TCM Prescription: Yang Xin Ning Shen Pills



Prescription Description
Prescription IDTCMF5974
Pinyin NameYang Xin Ning Shen Wan
Chinese Name养心宁神丸
English NameYang Xin Ning Shen Pills
Function Description心悸, 不寐, 耳鸣, 眩晕
IndicationsTinnitus disorder, Vertigo disorder, Insomnia disorder, Insomnia, Tinnitus, Palpitations, Dizziness
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC41 [Tinnitus, 耳鸣 ];
MC81.2 [Palpitations, 心悸 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1275 Nelumbo nucifera 莲子 TCMH1275 ITSAI3109-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
TCMH1329 Arillus longan 龙眼肉 TCMH1329
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 13.0637
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, INSR, KCNH2, KDR, MET, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 13.0637
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTAFR, RORC, SLC6A4, SRC, TEK, TYR 13.0637
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTAFR, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 12.4649
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTAFR, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 11.1691
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 11.14
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.188
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.188
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.0728
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FLT3, PTAFR, RORC, SLC6A4, SRC, TEK, TYR 10.0728
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, SLC6A4, SMAD3, SRC, TEK 10.0429
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 9.9465
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.66038
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.63113
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PTAFR, RORC, SLC6A4, SMAD3, SRC, TERT 9.25124
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 9.06145
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, SMAD3, SRC, TERT 8.63289
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 8.60294
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HMGCR, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, TEK, TERT 8.5266
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 8.49414
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 8.49414
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 8.43487
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 8.36813
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.36813
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.34868
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B2, MET, PPARA 8.32464
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PTAFR, SLC6A4, SRC, TEK 8.32464
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.99587
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, HMGCR, KDR, SLC6A4, SRC 7.89102
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 7.89102
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.7967
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.77045
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A 7.61627
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.59003
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HMGCR, KCNH2, KDR, PTAFR, SLC6A2, SLC6A4, SRC 7.59003
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PTAFR, RORC, SLC6A4, SMAD3, SRC 7.58063
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.58063
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, HMGCR, HSD11B1, HSD17B2 7.54671
[BP] GO:0003018 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4, SRC, TEK 7.42916
[BP] GO:0007188 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8, HTR1A 7.40708
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, INSR, SLC1A1, SLC6A2, SLC6A4, SMAD3 7.40679
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, SMAD3 7.40251
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, INSR, KCNH2, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SMAD3, SRC, TERT 7.23335
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 7.20049
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 7.17358
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 7.15235
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.15162
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8 7.15162
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.12769
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.06603
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.02636
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 7.01325
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 7.01325
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTAFR, RORC, SLC6A4, SRC, TYR 7.01325
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, PTAFR, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 7.00508
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.91913
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.85102
[BP] GO:0007187 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8, HTR1A 6.80555
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.79855
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FUT7, GLO1, HMGCR, HSPA1A, PIM1, PPARA, PTAFR, TYR, XDH 6.74798
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, SLC6A4, SRC, TEK, TYR 6.67991
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 6.66758
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.62837
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.62837
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.62837
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 6.60806
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.57092
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.50158
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.4458
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.44099
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 6.43616
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.42611
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC, TERT 6.39396
[BP] GO:0003013 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4, SRC, TEK 6.39012
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.37526
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 6.29797
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 6.23646
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, SLC6A4, SRC, TEK, TYR 6.22865
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 6.10242
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HMGCR, HTR1A, PTAFR, TYR 6.08703
[BP] GO:0097746 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 6.06102
[BP] GO:0035296 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 6.06102
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK 6.04067
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, DRD5, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PTAFR, RORC, SLC6A4, SRC 6.02729
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 6.02729
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, PTAFR, RORC, SLC6A4, SRC 6.00653
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.9824
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 5.97692
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, KCNH2, MMP12, PTAFR, SLC6A4, SMAD3, SRC, TERT 5.92059
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PPARA 5.91681
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A 5.90814
[BP] GO:0050880 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 5.86442
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.8615
[BP] GO:0035150 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 5.84298
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.67997
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 5.677
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTAFR, PTPN1, SRC, TEK, XDH 5.65281
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.52984
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.49929
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, BCL2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.47906
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PTAFR, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.4674
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 5.45364
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HMGCR, KDR, SRC 5.42684
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK 5.37182
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 5.3314
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA, PTAFR 5.30399
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH 5.26076
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTAFR, PTPN1, SRC, TEK, XDH 5.26076
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTAFR, SLC1A1, SMAD3, SRC, TEK, TERT 5.25473
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, KCNH2, SMAD3 5.23257
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, RORC 5.18957
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.15454
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, TERT 5.1523
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, DRD1, DRD5, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTAFR, SLC6A4, SMAD3, SRC 5.13002
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.08627
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.01354
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 5.00885
[BP] GO:0007268 None DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.00147
[BP] GO:0098916 None DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.00147
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, GRM5, HTR1A, KCNH2, MMP9, PTAFR, SLC6A4 5.00147
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC, TEK 4.99839
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.98085
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.98085
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.96767
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.95628
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, HMGCR 4.9403
[BP] GO:0099536 None DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.93048
[BP] GO:0099537 None DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.93048
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, DRD5, ESRRB, GRM3, GRM8, INSR, PPARA 4.93048
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 4.92806
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.91972
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 4.87852
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.84753
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, DRD5, ESRRB, GRM3, GRM8, INSR, PPARA 4.82896
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HMGCR, HTR1A, INSR, KCNH2, PTAFR, SLC6A4, SRC, TEK, TYR 4.82638
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 4.80064
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, SMAD3 4.75888
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.75867
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.73725
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.7043
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.69504
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 4.68688
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, SLC6A4, SRC 4.67859
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.66739
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, GPR35, KCNH2, MMP9 4.59579
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.53811
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 4.51206
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.47899
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.47899
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, MMP12, PTAFR, SLC6A4, SRC 4.46267
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, SMAD3, TEK 4.44586
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 4.44586
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 4.44497
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42754
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.41149
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HMGCR, INSR, SLC6A4 4.40791
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 4.39975
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5, SLC6A4 4.36867
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, DRD2, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 4.36867
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.36372
[BP] GO:0023052 None ADORA1, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2, TEK 4.35916
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 4.35916
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, SLC6A4, SRC 4.35718
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 4.32393
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, KCNH2, PTAFR, SLC1A1, SMAD3 4.30704
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.30505
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.30059
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 4.30016
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KCNH2, KDR, PTAFR, SRC 4.29554
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.27665
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, DRD2, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 4.22857
[BP] GO:0032225 None DRD1, DRD2, DRD3, SLC6A4 4.19441
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 4.18758
[BP] GO:0007267 None ADORA1, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 4.18758
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, SMAD3 4.17307
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 4.172
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 4.16317
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA 4.14303
[BP] GO:0007610 None BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, HMGCR, HTR1A, INSR, PPARA, SLC6A4 4.14303
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.14153
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, MMP12, PTAFR, SLC6A4, SRC 4.12915
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA 4.12915
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.12346
[BP] GO:0097756 None ADORA1, DRD5, HMGCR, HTR1A, SLC6A4 4.12346
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA 4.11932
[BP] GO:0030814 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 4.09683
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 4.07946
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 4.05938
[BP] GO:0030802 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 4.02774
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MMP12, PTAFR, SLC6A4, SRC 4.02774
[BP] GO:0007611 None DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HMGCR, INSR, SLC6A4 4.02763
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.00823
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.00823
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.99309
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 3.96485
[BP] GO:0007154 None ADORA1, AXL, BCL2, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.94352
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.88111
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.87216
[BP] GO:0042391 None ADORA1, BCL2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 3.85104
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, PTAFR, SLC6A4, SRC, TOP2A 3.84908
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, DRD5, GRM3 3.84103
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, TERT 3.84103
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.83438
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B2 3.83116
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.82581
[BP] GO:1900371 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 3.82525
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.80617
[BP] GO:0030808 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 3.80617
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.80557
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.80122
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, HSD11B1, HSD17B2, TYR, XDH 3.79859
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC 3.7902
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.78874
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.7666
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.76629
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.76613
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.76538
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.72693
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.70345
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 3.70345
[BP] GO:0007200 None ADRA2A, DRD1, DRD2, DRD5, ESR1, GRM5 3.70146
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A 3.70146
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, GRM5, HMGCR, INSR 3.70146
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PTAFR, PTPN1, SRC, TEK 3.69615
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.69615
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.69615
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A 3.65746
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.65662
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A, SLC6A4 3.62863
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, CA2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, INSR, PTAFR, SRC 3.61831
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SLC6A4, SMAD3, SRC, TERT, TOP2A 3.61092
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 3.5923
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 3.58021
[BP] GO:0010676 None ESRRB, INSR, PPARA, PTAFR, SRC 3.58021
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.56895
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4 3.5596
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 3.5596
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.53533
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.53357
[BP] GO:0034762 None ADRA2A, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, GRM5, KCNH2, MMP9, PTAFR 3.53357
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.50859
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, HMGCR, PPARA, SMAD3, TEK 3.50555
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 3.47191
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, PPARA, PTAFR, SMAD3 3.47188
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.46164
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.46164
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A 3.44006
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.43035
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 3.42647
[BP] GO:0055065 metal ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, SMAD3 3.42647
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.42492
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.40513
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.3978
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.3747
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3 3.36106
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 3.35532
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 3.35506
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.327
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 3.28699
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.28162
[BP] GO:0031279 None ADRA2A, DRD2, DRD3, DRD5, GRM3 3.27781
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.27623
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 3.27503
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A 3.27443
[BP] GO:0022898 None ADRA2A, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PTAFR 3.26053
[BP] GO:0051339 None ADRA2A, DRD2, DRD3, DRD5, GRM3 3.25103
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.23577
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.23368
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.23368
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PPARA 3.22437
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3 3.20604
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.20383
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.20378
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.20378
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.19784
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 3.19648
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 3.19127
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, KDR 3.1872
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.1872
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.17928
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.16924
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 3.15783
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 3.15604
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.14374
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.14374
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 3.13387
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.12476
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, GRM3 3.12288
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.12288
[BP] GO:0045936 None ADRA2A, DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 3.12032
[BP] GO:0010563 None ADRA2A, DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 3.11474
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, TERT 3.11474
[BP] GO:0032409 None ADRA2A, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PTAFR 3.11384
[BP] GO:0045913 None ESRRB, INSR, PPARA, PTAFR, SRC 3.09321
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, SLC6A4, SRC 3.08733
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.08402
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.07939
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.0682
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 3.06671
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, GRM3 3.03137
[BP] GO:0008306 None DRD1, DRD2, DRD3, DRD5, HMGCR 3.01219
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR 3.00019
[BP] GO:0010675 None ESRRB, INSR, PPARA, PTAFR, RORC, SRC 3.00019
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC 2.98852
[BP] GO:0007189 None ADRA2A, DRD1, DRD2, DRD3, DRD5 2.98852
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.98852
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.96638
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, GRM3 2.94126
[BP] GO:0046960 None DRD1, DRD5 2.94048
[BP] GO:0009115 None AOX1, XDH 2.94048
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.91557
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HMGCR, HSD11B1, HSD17B2 2.91413
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.91413
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CES1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.91413
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 2.90464
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.90464
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.90223
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.90223
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3 2.89254
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.89254
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CYP19A1, DRD2, EGFR, HCAR2, HMGCR, HTR1A 2.89254
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.88187
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.87576
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.87576
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.87155
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 2.86915
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK 2.85432
[BP] GO:0051172 None ADRA2A, APEX1, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.83041
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, MMP12, PTAFR, SLC6A4, SRC 2.79119
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.78353
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.78353
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT 2.78214
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 2.78214
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.75854
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, SRC 2.75587
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC, SLC6A4 2.75587
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 2.75545
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A 2.75211
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A 2.7487
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.73428
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.71606
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.71513
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.70626
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.70417
[BP] GO:0050877 None ADORA1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, SLC6A4, TYR 2.69329
[BP] GO:0090066 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 2.69128
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.68565
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.68565
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.68565
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.68565
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, HMGCR, TYR 2.68418
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, DRD2, EGFR, KCNH2, PTAFR, SLC1A1 2.68418
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HMGCR, SRC 2.64072
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD5, PTAFR 2.63198
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.63198
[BP] GO:0070920 None EGFR, ESR1, TERT 2.63198
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.61704
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR, PTAFR 2.61332
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.59799
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 2.5891
[BP] GO:0019933 None ADRA2A, DRD1, DRD2, DRD3, DRD5 2.57076
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.56777
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTAFR, SRC 2.5609
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.55911
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 2.54438
[BP] GO:0099566 None GRM1, GRM5 2.54438
[BP] GO:0046110 None AOX1, XDH 2.54438
[BP] GO:0060160 None DRD2, DRD3 2.54438
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54438
[BP] GO:0032412 None ADRA2A, DRD2, DRD3, GPR35, GRM5, MMP9, PTAFR 2.53541
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, PTPN1, SMAD3, SRC 2.53083
[BP] GO:0008542 None DRD1, DRD2, DRD3, HMGCR 2.52729
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.49898
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTAFR, SRC 2.49126
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.47918
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.47421
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, GPR35, HMGCR, HSPA1A, KCNH2, MMP9 2.47421
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, KCNH2 2.43933
[BP] GO:0050730 None ADORA1, ADRA2A, EGFR, FLT3, GRM5, PTPN1, SRC 2.43652
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.43225
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.43225
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, DRD2, EGFR, GRM1, INSR, PTPN1, SRC 2.43108
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, XDH 2.43087
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.42681
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TERT 2.42681
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.40883
[BP] GO:0019935 None ADRA2A, DRD1, DRD2, DRD3, DRD5 2.40883
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.40863
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CES1, CYP19A1, HMGCR, PTAFR, TYR 2.40198
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, XDH 2.40039
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.39473
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.39473
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.39473
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.39473
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.39243
[BP] GO:0007632 None DRD1, DRD2, DRD3, HMGCR 2.38335
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.38147
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.38147
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.38147
[BP] GO:0043270 None ADORA1, ADRA2A, DRD1, DRD2, KCNH2, PTAFR, SLC6A4 2.37852
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.36155
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.3595
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, SLC6A2 2.3595
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.3595
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.33789
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.32996
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.32468
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.32468
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR 2.32468
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.32063
[BP] GO:0050708 None ACHE, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, SRC 2.30544
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.30454
[BP] GO:0034765 None ADRA2A, DRD1, DRD2, DRD3, GPR35, GRM5, KCNH2, MMP9, PTAFR 2.29587
[BP] GO:0006145 None AOX1, XDH 2.29587
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29587
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.28347
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, PTPN1, SRC 2.27818
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.27818
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.27818
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.27818
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, INSR, PPARA, PTAFR, RORC, SRC 2.26763
[BP] GO:0010628 positive regulation of gene expression DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, PTAFR, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 2.26281
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, SLC6A4, SRC, TYR 2.26145
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.26023
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.23387
[BP] GO:0060341 regulation of cellular localization ADRA2A, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, GRIK5, HMGCR, PTPN1, SMAD3, SRC, TERT 2.22739
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.22731
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.22731
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22731
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, SRC 2.22544
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.22269
[BP] GO:0043086 negative regulation of catalytic activity ADRA2A, CSNK2A1, DRD2, DRD3, DRD5, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PTPN1, SRC 2.22269
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SLC6A4, SMAD3 2.20452
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.18573
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B2 2.18573
[BP] GO:0051894 None KDR, SMAD3, TEK 2.17817
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.17817
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17817
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.17529
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, MET, MMP12, PIM1, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A 2.17228
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.17228
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PTAFR, SRC, TEK 2.16734
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, XDH 2.16674
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.16042
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CES1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD17B2 2.15717
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, PTPN1, SMAD3, SRC, TERT 2.15303
[BP] GO:0046888 None ADORA1, ADRA2A, DRD2, HMGCR 2.14182
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.13877
[BP] GO:0050927 None F3, KDR, SMAD3 2.13732
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.13732
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.13732
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, GPR35, KCNH2 2.13732
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, PTAFR, RORC, SLC6A4, SRC 2.1298
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A 2.12403
[BP] GO:0021853 None DRD1, DRD2 2.12035
[BP] GO:0010641 None F3, SRC 2.12035
[BP] GO:0090325 None DRD2, DRD3 2.12035
[BP] GO:1904936 None DRD1, DRD2 2.12035
[BP] GO:0042321 None ADORA1, DRD2 2.12035
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.11349
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.11257
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.11073
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, DRD2, GPR35 2.11073
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.11073
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.11073
[BP] GO:0050926 None F3, KDR, SMAD3 2.1069
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.1069
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1069
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, APEX1, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GRM3, GRM8, HSPA1A, IGF1R, INSR, MET, MMP12, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 2.08878
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.07571
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, SLC6A4, TYR 2.07565
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.07003
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.07003
[BP] GO:0071229 cellular response to acid chemical EGFR, KDR, MMP2, PTAFR, SLC6A4, SRC 2.06579
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, SLC6A4 2.06309
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.04816
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.04816
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, HMGCR, KDR, SRC, TEK 2.03286
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.02769
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.02591
[BP] GO:0051254 None DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.02349
[BP] GO:0051482 None DRD1, GPR35, GRM1 2.02349
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.02349
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.02349
[BP] GO:0031644 None ADORA1, GPR35, GRM1, PTAFR 2.00624
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 7.77045
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK 7.40679
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TEK 6.67991
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK 6.51415
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, DRD1, DRD2, DRD5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 6.49059
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.6529
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TEK, TYR 5.25821
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.25103
[CC] GO:0043235 receptor complex ADRA2A, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.08733
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, HSPA1A, KDR, PTPN1, XDH 3.00732
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.94126
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.79416
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.79416
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, CA12, CA14, CA4, CA9, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK, TYR 2.66033
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, EGFR, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTPN1 2.61577
[CC] GO:0044456 None ACHE, ADORA1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC 2.54438
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.52666
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC 2.42521
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC, TEK 2.30267
[CC] GO:0016021 None ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, CA12, CA14, CA9, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK, TYR 2.29028
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.13732
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC, TEK 2.11766
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.11349
[CC] GO:0043005 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC 2.11073
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, EGFR, GRIA2, HMGCR, HSD11B1, HSD17B2 2.10244
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.09392
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 13.0637
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 13.0637
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 11.6465
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 11.3422
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, SMAD3, TEK 11.3422
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 11.1691
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.71299
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, TEK 8.64686
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, TEK 8.64686
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.89283
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, ESRRA, ESRRB, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 7.80056
[MF] GO:0030594 None DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A 7.5986
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TERT, TOP2A, TYR, XDH 7.58059
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.01325
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 7.00806
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK, TOP2A 6.69618
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.45024
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.30416
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.02729
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3, DRD5 5.41326
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5, HTR1A, SLC6A4 5.25473
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, XDH 5.21327
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 5.1523
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.13002
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.09708
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.01825
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 4.98085
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.9698
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.9698
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.90945
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.84233
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, HSD11B1, HSD17B2, TYR, XDH 4.82207
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.79384
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.67859
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 4.59579
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.54984
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.53604
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 4.3303
[MF] GO:0019899 enzyme binding ADRA2A, ALPI, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KCNH2, MET, PPARA, PTAFR, PTPN1, SLC6A4, SMAD3, SRC, TEK, TOP2A 4.30505
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 4.00807
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC 3.84103
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD17B2, XDH 3.70146
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC 3.66553
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 3.3747
[MF] GO:0004930 None ADORA1, ADORA3, ADRA2A, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, PTAFR 3.34348
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.30842
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.23599
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.21719
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, DRD2, FLT3, HMGCR, KCNH2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.17576
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6 3.03137
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.94048
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 2.86286
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, DRD2, EGFR, FLT3, HMGCR, KCNH2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.73635
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, SMAD3, SRC, TOP2A 2.73136
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 2.70365
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, RORC 2.67558
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.65089
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, SMAD3, SRC, TOP2A 2.59666
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, SRC, XDH 2.55278
[MF] GO:0005330 None SLC6A2, SLC6A4 2.54438
[MF] GO:0099583 None GRM1, GRM5 2.54438
[MF] GO:0047374 None CES1, CES2 2.54438
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43225
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43225
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.38147
[MF] GO:0001588 None DRD1, DRD5 2.29587
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.29587
[MF] GO:0004971 None GRIA2, GRIA4 2.29587
[MF] GO:0032795 None ADORA1, ADRA2A 2.29587
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.28347
[MF] GO:0016788 None ACHE, ADORA1, ALPI, ALPL, APEX1, CA1, CA2, CDC25B, CES1, CES2, DUSP3, PTPN1 2.27236
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.14182
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.13877
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.13732
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.13732
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B2 2.12265
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12035
[MF] GO:0043559 insulin binding IGF1R, INSR 2.12035
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.11257
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2 2.11073
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, PPARA, PTAFR, RORC 2.11073
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.02349


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, PTAFR, HTR1A, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, DRD5, GRIA4 12.3765
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.4972
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.1372
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.2718
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 6.476
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.0707
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, HTR1A, DRD1, DRD2, PPARA, DRD5, GRIA4 5.4217
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.4217
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.415
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.3283
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.8122
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD1, DRD2, GRM1, EGFR 4.4604
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, CYP2C19, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH, CES1 3.6942
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, DRD5, GRIA4 3.6765
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 3.357
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.7167
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.4859
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.2437
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP2C19 3.587
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, DRD1, GRM1, EGFR, DRD5 3.0911
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0911
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.587
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.2234
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, HTR1A, CYP2C19, SLC6A4 3.0911
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 2.8837
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.3316
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.8207
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.656
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 2.4896
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.8371
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1, CYP2C19 2.8955
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.3509
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8955
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 1.9003
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2A 1.7185
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9642
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1076
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.033
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 1.95
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.95
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.9003
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.95
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.67
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6476
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.9559
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9003
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6603
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9416
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4943
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2233
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.4167
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.3315
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4044
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.2333
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.3737
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1959
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1715
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.9523
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8233
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2303
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2441
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2506
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2622
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7176
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9115
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2503
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2622
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9662
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7612
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7291
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7926
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7926
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7156
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7162
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 0.997
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7162
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2984
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9333
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3059
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6251
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9477
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7156
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6824
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3205
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9303
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5941
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5941
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5117
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9508
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3316
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6592
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.4358
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9363
Platelet activation_Homo sapiens_hsa04611 SRC 0.3538
Axon guidance_Homo sapiens_hsa04360 MET 0.3462
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3561
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3538
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.04
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3824
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3986
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4057
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4057
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4057
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.407
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4118
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1878
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4113
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2169
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.167
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4295
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4358
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4295
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1605
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.1083
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4286
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4313
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4278
Peroxisome_Homo sapiens_hsa04146 XDH 0.4358
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.187
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4678
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.202
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4489
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4549
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4662
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.167
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4799
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.187
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4985
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.287
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5031
Shigellosis_Homo sapiens_hsa05131 SRC 0.5007
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5468
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5468
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5468
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5646
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4588
Malaria_Homo sapiens_hsa05144 MET 0.584
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5884
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5891
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5884
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6536
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6434
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5476
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.6657
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5317
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6788
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6373
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6153
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7326
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7156
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6944
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8377
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7169
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7387
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7162
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7326
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7926
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.1459
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9527
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.215


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)