TCM Prescription: Yi Gan Fu Zheng Capsules



Prescription Description
Prescription IDTCMF6381
Pinyin NameYi Gan Fu Zheng Jiao Nang
Chinese Name乙肝扶正胶囊
English NameYi Gan Fu Zheng Capsules
Function Description胁痛
IndicationsHypochondrium pain disorder
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH719 Dryopteris crassirhizoma 贯众 TCMH719 GBVM2585-11
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH54 Alumen 白矾 TCMH54
TCMH1944 Punica granatum 石榴皮 TCMH1944 ITSAJ1428-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT393 MERTK Proto-oncogene tyrosine-protein kinase MER Kinase Q12866
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1316 Leishmania sp.
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.1102
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5924
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.309
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, MIF, PTGS1, PTGS2 10.1022
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.0683
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 9.96079
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.93987
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, MIF, PTGS1, PTGS2 9.93987
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, BCHE, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.62868
[BP] GO:0006805 xenobiotic metabolic process BCHE, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 9.54204
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SLCO1B1, SMAD3, SRC, TEK, TERT, XDH 9.26728
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 8.87621
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.87621
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.85405
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 8.85405
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PTGS2, SLC6A4, SRC, TEK 8.60255
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 8.57106
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.54463
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.35614
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.3026
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 8.24554
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2 8.22724
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, MIF, PTGS1, PTGS2 8.22509
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, HSD11B1, HSD17B1, HSD17B2 8.18341
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, FABP3, FABP4, FUT7, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.14452
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK 7.98062
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.85669
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.50395
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.4561
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.31153
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTGS2, RORC, SLC6A4, SRC, TYR 7.24455
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 7.20119
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.13182
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BACE1, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.97478
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.90665
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.83189
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BACE1, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.83189
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.79351
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.74703
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.73433
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT 6.68675
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PPARA, PTGS1, PTGS2 6.56389
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.53212
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.45886
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 6.45886
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.39333
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.02735
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 5.99679
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT 5.91408
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F2, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 5.89905
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.88636
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.86123
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.84235
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F2, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.67999
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCHE, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F2, FABP4, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC5A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 5.67455
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.61428
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLCO1B1, SLCO1B3 5.59495
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 5.51068
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MIF, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 5.48579
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.38847
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.38847
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.32306
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCHE, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.32306
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCHE, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.30297
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.14949
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.14766
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.12933
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.12933
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.12933
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 5.12933
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC 5.08997
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.07119
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.03338
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.03338
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, EGFR, F2, HCAR2, KDR, MIF, PIK3CB, PTGS2, SRC 4.99222
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.95404
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.9018
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 4.86012
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.83128
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCHE, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 4.81396
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.76992
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.75755
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 4.74364
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.72011
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, EGFR, F2, HCAR2, INSR, KCNH2, MIF, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT 4.72011
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2, SLCO1B1 4.67403
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.63204
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, F2, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 4.59356
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESRRB, F2, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.5713
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.43775
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DUSP3, EGFR, ESR1, F2, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.43751
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 4.4044
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.39826
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.39499
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLCO1B1, SLCO1B3 4.36875
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, F2, GPR35, HCAR2, HSPA1A, INSR, KCNH2, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT 4.35143
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.34629
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, BCL2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.33923
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 4.30572
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, PTGS2, SLC6A2, SLC6A4, SRC 4.29245
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 4.27853
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.26298
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 4.23827
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.22801
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 4.22088
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.2057
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 4.11475
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.0648
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PIK3CB, PTPN1, SRC 4.0594
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.0248
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.00606
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.97037
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 3.96357
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.9588
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.95605
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.95605
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 3.94967
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 3.89176
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.89176
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.87255
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, BCHE, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, EGFR, HSPA1A 3.80755
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.80397
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.74379
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, INSR, PTGS2, SMAD3, XDH 3.74379
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.7437
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SLC6A4, SRC, TERT 3.74195
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.68597
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 3.68204
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.67119
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.66456
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, F2, FLT3, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.66036
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.65363
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 3.64537
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.62846
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.60103
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.59711
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, F2, PPARA, SMAD3 3.59711
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.59711
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.59639
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNH2, PPARA, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3 3.57131
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, SRC, TEK, TYR 3.57131
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC 3.56161
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 3.53882
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, BCHE, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 3.51958
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, HSPA1A, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A 3.50292
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.50161
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.49849
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 3.48797
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 3.46938
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, EGFR, INSR, PTGS2, SLC6A2, SLC6A4, SMAD3 3.4362
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.42298
[BP] GO:0009820 alkaloid metabolic process BCHE, CYP1A2, CYP2D6 3.40673
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.3863
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, F2, FLT3, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.38214
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.3713
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 3.36387
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, GPR35, HCAR2, HSPA1A, INSR, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.35533
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 3.35107
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PTGS2, SMAD3, XDH 3.34914
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, MIF, PIK3CB, PTPN1, SRC 3.34193
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.33914
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.32144
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.32096
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, GPR35, KCNH2, MMP9, PTGS2 3.31991
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.3163
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, EGFR, FLT3, INSR, KDR, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 3.29933
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.25189
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.25047
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.2086
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 3.20687
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.20687
[BP] GO:0006693 None CES2, MIF, PTGS1, PTGS2 3.20066
[BP] GO:0006692 None CES2, MIF, PTGS1, PTGS2 3.20066
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 3.19534
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, BCHE, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 3.19534
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.17127
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 3.1711
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F2, HCAR2, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 3.16203
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KCNH2, KDR, PTGS2, SRC 3.15432
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TOP2A 3.15432
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.15432
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.10856
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2, SRC 3.09622
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 3.09622
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF, PIK3CB 3.09585
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.07837
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 3.07744
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.07629
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.05585
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 3.05585
[BP] GO:0001775 cell activation ADRA2A, ALOX5, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 3.05585
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.04793
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, F2, HCAR2, PIK3CB, PTGS2 2.99593
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 2.98327
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.98101
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BACE1, BCHE, CA2, CA7, EGFR, PTGS2, SLC6A4 2.97481
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BACE1, BCHE, CA2, CA7, EGFR, PTGS2, SLC6A4 2.97481
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, PTGS2, SLC6A4 2.96409
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 2.96409
[BP] GO:0030168 platelet activation ADRA2A, AXL, F2, PIK3CA, PIK3CB, SRC 2.9439
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.92741
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PTGS2, SMAD3, TEK 2.91804
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.91804
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BACE1, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.87201
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, F2, MMP12, PPARA, SMAD3, TEK 2.86743
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.86694
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.85513
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.85513
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, SMAD3, TEK 2.85023
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, KDR, MET, MIF, MMP12, PPARA, PTGS2, SMAD3, TEK 2.84651
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SMAD3, SRC 2.82204
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.81827
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.81462
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2, TERT 2.80463
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.76461
[BP] GO:0009115 None AOX1, XDH 2.76461
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.75242
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PIK3CB, PTPN1, SRC 2.7254
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 2.72451
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.69126
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGS1, PTGS2 2.68355
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.67493
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.67493
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.67493
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.67493
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, F2, GPR35, KCNH2, MIF, MMP9, PTGS2, SLC6A4 2.67337
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.66259
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.65608
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.62697
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.59347
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, F2, PTGS2, SMAD3, SRC, TERT 2.59347
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, F2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.5855
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.5855
[BP] GO:0007584 response to nutrient ALPL, BCHE, CYP1A1, EGFR, PTGS2, SLC6A4, TYR 2.5855
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TYR 2.5808
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.54314
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.53085
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.53085
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, MIF, PIK3CB, PTPN1, SRC 2.52962
[BP] GO:0050900 leukocyte migration F2, FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.52962
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.51713
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.45523
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2 2.44914
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F2, FABP4, KDR, MET, MIF, PTGS2, SMAD3 2.43879
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 2.43764
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.43764
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.42648
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.42648
[BP] GO:0070920 None EGFR, ESR1, TERT 2.42648
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, PTGS2, SLC6A4, SRC, TOP2A 2.42178
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.41723
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, F2, KDR, SRC 2.4088
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.3815
[BP] GO:0046110 None AOX1, XDH 2.36198
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36198
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.36198
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, GPR35, KCNH2, PIK3CB, SMAD3 2.33074
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.32871
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.29632
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCHE, BCL2, CDC25B, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.29562
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SLC6A4, SRC 2.29261
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, ESRRA, F2, HCAR2, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.29261
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.27472
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, F2, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.26496
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.23905
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.22978
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.2202
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, F2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.20934
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 2.19493
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation BCL2, EGFR, MIF, PIK3CA, PTGS2 2.18874
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.18874
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.18874
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.18874
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.18874
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.1735
[BP] GO:0050730 None ADORA1, ADRA2A, EGFR, FLT3, MIF, PTPN1, SRC 2.1735
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MIF, PTGS2, TERT 2.1735
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, EGFR, F2, HCAR2, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.1735
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCHE, BCL2, CYP1B1, FABP3, HSPA1A, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.16392
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.16039
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.16039
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.16039
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.16039
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.15365
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.15365
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.14493
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.1436
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.1436
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TYR 2.13949
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.13163
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.12373
[BP] GO:0006145 None AOX1, XDH 2.12373
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12373
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, TYR, XDH 2.11601
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.09678
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.08768
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.08768
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.08768
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.08768
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.08768
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.08768
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.08058
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.08058
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.07699
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, EGFR, F2, HCAR2, MIF, MMP12, PTGS2, SMAD3, SRC 2.07277
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.05113
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.04166
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.04166
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, MIF, PTPN1, SRC 2.04068
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.03158
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 2.0001
[CC] GO:0044432 endoplasmic reticulum part BACE1, BCHE, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, F10, F2, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 4.7023
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, SLCO1B1, SLCO1B3, TEK 4.39499
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, F2, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC5A1, SLC5A2, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, SMAD3, SRC, TEK, TERT 3.40601
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, BACE1, CA4, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, TEK 3.40379
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, AXL, BACE1, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, F10, F2, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC5A1, SLC5A2, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, SMAD3, SRC, TEK, TERT, TYR 3.12968
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, F10, F2, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PTGS2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, SRC, TEK 3.06298
[CC] GO:0045121 membrane raft BACE1, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.05071
[CC] GO:0098857 membrane microdomain BACE1, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.03065
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, SRC, TEK, TYR 2.98991
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, BACE1, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, TEK 2.70842
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BACE1, BCHE, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.59347
[CC] GO:0098589 membrane region BACE1, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.50382
[CC] GO:0005788 None BACE1, BCHE, CES1, CES2, F10, F2, FLT3, PTGS2 2.27883
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, HSD11B1, HSD17B2, PTGS1, PTGS2 2.20686
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.12657
[CC] GO:0031974 None ALOX5, BACE1, BCHE, CA5A, CA5B, CES1, CES2, EGFR, F10, F2, FLT3, HSPA1A, INSR, MIF, MMP9, PTGS2 2.08058
[CC] GO:0043233 None ALOX5, BACE1, BCHE, CA5A, CA5B, CES1, CES2, EGFR, F10, F2, FLT3, HSPA1A, INSR, MIF, MMP9, PTGS2 2.08058
[CC] GO:0070013 None ALOX5, BACE1, BCHE, CA5A, CA5B, CES1, CES2, EGFR, F10, F2, FLT3, HSPA1A, INSR, MIF, MMP9, PTGS2 2.08058
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 16.9517
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.9842
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, F10, F2, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TOP2A, TUBB3, TYR, XDH 15.0768
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, TYR, XDH 12.6142
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.96079
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.90717
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 8.87621
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 8.65563
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 8.18054
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.95425
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 7.90524
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.85669
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 7.58203
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.48044
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 7.11446
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 6.97499
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.73047
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 6.62444
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.51223
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.278
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TEK, TOP2A 6.00821
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.96056
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.68392
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.52177
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.67403
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.67403
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.58117
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.56276
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.54682
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.47438
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCHE, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MIF, MMP9, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 4.26428
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.26274
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.22614
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.97037
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 3.76944
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BACE1, BCHE, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, KCNH2, MET, MIF, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TOP2A 3.66444
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.60103
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.55671
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.46347
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.4362
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.39611
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 3.33076
[MF] GO:0015370 None SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 3.25208
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.1053
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 3.10169
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK 3.0083
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.98101
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 2.93593
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.79352
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.76461
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.76461
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.76461
[MF] GO:0008389 None CYP2A13, CYP2A6 2.76461
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.42648
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, BCHE, CA1, CA2, CES1, CES2 2.41126
[MF] GO:1901618 None SLC6A2, SLC6A4, SLCO1B1, SLCO1B3 2.39454
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.36198
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.36198
[MF] GO:0005330 None SLC6A2, SLC6A4 2.36198
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.36198
[MF] GO:0047374 None CES1, CES2 2.36198
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, EGFR, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.32503
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F2, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK 2.32503
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, HSD17B1, PPARA, RORC 2.29562
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, XDH 2.20784
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.17439
[MF] GO:0015294 None SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 2.14493
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.13248
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.13163
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12373
[MF] GO:0032795 None ADORA1, ADRA2A 2.12373
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, TYR, XDH 2.10981
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.08768
[MF] GO:0015291 None SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SLCO1B1, SLCO1B3 2.08559
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, XDH 2.07642
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.03133
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, BCHE, INSR 2.00532


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.149
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.0077
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.4231
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.1878
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.7724
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.2221
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 6.9237
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.7298
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 5.3984
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.1291
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.1599
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.1792
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.5698
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.3971
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.1878
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.1219
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.1349
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.871
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.1349
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, PTGS2, CYP2C19, PTGS1, SLC6A4 4.0411
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 3.8159
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.0753
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.0168
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.9296
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9169
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 3.9727
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.7371
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.539
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.539
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA2A 3.2434
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1028
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.1816
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.0671
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.0652
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.1969
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.7768
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.0652
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1028
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7371
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6187
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.6187
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, CYP2C19, PTGS1 3.1028
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.0513
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.6586
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.0652
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.5379
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8022
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5063
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.6688
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.5658
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.3366
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3436
Bile secretion_Homo sapiens_hsa04976 SLCO1B1, CA2, SLCO1B3, SLC5A1 2.9488
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.2356
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9867
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.2571
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, F2, EGFR 2.1472
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.2609
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2354
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2609
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.2163
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.1194
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.0971
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.0266
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.0753
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.971
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, F2, ADRA2A 1.76
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7464
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2429
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2516
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2894
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.248
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3278
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.2623
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2853
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2853
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.2871
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2596
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3226
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.2871
Axon guidance_Homo sapiens_hsa04360 MET 0.337
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3445
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.4974
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7747
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 0.9957
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.1377
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6415
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.7131
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.6826
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.614
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.0758
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4075
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4075
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.7983
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.6582
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4075
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7582
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.768
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4173
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7768
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4165
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7467
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8063
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.0067
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4295
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7595
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4355
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4355
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.446
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9172
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4344
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9274
Peroxisome_Homo sapiens_hsa04146 XDH 0.4473
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1001
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9527
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9602
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.9957
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.3293
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.2577
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0126
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4713
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4848
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4828
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4972
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0756
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1534
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5242
Shigellosis_Homo sapiens_hsa05131 SRC 0.5216
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2 1.1003
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5455
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.4078
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2006
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1709
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.6238
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, SLC5A1, PIK3CB 2.4817
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5753
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5753
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2868
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.232
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5979
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2871
Malaria_Homo sapiens_hsa05144 MET 0.607
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.5979
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.614
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6117
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7366
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.67
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7196
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7929
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7582
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7399
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7711
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7747
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8008
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7645
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7929
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.7978
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7464
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6627
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9423
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9788
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9574
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.019
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3177


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)