TCM Prescription: Zhen He Ling Tablets



Prescription Description
Prescription IDTCMF6097
Pinyin NameZhen He Ling Pian
Chinese Name珍合灵片
English NameZhen He Ling Tablets
Function Description心悸, 不寐
IndicationsInsomnia disorder, Insomnia, Palpitations
Disease ICD-11 Category SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC81.2 [Palpitations, 心悸 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2605 Margarita 珍珠 TCMH2605
TCMH1299 Ganoderma lucidum 灵芝 TCMH1299 MGEN736-15
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1351 Nocardia sp.
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.17065
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.08856
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 8.93751
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7 7.11483
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GBA2, GLO1, PIM1, PPARA, TYR, XDH 7.03207
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 6.97474
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 6.90244
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.84901
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.83561
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH 6.48075
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7 6.07649
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, PPARA, SRC, TYR 6.05246
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, PPARA, SRC, TYR 6.01732
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 5.99072
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 5.78161
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TOP2A, XDH 5.76154
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 5.68636
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.59772
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, KDR, MET, PIM1, PPARA, SRC, TNKS2, TOP2A, TYR 5.57754
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR 5.21523
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, PIM1, PTPN1, SRC, TOP2A, XDH 5.11269
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.00875
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.93277
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.89205
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.86546
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 4.56734
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, SRC 4.56734
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC 4.56734
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, PPARA, SRC, TYR 4.51935
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.51935
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37932
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.18736
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, PIM1, SRC, XDH 3.9625
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC 3.9625
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 3.9438
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 3.92922
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FDPS, FUT7, GBA2, MET, PPARA 3.92922
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, PIM1, PPARA, SRC, TYR 3.82936
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 3.75409
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 3.75112
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.69512
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.69512
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.69512
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, PIM1, PTPN1, SRC 3.68441
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, SRC, TNKS, TNKS2 3.63677
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.62427
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.58744
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.43632
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.38942
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.37743
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 3.33926
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.32223
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, TYR 3.24577
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 3.21719
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 3.21143
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17699
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.151
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, PIM1, PTPN1, SRC 3.0672
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, SRC 2.9429
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, PPARA, PTPN1, SRC, TOP2A, TYR 2.91604
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, SRC 2.90687
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.90398
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.894
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85743
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.85743
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.79513
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.77769
[BP] GO:0009115 None AOX1, XDH 2.77718
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.76973
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.72389
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, SRC 2.71247
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.63124
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 2.62864
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.62864
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.61673
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, SRC 2.60706
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, XDH 2.60706
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, SRC 2.60706
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.60706
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.60546
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, SRC, TOP2A 2.59523
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.59478
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.58415
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.58415
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 2.58415
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 2.57533
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.55233
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.54518
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 2.51343
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.51293
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 2.50922
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.4856
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.4856
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.455
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, PIM1, PPARA, SRC, TNKS2, TYR 2.45314
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.44052
[BP] GO:0046110 None AOX1, XDH 2.43118
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43118
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.42114
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, PTPN1, SRC, XDH 2.4182
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.41533
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.40206
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.39832
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.39464
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.39464
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, SRC, XDH 2.39464
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, PIM1 2.37472
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.34614
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34614
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.32294
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.31517
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.29966
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29788
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.27059
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC 2.2619
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.24924
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.24182
[BP] GO:0070213 None TNKS, TNKS2 2.20742
[BP] GO:0006145 None AOX1, XDH 2.20742
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20742
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, PPARA, SRC 2.16985
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.16985
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.16734
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PPARA 2.16734
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, SRC 2.16296
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, PTPN1, SRC, TOP2A 2.16152
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, PPARA, PTPN1, SRC 2.15952
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 2.13753
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.13457
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, PPARA, SRC 2.08898
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.08065
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, XDH 2.06473
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, SRC, TOP2A 2.05857
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, SRC 2.05857
[BP] GO:0043696 None CDK6, ESRRB 2.04198
[BP] GO:0043697 None CDK6, ESRRB 2.04198
[BP] GO:0010641 None F3, SRC 2.04198
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.02656
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, TNKS, TOP2A 2.02213
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, PPARA, SRC 2.01683
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.01462
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.55723
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.39464
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.90741
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, GBA2, KDR, PTPN1, XDH 1.63846
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 1.47428
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 10.635
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 10.635
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 10.3883
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 8.73778
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7 7.11483
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.62555
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.01732
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, GLO1 5.75185
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.51947
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, PIM1, PPARA, PTPN1, TNKS, TNKS2, TOP2A, TYR, XDH 5.00875
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, ESR1, ESR2, ESRRA, ESRRB, GLO1, PPARA, PTPN1, TNKS 4.69802
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, PIM1, PPARA, PTPN1, TNKS, TNKS2, TOP2A, TYR, XDH 4.63392
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.16288
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.9625
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.9625
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.90979
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.75112
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.65468
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.58744
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.57967
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.53427
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.51098
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.42341
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.21357
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 3.15061
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.14635
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.79706
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.79706
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, SRC, XDH 2.79513
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.77718
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.77718
[MF] GO:0003845 None HSD11B1, HSD11B2 2.77718
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.63455
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.62864
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.60706
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, PIM1, PPARA, PTPN1, SRC 2.58415
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.36696
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.24182
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20742
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.14661
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, PPARA, PTPN1, SRC 2.11281
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.08778
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.05857
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04198
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA 2.02022


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA14 11.759
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.7305
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5549
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.5032
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3616
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.055
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.0747
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MET, CDC25B 2.7224
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 2.6264
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9846
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.6264
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0989
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1382
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0989
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.7945
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.0989
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3 1.7945
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7945
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 1.7945
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, BCL2, MET, IGF1R 1.6828
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6112
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6828
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2 1.4877
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.4086
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3228
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3724
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3714
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1467
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.3135
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3413
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3561
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3004
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6828
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8713
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1438
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0283
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2997
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.753
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0856
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1513
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0227
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.299
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2202
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0552
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0283
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.118
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7169
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6828
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9133
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.969
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8952
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9041
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8111
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7807
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7212
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7212
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.7212
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6045
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2974
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2972
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3488
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4103
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.39
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4034
Influenza A_Homo sapiens_hsa05164 FDPS 0.4034
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4585
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3898
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.446
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4425
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4585
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4302
Platelet activation_Homo sapiens_hsa04611 SRC 0.4839
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4572
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4697
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4844
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4697
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4839
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4839
Axon guidance_Homo sapiens_hsa04360 MET 0.479
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5561
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.506
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5409
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5561
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5442
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5409
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5481
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5561
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5561
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5481
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5561
Gap junction_Homo sapiens_hsa04540 SRC 0.5561
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5481
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5561
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5974
Peroxisome_Homo sapiens_hsa04146 XDH 0.561
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5967
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5756
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6133
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6133
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6045
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6153
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6133
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6045
Bile secretion_Homo sapiens_hsa04976 CA2 0.6036
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6133
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6133
Shigellosis_Homo sapiens_hsa05131 SRC 0.6133
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6375
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6133
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.67
Malaria_Homo sapiens_hsa05144 MET 0.6807
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6863
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6834
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7212
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9846
Bladder cancer_Homo sapiens_hsa05219 SRC 0.7212
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6863
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6863
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7212
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7902
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8111
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7773
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8111
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8289
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8202
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8918
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9462
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0203
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2782


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)