TCM Prescription: Zhong Sheng Pills



Prescription Description
Prescription IDTCMF6302
Pinyin NameZhong Sheng Wan
Chinese Name众生丸
English NameZhong Sheng Pills
Function Description疮疡, 喉痹, 喉痈
IndicationsPharyngitis
Disease ICD-11 Category CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患,未特指的 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH2711 Viola yedoensis 紫花地丁 TCMH2711
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH667 Radix ilicis asprellae 岗梅 TCMH667
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2570 Spina gleditsiae 皂角刺 TCMH2570
TCMH1716 Calculus bovis artificiosus 人工牛黄 TCMH1716
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH404 Rhizoma arisaema cum bile 胆南星 TCMH404
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DHFR 12.0183
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 11.8784
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.8244
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.8244
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 11.7188
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, FUT7, GLO1, HSPA1A, IDO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.4899
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP1, TYR 11.4899
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 11.4899
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4554
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 11.3108
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.9276
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.5477
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.5477
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.5335
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.87458
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.82732
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.30617
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.23435
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.23435
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCHE, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 9.04338
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 9.02961
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.84413
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.67944
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 8.64778
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.56966
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT 8.38433
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 8.28317
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.27003
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.25127
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 8.25127
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, GSK3B, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 8.24444
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.2364
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR 8.23348
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 8.23348
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TEK, TYR 8.17167
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.14105
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.08807
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TERT 7.92172
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.63371
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.41425
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, IDO1, PTGS2, RORC, SRC, TYR 7.37324
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.32295
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 7.12603
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.08508
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.95272
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.92506
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 6.92506
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.92309
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.91813
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.71762
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.71762
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.51425
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.51425
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS, TOP1 6.41197
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.39069
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 6.33384
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCHE, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TOP1, TYR 6.25407
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.07006
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.9903
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 5.98328
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 5.98328
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.98328
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.96697
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.82395
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.78117
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1, HSD17B2 5.76194
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS, TOP1 5.71026
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 5.67275
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.64785
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PPARA, PTGS1, PTGS2 5.56544
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.5197
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, BCHE, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.48444
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.48289
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.46372
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.37594
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.37594
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.37594
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.37144
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.32894
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.32221
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 5.26306
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 5.26038
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, GSK3B, PPARA, RORC, SRC, TOP1, TOP2A 5.23809
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, IDO1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 5.20981
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GSK3B, HCAR2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 5.20657
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, BCHE, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.07403
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCHE, BCL2, DUSP3, EGFR, ESR1, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.01831
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCHE, BCL2, DUSP3, EGFR, ESR1, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 4.9992
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.9992
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, KDR, PTGS2, SRC, TOP1 4.96005
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, EGFR, PPARA, SMAD3 4.93648
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FLT3, GSK3B, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 4.92273
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.83863
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.83275
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 4.82507
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.82507
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GSK3B, HCAR2, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT 4.82507
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 4.81717
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2, TERT 4.8001
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.79798
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.78417
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.75871
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.74585
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.74585
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP1, TOP2A 4.73921
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.73921
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, EGFR, ESR1, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.73812
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.72752
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.7163
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 4.70519
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CYP19A1, DUSP3, EGFR, ESR1, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 4.70325
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.69579
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 4.65139
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.58537
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 4.54462
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.53746
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.47786
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.47786
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.45641
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.44248
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 4.43844
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.43636
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.42532
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.41437
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.40291
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, BCHE, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, EGFR, HSPA1A, IDO1 4.40291
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.40291
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.35131
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.34119
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.32808
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.32808
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.29462
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.26751
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, GSK3B, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC, TERT 4.2593
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.24937
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.23846
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 4.21082
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.1889
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.17869
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 4.15976
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.15738
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.12153
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 4.07368
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.07368
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.06932
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 4.04694
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.03555
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 4.02306
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GSK3B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 3.98297
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.96051
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, DHFR, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.949
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.89899
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.89899
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.88043
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.88043
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 3.85467
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 3.85467
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TNKS, TOP2A 3.84426
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.80401
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.77213
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCHE, BCL2, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 3.77213
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.77213
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.77113
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.76697
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 3.74834
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, XDH 3.58779
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.58769
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.58769
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.58769
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.58769
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.58769
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 3.53471
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.52578
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.52401
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.52401
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.49398
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 3.46695
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, HCAR2, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC 3.43415
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 3.42101
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2, SRC 3.40729
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 3.37102
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.35812
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.33941
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.33941
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.33705
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.32834
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, EGFR, ESR1, FLT3, GSK3B, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.32406
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.32406
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.2746
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 3.265
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.265
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.25087
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCHE, BCL2, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SMAD3, TERT, XDH 3.20448
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 3.20059
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.15109
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.14943
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GSK3B, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 3.13215
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.1315
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1315
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 3.11236
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DHFR, TYR 3.10805
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.10209
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GSK3B, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 3.0998
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.05752
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 3.05149
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, IDO1, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 3.05061
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.05061
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.0335
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.02726
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.01687
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3 3.01339
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.00684
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 3.00639
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.98682
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.98597
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.97969
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.9776
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A 2.94888
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.94081
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 2.93428
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.92329
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.88847
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.86949
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.85956
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, GSK3B, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.82792
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.82646
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.82217
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.8104
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GLO1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 2.79977
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, EGFR, FLT3 2.7651
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.75465
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.75192
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.75192
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.74715
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DHFR, DUSP3, ESR1, FABP4, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.74314
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73666
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.72572
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.72572
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2 2.72474
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, INSR, SRC 2.71111
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.70654
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 2.70546
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.67649
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, GSK3B, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.66095
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.65652
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.65652
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.65652
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, GSK3B, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.6093
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.6093
[BP] GO:0001954 positive regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, TEK 2.58595
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BCHE, CA2, CA7, EGFR, PTGS2 2.58595
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BCHE, CA2, CA7, EGFR, PTGS2 2.58595
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.58595
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.58595
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.58595
[BP] GO:0070920 None EGFR, ESR1, TERT 2.58595
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.58595
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, GSK3B, PTGS2, SMAD3, SRC, TERT 2.57238
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 2.56895
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 2.54574
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.53144
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, GSK3B, HSPA1A, MET, MMP1, SRC 2.52829
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.51099
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.50998
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.49464
[BP] GO:0010906 None GSK3B, INSR, PPARA, RORC, SRC 2.46879
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46879
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.45914
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.43958
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, GSK3B, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.4304
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, GSK3B, IDO1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, XDH 2.41766
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.41187
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.40517
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.38054
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.38054
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.38054
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.38054
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.38054
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.38054
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.37854
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, GSK3B, SRC, TNKS, TOP1 2.37356
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.36589
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.35205
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.35055
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.32491
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.32491
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, EGFR, PTGS2, SRC, TYR 2.30788
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.29999
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, TEK 2.29785
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, DUSP3, ESR1, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC 2.28692
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SMAD3, TNKS2 2.28249
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.28209
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.27265
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.27265
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 2.26432
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.24741
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.24741
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.24741
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.23096
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.22053
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.22053
[BP] GO:0070213 None TNKS, TNKS2 2.22053
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22053
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 2.20605
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.18687
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17118
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1684
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1684
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.16236
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.16181
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.15726
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, GSK3B, SRC, TNKS, TOP1 2.15428
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.15297
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.15297
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.15297
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 2.14828
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 2.13931
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GSK3B, PIK3CA, PPARA, TERT 2.13645
[BP] GO:0051894 None KDR, SMAD3, TEK 2.12633
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12633
[BP] GO:0030154 cell differentiation ALPL, AXL, BCHE, BCL2, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, MMP2, MMP9, PTGS2, RORC, SMAD3, TOP2A 2.12361
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.12298
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.11816
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.11816
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.11537
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, GSK3B, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.11376
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.09134
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, PTGS2 2.09065
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.09065
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, INSR, TERT 2.08743
[BP] GO:0010675 None GSK3B, INSR, PPARA, RORC, SRC 2.07873
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06766
[BP] GO:0007584 response to nutrient ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 2.06745
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.06259
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK 2.05403
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.04656
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.04385
[BP] GO:1903393 None KDR, SMAD3, TEK 2.04385
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.03881
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, SRC, TEK 2.03019
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.03019
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.03019
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.02836
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, GSK3B, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.02741
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.02659
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.02632
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, APP, AXL, BCL2, EGFR, GPR35, GSK3B, IDO1, PTGS2, PTPRS, SMAD3, TEK, TERT, XDH 2.01936
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, DUSP3, PTPN1, PTPRS 2.01376
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.0074
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.0074
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.19302
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, BCHE 3.40937
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, FLT3, GLO1, GPR35, GSK3B, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT 2.92913
[CC] GO:0009330 None TOP1, TOP2A 2.86788
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GPR35, GSK3B, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 2.84018
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 2.67649
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 2.36589
[CC] GO:0044432 endoplasmic reticulum part APP, BCHE, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, HSD17B2, PTGS1, PTGS2, PTPN1 2.31323
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.13645
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 20.3116
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 18.5121
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.6935
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 16.3088
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7278
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5477
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.91516
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 8.91516
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS 8.20181
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.13353
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.11084
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DHFR, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP1, TOP2A 7.93884
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, PTGS1, PTGS2, SRC 7.24309
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.13394
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, PTGS1, PTGS2, SRC 6.95272
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.51425
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.38055
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 5.56852
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, SRC, XDH 5.52481
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 5.3943
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 5.3277
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.30972
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.13574
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, EGFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 4.92788
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.90626
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.83996
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.79798
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.65139
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT, TOP1 4.62184
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 4.39256
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 3.98285
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 3.98139
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.85467
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.77213
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 3.64387
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.52401
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 3.51305
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 3.47343
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.40453
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.34213
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.32406
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP1, TOP2A, TUBB3 3.2818
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.265
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.25087
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK, TOP1 3.18038
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, EGFR, ESR1, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TUBB3, XDH 3.06899
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, EGFR, ESR1, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TUBB3, XDH 3.02869
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.99951
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3 2.98077
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.86788
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.86788
[MF] GO:0008389 None CYP2A13, CYP2A6 2.86788
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3 2.8496
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3 2.81491
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3 2.80741
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.7651
[MF] GO:0042802 identical protein binding ACHE, APP, BCHE, BCL2, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.62638
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.58595
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.46879
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.46879
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.38054
[MF] GO:0019899 enzyme binding APP, AURKB, BCHE, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, GSK3B, HSPA1A, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 2.37651
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.32499
[MF] GO:0051425 None APP, INSR 2.22053
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.11298
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.10733
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.04656
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04385
[MF] GO:0008134 transcription factor binding APEX1, BCL2, ESR1, FLT3, GSK3B, PIM1, PPARA, SMAD3, SRC, TERT 2.03881


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.6792
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.4747
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4694
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, BCL2, MET 6.7305
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.9512
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.6576
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 6.7305
Focal adhesion_Homo sapiens_hsa04510 GSK3B, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.6774
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.563
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.0743
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, DHFR, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.3588
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 5.3751
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.563
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.6774
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.9698
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.2585
Prostate cancer_Homo sapiens_hsa05215 GSK3B, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.8502
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.5507
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.5203
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.205
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB, PPARA 4.4552
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.4552
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3, PIK3CA, BCL2, PIK3CB 4.4552
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.4552
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.4136
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.0381
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.223
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 4.2084
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.8502
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.3314
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.4013
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, PIK3CA, SRC, PIK3CB, EGFR 3.8502
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2, PTGS1 3.3873
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 3.1844
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.303
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 3.303
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.2797
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 3.0861
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, PPARA, EGFR 3.1216
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4035
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, PIK3CA, PIK3CB, EGFR 3.5484
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, INSR, PIK3CB, PPARA 2.9122
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, PIK3CA, PIK3CB, IGF1R 3.02
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB 3.0514
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.2489
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.8392
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.2335
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 2.7542
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.7011
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 3.9638
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.7542
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.4506
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.5214
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5286
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.8752
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.02
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1787
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, PIK3CA, BCL2, PIK3CB 2.4246
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4117
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4375
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.3924
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.1817
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, PIK3CA, TERT, PIK3CB 2.0589
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.0615
Influenza A_Homo sapiens_hsa05164 GSK3B, PIK3CA, PIK3CB, HSPA1A 1.9219
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8959
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, PIK3CA, SRC, PIK3CB 1.8542
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.6889
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2761
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2854
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2814
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4639
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3237
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8959
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.471
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4188
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3655
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.841
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.4217
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1036
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, PIK3CA, PIK3CB 2.1285
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 0.845
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.4639
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.3754
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3885
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.9241
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.1285
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.8128
Cell cycle_Homo sapiens_hsa04110 GSK3B, SMAD3, CDC25B 1.5964
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7881
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7238
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, PIK3CA, PIK3CB 1.7881
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8462
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6923
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8854
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.7734
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8277
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.7238
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.8671
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.845
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4536
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4536
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.467
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4661
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2281
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.994
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4795
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.486
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.486
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.0343
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4972
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0343
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1975
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4848
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0418
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.078
Peroxisome_Homo sapiens_hsa04146 XDH 0.4987
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2406
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0993
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5139
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.4117
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5204
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5343
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5322
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.547
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5748
Shigellosis_Homo sapiens_hsa05131 SRC 0.572
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.5513
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5965
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2989
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.277
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.277
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2915
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6269
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6269
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.7854
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6269
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3908
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3307
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.647
Malaria_Homo sapiens_hsa05144 MET 0.6564
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6515
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4001
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6696
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6923
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5901
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7675
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7675
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7238
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5766
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7994
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.845
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7675
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7775
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8462
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8801
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8094
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8959
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.845
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.841
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7617
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0615
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9435
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.205
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.4246


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)