TCM Prescription: Xiao Yu Ding Tong Ointment



Prescription Description
Prescription IDTCMF6452
Pinyin NameXiao Yu Ding Tong Gao
Chinese Name消瘀定痛膏
English NameXiao Yu Ding Tong Ointment
Function Description跌打损伤, 痹病, 痛症
IndicationsArthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2161 Vaccaria segetalis 王不留行 TCMH2161
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH1032 Impatiens balsamina 急性子 TCMH1032 ITSAD363-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH2267 Periploca sepium 香加皮 TCMH2267 ITSAJ4400-14, GBVP4570-15
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH471 Atropa belladonna 颠茄浸膏 TCMH471 AY028147
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT701 PTPN22 Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP Hydrolase Q9Y2R2
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4038
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 11.796
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4742
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, IDO1, MIF, PIM1, PPARA, TYR, XDH 10.5173
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA 7.36168
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, TYR, XDH 6.56106
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.34801
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 6.25415
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PPARA, PRKCD, RORC, SRC, TYR 6.25415
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 6.04628
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.98133
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, TYR, XDH 5.98133
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTPN1, SRC 5.78762
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.73129
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.73129
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, RORC, SRC, TYR 5.71786
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD17B1, HSD17B2 5.65784
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.61342
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.58856
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, PTPN1, SRC 5.58686
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTPN1, SRC, XDH 5.45229
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MMP2, PPARA, PRKCD, RORC, SRC, TYR 5.42902
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, FLT3, MET, MIF, PIM1, PRKCD, SRC, TYR 5.40958
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, PTPN1, SRC, XDH 5.2605
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, SRC 5.21596
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.15634
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, PPARA, PRKCD, RORC, SRC, TYR 5.08314
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, MET, MIF, PPARA 5.04516
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA 5.04516
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 5.00921
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTPN1, SRC 4.90955
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, FABP3, FLT3, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, XDH 4.82336
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SRC, XDH 4.77852
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SRC, XDH 4.75582
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.74634
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, IDO1, TYR, XDH 4.69039
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTPN1, SRC, XDH 4.682
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.56246
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, PRKCD, SRC, XDH 4.48358
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42085
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PRKCD, RORC, SRC 4.33248
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.32523
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, RORC, SRC, TYR 4.21217
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, IDO1, MIF, PPARA 4.21217
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PRKCD, RORC, SRC, TYR 3.93323
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, PRKCD, SRC 3.7372
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.7372
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.70218
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.70218
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.6299
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, IDO1, MIF, PIM1, PPARA, TYR 3.58067
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.58067
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.58067
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.58067
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.56812
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, PRKCD, SRC 3.50489
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, RORC 3.47001
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.47001
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, XDH 3.46231
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PPARA, PRKCD, PTPN1, RORC, SRC, TYR 3.44379
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.43174
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, IDO1, MIF, PIM1, PPARA, TYR 3.42746
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.42598
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 3.40514
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.38927
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, XDH 3.36994
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 3.31277
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.30281
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, PRKCD, SRC 3.21694
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.18252
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.14823
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, PRKCD, SRC 3.13207
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.118
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, IDO1, MIF, PIM1, PPARA, TYR 3.01589
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, SRC 2.99759
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, MIF 2.9759
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF, PRKCD 2.9759
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PRKCD, RORC, SRC 2.87635
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81608
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SRC, XDH 2.77778
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, PTPN1, SRC 2.77767
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.7598
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SRC 2.75221
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 2.71008
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 2.71008
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.70527
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, PRKCD, SRC 2.64497
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.63035
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, KDR, MIF, SRC 2.62837
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.61738
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, PRKCD, RORC, SRC 2.61266
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, IDO1, KDR, MET, MIF, MMP12, MMP2, MMP9, PRKCD, PTPN1, SRC, XDH 2.58019
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.5072
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PRKCD, PTPN1, RORC, SRC 2.5072
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.5072
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.48972
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.4894
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD 2.4894
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.48928
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PRKCD, PTPN1, SRC, XDH 2.473
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.4417
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 2.43903
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, IGF1R, MET, MIF, MMP9, PRKCD, PTPN1, SRC, XDH 2.38904
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.3887
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36575
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.36575
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CHRM1, CYP19A1, HCAR2, MIF, MMP12, PRKCD, SRC 2.34586
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, IDO1 2.3395
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD 2.30127
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, FLT3, KDR, MET, MIF, PTPN1, SRC, XDH 2.29811
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, TYR, XDH 2.28501
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.28501
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.27338
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.27338
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, SRC 2.26849
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, TYR, XDH 2.24934
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.24288
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.23501
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, PTPN1, SRC, XDH 2.19285
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19285
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, FLT3, FUT7, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, SRC, TYR, XDH 2.19285
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.19285
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.19285
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, IDO1, XDH 2.16531
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, PTPN1, SRC, XDH 2.15977
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15002
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13265
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.10693
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, TYR, XDH 2.06272
[BP] GO:0050730 None ADORA1, FLT3, MIF, PRKCD, PTPN1, SRC 2.02397
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.02397
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.02397
[BP] GO:0006810 None ABCG2, ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, MIF, MMP12, MMP9, PPARA, PRKCD, SRC, XDH 2.01152
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, MIF, PRKCD, PTPN1, SRC 2.01122
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.84077
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, MET, SRC 1.7887
[CC] GO:0032279 None CHRM2, CHRM3 1.66409
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PRKCD, PTPN1, SRC, TYR 1.66397
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3 1.66397
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.6897
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.0739
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PRKCD, PTPN1, SRC, TYR, XDH 13.1378
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5195
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2633
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.62899
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SRC, TYR, XDH 8.27394
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.99335
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, IDO1, SRC 6.56224
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.56106
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, IDO1, SRC 6.35346
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.34801
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.30252
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.96598
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 5.8669
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, TYR, XDH 5.73129
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PRKCD, SRC 5.73129
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, IDO1, TYR, XDH 5.66599
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.58617
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.00921
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, TYR, XDH 4.89416
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.66848
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, IDO1, SRC, XDH 4.18257
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.12788
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.47001
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.47001
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.32363
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.03903
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.95805
[MF] GO:0008389 None CYP2A13, CYP2A6 2.75221
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.48372
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.38143
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.36575
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.26849
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.15002
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.10384
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.014


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.2587
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1049
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1055
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.6214
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 4.7111
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3211
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 3.8931
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.0849
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.1581
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.5027
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0849
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.8539
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1 2.8539
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PRKCD, BCL2, PIM1 2.7696
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2943
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9 2.7742
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.7696
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 2.6906
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.683
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, BCL2, MET, IGF1R 2.5372
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.5894
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 2.0113
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2031
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2802
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0113
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.2233
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.8187
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD 1.945
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCD, PPARA 1.7817
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5907
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.704
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.517
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.5581
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1278
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4161
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1345
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3766
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4121
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3094
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2659
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD 1.0991
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2906
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0223
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0991
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.307
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0675
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3939
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1164
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2321
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0994
Bile secretion_Homo sapiens_hsa04976 CA2, ABCG2 1.2906
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5 1.0223
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.9987
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9987
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8099
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9987
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7921
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6807
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7542
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, PRKCD 0.73
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5581
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8187
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.7284
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2745
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3377
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3673
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3804
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3905
Platelet activation_Homo sapiens_hsa04611 SRC 0.4546
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4362
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4368
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4362
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4409
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4746
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4253
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4218
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4362
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4546
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4098
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4546
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4546
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4362
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4409
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5204
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5204
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD 0.4546
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4546
Axon guidance_Homo sapiens_hsa04360 MET 0.4499
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7817
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5022
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5204
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5022
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7174
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.5168
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5204
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5204
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5168
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5204
Gap junction_Homo sapiens_hsa04540 SRC 0.5204
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5204
Peroxisome_Homo sapiens_hsa04146 XDH 0.5204
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5204
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5168
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5204
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5204
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5556
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5618
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5809
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5809
Glioma_Homo sapiens_hsa05214 IGF1R 0.5809
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5799
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5809
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5809
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0027
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5809
Shigellosis_Homo sapiens_hsa05131 SRC 0.5809
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5809
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6353
Malaria_Homo sapiens_hsa05144 MET 0.6459
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCD 0.6484
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.678
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7542
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7921
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8008
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8265
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7932
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8173
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9987
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0375


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)