TCM Prescription: Yi Kang Pills



Prescription Description
Prescription IDTCMF6415
Pinyin NameYi Kang Wan
Chinese Name抑亢丸
English NameYi Kang Pills
Function Description瘿瘤
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2102 Concretio silicea bambusae 天竺黄 TCMH2102
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1937 Concha haliotidis 石决明 TCMH1937
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH999 Dioscorea bulbifera 黄药子 TCMH999 GENG424-14, GBVW2132-13
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 8.75515
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 8.75515
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA12, CA2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH 8.08985
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.28416
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.28416
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 7.20265
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FDPS, FUT7, HSD17B1, MET, PPARA 7.12924
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AXL, CYP1B1, DRD2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 6.77588
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.38111
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 6.28034
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 6.17175
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 6.17175
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, XDH 6.07611
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 6.07611
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, PIM1, SRC, XDH 6.06733
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FDPS, FLT3, HTR2A, HTR2B, PPARA, RORC, SRC 5.95759
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 5.86077
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.8218
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.79481
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.79481
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KDR, SRC 5.75734
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.71423
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 5.60826
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 5.56791
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.56791
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR5A, IGF1R, KDR, PPARA, RORC, SRC 5.55042
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, PPARA, RORC, SRC 5.38663
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.34775
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FDPS, FUT7, MET, PPARA 5.3041
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS, HSD17B1 5.29614
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.23343
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FDPS, FUT7, HTR2B, PIM1, PPARA, XDH 5.10846
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 5.10846
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FLT3, HTR5A, RORC, SRC 4.99764
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.96175
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.96175
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2 4.92385
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.83783
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.80189
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP4, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, PIM1, PPARA, RORC, SRC, TNKS2 4.79262
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.79262
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.77691
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 4.69315
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 4.69315
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.69315
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR5A, IGF1R, PPARA, RORC, SRC 4.6421
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 4.604
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.604
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FDPS, HTR1A 4.59403
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA9 4.56404
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.44046
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, HTR2A, HTR2B, HTR5A, KDR, MET, PIM1, PPARA, RORC, SIGMAR1, SRC, TNKS2 4.43729
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 4.39004
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, SRC 4.36011
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, AXL, CA12, CA2, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, MET, SRC 4.34126
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.31531
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.28261
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, SRC 4.21692
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, PIM1 4.17478
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, SRC 4.14617
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.12671
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS 4.11127
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, SRC 3.96775
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, PPARA, PTPN1, RORC, SRC 3.94702
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.93494
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 3.92318
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.90033
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 3.90033
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HSD17B1, HTR1A, HTR2A 3.90033
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.89351
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS, XDH 3.89351
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC 3.89351
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, HTR7, PPARA, RORC, SRC 3.89351
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.8831
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, PIM1, PTPN1, SIGMAR1, SRC, XDH 3.86249
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.86249
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.83116
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, HTR5A, PPARA, SRC 3.82854
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 3.81419
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS 3.80387
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3 3.80387
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.78502
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, HTR5A, IGF1R, PPARA, SRC 3.77698
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.77698
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.77698
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, SRC 3.77426
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.77426
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, DRD1, DRD2, DRD3, HTR2A 3.76895
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, DRD1, DRD2, DRD3, HTR2A 3.76895
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.76895
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.72811
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA9, DRD2, DRD3, FABP3, PPARA 3.72472
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.70062
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.69481
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.69114
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.68345
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, DRD2 3.65037
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.65037
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.6098
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC 3.58298
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A 3.55995
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 3.55965
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, DRD1, DRD2, DRD3, TNKS, TNKS2 3.55429
[BP] GO:0006793 phosphorus metabolic process ACHE, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.55143
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HTR5A, RORC, SRC 3.55143
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.54922
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.53405
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.5311
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS, XDH 3.52169
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, AURKB, CDC25B, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.51781
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.5027
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, SRC 3.4955
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA9 3.4955
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.49049
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 3.48047
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.45524
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 3.45075
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.42851
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA1, CA12, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2, XDH 3.4085
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B 3.38362
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.35854
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.35854
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 3.34301
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FDPS, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.3271
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 3.30375
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.30375
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, MET 3.29028
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 3.26569
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, PTPN1, SRC 3.23462
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 3.23462
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 3.23462
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.23462
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 3.20323
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.19511
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.18525
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 3.17818
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 3.14979
[BP] GO:0051580 None DRD1, DRD2, DRD3 3.14979
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 3.14979
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 3.14484
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 3.11705
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 3.07532
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.07145
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, HTR2A, HTR2B, PPARA, SRC 3.07145
[BP] GO:0001963 None DRD1, DRD2, DRD3 3.07034
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 3.03478
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS 3.02843
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 3.02599
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PTPN1, SRC, TNKS 3.0142
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 3.00918
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.99924
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.99924
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.99756
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, PIM1, PTPN1, SRC 2.98186
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA9, DRD2, DRD3, FABP3, PPARA 2.97983
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA 2.93744
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.93587
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.92894
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, RORC 2.91455
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, SRC 2.91191
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.91191
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.89103
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.88632
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.88632
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.86549
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, DRD1, DRD2 2.80574
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.7979
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA1, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FDPS, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.77897
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.77679
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.7497
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.73833
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.7354
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HTR1A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.7257
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 2.71003
[BP] GO:0060160 None DRD2, DRD3 2.70873
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HTR5A, KDR, PIM1, PPARA, RORC, SIGMAR1, SRC 2.69576
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.68609
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.68609
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FDPS, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.66187
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.66187
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.66187
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 2.63012
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.62385
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.61078
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, RORC 2.60025
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.59242
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F3, FABP4, KDR, MET, PPARA 2.59052
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.58431
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.58431
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.57441
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.56975
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.55282
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.53997
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.53997
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.53997
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.51775
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, RORC, SRC, TNKS, TNKS2 2.51182
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.49436
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 2.48811
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, PPARA, SRC 2.46647
[BP] GO:0070213 None TNKS, TNKS2 2.46243
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.46243
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, SRC, XDH 2.45626
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.45455
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.45455
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA 2.45455
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA1, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.45455
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 2.43309
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.42265
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.41887
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.41384
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.39578
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B 2.39334
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A 2.39334
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, AURKB, CDC25B, DRD2, F3, FLT3, HTR2A, HTR2B, PTPN1, SRC, TNKS, XDH 2.39334
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.39334
[BP] GO:0051100 negative regulation of binding AURKB, CYP2D6, MET, PPARA, TNKS 2.39334
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.39334
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, IGF1R, MET, PTPN1, SRC, XDH 2.39118
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.38354
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.38354
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, SRC 2.36286
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.36268
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, SRC 2.34829
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.32658
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.31367
[BP] GO:0021853 None DRD1, DRD2 2.29555
[BP] GO:0010641 None F3, SRC 2.29555
[BP] GO:0007598 None F10, F3 2.29555
[BP] GO:1904936 None DRD1, DRD2 2.29555
[BP] GO:0042321 None ADORA1, DRD2 2.29555
[BP] GO:0090325 None DRD2, DRD3 2.29555
[BP] GO:0010513 None HTR2A, HTR2B 2.29555
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.2721
[BP] GO:0045744 None DRD2, DRD3, MET 2.2721
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F10, F3, MET, XDH 2.2606
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.2437
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.23621
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.23621
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA 2.21871
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR2A, IGF1R, MET, PTPN1, SRC, XDH 2.20775
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, PTPN1, SRC 2.20598
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, HTR2A, HTR2B 2.20206
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, XDH 2.20206
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR2A, IGF1R, MET, PTPN1, SRC, XDH 2.20206
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC 2.20206
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A 2.19806
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.19165
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.17256
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, AURKB, CDC25B, DRD2, F3, FLT3, HTR2A, HTR2B, MET, PTPN1, SRC, TNKS, XDH 2.15861
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, PPARA 2.15861
[BP] GO:0021843 None DRD1, DRD2 2.15861
[BP] GO:0021830 None DRD1, DRD2 2.15861
[BP] GO:0021826 None DRD1, DRD2 2.15861
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.15861
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, SRC 2.1578
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.14651
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.14189
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.14189
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR2B 2.12957
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AXL, CA2, CYP1B1, DRD2, DRD3, F3, HTR2A, HTR2B, KDR, MET, PIM1, SRC 2.12933
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, HTR2A, HTR2B 2.12146
[BP] GO:0032205 None SRC, TNKS, TNKS2 2.12146
[BP] GO:1904358 positive regulation of telomere maintenance via telomere lengthening AURKB, TNKS, TNKS2 2.12146
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, DRD2 2.11881
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 2.11136
[BP] GO:0099536 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.09932
[BP] GO:0099537 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.09932
[BP] GO:0007212 None DRD1, DRD2, DRD3 2.09369
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, IGF1R, MET, PPARA, RORC, SRC, TNKS, TNKS2 2.09356
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A 2.09356
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, XDH 2.08883
[BP] GO:0014075 None DRD1, DRD2, DRD3 2.0649
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, PPARA, SRC 2.0649
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.0649
[BP] GO:0030335 positive regulation of cell migration DRD1, F10, F3, IGF1R, KDR, MET, SRC 2.05627
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, HTR2A, MET, SRC 2.05627
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, HTR2A, MET, SRC 2.05627
[BP] GO:0030260 entry into host cell AXL, HTR2A, MET, SRC 2.05627
[BP] GO:0044409 entry into host AXL, HTR2A, MET, SRC 2.05627
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6 2.05627
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2D6 2.05627
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2D6 2.05627
[BP] GO:0010511 None HTR2A, HTR2B 2.05627
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, HTR2B, SRC 2.00461
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.73481
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.56791
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, AXL, CA2, CA9, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SRC 4.85782
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, AXL, CA12, CA14, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PTPN1, SIGMAR1, SRC, TNKS, TNKS2 4.10592
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, AXL, CA12, CA14, CA2, CA9, CSNK2A1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PTPN1, SRC 4.05123
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, AXL, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPN1, SIGMAR1, SRC 3.05692
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.15861
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.75515
[MF] GO:0043167 ion binding ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 8.75515
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.13541
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 7.70062
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.63237
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.28416
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.28416
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.20265
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.20265
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SRC 7.12924
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 7.11332
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.93752
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.93752
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 6.92338
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA9 6.59724
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 6.46503
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.33625
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.76543
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.6723
[MF] GO:0043169 cation binding ACHE, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, FDPS, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, XDH 5.56791
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PIM1, PPARA, PTPN1, RORC, TNKS, XDH 5.56791
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.56791
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F10, F3, FDPS, FLT3, FUT7, HSD17B1, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 4.66053
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.5194
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 4.34126
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.24404
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA9 4.14115
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.91891
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.77084
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA9 3.63203
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.62384
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.54922
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.32355
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.23462
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.23462
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 3.07532
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, XDH 2.81629
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.73833
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, SRC, XDH 2.54858
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HTR2A, IGF1R, KDR, PIM1, PPARA, PTPN1, SRC 2.49436
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.45626
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.39334
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.2721
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6 2.17256
[MF] GO:0004064 arylesterase activity CA1, CA2 2.15861
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA9 2.11839
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.05627
[MF] GO:0001609 None ADORA1, ADORA3 2.05627


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, HTR2A, DRD1, HTR5A, DRD2, ADRA1A, DRD3 9.4459
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 7.7158
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.1052
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA9, CA14 7.7158
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 5.1808
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.1808
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.7147
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 4.3982
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.8781
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.4007
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.7807
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8661
Metabolic pathways_Homo sapiens_hsa01100 FDPS, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AKR1B1, CYP19A1, XDH 2.1686
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, IGF1R 1.9594
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9594
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2307
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.9226
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.8368
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.0707
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.704
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.704
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET, CDC25B 1.5283
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.446
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.4262
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.446
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4459
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4262
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5272
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4312
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3781
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1, F3 1.1322
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3658
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1088
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1462
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8368
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3781
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3907
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7196
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1957
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.3779
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3002
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0908
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.8993
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3002
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.024
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 1.0075
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8013
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9197
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9274
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MET, IGF1R 0.806
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8108
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5387
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5387
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5387
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3207
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4987
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.3206
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5827
Platelet activation_Homo sapiens_hsa04611 SRC 0.4847
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5352
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5387
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3849
Glioma_Homo sapiens_hsa05214 IGF1R 0.5827
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4851
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC 0.5278
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5827
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5387
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3731
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5223
Measles_Homo sapiens_hsa05162 CSNK2A1 0.468
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5348
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5251
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4719
Hepatitis B_Homo sapiens_hsa05161 SRC 0.4589
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4847
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4167
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3837
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4648
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.572
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4851
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4648
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4073
Influenza A_Homo sapiens_hsa05164 FDPS 0.4167
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4467
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4847
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4719
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5387
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4648
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.458
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4549
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.567
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4166
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5387
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4847
Peroxisome_Homo sapiens_hsa04146 XDH 0.5387
Axon guidance_Homo sapiens_hsa04360 MET 0.4802
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5348
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4467
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5348
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5827
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4073
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5348
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.572
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5827
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5827
Bile secretion_Homo sapiens_hsa04976 CA2 0.572
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5827
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5827
Shigellosis_Homo sapiens_hsa05131 SRC 0.5827
Malaria_Homo sapiens_hsa05144 MET 0.6503
Bladder cancer_Homo sapiens_hsa05219 SRC 0.7093
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6692
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8156
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8108
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8456
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8108
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2 0.8887
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8377
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1772
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8993


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)