TCM Prescription: Xin Wu You Tablets



Prescription Description
Prescription IDTCMF6020
Pinyin NameXin Wu You Pian
Chinese Name心无忧片
English NameXin Wu You Tablets
Function Description胸痹, 真心痛, 心悸
IndicationsTrue heart pain disorder, Palpitations, Chest pain
Disease ICD-11 Category SA20 [True heart pain disorder (TM1), 真心痛 (TM1) ];
MC81.2 [Palpitations, 心悸 ];
MD30.Z [Chest pain, unspecified, 胸痛，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH998 Buxus sinica 黄杨木 TCMH998 MG730467
TCMH1870 Belamcanda chinensis 射干 TCMH1870
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1693 Aristolochia debilis 青木香 TCMH1693 GBVE1975-11
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH706 Trichosanthes kirilowii 瓜蒌皮 TCMH706 ITSAO4359-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 13.5459
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, AKR1C3, APP, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 10.7691
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 9.65951
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AKR1C3, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 9.2985
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.1371
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 8.90895
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 8.8986
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, XDH 8.8986
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 8.8986
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 8.70457
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B1, HSD17B2 8.63656
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 8.63656
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 8.63656
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 8.62509
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TERT 8.34781
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, PTGS2, SLC6A4, SRC 8.33445
[BP] GO:0033993 response to lipid AKR1C3, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTGS2, RORC, SLC6A4, SRC, TYR 7.78611
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, KIT, PIK3CA, PPARA, SRC, TYR 7.73993
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, KIT, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 7.68999
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 7.61391
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AXL, CYP1B1, EGFR, ERBB2, FLT3, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.58121
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 7.58121
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 7.57733
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AKR1C3, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, KIT, PPARA, PTGS2, SLC6A4, SRC 7.54894
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 7.51186
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TYR 7.35755
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 7.35755
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA9, CACNA1C, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TYR 7.32896
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.14489
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NQO2, PTGS1, RORC 7.05744
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, PTGS2, RORC, SLC6A4, SRC, TYR 7.01105
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 7.00518
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 6.94822
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, APP, AXL, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SLC6A4, SRC 6.94822
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 6.90906
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 6.90629
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.84586
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 6.83157
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, TYR 6.79471
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, FABP4, FLT3, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 6.72332
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.71631
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 6.63934
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 6.44124
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, PIM1, SRC 6.39645
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT 6.33675
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 6.25989
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, ADRB1, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, SRC, TERT 6.18821
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB, SRC 6.13806
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.13806
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 6.13806
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRB1, APP, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.13806
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRB1, APP, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.13806
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRB1, AKR1C3, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 6.10818
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 6.10509
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 6.05013
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 6.04029
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.88478
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.87645
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APP, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 5.73908
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRB1, AKR1C3, APP, AURKB, CDC25B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 5.65681
[BP] GO:0010038 response to metal ion AKR1C3, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 5.61383
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.60438
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.57472
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 5.54636
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.52503
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.51005
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B1, HSD17B2 5.51005
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.45974
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRB1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 5.44426
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, ESRRB, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.33789
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CYP1B1, EGFR, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC 5.2798
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 5.27386
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRB1, APP, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.25685
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.25685
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRB1, APP, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.20599
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, APP, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, KIT, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 5.20599
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.19057
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.17757
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.16962
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, RORC, SRC 5.16883
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9, TERT 5.1654
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.09893
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.09893
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 5.07718
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 5.05724
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APP, EGFR, ERBB2, ESR1, FLT3, IGF1R, KIT, MMP2, PTGS2, SLC6A4, SRC 5.01765
[BP] GO:0032787 None AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 4.95054
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.94946
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, SRC 4.94946
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.92984
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.90102
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 4.89145
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 4.87073
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT 4.84657
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.70937
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 4.70484
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TYR, XDH 4.70484
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, APP, EGFR, ERBB2, FLT3, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 4.70484
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.70484
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.68323
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, KIT, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT, TYR 4.60607
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRB1, APP, AXL, CA2, CACNA1C, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A4, SRC, TERT, XDH 4.56574
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 4.55403
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, IGF1R, KIT, PIK3CB, PTPN1, SRC 4.5236
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 4.50639
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 4.49768
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, CYP1B1, EGFR, MMP9, PTGS1, PTGS2, SRC 4.49768
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 4.49519
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ERBB2, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, SRC, TYR 4.46418
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, EGFR, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.45078
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, KIT, PIK3CB, PTPN1, SRC 4.44678
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.39898
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 4.36584
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, EGFR, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.31187
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 4.26071
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB 4.22444
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.22153
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, KIT, PPARA, RORC, SLC6A4, SRC 4.21685
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, EGFR, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.21685
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, EGFR, KDR, PIK3CB, PTGS2, SRC 4.18328
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, EGFR, ERBB2, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT 4.13417
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TYR, XDH 4.08698
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, EGFR, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.08106
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ADRB1, APP, AURKB, CDC25B, EGFR, ERBB2, ESR1, ESR2, FLT3, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TERT, XDH 4.07235
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.07227
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, APP, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 4.07179
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.06167
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 4.04455
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT, PTGS2, SLC6A4 4.04053
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT, PTGS2, SLC6A4 4.04053
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRB1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 4.0129
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 4.00133
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.99918
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.99005
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, PTGS2, SLC6A2, SLC6A4, SRC 3.97634
[BP] GO:0003018 None ADORA1, ADRA2A, ADRB1, EGFR, PTGS2, SLC6A4, SRC 3.96724
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 3.95099
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.94649
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, ERBB2, MMP9 3.92179
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 3.92179
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, ERBB2, FLT3, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.912
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, KIT, PTPN1, SRC 3.912
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.90985
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.87512
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRB1, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.86681
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.86681
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.77825
[BP] GO:0044236 multicellular organism metabolic process ADRB1, AKR1C3, MMP1, MMP12, MMP2, MMP9 3.76581
[BP] GO:0006693 None AKR1C3, CES2, PTGS1, PTGS2 3.73207
[BP] GO:0006692 None AKR1C3, CES2, PTGS1, PTGS2 3.73207
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, KIT, MMP2, MMP9, PTGS2, SLC6A4, SRC 3.7244
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 3.71329
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.71057
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.70122
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 3.68482
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 3.68361
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, ERBB2, FLT3, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.68002
[BP] GO:0046834 lipid phosphorylation EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 3.67655
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.67655
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.67431
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.67431
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.67431
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC 3.62771
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.59578
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, KIT, PIK3CB, PTPN1, SRC 3.58071
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.57326
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, ERBB2, FLT3, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.57176
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.51775
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.51404
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.49811
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRB1, APP, AURKB, CDC25B, EGFR, ERBB2, ESR1, FLT3, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TERT, XDH 3.49811
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.49348
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 3.48604
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.47681
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, IGF1R, PIK3CA, PIK3CB 3.47681
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 3.45992
[BP] GO:0097746 None ADORA1, ADRA2A, ADRB1, EGFR, PTGS2, SLC6A4 3.44717
[BP] GO:0035296 None ADORA1, ADRA2A, ADRB1, EGFR, PTGS2, SLC6A4 3.44717
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 3.44717
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 3.42871
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, HSD17B1, HSD17B2 3.41067
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, APP, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.39497
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.3921
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.37668
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, PTGS2, SRC 3.3733
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 3.3714
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, EGFR, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.36607
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT 3.3507
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRB1, CACNA1C, EGFR, KCNH2, PTGS2 3.3468
[BP] GO:0050880 None ADORA1, ADRA2A, ADRB1, EGFR, PTGS2, SLC6A4 3.31406
[BP] GO:0035150 None ADORA1, ADRA2A, ADRB1, EGFR, PTGS2, SLC6A4 3.29848
[BP] GO:0003013 None ADORA1, ADRA2A, ADRB1, EGFR, PTGS2, SLC6A4, SRC 3.29848
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.29848
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.29111
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, CYP19A1, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.28838
[BP] GO:0019371 None AKR1C3, PTGS1, PTGS2 3.28838
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, IGF1R, KIT, PIK3CB, PTPN1, SRC 3.24721
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 3.17688
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, AKR1C3, APP, AXL, CDC25B, CES1, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT 3.1483
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRB1, AKR1B1, AXL, CACNA1C, CYP1B1, EGFR, ERBB2, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PTPN1, SRC 3.14112
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, ESR1, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.12781
[BP] GO:0038128 None EGFR, ERBB2, PIK3CA, SRC 3.12457
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRB1, APP, AXL, CA2, CYP1B1, EGFR, ESRRB, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 3.11999
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP19A1, CYP1A1, CYP1B1, TYR 3.08624
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 3.07854
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.07408
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.07203
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 3.06454
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 3.06454
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.06454
[BP] GO:0016488 None AKR1B10, AKR1C3 3.04933
[BP] GO:0016487 None AKR1B10, AKR1C3 3.04933
[BP] GO:0016107 None AKR1B10, AKR1C3 3.04933
[BP] GO:0009115 None AOX1, XDH 3.04933
[BP] GO:0006714 None AKR1B10, AKR1C3 3.04933
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.98945
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.98553
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AKR1C3, APP, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.96058
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, EGFR, ESR1, KIT, PTGS2, SLC6A4, SRC 2.95401
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.93719
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CACNA1C, EGFR, ERBB2, MMP12, PTGS2, PTPN1, SRC 2.93503
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT 2.91027
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.90065
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 2.89669
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 2.89368
[BP] GO:0030258 lipid modification CYP1A1, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 2.88201
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.87617
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.84737
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.84737
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1C3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.84351
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.8291
[BP] GO:0070920 None EGFR, ESR1, TERT 2.8291
[BP] GO:0071396 cellular response to lipid AKR1C3, AXL, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 2.73178
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, KIT, PTPN1, SRC 2.7269
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.67511
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, CA2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, KDR, KIT, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, XDH 2.65007
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, ERBB2, PPARA 2.64947
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.62431
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, EGFR, SLC6A4, SRC, TERT 2.62431
[BP] GO:0046110 None AOX1, XDH 2.62431
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.62431
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.62431
[BP] GO:0016095 None AKR1B10, AKR1C3 2.62431
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.62258
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, CACNA1C, KCNH2, MMP9, PTGS2, SLC6A4 2.62137
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.61548
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT 2.55712
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, APP, AXL, CYP1B1, EGFR, ERBB2, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.5164
[BP] GO:0003008 None ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, CYP1B1, EGFR, KCNH2, KIT, PIK3CA, PTGS2, SLC6A4, SRC, TYR 2.50697
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRB1, AKR1C3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.50609
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.49595
[BP] GO:0007584 response to nutrient AKR1C3, CYP1A1, EGFR, PTGS2, SLC6A4, TYR 2.49477
[BP] GO:0071229 cellular response to acid chemical AKR1C3, EGFR, KDR, MMP2, SLC6A4, SRC 2.48363
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, MET, PIK3CA 2.48309
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, IGF1R, MMP2, PTGS2, SLC6A4, SRC 2.45298
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.44758
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1C3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.44552
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.44552
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.44552
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRB1, CACNA1C, EGFR, KCNH2, KIT, PTGS2 2.42108
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.41173
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.41173
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.39643
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.39637
[BP] GO:0046488 phosphatidylinositol metabolic process EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 2.38644
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.38644
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, PTGS2, SLC6A4 2.38644
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.38644
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.37835
[BP] GO:0006644 phospholipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 2.37632
[BP] GO:0006145 None AOX1, XDH 2.37632
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.37632
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.37632
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.37136
[BP] GO:0006940 None ADORA1, ADRA2A, KIT, PTGS2 2.37136
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.35862
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.35606
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, KCNH2, PIK3CB 2.32903
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, EGFR, FLT3, KIT, MMP9, PIK3CA, PIK3CB, RORC, SRC 2.32612
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SRC, TERT 2.32552
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.32211
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.31453
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.29514
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.28314
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, IGF1R, MMP2, PTGS2, SLC6A4, SRC 2.2594
[BP] GO:0048545 response to steroid hormone AKR1C3, CA2, EGFR, FLT3, PTGS2, SRC 2.24735
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT 2.24034
[BP] GO:0009991 response to extracellular stimulus AKR1C3, AXL, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TYR 2.235
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.22536
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.22046
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2 2.21896
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.19945
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CES1, CYP19A1, CYP1A1, PTGS1, PTGS2 2.19502
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.19047
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.19047
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, PIK3CB, PTGS2 2.1892
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, KCNH2, MMP9, PTGS2 2.1892
[BP] GO:0050873 None ADRB1, FABP4, PTGS2 2.1892
[BP] GO:0071383 None AKR1C3, EGFR, FLT3, SRC 2.1892
[BP] GO:0061097 None ADORA1, ADRA2A, APP, PTPN1 2.1892
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, ERBB2, FABP3, PTGS2, SLC6A4, TERT, XDH 2.18721
[BP] GO:1901342 regulation of vasculature development CYP1B1, ERBB2, KDR, KIT, PTGS2, TERT, XDH 2.16166
[BP] GO:0007176 None ADORA1, ADRA2A, APP 2.15093
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.15093
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, KIT, PIK3CA 2.1311
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.1311
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, CA2, CYP19A1, ERBB2, ESR1, ESRRA, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.12036
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.11317
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.11317
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.11317
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.10741
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, PIK3CB, SRC, XDH 2.10298
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.09958
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.09958
[BP] GO:0008217 None ADORA1, ADRB1, PPARA, PTGS1, PTGS2 2.09958
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, CACNA1C, CSNK2A1, EGFR, ERBB2, MMP12, PTGS2, PTPN1, SRC, TERT 2.09706
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.08905
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.08905
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, AKR1C3, EGFR, ESR1, FLT3, KIT, SRC 2.08905
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, XDH 2.08905
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.08535
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 2.08107
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.06766
[BP] GO:0046113 None AOX1, XDH 2.06466
[BP] GO:0051934 None SLC6A2, SLC6A4 2.06466
[BP] GO:0090494 None SLC6A2, SLC6A4 2.06466
[BP] GO:0090493 None SLC6A2, SLC6A4 2.06466
[BP] GO:0051583 None SLC6A2, SLC6A4 2.06466
[BP] GO:0016115 None AKR1B10, AKR1C3 2.06466
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19 2.06466
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC 2.06223
[BP] GO:0033273 response to vitamin CYP1A1, EGFR, PTGS2, TYR 2.06223
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.06223
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.06223
[BP] GO:0031960 response to corticosteroid AKR1C3, EGFR, FLT3, PTGS2, SRC 2.04691
[BP] GO:0038127 None EGFR, ERBB2, PIK3CA, SRC 2.04649
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PTGS2 2.04649
[BP] GO:1901989 None APP, CDC25B, CYP1A1, TERT 2.03025
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.03025
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, KIT 2.03025
[BP] GO:0010907 None ESRRB, PPARA, SRC 2.03025
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, ERBB2 3.52036
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 3.45289
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KCNH2, KDR, KIT, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A4, SRC, TERT, TYR, XDH 3.3733
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ADRB1, APP, AXL, CA2, CA4, CA9, CACNA1C, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PTGS2, SLC6A2, SLC6A4, SRC 2.6091
[CC] GO:0045121 membrane raft APP, EGFR, KDR, PTGS2, SLC6A2, SLC6A4, SRC 2.42471
[CC] GO:0098857 membrane microdomain APP, EGFR, KDR, PTGS2, SLC6A2, SLC6A4, SRC 2.41173
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FLT3, HSD17B2, PTGS1, PTGS2, PTPN1 2.29726
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, FLT3, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TYR 2.19922
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.06466
[CC] GO:0098589 membrane region APP, EGFR, KDR, PTGS2, SLC6A2, SLC6A4, SRC 2.03027
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.6859
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 11.915
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR, XDH 10.0966
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0966
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 7.58772
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 7.58772
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 7.30319
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 7.17603
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.00518
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 6.94822
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.58963
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, TYR 6.10509
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC 5.9204
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.75517
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP9, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 5.67247
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.58612
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, SRC 5.53045
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.44576
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.44576
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR, KIT 5.44436
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, SRC 5.32392
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, SRC 5.20599
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 5.17757
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 5.10635
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.05087
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 4.92984
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.92984
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 4.87111
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 4.80275
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 4.70484
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 4.69507
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 4.69445
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 4.56574
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 4.54928
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 4.34227
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.28009
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD17B1, HSD17B2, XDH 4.28009
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.23796
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.21685
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 4.17335
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, ADRB1, AOX1, AXL, EGFR, ERBB2, FLT3, KCNH2, KIT, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 4.10129
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 3.99982
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.92611
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73207
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.7272
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 3.64367
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.54946
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRB1, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.51404
[MF] GO:0019899 enzyme binding ADRA2A, ADRB1, APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRB, KCNH2, KIT, MET, PPARA, PTGS2, PTPN1, SLC6A4, SRC 3.31932
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.28838
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, NQO2 3.08094
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.04933
[MF] GO:0045550 None AKR1B10, AKR1C3 3.04933
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.04933
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, KCNH2, KIT, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 3.02807
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.78433
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, XDH 2.67945
[MF] GO:0047718 None AKR1B10, AKR1C3 2.62431
[MF] GO:0005330 None SLC6A2, SLC6A4 2.62431
[MF] GO:0047374 None CES1, CES2 2.62431
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.55632
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD17B1, HSD17B2 2.46693
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, KDR, KIT 2.42471
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTPN1, SRC 2.39643
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.37632
[MF] GO:0032795 None ADORA1, ADRA2A 2.37632
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC 2.29775
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.26546
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2 2.22255
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.19047
[MF] GO:0051380 None ADRA2A, ADRB1 2.19047
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, CA1, CA2, CES1, CES2 2.17874
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2 2.15093
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, XDH 2.11094
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, XDH 2.10941
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.08528
[MF] GO:0005329 None SLC6A2, SLC6A4 2.06466
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06466
[MF] GO:0043546 None AOX1, XDH 2.06466
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.06466


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.3807
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, ERBB2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 8.5759
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.3807
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, ADRB1, PIK3CB, PTGS2, PTGS1 7.6482
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2 7.5399
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, KIT, ERBB2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 7.1014
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 7.6347
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, ERBB2, PIK3CB, MET, EGFR 7.3295
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 7.1305
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 7.1305
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, CACNA1C, PTGS2, CYP2C19, PTGS1, SLC6A4 5.9559
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, ERBB2, KDR, PIK3CB, MET, EGFR, IGF1R 5.4118
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KIT, KDR, PIK3CB, MET, EGFR, IGF1R 5.3024
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, ERBB2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 5.2607
Metabolic pathways_Homo sapiens_hsa01100 AKR1C3, AKR1B1, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 4.8462
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, ADRB1, CACNA1C, PIK3CB, ADRA2A 4.937
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.937
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.8462
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3, PTGS2, CYP2C19, PTGS1 4.8345
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5627
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, EGFR, IGF1R 4.2314
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.5538
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 4.1329
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, ERBB2, PIK3CB, EGFR, IGF1R 4.1927
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R 3.9311
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, ERBB2, PIK3CB, EGFR 4.224
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 4.2948
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, ERBB2, PIK3CB, EGFR, IGF1R 3.9311
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, ADRB1, CACNA1C, PIK3CB, PPARA 3.6419
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KIT, KDR, PIK3CB, MET, EGFR, IGF1R 3.2945
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.5415
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.2314
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, ERBB2, PIK3CB, EGFR 3.7706
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, ERBB2, PIK3CB, EGFR 3.8844
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, ERBB2, PIK3CB, EGFR 3.5284
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.8935
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 3.0452
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.9329
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, CACNA1C, PIK3CB 2.7781
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.7833
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7833
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2929
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4652
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6692
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.7058
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.7058
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.6874
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, EGFR, IGF1R 2.5459
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.5459
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.4626
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PIK3CB, EGFR 2.4578
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.4508
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, ADRB1, CACNA1C, PIK3CB 2.4362
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.3667
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.3667
Calcium signaling pathway_Homo sapiens_hsa04020 ERBB2, ADRB1, CACNA1C, EGFR 2.1873
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1873
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.9678
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4626
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.0572
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.096
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRB1, ADRA2A 1.6304
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.4626
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4508
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 2.0322
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.1873
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7254
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6182
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.4578
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.7049
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.8726
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.8242
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.7506
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 2.1708
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.3346
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.343
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3535
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3526
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3227
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.4313
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4072
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.3667
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.7833
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.4201
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4222
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.461
Axon guidance_Homo sapiens_hsa04360 MET 0.4554
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.461
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4527
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.1403
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 1.1318
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.467
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4824
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.841
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.983
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8668
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9846
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0027
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0158
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5236
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5403
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5394
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.0845
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5403
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5505
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5516
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1686
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.198
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5528
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2427
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.198
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1795
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5699
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1795
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2056
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5528
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.564
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 1.1943
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5699
Peroxisome_Homo sapiens_hsa04146 XDH 0.5699
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2427
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2736
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2736
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.2601
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5699
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5812
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5981
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5981
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6066
Bile secretion_Homo sapiens_hsa04976 CA2 0.6045
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5981
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4058
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4058
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.6229
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.6203
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4449
Shigellosis_Homo sapiens_hsa05131 SRC 0.6254
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4145
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6254
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6501
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5328
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.5107
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5418
Malaria_Homo sapiens_hsa05144 MET 0.7272
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7368
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7319
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7414
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.8511
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9462
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.035
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.9263
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9201
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 2.0572
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9914
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.908
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9097
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9462
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2144
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3379
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4684


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)