TCM Prescription: Yang Yin Jiang Tang Tablets



Prescription Description
Prescription IDTCMF6069
Pinyin NameYang Yin Jiang Tang Pian
Chinese Name养阴降糖片
English NameYang Yin Jiang Tang Tablets
Function Description消渴
IndicationsWasting thirst disorder, Diabetes
Disease ICD-11 Category SD71 [Wasting thirst disorder (TM1), 消渴 (TM1) ];
5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ];
Human Tissues Associated with IndicationPancreas, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH2551 Polygonatum odoratum 玉竹 TCMH2551 ITSAM921-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 10.6856
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MAOB, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR 10.1719
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MAOB, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TRPV1, XDH 9.47194
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR 9.34966
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, NR3C1, PPARA, PTGS2, SRC, TRPV1 9.18227
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1, TYR, XDH 8.95034
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, MAOB, NR3C1, PTGS2, SRC, TYR 8.60837
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, MAOB, NR3C1, PTGS2, SRC, TRPV1, TYR 8.58796
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, PDE5A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 8.5822
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MAOB, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 8.23754
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 8.22096
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP2A, TRPV1, XDH 8.10261
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 8.09414
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR 8.05515
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA9, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TYR 7.8533
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, PTGS2, SRC 7.5804
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 7.49578
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP2A, TRPV1, XDH 7.45459
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.99167
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 6.65963
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.62523
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.42836
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 6.42836
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.42836
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 6.28403
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.17292
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, BCHE, BCL2, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PDE5A, PIM1, PTGS1, PTGS2, SRC, XDH 6.13801
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.03408
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.03408
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.98233
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.98233
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.86099
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 5.53643
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 5.49152
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCHE, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, SRC, TRPV1, TYR 5.44531
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 5.4445
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.39578
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 5.36413
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC 5.36413
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, MAOB, NR3C1, PTGS2, SRC, TRPV1 5.21858
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.16949
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC 5.13142
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 5.00582
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1, TYR, XDH 4.98612
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.83273
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, FLT3, MAOB, NR3C1, PTGS2, SRC 4.81787
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, FLT3, MAOB, NR3C1, PTGS2, SRC 4.81787
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.81787
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.81787
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 4.80172
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.79822
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.79026
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1, TYR 4.71609
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 4.51791
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.51235
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1, TYR, XDH 4.50274
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC 4.50274
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, SRC 4.47647
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.41936
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.41616
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 4.36227
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.28844
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.28844
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 4.28844
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1 4.20548
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 4.18887
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MAOB, MMP1, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 4.13225
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TRPV1 4.09295
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 4.03105
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, FLT3, MAOB, NR3C1, PTGS2 4.02795
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 3.97752
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGS1, PTGS2 3.95023
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TOP2A, TRPV1 3.93537
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, PIK3CB, PPARA, PTGS2, SRC, TRPV1 3.93331
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.88325
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.83683
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, MAOB, SRC 3.76298
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.72151
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.72151
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 3.6718
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, MAOB, TYR 3.6671
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, PTGS2 3.6671
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.6671
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.6671
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.6671
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 3.66574
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.65832
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, BCL2, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.65832
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.65832
[BP] GO:0009820 alkaloid metabolic process BCHE, CYP1A2, CYP3A4 3.65832
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 3.59987
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.59466
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.55111
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.55111
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.49958
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.49958
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.48544
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.47201
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.38878
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 3.38878
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 3.35863
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.34166
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC 3.29862
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 3.21438
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.21438
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.20786
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.20262
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.20083
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.16405
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.16405
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.09321
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.07004
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 3.06105
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 3.04084
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 3.00278
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.00171
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.99668
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, BCHE, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 2.98939
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 2.97345
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1, XDH 2.97345
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, PTGS2, TYR 2.97122
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.93286
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, KDR, MET, MMP9, PDE5A, PIK3CA, PIM1, PTGS2, SRC, TRPV1, XDH 2.91605
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88839
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.88036
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.87244
[BP] GO:0009115 None AOX1, XDH 2.87244
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.87244
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.87244
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.87244
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CHRM5, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.86509
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.84233
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CHRM5, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.82203
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.81887
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.81766
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB, TRPV1 2.81161
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, PTGS2, SRC, TRPV1, TYR 2.80541
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.79675
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.78611
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, ESRRB, FABP3, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.78532
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, ESRRB, FABP3, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.78532
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 2.77398
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 2.76358
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 2.75897
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.7486
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, BCHE, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 2.74075
[BP] GO:0006937 None ADORA1, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2 2.73961
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.73961
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.72668
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCHE, BCL2, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, ESR1, FLT3, FUT7, GLO1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, SRC, TOP2A, TYR, XDH 2.71129
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1, TYR, XDH 2.70273
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.69668
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.68267
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.68267
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.64613
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, ESRRB, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.64439
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.59644
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.57506
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.52604
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, MAOB, NR3C1, SRC 2.51877
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 2.51641
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.50916
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.50082
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH 2.49077
[BP] GO:0046110 None AOX1, XDH 2.49077
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49077
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.48955
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.48773
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TRPV1 2.47572
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH 2.46258
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CHRM3, CYP1B1, ESRRB, HCAR2, KDR, MET, MMP9, PDE5A, PIM1, PTGS2, SRC, TRPV1 2.45694
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.4488
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.43398
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.42584
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.42286
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.38168
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.38168
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.38168
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, SRC, TOP2A 2.38168
[BP] GO:0007584 response to nutrient ALPL, BCHE, CYP1A1, PTGS2, TRPV1, TYR 2.3811
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2 2.37603
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.3739
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.33887
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.33592
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.33158
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.32894
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, HCAR2, PDE5A, PTGS2, TRPV1 2.30833
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.2981
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.28919
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.28605
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.28567
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.28567
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CYP1A1, PTGS2, SRC, TRPV1, TYR 2.28527
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.27654
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, PTGS2 2.27583
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.27196
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.27196
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, BCHE, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MAOB 2.27196
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.27196
[BP] GO:0006145 None AOX1, XDH 2.27196
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27196
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.27196
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH 2.26451
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1 2.23005
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CYP1B1, KDR, PDE5A, PIK3CA, PIK3CB, PPARA, SRC 2.22429
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.21978
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.20505
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.20221
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SRC, TRPV1 2.15752
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.15752
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.11183
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, HCAR2, MAOB, MMP9, PIK3CB, PPARA, PTGS2, SRC, TRPV1 2.10718
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TOP2A, XDH 2.0939
[BP] GO:0046541 None CHRM1, CHRM3 2.08484
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.08484
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.08484
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 2.08484
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, MAOB, MMP9, PTGS2 2.08484
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.08484
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.08484
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.08207
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 2.07345
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2 2.07249
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.06919
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 2.06919
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 2.05397
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.0532
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.0532
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.02928
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, MAOB, PDE5A, XDH 2.01792
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.01792
[BP] GO:0018958 None AKR1B1, BCL2, MAOB, TYR 2.01792
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.01792
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.01792
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, PTGS2, SRC, TOP2A 2.01425
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, PTGS1, PTGS2 2.01309
[BP] GO:0044248 cellular catabolic process ACHE, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MAOB, PDE5A, PIK3CB, SRC, XDH 2.00744
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TRPV1, XDH 2.00623
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.00401
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FLT3, FUT7, GLO1, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TRPV1, TYR 3.3553
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA7, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, KDR, MAOB, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TOP2A, TRPV1, TYR, XDH 2.75311
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, SRC, TRPV1 2.45681
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, MET, PTGS2, SRC, TRPV1 2.14855
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TRPV1, TYR 2.08484
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, TYR, XDH 14.6859
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TRPV1, TYR, XDH 12.732
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 11.6706
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0966
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 9.37097
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, TOP2A, TRPV1, TYR, XDH 8.78944
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, TOP2A, TRPV1, TYR, XDH 7.15706
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 6.95137
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.93667
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.42836
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.41246
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A, TRPV1 6.41246
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA 6.25621
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, SRC, XDH 5.52878
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.36413
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.36232
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.33673
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1 5.23378
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.14303
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.09318
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 4.82902
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TYR 4.81787
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 4.67444
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 4.67444
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 4.10889
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.09295
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.03427
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NQO2, NR3C1 4.03427
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.96923
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, PDE5A 3.89285
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.88974
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.88974
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.80257
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.80067
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCHE, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MAOB, MET, MMP9, NQO2, PTGS2, TOP2A, TRPV1, TYR, XDH 3.71431
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.55148
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.49958
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.47873
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.46233
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.34166
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.34166
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.0797
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.05141
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.02696
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1, XDH 2.98141
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.98141
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.87244
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87244
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.87244
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.87244
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.81766
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.49077
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.49077
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.49077
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.49077
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.49077
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.49077
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, BCHE, CA1, CA2, CHRM1, CHRM3, CHRM5, PDE5A 2.43398
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.42735
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1, XDH 2.42584
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1, XDH 2.42584
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1, XDH 2.37603
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.30979
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.28567
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.27196
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.27196
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.27196
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, SRC 2.11358
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.11358
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.11358
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08484
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08484
[MF] GO:0050660 flavin adenine dinucleotide binding AOX1, MAOB, NQO2, XDH 2.08478
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.0532
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.0532


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.5178
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0851
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.15
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PIK3CB 6.971
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.6078
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.307
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.2215
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.1948
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.0838
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.4841
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.3722
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7073
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 4.7073
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, TRPV1, NR3C1 4.4833
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 4.7073
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA 4.4676
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.4676
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.4676
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB 4.3251
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.9897
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.4676
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.8959
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.9408
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.5385
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.4633
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.5699
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6521
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1505
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.3176
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.4538
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 3.1808
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.4756
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.3964
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1, CYP3A4 3.4317
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PDE5A, PIK3CB 3.1111
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.3391
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4317
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.12
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1563
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2984
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7983
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.8972
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.568
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6657
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.7113
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.7113
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.7113
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.4519
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.3075
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 2.1248
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1248
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.9813
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 1.9987
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.1233
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.8834
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0426
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7744
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6692
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.4405
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.679
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7484
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0486
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.679
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4519
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4752
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.6698
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6533
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4292
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5993
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5817
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3007
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3839
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.343
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3666
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3508
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0769
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.422
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 0.9626
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9727
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9626
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9855
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9404
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.624
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8315
Axon guidance_Homo sapiens_hsa04360 MET 0.4552
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4526
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4637
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8321
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8271
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1616
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.221
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2084
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1412
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1649
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1518
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1763
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1518
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.188
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5319
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5319
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5319
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5458
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5589
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.56
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5613
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5613
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5693
Gap junction_Homo sapiens_hsa04540 SRC 0.5613
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5613
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5634
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5613
Peroxisome_Homo sapiens_hsa04146 XDH 0.5693
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.416
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3832
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3832
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3909
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.3771
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4299
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6121
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3909
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.624
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.416
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4974
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6356
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.647
Shigellosis_Homo sapiens_hsa05131 SRC 0.6442
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.669
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 3.12
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5488
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5993
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.3176
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6722
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.679
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6533
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7268
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7314
Malaria_Homo sapiens_hsa05144 MET 0.7361
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7361
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7742
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7423
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7375
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6698
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.8041
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8041
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8894
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8794
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8321
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8611
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8703
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8996
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1561
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.937
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9252
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9626
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.0829
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1518
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4299
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3311


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)