TCM Prescription: Xiao Er Tong Ding



Prescription Description
Prescription IDTCMF6014
Pinyin NameXiao Er Tong Ding
Chinese Name消尔痛酊
English NameXiao Er Tong Ding
Function Description痹病, 跌打损伤
IndicationsArthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH296 Radix aconiti 川乌 TCMH296
TCMH1405 Strychnos nux-vomica 马钱子 TCMH1405 PPBI045-16
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH508 NA 动物多肽 TCMH508
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 10.2377
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PRKCD, SRC, TYR 9.64972
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PRKCD, SRC, TERT, TYR 8.95256
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, PRKCD, SRC, TYR 8.91061
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, SRC, TYR 8.80841
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.71672
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 8.61179
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, NR3C1, PRKCD, SRC 8.47935
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PRKCD, SRC, TERT 7.65299
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, PRKCD, SRC 7.54033
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.10326
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.03535
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PGR, PIM1, SRC, TERT, XDH 7.03535
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PRKCD, SRC, TERT 7.03535
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET 7.03535
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, SRC, TYR 7.03535
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 7.03535
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.90942
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, PRKCD, SRC, TERT, TNKS, TNKS2, XDH 6.70742
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.66496
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, SRC 6.56755
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.53114
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, PRKCD, SRC, TERT, TNKS2, TYR 6.48724
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.31602
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.29257
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, PRKCD, SRC 6.28213
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 6.28213
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.01096
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, SRC 5.71543
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, SRC, TYR 5.66418
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC, TNKS 5.58525
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, SRC 5.5793
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT, XDH 5.48659
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PRKCD, SRC 5.37694
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PRKCD, SRC 5.32566
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT 5.26245
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PRKCD, PTPN1, SRC, TERT 5.26245
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.24034
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, TERT 5.1783
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, PRKCD, SRC, TYR 5.13219
[BP] GO:0010941 regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT, XDH 5.01672
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PGR, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.96606
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.88317
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.88317
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT 4.79611
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.79611
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.78304
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR 4.77869
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, SRC, TYR 4.77504
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PIM1, TYR, XDH 4.7538
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.71627
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PGR, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.68333
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PGR, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.646
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, NR3C1, PRKCD, SRC 4.61183
[BP] GO:0009893 positive regulation of metabolic process APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PGR, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.59615
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC, TNKS 4.50605
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PRKCD, SRC 4.50061
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42243
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, PRKCD, SRC, TNKS, TNKS2 4.42162
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, XDH 4.38803
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, KIT, MET, MMP2, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.38803
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT, XDH 4.31611
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PGR, SRC 4.27804
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.2763
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, PRKCD, SRC 4.15265
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR 4.08346
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PRKCD, SRC, TERT 4.08346
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, SRC 3.94957
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT 3.90635
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, PTPN1, SRC, TNKS, XDH 3.9007
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 3.88503
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PRKCD, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.86098
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.7227
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT 3.70106
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 3.70106
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.66075
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PRKCD, SRC, TNKS2, TYR 3.65927
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.64524
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, PTPN1, SRC, TNKS, XDH 3.62221
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, KIT, MET, MMP2, MMP9, PGR, PRKCD, SRC, TERT 3.60979
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PRKCD, PTPN1, SRC, TERT, TYR 3.57898
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.54743
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.54743
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.54743
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.51896
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.51896
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PRKCD, SRC, TERT, TNKS 3.50469
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, XDH 3.48611
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DNMT1, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, PRKCD, SRC 3.46787
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, SRC 3.43757
[BP] GO:2000145 regulation of cell motility APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.41425
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.40878
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.37043
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, KDR, KIT, MET, PTPN1, SRC, XDH 3.36154
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.33767
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.33705
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.32878
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.23784
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SRC, XDH 3.22188
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, PRKCD, SRC 3.22174
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, PRKCD, SRC 3.21872
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.21872
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.21843
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PGR, SRC 3.21535
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.21045
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21045
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PRKCD, SRC, TNKS 3.18131
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.15212
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 3.12517
[BP] GO:0040012 regulation of locomotion APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.12123
[BP] GO:0051270 regulation of cellular component movement APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.10845
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.09719
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.09719
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.09719
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.09719
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCD, TNKS 3.09046
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, PRKCD, SRC 3.06816
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, PRKCD, SRC, TNKS, TNKS2 3.06816
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PRKCD, PTPN1, SRC, XDH 3.05131
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, NR3C1, PGR, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2 3.05131
[BP] GO:0030334 regulation of cell migration APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.04034
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.98033
[BP] GO:0009892 negative regulation of metabolic process APP, AR, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.98033
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.95003
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCD, TNKS 2.93507
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89782
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.87265
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.87265
[BP] GO:0009115 None AOX1, XDH 2.85697
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.8269
[BP] GO:0051247 positive regulation of protein metabolic process APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.82341
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, KIT, MET 2.82169
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.82059
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, NR3C1, PGR, PRKCD, SRC, TERT, TNKS, TNKS2 2.80598
[BP] GO:0007165 signal transduction AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.80295
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CDK6, CYP19A1, DYRK1A, ESR1, F3, FABP4, IGF1R, MET, MMP2, PRKCD, PTPN1, SRC, TERT, XDH 2.77612
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.74478
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 2.73414
[BP] GO:0042327 positive regulation of phosphorylation APP, AR, BCL2, CDC25B, ESRRB, FLT3, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.73125
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.71859
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, PRKCD, SRC, TNKS 2.71354
[BP] GO:0032879 regulation of localization ABCB1, ACHE, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCD, PTPN1, SRC, TERT 2.71354
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.67246
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP9, NR3C1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.66817
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PRKCD, PTPN1, SRC, TNKS 2.65554
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.64875
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.60211
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.60211
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MMP9, NR3C1, PGR, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.60211
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, KDR, SRC, TNKS, TNKS2 2.59664
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.5706
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.55415
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.54062
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.53242
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.53026
[BP] GO:0031401 positive regulation of protein modification process APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.52305
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, PRKCD, SRC, TNKS 2.49721
[BP] GO:0051128 regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, CSNK2A1, DNMT1, ESR1, ESR2, IGF1R, KDR, KIT, MET, MMP1, MMP9, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.49211
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.4864
[BP] GO:0060748 None AR, PGR 2.48606
[BP] GO:0046110 None AOX1, XDH 2.48606
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48606
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PRKCD, SRC, TYR 2.48371
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.46481
[BP] GO:0043412 macromolecule modification ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, NR3C1, PIM1, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.44704
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.43288
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, NR3C1, PGR, PRKCD, SRC, TERT, TNKS, TNKS2 2.40353
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.39325
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.37549
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.36213
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD 2.35264
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.33768
[BP] GO:0001934 positive regulation of protein phosphorylation APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.32462
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.32462
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.32462
[BP] GO:0019222 regulation of metabolic process ACHE, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.31659
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PRKCD, SRC 2.31305
[BP] GO:0010648 negative regulation of cell communication ACHE, AR, BCL2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PRKCD, PTPN1, SRC, TERT, XDH 2.28536
[BP] GO:0023057 negative regulation of signaling ACHE, AR, BCL2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PRKCD, PTPN1, SRC, TERT, XDH 2.27452
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.27452
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.27271
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.24379
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.24238
[BP] GO:0070213 None TNKS, TNKS2 2.24238
[BP] GO:0006145 None AOX1, XDH 2.24238
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24238
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PRKCD, SRC, TYR 2.24142
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.24142
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, NR3C1, PGR, SRC, TERT, TNKS, TNKS2 2.24142
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC, XDH 2.24142
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTPN1, SRC, TERT 2.24142
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.23872
[BP] GO:0048585 negative regulation of response to stimulus AR, BCL2, CDK6, CYP19A1, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PRKCD, PTPN1, SRC, TERT, XDH 2.22539
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCD, PTPN1, SRC 2.22539
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, ESR1, KIT, PGR, SRC 2.21535
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.19899
[BP] GO:0042325 regulation of phosphorylation APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.17164
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.15064
[BP] GO:0051172 None APP, AR, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MMP9, NR3C1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.14722
[BP] GO:0065009 regulation of molecular function ABCB1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, XDH 2.14722
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, SRC 2.14618
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.1455
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.1455
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, KIT, MMP2, SRC, TERT, TYR 2.14346
[BP] GO:0050790 regulation of catalytic activity APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, KIT, MMP9, PRKCD, PTPN1, SRC, TERT, TNKS, XDH 2.13006
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1 2.12323
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.11912
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 2.09692
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PRKCD, PTPN1, SRC, TERT, XDH 2.09052
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.08855
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 2.08392
[BP] GO:0043408 regulation of MAPK cascade APP, AR, FLT3, IGF1R, KDR, KIT, PRKCD, PTPN1, SRC, XDH 2.08103
[BP] GO:0043696 None CDK6, ESRRB 2.08103
[BP] GO:0043697 None CDK6, ESRRB 2.08103
[BP] GO:0010641 None F3, SRC 2.08103
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.08103
[BP] GO:0050730 None APP, FLT3, KIT, PRKCD, PTPN1, SRC 2.07682
[BP] GO:0019220 regulation of phosphate metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.06798
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.06382
[BP] GO:0040007 None APP, AR, BCL2, CYP19A1, ESR1, SRC, TNKS2 2.06382
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.04355
[BP] GO:0001932 regulation of protein phosphorylation APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.04215
[BP] GO:0051174 regulation of phosphorus metabolic process APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PRKCD, PTPN1, SRC, XDH 2.03636
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.02637
[BP] GO:0032870 cellular response to hormone stimulus AR, ESR1, FLT3, KIT, NR3C1, PRKCD, SRC 2.02402
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.01654
[BP] GO:0080090 regulation of primary metabolic process APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.01654
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.01096
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PRKCD, PTPN1, SRC, TNKS, TNKS2 2.00097
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.82341
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 2.53165
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTPN1 2.26735
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.23019
[CC] GO:0005654 None AKR1B1, ALOX5, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PIM1, PRKCD, SRC, TERT, TNKS 1.95399
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, TNKS, TYR, XDH 16.348
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 11.8927
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PRKCD, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 10.8337
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1169
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR 9.23243
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PTPN1, TNKS 8.89149
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR 7.65299
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, TERT, TNKS, TNKS2, TYR, XDH 7.28148
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, TERT, TNKS, TNKS2, TYR, XDH 7.00626
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.48177
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.60773
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PRKCD, SRC 5.47081
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR 5.27959
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR 5.27959
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.24057
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR 4.96807
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.77504
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.65074
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC 4.38803
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.2483
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.70106
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.70106
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC 3.59246
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC 3.53651
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.53651
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.48611
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.38743
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.38041
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.36154
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, PGR, TERT, TYR, XDH 3.32042
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC 3.26021
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC, TERT 3.21872
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 2.93507
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85697
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85697
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, ESR1, ESR2, ESRRB, F3, KIT, MET, NR3C1, PGR, PRKCD, PTPN1, SRC, TNKS2 2.81741
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.79813
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.76375
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.74569
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC, XDH 2.70677
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC, XDH 2.55086
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC, XDH 2.55086
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, SRC, XDH 2.55086
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.53165
[MF] GO:0038023 signaling receptor activity AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR 2.53165
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PRKCD, PTPN1, SRC 2.4219
[MF] GO:0060089 molecular transducer activity AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR 2.38659
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.24379
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24238
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.13303
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCD, SRC, XDH 2.12323
[MF] GO:1901363 heterocyclic compound binding ABCB1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, XDH 2.09496
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08103
[MF] GO:0097159 organic cyclic compound binding ABCB1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTPN1, SRC, TERT, XDH 2.06798
[MF] GO:0004872 receptor activity AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR 2.06576


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2725
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.1751
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0742
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 4.9606
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.9606
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.743
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, ESR2 4.8333
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2879
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2879
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PRKCD, BCL2, PIM1, F3 3.7493
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0142
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.012
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.086
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.453
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, MET, IGF1R 2.2964
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.3931
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9512
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.1463
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.1406
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.2805
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1463
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.1406
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.1225
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1221
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9385
Prostate cancer_Homo sapiens_hsa05215 AR, BCL2, IGF1R 1.9062
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD 1.8938
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.1406
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.817
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.6866
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.6308
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.5031
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.369
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.5031
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2804
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3226
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD 1.031
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0232
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9731
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1094
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.008
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCD 0.9792
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3398
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2629
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0996
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0641
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.179
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2603
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9731
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9543
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2462
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.9535
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9543
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9543
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8732
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8471
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9367
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6655
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.76
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.724
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, PRKCD 0.6946
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6655
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, NR3C2 1.6308
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 NR3C1 0.2327
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.249
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.249
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2971
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6866
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.791
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3392
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3519
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3617
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4074
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3806
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4074
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3991
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4062
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4049
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4178
Platelet activation_Homo sapiens_hsa04611 SRC 0.437
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.439
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.435
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4626
Axon guidance_Homo sapiens_hsa04360 MET 0.4303
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD 0.439
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5168
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.5088
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5088
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5088
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5088
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5167
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5168
Gap junction_Homo sapiens_hsa04540 SRC 0.5168
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5168
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5622
Peroxisome_Homo sapiens_hsa04146 XDH 0.5262
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7491
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6866
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5615
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5406
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9465
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5924
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5924
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5924
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5795
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6015
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.624
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5983
Shigellosis_Homo sapiens_hsa05131 SRC 0.5924
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.624
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5983
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6513
Malaria_Homo sapiens_hsa05144 MET 0.6623
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6655
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCD 0.6655
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6655
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6655
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6655
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6655
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6655
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.777
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7986
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7986
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8254
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8159
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0485
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9535
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0019
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2695


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)