TCM Prescription: Gu Shen Ding Chuan Pills



Prescription Description
Prescription IDTCMF640
Pinyin NameGu Shen Ding Chuan Wan 
Chinese Name固肾定喘丸
English NameGu Shen Ding Chuan Pills
Function Description咳嗽, 哮喘, 喘病
IndicationsAsthma
Disease ICD-11 Category CA23 [Asthma, 哮喘 ];
Human Tissues Associated with IndicationLung
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH2491 Alpinia oxyphylla 益智仁 TCMH2491 ITSAJ4276-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1134 Rosa laevigata 金樱子肉 TCMH1134 ITSAJ4477-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PPARG, PRKCA, SLC1A1, SMAD3, SRC, TEK, XDH 11.0284
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 9.45086
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 9.45086
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK 9.45086
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 8.32292
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, MET, PPARG, SMAD3, SRC 8.32292
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 8.32292
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 8.32292
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 8.28527
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 8.1743
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 7.86729
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, MET, PPARA, PPARG 7.86729
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, PIM1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 7.73883
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK 7.73883
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 7.59545
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, PPARA, PPARG, RORC, SRC, TEK 7.46143
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 7.38009
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 7.37446
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 7.31522
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.15946
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 7.15946
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK, XDH 7.15946
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 7.13117
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 7.03713
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK 6.98784
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 6.94834
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.62965
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK 6.60167
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.58239
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK 6.55676
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK 6.53011
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, PPARG, RORC, SMAD3, SRC 6.50248
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PPARG, SMAD3 6.48499
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.48499
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, KDR, PPARG, RORC, SMAD3, SRC 6.42349
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FLT3, HSP90AB1, PPARG, RORC, SRC, TEK 6.38824
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, GRM1, HSP90AB1, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.38824
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK, XDH 6.29485
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 6.29485
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, PPARG, SMAD3, SRC, TEK 6.26759
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PPARG, SRC, TEK 6.06367
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.92339
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.92339
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 5.75439
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.68038
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.68038
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PPARG 5.58463
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, SLC1A1, SMAD3 5.51213
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PIM1, PPARA, PPARG, XDH 5.49376
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.39998
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PPARG, PTPN1, RORC, SMAD3, SRC 5.39998
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD3, EGFR, GRM1, HSP90AA1, HSP90AB1, HSPA1A, PPARA, PPARG, SMAD3, SRC, TEK 5.36842
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, PTPN1, SRC, TEK 5.29849
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD3, EGFR, IGF1R, INSR, KDR, MET, PPARG, PRKCA, SMAD3, SRC, TEK 5.27246
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PPARG, PRKCA, SMAD3, SRC, TEK 5.24817
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRM1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.24817
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.24817
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, PIM1, PPARA, PPARG, PRKCA, PTPN1, SRC 5.24817
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 5.23692
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.23692
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PPARG, RORC, SRC, TEK 5.21765
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, EGFR, ESR1, PPARA, PPARG, RORC, SRC 5.17788
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.14268
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.14215
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, FABP4, FLT3, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.11927
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 5.04164
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 5.03324
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.00489
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, INSR, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC 5.00489
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PPARG, PRKCA, SMAD3, SRC, TEK 4.97314
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.97059
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 4.9386
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.91126
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.91126
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK 4.86478
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, PPARG, RORC, SRC 4.86478
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, DRD3, EGFR, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.8488
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.81178
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.81178
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.81178
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 4.80932
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.76625
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.7432
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 4.734
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, PPARA, PPARG, SLC1A1 4.72609
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.70977
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1 4.70432
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.69372
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.68719
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.68719
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.6098
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PPARG, PRKCA, SMAD3, SRC, TEK 4.60867
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, PRKCA, SMAD3 4.5185
[BP] GO:0007193 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 4.50781
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, PPARA, PRKCA, PTPN1, SRC, TEK, XDH 4.49848
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, PPARG, RORC, SRC 4.47835
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 4.43455
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 4.43455
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK 4.43455
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.40256
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.36966
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, PTPN1, SRC, TEK 4.36552
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 4.36552
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK 4.36407
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.34229
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.31522
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSP90AB1, INSR, PRKCA, SRC 4.30015
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.24797
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.20207
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, INSR, MET, SRC, TEK, XDH 4.20089
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.18055
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.17318
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, PTPN1, SRC, TEK 4.155
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 4.15023
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, PPARG, PTPN1, SMAD3, SRC, XDH 4.14408
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.14281
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, PPARG, PTPN1, SMAD3, SRC, XDH 4.13098
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, XDH 4.13035
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 4.12039
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD3, HSP90AA1, KDR, SRC 4.04518
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, PRKCA 4.02982
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK 4.02328
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, GRM1, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.0203
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.0203
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 4.01858
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PRKCA, SMAD3, SRC 4.01858
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.00079
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, PIM1, PRKCA, TEK 4.00079
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.98228
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.98228
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, PPARA, PPARG, SRC, TEK 3.96075
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSP90AB1, INSR, KDR, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK 3.9594
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.95033
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD3, EGFR, HSPA1A 3.91288
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSP90AB1, INSR, KDR, MET, PIM1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK 3.90473
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PTPN1, SMAD3 3.85792
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.85792
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.85792
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.85766
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD3, EGFR, ESR1, FABP4, KDR, MET, PPARA, PPARG, PRKCA, SMAD3, TEK 3.84586
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 3.82362
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, PTPN1, SRC 3.81373
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, PPARA, PPARG, SLC1A1 3.80649
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, ESR1, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PIM1, PPARG, PRKCA, SLC1A1, SMAD3, SRC, TEK, XDH 3.80649
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PTPN1, SRC, TEK 3.7913
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, SMAD3 3.77942
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PTPN1, SRC 3.77021
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.7609
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, PPARG, RORC, SRC 3.74482
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.73081
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, INSR, PPARA, PPARG, SRC, TEK 3.69256
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.69256
[BP] GO:0051246 regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.68582
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, RORC 3.68582
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.67774
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK 3.66947
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, PPARA, PPARG, SRC, TEK 3.66947
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD3, EGFR, HCAR2, HSP90AB1, INSR, PPARG, SMAD3, SRC 3.65366
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.65287
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, HSP90AB1, MET, PPARA, SMAD3 3.64706
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1 3.61638
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSP90AB1, INSR, PPARG, SRC 3.56646
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.55269
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD3, EGFR, HCAR2, KDR, SRC 3.5241
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC, TEK 3.51846
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 3.49578
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSP90AB1, INSR, PPARG, SRC 3.47113
[BP] GO:1900543 None DRD3, GRM3, GRM8, PPARA, PRKCA 3.46095
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, FABP4, GRM1, GRM5, GRM8, IGF1R, INSR, MET, PIM1, PPARA, RORC, SMAD3, SRC, TEK 3.44214
[BP] GO:0045980 None DRD3, GRM3, GRM8, PPARA, PRKCA 3.43797
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.43797
[BP] GO:0007154 None ADORA1, AXL, BCL2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, SLC1A1, TEK 3.43535
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, HSP90AB1, KDR, PPARG, SRC 3.42468
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.42468
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.42468
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 3.4046
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, SMAD3, TEK 3.37579
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, PPARA, PPARG, SMAD3, SRC, TEK 3.36751
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 3.34275
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HSP90AB1, IGF1R, INSR, PTPN1, SRC 3.34275
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, PPARG, RORC, SRC 3.33655
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD3, KDR, SRC 3.33272
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.32263
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, PPARG, XDH 3.31917
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3, PPARG 3.31372
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, HCAR2, HSPA1A, KDR, MET, PIM1, PPARG, PRKCA, SLC1A1, SMAD3, SRC, TEK 3.29283
[BP] GO:0042391 None ADORA1, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.29283
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PTPN1, SRC 3.27768
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC 3.27768
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 3.27625
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, PTPN1, SRC, XDH 3.25965
[BP] GO:0044057 None ADORA1, ADORA3, DRD3, EGFR, GPR35, GRM1, HCAR2, PRKCA, SLC1A1, SMAD3 3.2467
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 3.24098
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.20757
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA 3.18863
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK 3.17205
[BP] GO:0038128 None EGFR, HSP90AA1, PRKCA, SRC 3.17205
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.16489
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.11396
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.06613
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, PRKCA, RORC, SMAD3, SRC 3.03373
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.01705
[BP] GO:0007188 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 3.01266
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.01266
[BP] GO:0030818 None DRD3, GRM3, GRM8, PRKCA 2.98168
[BP] GO:0051098 regulation of binding AURKB, BCL2, HSP90AB1, MET, PPARA, PPARG, SMAD3, SRC 2.90714
[BP] GO:0030803 None DRD3, GRM3, GRM8, PRKCA 2.90714
[BP] GO:0042752 None ADORA1, DRD3, PPARA, PPARG, RORC 2.86262
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.85495
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, HSP90AB1, INSR, PTPN1, SRC 2.8438
[BP] GO:0030815 None DRD3, GRM3, GRM8, PRKCA 2.8438
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.8438
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.8438
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CSNK2A1, DRD3, DUSP3, ESR1, ESR2, FABP4, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MET, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, XDH 2.83875
[BP] GO:0010564 regulation of cell cycle process AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR 2.8275
[BP] GO:1900372 None DRD3, GRM3, GRM8, PRKCA 2.81961
[BP] GO:0030809 None DRD3, GRM3, GRM8, PRKCA 2.81961
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.81961
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.81961
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.81961
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.81961
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK 2.81864
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, PPARG, SMAD3, SRC, TEK 2.81864
[BP] GO:0045936 None DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PTPN1, XDH 2.80834
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.80653
[BP] GO:0010563 None DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PTPN1, XDH 2.80511
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.80007
[BP] GO:0030800 None DRD3, GRM3, GRM8, PRKCA 2.79779
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.79203
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, SRC 2.78818
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, PPARG, PTPN1, SMAD3, SRC, XDH 2.7774
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD3, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PTPN1, SRC, TEK 2.76816
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, PPARG, PRKCA, PTPN1, SMAD3, SRC 2.76614
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.76051
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.76014
[BP] GO:0051172 None AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, XDH 2.75103
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.73252
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC 2.73252
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.72819
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.71299
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1 2.71299
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.71299
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.70998
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.69944
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 2.69937
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.69475
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.69475
[BP] GO:0007187 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 2.69364
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 2.67966
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CSNK2A1, DRD3, EGFR, ESR1, ESR2, GRIK5, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, PPARG, PTPN1, SMAD3, SRC, TEK 2.67728
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.67359
[BP] GO:0099566 None GRM1, GRM5 2.67107
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.67107
[BP] GO:0007267 None ADORA1, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.65484
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 2.6446
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD3, PPARA, PPARG, SMAD3, TEK 2.6446
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.62188
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.61905
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HSP90AB1, KDR, SRC 2.61905
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC 2.61688
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.57599
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.53588
[BP] GO:0007268 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.53482
[BP] GO:0098916 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.53482
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, PPARG, SMAD3 2.52124
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3 2.52124
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, SMAD3, SRC 2.51217
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.50713
[BP] GO:0099536 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.48001
[BP] GO:0099537 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.48001
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.46565
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, PRKCA, SRC, TEK 2.46565
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, HSP90AB1, MET, PPARA, SRC 2.46565
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.45626
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, DRD3, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PPARG, SRC 2.45505
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.45505
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, SRC, XDH 2.45202
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PRKCA, SMAD3, SRC, TEK 2.4508
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD3, EGFR, HCAR2, HSP90AB1, PRKCA, PTPN1, SMAD3, SRC 2.44891
[BP] GO:1901653 cellular response to peptide AKR1B1, GRM5, IGF1R, INSR, PPARG, SRC 2.43929
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 2.42451
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.42451
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, ESR1, HSP90AB1, INSR, KDR, NUAK1, PIM1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK, XDH 2.42451
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.42451
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.42451
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.42451
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 2.42233
[BP] GO:0051894 None KDR, SMAD3, TEK 2.42233
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.42233
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.42233
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, SMAD3, SRC 2.42233
[BP] GO:0015908 None DRD3, FABP3, PPARA, PPARG 2.40089
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 2.39981
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, PPARG, SMAD3, SRC 2.39981
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.39587
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.38587
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, PPARG, PRKCA, SRC, TEK 2.38587
[BP] GO:0001936 None KDR, PPARG, PRKCA, TEK, XDH 2.37483
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.36118
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.34853
[BP] GO:0023052 None ADORA1, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.33755
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.33755
[BP] GO:1903393 None KDR, SMAD3, TEK 2.33755
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.32609
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.32609
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD3, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.31695
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRM1, GRM5, SMAD3 2.31091
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.30416
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.30416
[BP] GO:0032868 None FABP3, INSR, PPARA, PPARG, SRC 2.30318
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 2.29862
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD3, EGFR, HCAR2 2.29112
[BP] GO:0043627 response to estrogen CA2, ESR1, PPARG, TEK 2.28771
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.28502
[BP] GO:0050678 None EGFR, KDR, PPARG, PRKCA, SMAD3, TEK, XDH 2.27802
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.25684
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.25339
[BP] GO:0010891 None PPARA, PPARG 2.25339
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRM1, GRM5, SMAD3 2.25079
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, PTPN1, SRC 2.25079
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, XDH 2.22668
[BP] GO:1900542 None DRD3, GRM3, GRM8, INSR, PPARA, PRKCA 2.22221
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.21978
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, SRC 2.18875
[BP] GO:0008217 None ADORA1, DRD3, PPARA, PPARG, SMAD3 2.18366
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.18366
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.18366
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.18366
[BP] GO:0006140 None DRD3, GRM3, GRM8, INSR, PPARA, PRKCA 2.16167
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3 2.15393
[BP] GO:1901890 None KDR, SMAD3, TEK 2.14665
[BP] GO:1901655 None AKR1B1, EGFR, PPARG, SRC 2.14135
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, PPARA, PPARG, RORC, SMAD3, SRC 2.13699
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.12473
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG 2.12473
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.12473
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, SRC 2.11953
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.11805
[BP] GO:0007194 None DRD3, GRM3, PRKCA 2.11805
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.11805
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, PPARG, RORC, SRC 2.11805
[BP] GO:0010594 regulation of endothelial cell migration KDR, MET, PPARG, PRKCA, TEK 2.11805
[BP] GO:0038127 None EGFR, HSP90AA1, PRKCA, SRC 2.11805
[BP] GO:0010887 None PPARA, PPARG 2.11805
[BP] GO:0010871 None PPARA, PPARG 2.11805
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.11805
[BP] GO:0031647 None BCL2, HSP90AA1, HSP90AB1, HSPA1A, SMAD3, SRC 2.11056
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.08838
[BP] GO:0010907 None INSR, PPARA, SRC 2.08838
[BP] GO:0030308 None BCL2, ESR2, HSPA1A, PPARG, SMAD3 2.08554
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, TEK 2.08499
[BP] GO:0045934 None AURKB, DRD3, ESR1, ESR2, FABP4, GRM3, GRM8, HSPA1A, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC 2.08354
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, HSPA1A, KDR, MET, PRKCA, SMAD3, SRC, TEK 2.07764
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, PPARA, PPARG, RORC 2.07764
[BP] GO:0031280 None DRD3, GRM3, PRKCA 2.05599
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CYP1B1, HSP90AB1, INSR, KDR, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK 2.05131
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, PPARG, RORC 2.01234
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, SLC1A1, SRC, TEK 6.29485
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CSNK2A1, DRD3, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, PIM1, PRKCA, PTPN1, SLC1A1, SMAD3, SRC, TEK 5.27246
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, DRD3, DUSP3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK 4.78182
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PIM1, PRKCA, PTPN1, SLC1A1, SMAD3, SRC, TEK 4.47505
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PTPN1, SLC1A1, SRC, TEK 4.291
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.05069
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, SMAD3 3.92036
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.7196
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.71302
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, EGFR, HSP90AB1, TEK 2.66772
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.57454
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.53482
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.53482
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.34853
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 2.11814
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.11805
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, XDH 2.02492
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, TEK 8.88592
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, XDH 8.39184
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.32292
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, TEK 8.1743
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.1743
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, SMAD3, TEK 8.14475
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD3, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, SRC, TEK 8.09082
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, TEK 7.96659
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.64734
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.96102
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK 6.94834
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK 6.94834
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.93862
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.73483
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 6.50859
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 6.11002
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.89481
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.49046
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 5.23692
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 5.20365
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.20365
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.95023
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.80025
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.53518
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.47254
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.291
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.26488
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, PIM1, PPARA, PTPN1, SMAD3, SRC 4.14808
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 4.12039
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 4.12039
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.04518
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.04518
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, GRM5, HSP90AA1, HSP90AB1, HSPA1A, MET, PPARA, PPARG, PRKCA, PTPN1, SMAD3, SRC, TEK 4.01925
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 3.89133
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, PRKCA, SLC1A1, SRC, TEK, XDH 3.86666
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.79867
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, PPARA, PTPN1, SMAD3, SRC 3.79867
[MF] GO:0030594 None DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 3.77559
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3 3.71302
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.5508
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.48248
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, XDH 3.4556
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.37576
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.37232
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.34129
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, PTPN1, SMAD3, SRC 3.14436
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 3.06909
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.05374
[MF] GO:0008389 None CYP2A13, CYP2A6 3.05374
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.02439
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, PTPN1, SMAD3, SRC 2.87564
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, ESR2, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, XDH 2.81864
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR 2.76051
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, PRKCA, SLC1A1, SRC, TEK, XDH 2.70998
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.68173
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.67359
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.67359
[MF] GO:0099583 None GRM1, GRM5 2.67107
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, MET, PPARG, PTPN1 2.565
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.51042
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PPARG, SMAD3, XDH 2.50279
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.42451
[MF] GO:0004971 None GRIA2, GRIA4 2.42451
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.4163
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.41142
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.38821
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.38295
[MF] GO:0019904 None BCL2, DRD3, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARA, PPARG, SRC 2.35144
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, XDH 2.33755
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, XDH 2.30416
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, XDH 2.30318
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.29862
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.25339
[MF] GO:0043559 insulin binding IGF1R, INSR 2.25339
[MF] GO:0005102 receptor binding ADORA1, DRD3, EGFR, ESR1, ESR2, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, PPARG, PTPN1, SMAD3, SRC 2.25173
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.2211
[MF] GO:0035257 None ESR1, FLT3, PPARG, SMAD3, SRC 2.19516
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.15559
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.14665
[MF] GO:0097718 None HSP90AA1, HSP90AB1, HSPA1A 2.14665
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, XDH 2.14235
[MF] GO:0050543 None FABP3, PPARG 2.11805
[MF] GO:0004064 arylesterase activity CA1, CA2 2.11805
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, XDH 2.08924
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR 2.08499


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 8.3337
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.3337
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.8179
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.4991
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, DRD3, GRM1, GRIA4 7.4991
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 7.0804
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.6476
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, HSP90AB1, INSR, KDR, BCL2, PRKCA, TEK, MET, EGFR, IGF1R 5.7181
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.7889
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, SMAD3, HSP90AB1, FLT3, BCL2, PPARG, PRKCA, MET, EGFR, IGF1R 5.2685
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.3273
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, PRKCA, GRM1, EGFR 5.3273
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, PRKCA, TEK, EGFR, IGF1R 4.9927
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, PRKCA, MET, ESR1, EGFR, IGF1R 4.4787
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 4.4787
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 4.1846
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.9322
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, BCL2, EGFR, IGF1R 4.1325
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.9
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PRKCA, GRM1, GRIA4 3.9
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, PRKCA, GRM1, EGFR 4.1342
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PRKCA, MET, EGFR, CDC25B 3.5574
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.4036
Long-term depression_Homo sapiens_hsa04730 GRIA2, PRKCA, GRM1, IGF1R 3.5622
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, PRKCA, GRM1 3.435
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1, PRKCA 2.7967
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.817
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, CBR1, CYP2A6, FUT7, AKR1B10, ALOX5, CYP1A2, CYP1A1, ALPL, AKR1B1, CYP19A1, XDH 2.6588
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, PPARA, GRIA4 2.6629
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARG, PPARA 3.3924
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1, PRKCA 2.5539
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, PRKCA, DRD3, GRIA4 2.4614
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, PRKCA 2.3202
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, PRKCA, EGFR, CDC25B, HSPA1A 2.3202
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4614
Glioma_Homo sapiens_hsa05214 PRKCA, EGFR, IGF1R 2.3202
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.3651
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3202
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PRKCA, GRM1, EGFR 2.0922
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2, HSPA1A 2.1652
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, PRKCA, GRIA4 2.3202
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MET, IGF1R 2.0922
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3202
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8122
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3202
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2709
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.263
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, PRKCA, EGFR 2.0339
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3153
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA, EGFR 2.081
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 2.0022
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, PRKCA 1.8383
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, PRKCA, GRIA4 1.9974
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8529
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 2.1885
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA, ESR1 1.7862
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7862
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6392
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, IGF1R 1.7471
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.6392
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PRKCA 1.6253
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA, EGFR 1.5246
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4829
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.309
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2524
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9378
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3179
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9144
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.345
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.8918
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9259
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9504
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3584
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8894
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3442
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6899
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9991
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8684
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.7508
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4023
Influenza A_Homo sapiens_hsa05164 PRKCA, HSPA1A 0.8133
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8049
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 1.1636
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA, EGFR 1.1446
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, PRKCA 1.0731
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4299
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4399
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4399
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.4423
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.2079
Platelet activation_Homo sapiens_hsa04611 SRC 0.4617
Axon guidance_Homo sapiens_hsa04360 MET 0.4531
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4647
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCA 0.465
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4616
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.1752
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1955
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4647
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.2297
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5081
Melanogenesis_Homo sapiens_hsa04916 PRKCA 0.5167
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5158
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.5167
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.5181
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.5317
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5268
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5409
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5464
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5409
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.545
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.5409
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3164
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.3539
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5438
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5409
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5426
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5491
Peroxisome_Homo sapiens_hsa04146 XDH 0.5464
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5409
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5859
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5933
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.6
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.4366
Bile secretion_Homo sapiens_hsa04976 CA2 0.5933
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5933
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6082
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.4056
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCA, EGFR 1.5246
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5246
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6133
Shigellosis_Homo sapiens_hsa05131 SRC 0.6107
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.6351
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4773
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4439
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5017
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.5246
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.4773
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6661
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6813
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6661
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.5938
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.6392
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.6211
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6855
Malaria_Homo sapiens_hsa05144 MET 0.6942
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, PRKCA 1.755
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6426
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.7328
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6988
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7471
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9274
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3273
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8798
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8133
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.8133
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8016
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.87
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8894
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8542
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0984
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.87
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8918
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8639
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8894
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1199


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)