, PTPN1 3.393
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TYR 3.26287
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 2.68523
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, CA2, CA4, CA9, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2 2.25524
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.0838
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.0838
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.8918
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PTPN1, RORC, TNKS, TYR, XDH 14.0225
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.8373
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.4158
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 10.565
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3683
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.0224
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 9.88351
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.88057
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PTPN1, RORC, TNKS 8.66992
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, RORC 7.19718
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CDK6, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, RORC 6.73173
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.71075
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.37902
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, RORC 6.3111
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PRKCA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 5.71983
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, RORC 5.58902
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.55209
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.2453
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.2453
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.22325
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.15355
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.83248
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.27336
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.97481
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 3.7898
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.7507
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.7507
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.68672
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.67968
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.60907
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.48751
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.45933
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.43326
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.32707
[MF] GO:0008289 lipid binding ALOX15, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.29746
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.27241
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.26261
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.11471
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.95681
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.84109
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.84109
[MF] GO:0003845 None HSD11B1, HSD11B2 2.84109
[MF] GO:0071886 None HTR2A, HTR2C 2.84109
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.74349
[MF] GO:0008144 drug binding ACHE, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PPARA, PRKCA 2.73969
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.70863
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.67212
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.45055
[MF] GO:0004949 None CNR1, CNR2 2.45055
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2012
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01604


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7 17.5583
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 11.8781
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.1574
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4578
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 7.4318
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1 6.3696
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.1331
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, PRKCA, HTR2A, HTR5A, HTR4 5.5122
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.0863
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PRKCA, PIK3CB, PTGS2, MMP9 4.908
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PRKCA, PIK3CB, HTR2A 4.8781
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PRKCA, PIK3CB, F3 4.8617
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1, ESR2 4.8781
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, CYP1B1, PRKCA, PTGS2, MMP9, CDC25B 4.1519
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PRKCA, PIK3CB 4.4557
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, BCL2, PRKCA, PIK3CB, MMP9 4.0897
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PRKCA, PIK3CB 3.5674
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.0841
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.0897
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9, ESR1 3.409
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PRKCA, PIK3CB 3.5667
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PRKCA, PIK3CB 4.0897
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.4795
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0897
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PRKCA, PIK3CB, PTGS2 3.4574
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PRKCA, PIK3CB 3.3835
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1, ESR2 3.2416
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.0459
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2335
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2982
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PRKCA, PIK3CB 2.7265
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2C, PRKCA, HTR2A 2.9618
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.643
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.6459
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PRKCA, PIK3CB, ESR1 2.5402
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.3446
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.2774
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, AOX1, PIK3CB 2.2101
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PRKCA, PIK3CB, PTGS2 2.2101
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.1312
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.3537
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIK3CB 2.4074
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.2862
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.2774
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3446
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB 2.2774
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.2101
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB 2.2325
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.937
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.768
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX15, PTGS2, PTGS1 2.3446
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2953
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.0121
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PRKCA, PIK3CB 2.032
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PRKCA, PIK3CB 1.937
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 1.9739
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B 1.937
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, BCL2, PRKCA, PIK3CB 1.8761
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PRKCA, PIK3CB 1.8857
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 1.937
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9739
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 1.937
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PRKCA, PIK3CB 1.8
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB 1.937
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PRKCA, PTGS2 1.937
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.7657
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7796
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.7937
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.6633
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6751
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6424
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6455
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB 1.6312
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB 1.62
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5751
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3 0.228
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCA, PIK3CB 1.4307
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3308
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3411
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3513
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3403
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, PIK3CB 1.2863
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, PIK3CB 0.6936
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.7894
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.6092
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.4394
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6087
Tight junction_Homo sapiens_hsa04530 CSNK2A1, PRKCA 0.9477
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.766
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.9355
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4621
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9788
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4774
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 0.9767
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.022
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.022
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5184
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.1591
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1303
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.141
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2, PRKCA 1.2203
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.141
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5381
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.1991
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.5381
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.2203
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5524
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.1868
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5536
GABAergic synapse_Homo sapiens_hsa04727 PRKCA 0.5536
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.5536
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5591
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5536
Peroxisome_Homo sapiens_hsa04146 XDH 0.565
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5712
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5776
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3695
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6047
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6092
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.3298
Bile secretion_Homo sapiens_hsa04976 CA2 0.6092
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.6183
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6092
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.3676
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.6092
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.6156
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3872
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.3676
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6236
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.4323
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.4476
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6209
Long-term depression_Homo sapiens_hsa04730 PRKCA 0.6455
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.4057
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6765
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5092
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6998
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6998
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6033
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7172
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6751
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6455
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.6556
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7222
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7272
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.937
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.937
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.8274
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8511
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8735
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9083
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8333
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0905
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8938
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9318
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8834
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9197
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0584
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1483
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2295
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.443


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)