TCM Prescription: Yu Ye Jie Du Granules



Prescription Description
Prescription IDTCMF6407
Pinyin NameYu Ye Jie Du Ke Li
Chinese Name玉叶解毒颗粒
English NameYu Ye Jie Du Granules
Function Description感冒, 热淋, 中暑
IndicationsCommon cold disorder, Heat stranguria disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2548 Mussaenda hirsutissim 玉叶金花 TCMH2548
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH2452 Chrysanthemum indicum 野菊花 TCMH2452 ITSAB1463-14
TCMH667 Radix ilicis asprellae 岗梅 TCMH667
TCMH1859 Helicteres angustifolia 山芝麻 TCMH1859 GBVH4071-11
TCMH1033 Centella asiatica 积雪草 TCMH1033 ITSAJ4523-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT754 GSTP1 Glutathione S-transferase Pi Transferase P09211
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT865 GSTA1 Glutathione S-transferase A1 Transferase P08263
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.2377
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 8.73659
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TYR 8.73659
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.40094
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDK6, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, TERT, XDH 8.365
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.365
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.365
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.3607
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AR, AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TYR 8.35373
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, CA2, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 8.35373
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.97444
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.82153
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA 7.82153
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AR, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TERT 7.81301
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.53745
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TERT 7.03065
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.02087
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.98765
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.93189
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.91356
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, CA2, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK 6.89408
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TERT 6.87437
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 6.8421
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.44478
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PHF8, PPARA, SMAD3, SRC, TEK, TYR 6.44478
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CDK6, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.35478
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.35109
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, CDK6, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC 6.311
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.311
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 6.311
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TEK, TYR 6.27866
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, TERT 6.17225
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, CA2, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK 5.93953
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.93953
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CDK6, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.93953
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.93953
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.93953
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CDK6, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.93953
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, RORC, SMAD3, SRC, TERT, TOP2A 5.93826
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.58834
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.58834
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2 5.54187
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.49488
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.45789
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TYR, XDH 5.42356
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.41699
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.40457
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TERT 5.34012
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TNKS2, TYR 5.3205
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC 5.3205
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.29463
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC 5.27326
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 5.18292
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, XDH 5.16765
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 5.05837
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.96036
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, APP, AR, AURKB, AXL, CDK6, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.96036
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, XDH 4.83139
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.76457
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 4.7362
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 4.59117
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.52036
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, TERT, XDH 4.50752
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK, TERT 4.50212
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.46841
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 4.45454
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, PHF8, TYR, XDH 4.44852
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1, HSD17B2 4.4196
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 4.38241
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.38147
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.38046
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TERT 4.30423
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 4.29535
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.29535
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.25572
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.19313
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 4.18011
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.16156
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, NR3C1, SRC 4.16156
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.16156
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.12081
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA 4.1194
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.10958
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.0464
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.03419
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.9958
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.95467
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TERT, TYR 3.93775
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 3.9199
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TERT, TNKS, TOP2A 3.858
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.83719
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.81913
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.79849
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.72442
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, CBR1, CDK6, CYP1A1, EGFR, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, TERT, TOP2A 3.68397
[BP] GO:0050678 None AR, CDK6, EGFR, KDR, MMP12, PGR, SMAD3, TEK, XDH 3.6829
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.6829
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.61842
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.58085
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.57932
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AR, AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.57932
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, PPARA, RORC, SRC 3.57932
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.57932
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 3.57932
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.57889
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.57111
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, EGFR, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC 3.54071
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.53023
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.51843
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.50301
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.50301
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CDK6, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.50191
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.44298
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.43863
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PHF8, PIM1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.41667
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, EGFR, KDR, SRC, TNKS, TNKS2 3.36598
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK, XDH 3.35615
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 3.35221
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AR, AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PHF8, PIM1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.31089
[BP] GO:0051254 None APP, AR, EGFR, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 3.29413
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.29263
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CDK6, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TERT, XDH 3.28401
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, PGR, PPARA, RORC, SRC, TOP2A 3.27214
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS 3.26856
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26647
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 3.23695
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 3.2347
[BP] GO:0010638 positive regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.22949
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.21084
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.21084
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.20435
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 3.1908
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD11B1, HSD17B1, HSD17B2 3.14751
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.13906
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, FLT3, INSR, KDR, SRC, TEK, XDH 3.13776
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.11996
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.10722
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AR, AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PHF8, PIM1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.10407
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AR, AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PHF8, PIM1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.10407
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 3.07991
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.07076
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.06102
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, NR3C1, SRC 3.06102
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.0479
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CYP1A1, DUSP3, INSR, TERT 3.04529
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 3.02766
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.02356
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.02356
[BP] GO:0045893 None APP, AR, EGFR, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.99393
[BP] GO:1903508 None APP, AR, EGFR, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.99393
[BP] GO:1902680 None APP, AR, EGFR, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.99241
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT 2.98144
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.98097
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97058
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.93436
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.92855
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.88371
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, TERT, XDH 2.86076
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CDK6, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 2.85522
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, TERT, XDH 2.84917
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.82528
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.82528
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.81956
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.80247
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.80247
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CDK6, CYP1B1, FABP3, HSPA1A, SMAD3, TERT, XDH 2.7884
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.76789
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CDK6, CYP1B1, EGFR, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TNKS2, XDH 2.72502
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.70993
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.70832
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.70543
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.70543
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.70543
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.70543
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, EGFR, FLT3, NR3C1, RORC, SRC 2.70543
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.70543
[BP] GO:0001952 regulation of cell-matrix adhesion CDK6, KDR, SMAD3, SRC, TEK 2.67206
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.66872
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.65567
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC, TEK 2.65526
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC 2.64478
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, CYP19A1, CYP1A1, EGFR, HSD17B2, INSR, MMP2, MMP9, PGR, SRC, TOP2A 2.64384
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT 2.63474
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.63474
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, EGFR, NR3C1, SRC 2.62843
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.61661
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.61323
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.60124
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.59747
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.59413
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.58189
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.57997
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.57997
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.57997
[BP] GO:0051128 regulation of cellular component organization APP, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PHF8, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.55875
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.55297
[BP] GO:0060748 None AR, PGR 2.54973
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54973
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.52614
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.52145
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.50621
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.5012
[BP] GO:0006355 regulation of transcription, DNA-templated ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.5012
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.49328
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP3, FABP4, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.48295
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.45371
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.45371
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, SRC 2.4509
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.44357
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 2.4336
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.4333
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, TERT, XDH 2.42804
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.42519
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.41218
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.41218
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.41218
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, EGFR, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.41143
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, EGFR, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.41143
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.41073
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.40088
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.39925
[BP] GO:0010556 regulation of macromolecule biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.39901
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.39031
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A 2.39031
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.36465
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.36465
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.36465
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35559
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.35461
[BP] GO:0010628 positive regulation of gene expression APP, AR, EGFR, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.35461
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.35461
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC, TERT 2.34962
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, SRC 2.339
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.33471
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.32975
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.32969
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.32969
[BP] GO:0070213 None TNKS, TNKS2 2.32969
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32969
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32969
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.32771
[BP] GO:0051894 None KDR, SMAD3, TEK 2.32699
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32699
[BP] GO:1903506 regulation of nucleic acid-templated transcription ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.32699
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.32483
[BP] GO:2001141 regulation of RNA biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.32483
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, SMAD3, SRC, TERT 2.32007
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, PPARA, SMAD3, SRC, TERT 2.31435
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.30965
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2 2.28426
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, SRC 2.28426
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.26684
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP3, FABP4, GLO1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.26448
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 2.26084
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.2466
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.24232
[BP] GO:1903393 None KDR, SMAD3, TEK 2.24232
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.23411
[BP] GO:2000112 regulation of cellular macromolecule biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.22708
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.22608
[BP] GO:0010639 None HSPA1A, MET, PHF8, SRC, TNKS, TNKS2, TOP2A 2.22286
[BP] GO:0010468 regulation of gene expression ADORA3, APEX1, APP, AR, AURKB, CDK6, CSNK2A1, CYP1A2, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, INSR, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A, XDH 2.22113
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.21355
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.21002
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, TNKS, TNKS2 2.20178
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.19862
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, SRC, TEK, TNKS 2.19773
[BP] GO:0051252 regulation of RNA metabolic process ADORA3, APEX1, APP, AR, AURKB, CSNK2A1, CYP1B1, EGFR, FABP4, GLO1, HSPA1A, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.13875
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.13569
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, EGFR, FLT3, HSPA1A, INSR, MET, MMP9, SMAD3, SRC, TEK, TERT, TNKS, XDH 2.12734
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 2.11719
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 2.11719
[BP] GO:0033043 regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, PHF8, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.10494
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.1045
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.1035
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.1035
[BP] GO:0032870 cellular response to hormone stimulus APEX1, AR, EGFR, FLT3, INSR, NR3C1, SRC 2.10091
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, TERT, TOP2A 2.09548
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09548
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09548
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.08837
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CYP19A1, EGFR, HSD17B2, INSR, PGR, SRC 2.07032
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 2.07032
[BP] GO:1901890 None KDR, SMAD3, TEK 2.06108
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06108
[BP] GO:2000352 None KDR, TEK, TERT 2.06108
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.05499
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.0368
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.0368
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, NR3C1, SRC 2.03427
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.03427
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.03031
[BP] GO:0051129 negative regulation of cellular component organization APP, AR, HSPA1A, MET, PHF8, SRC, TNKS, TNKS2, TOP2A 2.02946
[BP] GO:1990535 None APP, INSR 2.0284
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 2.02352
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.01083
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.00212
[BP] GO:1902893 None PPARA, SMAD3, TERT 2.00212
[BP] GO:0010907 None INSR, PPARA, SRC 2.00212
[BP] GO:0106027 None APP, IGF1R, INSR 2.00212
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, CBR1, CDK6, CYP1A1, FABP4, FLT3, FUT7, GLO1, KDR, MMP2, MMP9, RORC, SMAD3, TOP2A 2.00212
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.47649
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, SRC, TNKS2, TYR 2.43991
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.31814
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPI, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PHF8, PIM1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 2.22708
[CC] GO:0005654 None AKR1B1, ALOX5, APEX1, AR, AURKB, CDK6, CSNK2A1, DUSP3, HSPA1A, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.03031
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, TNKS, TYR, XDH 15.158
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 12.9154
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.7894
[MF] GO:0008270 zinc ion binding ALPI, AR, CA1, CA12, CA2, CA4, CA7, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PHF8, PPARA, RORC, SMAD3, TNKS 8.73659
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.1743
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.58665
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.36863
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.98923
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.89408
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.68515
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.54187
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, PHF8, TYR, XDH 5.45789
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 5.39964
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.39568
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 5.22623
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.12447
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA, RORC 4.96036
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.43262
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.36588
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.18011
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 4.1163
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 4.01014
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.98223
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 3.90197
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.79524
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, XDH 3.79344
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 3.6582
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.62142
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.60289
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 3.46466
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.433
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.39178
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK 3.13012
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 3.08532
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, TYR 2.89045
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.81956
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.80247
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.80247
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.75818
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, PGR, PPARA, RORC 2.70543
[MF] GO:0004879 nuclear receptor activity AR, PGR, PPARA, RORC 2.70543
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.70543
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.67338
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.64333
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, SRC, TEK 2.48769
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.37252
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.32975
[MF] GO:0008289 lipid binding AR, AXL, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 2.32969
[MF] GO:0051425 None APP, INSR 2.32969
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.32007
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.22113
[MF] GO:0000166 nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.21355
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.21321
[MF] GO:0043168 anion binding APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.21321
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.21002
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15941
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.12734
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.12734
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.07032
[MF] GO:0019899 enzyme binding ALPI, APP, AR, AURKB, CYP1A1, CYP1A2, DUSP3, EGFR, HSPA1A, MET, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, TNKS2, TOP2A 2.03573
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.03031
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0284
[MF] GO:0004035 alkaline phosphatase activity ALPI, ALPL 2.0284


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.389
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.575
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.1966
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.9397
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 5.0103
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.301
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.2289
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 4.1535
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1693
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.2289
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7488
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.7625
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.1253
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1653
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, TEK, MET, EGFR, IGF1R 3.1284
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.1661
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1848
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, EGFR 2.6503
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5619
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6657
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3256
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, MMP9 2.2494
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7062
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3567
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.2494
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2494
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.2494
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9809
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2452
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8248
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.9462
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2409
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9314
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.6345
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5051
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.5256
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, NR3C1 1.4499
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.35
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.978
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.0483
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1123
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.3836
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.978
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.2374
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0738
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3785
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.35
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9654
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1007
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.111
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9389
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1919
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9389
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9326
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9205
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8735
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8431
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3593
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8431
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8386
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8468
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3 0.9205
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3237
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8268
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8044
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3237
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3454
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6702
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.67
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.6757
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6546
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.5724
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.6353
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3631
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3563
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3498
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3555
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3559
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3563
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3631
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3788
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3864
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3495
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4253
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4159
Platelet activation_Homo sapiens_hsa04611 SRC 0.4515
Axon guidance_Homo sapiens_hsa04360 MET 0.4407
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4785
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4599
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4785
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5024
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5024
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4953
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5027
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5024
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5067
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5151
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5065
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5109
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5258
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.52
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.52
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.5209
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5197
Peroxisome_Homo sapiens_hsa04146 XDH 0.5262
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5685
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5621
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5508
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5711
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8248
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5766
Bile secretion_Homo sapiens_hsa04976 CA2 0.5698
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5724
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5724
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5797
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.596
Shigellosis_Homo sapiens_hsa05131 SRC 0.5781
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5877
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6921
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6436
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6258
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7812
Malaria_Homo sapiens_hsa05144 MET 0.6578
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6613
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.991
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.67
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7595
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.71
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8268
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7595
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7937
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7731
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8047
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8268
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8016
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.3199
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8268
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1284


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)