TCM Prescription: Zhen Zhu Ling Zhi Tablets



Prescription Description
Prescription IDTCMF6168
Pinyin NameZhen Zhu Ling Zhi Pian
Chinese Name珍珠灵芝片
English NameZhen Zhu Ling Zhi Tablets
Function Description眩晕, 不寐
IndicationsVertigo disorder, Insomnia disorder, Insomnia, Dizziness
Disease ICD-11 Category SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1296 Ganoderma lucidum 灵芝浸膏 TCMH1296 MGEN736-15
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2605 Margarita 珍珠 TCMH2605
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1351 Nocardia sp.
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES 8.47236
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GLO1, HSD17B3, PIM1, PPARA, PTGES, TYR, XDH 8.21529
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.9823
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MAP2K1, MCL1, MET, PIM1, PPARA, PTPN1, RELA, SRC, TOP2A, XDH 6.9823
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MAP2K1, MCL1, MET, PIM1, PTPN1, RELA, SRC, TOP2A, XDH 6.79694
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, HSD17B1, HSD17B2, HSD17B3 6.6729
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TOP2A, TYR, XDH 6.62566
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, XDH 6.27847
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, XDH 6.27326
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, PTPRS, RELA, SRC, TYR 6.24615
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MAP2K1, MCL1, PIM1, PTPN1, RELA, SRC, TOP2A, XDH 6.23062
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, PTGES, RELA, SRC 6.19687
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7 6.02657
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TOP2A, TYR, XDH 5.95394
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, PTPN1, RELA, SRC, XDH 5.8829
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, PPARA, PTGES, RELA, RORC, SRC, TYR 5.70242
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, KDR, MAP2K1, MCL1, MET, PIM1, PPARA, PTPRS, RELA, RORC, SRC, TOP2A, TYR 5.63241
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MCL1, MET, PPARA, SRC, XDH 5.44029
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, PIM1, PPARA, PTPN1, RELA, SRC 5.24349
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.24349
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, PPARA, PTGES, RELA, RORC, SRC, TYR 5.09422
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PTGES, RELA, RORC, SRC, TYR 5.04556
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MMP12, PIM1, PTGES, RELA, SRC, XDH 5.03578
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGES, RELA, RORC, SRC, TYR 5.03578
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, PIM1, PTPN1, RELA, SRC 4.96251
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, XDH 4.827
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 4.81182
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 4.80374
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 4.4641
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FUT7, MET, PPARA, PTGES 4.42361
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, PTPN1, RELA, SRC, XDH 4.35754
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, PIM1, PTPN1, RELA, SRC 4.24239
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, XDH 4.18269
[BP] GO:0042221 response to chemical AKR1B1, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, PPARA, PTGES, RELA, RORC, SRC, TYR 4.18269
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, XDH 4.09904
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, MCL1, PIM1, PPARA, PTPRS, RELA, RORC, SRC, TYR 4.01311
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TOP2A, XDH 3.98283
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MMP12, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TOP2A, TYR 3.94236
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, FDPS, HSD17B3, MAOA, TYR 3.91013
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TOP2A, XDH 3.83348
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 3.80035
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MCL1, MET, MMP12, PPARA, PTPN1, PTPRS, RELA, SRC, XDH 3.69302
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 3.69302
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 3.65427
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.59307
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 3.58086
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 3.58086
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 3.57491
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.50565
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 3.50565
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TOP2A, XDH 3.4833
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.45971
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TOP2A, TYR, XDH 3.45625
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TOP2A, TYR, XDH 3.4322
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.4322
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.41839
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, XDH 3.40983
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, XDH 3.38208
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.36236
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 3.33048
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, PTPN1, RELA, RORC, SRC, TOP2A 3.33048
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD17B1, HSD17B2, HSD17B3 3.33048
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, PTPN1, SRC 3.33048
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 3.32185
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.31191
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES 3.26389
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.26375
[BP] GO:0009725 response to hormone AKR1B1, APEX1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, RELA, SRC 3.19804
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, XDH 3.18039
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17034
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 3.14784
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, PPARA, RELA, SRC 3.07422
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD17B1, HSD17B2, HSD17B3, PTGES 3.06536
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TOP2A, XDH 3.0268
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, FLT3, MCL1, MET, SRC 2.94039
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 2.90748
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.90748
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85996
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, RELA, SRC 2.83443
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, RELA, RORC, SRC 2.83375
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, AR, CYP1A1, CYP1B1, FLT3, RORC, SRC 2.82458
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CACNA1C, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.79947
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGES 2.75642
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, PPARA, RORC, SRC 2.73823
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 2.69656
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 2.67927
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.66592
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, HSD17B3, MAP2K1, SRC 2.64001
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.64001
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, F3, FABP4, HSD17B2, IGF1R, MCL1, MET, MMP12, PIM1, PPARA, RELA, RORC, SRC, TYR 2.64001
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTPRS, RELA 2.62702
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.58747
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, RELA, RORC, SRC 2.58305
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, MAP2K1, MET, PIM1, SRC, TYR 2.54604
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA, SRC 2.54469
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, RELA, SRC 2.47656
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.46864
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 2.46479
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.46094
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, XDH 2.40784
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 2.39284
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39284
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32055
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, RELA, SRC 2.32055
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.32055
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, TYR 2.32029
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.32029
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, F3, FLT3, FUT7, GLO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTPN1, PTPRS, RELA, SRC, TOP2A, TYR, XDH 2.32029
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.25558
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.25114
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, PPARA, PTPN1, RELA, RORC, SRC, TOP2A, XDH 2.25114
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TOP2A 2.25114
[BP] GO:0006081 None AKR1B10, CYP1B1, GLO1, RELA 2.25114
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, PTGES, RELA, SRC 2.24302
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2387
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, F3, FLT3, IGF1R, KDR, MMP12, PIM1, RELA 2.23107
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.20731
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP12, SRC, XDH 2.20045
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19319
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.1619
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1619
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC 2.12268
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, IGF1R, RELA, RORC, SRC 2.12268
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, RELA, SRC 2.1036
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, PPARA, RELA, SRC, TYR 2.09455
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.07846
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.07846
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, PPARA, PTPN1, RELA, RORC, SRC, TOP2A, XDH 2.06392
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.03775
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, PPARA, PTPN1, RELA, RORC, SRC, TOP2A, XDH 2.03775
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.02299
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTPN1, SRC, XDH 2.01987
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, TYR 2.01987
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, FABP4, MAP3K7, MMP12, PPARA, PTPN1, PTPRS, RELA, SRC 2.00231
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.41839
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAP2K1, MAP3K7, MCL1, PIM1, PTGES, PTPN1, PTPRS, RELA, SRC, TOP2A, TYR, XDH 2.8901
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TOP2A, TYR, XDH 2.69656
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA6, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TOP2A, TYR, XDH 2.06564
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, FLT3, HSD17B3, KDR, MAP2K1, PTPN1, XDH 2.03775
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 9.7944
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, PIM1, PTGES, PTPN1, PTPRS, SRC, TOP2A, TYR, XDH 9.61605
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP12, PIM1, PPARA, PTPN1, RORC, TYR, XDH 8.47236
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TOP2A, TYR, XDH 8.47236
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.9823
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.44818
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.82107
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, GLO1 5.62299
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, HSD17B3, XDH 4.18269
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.65523
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, GLO1, MAP3K7, MMP12, PIM1, PPARA, PTPN1, RORC, TOP2A, TYR, XDH 3.52143
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.50565
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50565
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP2A 3.48663
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.48663
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, HSD17B3 3.42836
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.23124
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, GLO1, MMP12, PPARA, PTPN1, RORC 3.15127
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.10707
[MF] GO:0046872 metal ion binding ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, GLO1, MAP3K7, MMP12, PIM1, PPARA, PTPN1, RORC, TOP2A, TYR, XDH 3.09641
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, PIM1, PPARA, PTPN1, RELA, SRC 3.06419
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.97755
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.84363
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.78666
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.76297
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTPRS, RELA, SRC, TOP2A, XDH 2.65263
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.62545
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, PPARA, PTPN1, RELA, SRC 2.5864
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.32055
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.27441
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.1619
[MF] GO:0005497 None AR, SHBG 2.1619
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD17B1, HSD17B2, HSD17B3 2.06629
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, PTGES, SRC, XDH 2.03611


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA14 11.5342
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1553
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 7.8601
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, MAOA, HSD17B3, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES 5.2478
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.6094
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.8834
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, CACNA1C 3.4346
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.3879
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0132
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, RELA, IGF1R 2.8016
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, MET, CDC25B, MCL1 2.6396
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, ADORA1, CACNA1C, PPARA, RELA 2.5683
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, KDR, MET, IGF1R 2.5683
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.9024
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, IGF1R 2.5683
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, KDR, MET, RELA, MCL1, IGF1R 2.4825
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.5173
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.4424
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.4825
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MET, RELA, IGF1R 2.2371
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.2742
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2742
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGES 2.2742
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 2.1625
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.2294
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.2278
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.2054
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.2031
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, RELA, IGF1R 2.057
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1, F3, RELA 1.8755
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, CACNA1C 1.9666
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.9003
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2257
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 1.8633
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 1.9527
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.863
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.862
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.8471
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.848
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MAP3K7, RELA 1.848
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7016
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.7921
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.7602
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA, MCL1 1.6478
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.7016
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA 1.6741
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, RELA 1.6059
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.5284
Influenza A_Homo sapiens_hsa05164 FDPS, MAP2K1, RELA 1.446
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.4454
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.4413
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA 1.3933
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1331
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4985
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.4454
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.4634
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 1.08
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 1.0834
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC 1.207
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 1.0237
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.2041
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.9987
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.4454
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 1.064
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 1.0381
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9987
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 1.0237
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 1.08
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, IGF1R 0.9957
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.2432
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.9578
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.2911
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.9957
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.937
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.4454
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4702
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.4454
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.4454
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4054
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.4913
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.4004
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.7706
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.4158
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4454
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2911
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.909
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.7953
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.4454
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.639
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.4158
HTLV-I infection_Homo sapiens_hsa05166 FDPS, RELA 0.6724
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.8794
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.8791
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.2911
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.4454
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.4624
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4695
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.4454
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.4332
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4899
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3727
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.4158
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC 1.7016
Platelet activation_Homo sapiens_hsa04611 SRC 0.5184
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5153
Axon guidance_Homo sapiens_hsa04360 MET 0.5092
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.5948
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.4333
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.5406
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.4332
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8626
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.572
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5804
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5804
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5804
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5891
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5805
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5867
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5855
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5867
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5945
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5804
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5984
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.6089
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5957
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.6043
Salmonella infection_Homo sapiens_hsa05132 RELA 0.6043
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5971
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.6091
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.6043
Peroxisome_Homo sapiens_hsa04146 XDH 0.6089
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.6174
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.6089
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6156
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6315
Pertussis_Homo sapiens_hsa05133 RELA 0.6295
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.6517
Bile secretion_Homo sapiens_hsa04976 CA2 0.639
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.6315
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0066
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.7926
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6724
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.848
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6724
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1 0.6749
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9024
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7875
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.7122
Legionellosis_Homo sapiens_hsa05134 RELA 0.716
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.7352
Malaria_Homo sapiens_hsa05144 MET 0.752
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.7474
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.757
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7706
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.8167
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.8642
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8167
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.9151
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.937
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8993
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8794
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9151
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9404
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.909
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.937
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9654
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.9957
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0657


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)