TCM Prescription: Wen Jing Pills



Prescription Description
Prescription IDTCMF5924
Pinyin NameWen Jing Wan
Chinese Name温经丸
English NameWen Jing Pills
Function Description痛经
IndicationsDysmenorrhea disorder, Dysmenorrhea
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA34.3 [Dysmenorrhoea, 痛经 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0124
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2272
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, RELA, SMAD3, SRC, TEK, XDH 12.2272
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, RELA, SMAD3, SRC, TEK, XDH 12.2272
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MAOA, MET, MTNR1B, PPARA, SMAD3, SRC, TEK, XDH 12.1214
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1B, NUAK1, RELA, SMAD3, SRC, TEK, XDH 11.1965
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1B, NUAK1, RELA, SMAD3, SRC, TEK, XDH 11.0342
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, RELA, SRC, TEK, XDH 10.9938
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, PPARA, PTGES, RELA, SRC, TEK, TYR 10.9682
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TYR 10.9049
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MMP12, NUAK1, PIM1, PTGES, RELA, SMAD3, SRC, TEK, XDH 10.8771
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TYR 10.4878
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, RELA, SRC, TEK, XDH 10.4801
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, RELA, SMAD3, SRC, TEK, XDH 10.1449
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FLT3, PTGES, RELA, SRC, TEK, TYR 10.0621
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HSD17B3, HSPA1A, HTR2B, HTR2C, PIM1, PPARA, PTGES, TYR, XDH 9.60354
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MET, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 9.33651
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MET, PIM1, RELA, SMAD3, SRC, TEK, TOP2A, XDH 9.33651
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PPARA, RELA, SMAD3, SRC, TEK, TYR 9.33648
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTGES, RELA, SRC, TYR 9.22315
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR2C, MTNR1B 8.89952
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD3, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, SMAD3, SRC 8.88997
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 8.74497
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK, TOP2A, XDH 8.72369
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD3, EGFR, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, RELA, SMAD3, SRC, TEK, XDH 8.58037
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F2, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, MTNR1B, PPARA, SMAD3, SRC, TEK 8.46001
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, RELA, SRC, TEK 8.1009
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD3, EGFR, ESR1, F2, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, SMAD3 8.03245
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, PPARA, RELA, SMAD3, SRC, TEK 7.70692
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD3, F2, HTR2A, HTR2B, HTR2C, KDR, SRC 7.61225
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP12, NUAK1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, TYR 7.61225
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, DRD3, EGFR, F2, HCAR2, HTR2A, HTR2B, HTR2C, KDR, SRC 7.45599
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, HTR2A, HTR2B, HTR2C, KDR, RELA, SRC 7.36311
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 7.25888
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD3, EGFR, ESRRB, F2, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP12, PIM1, RELA, SMAD3, SRC, TEK 7.0979
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP12, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, XDH 7.03546
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 7.03546
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, F2, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, SRC, TEK 7.03546
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 7.00891
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PIM1, RELA, SMAD3, SRC, TEK, XDH 6.89788
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PPARA, RELA, SMAD3, SRC, TEK, XDH 6.87967
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 6.78944
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MTNR1A, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 6.73428
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, PTGES, RELA, SRC 6.72698
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, RELA, SMAD3, SRC, TEK, XDH 6.69487
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 6.69487
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MTNR1A, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 6.6858
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, DRD3, KDR, RELA, SRC 6.54148
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, RELA, SMAD3, SRC, TEK 6.46171
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, HTR2A, HTR2B, INSR, KDR, MAP2K1, MET, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, TYR 6.38644
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA 6.34923
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, PIM1, RELA, SMAD3, SRC, TEK 6.3165
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK 6.31172
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES 6.26028
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, SRC, TEK 6.25521
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD3, EGFR, ESR1, F2, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, TEK 6.23354
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, SRC, TEK, XDH 6.23354
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CSNK2A1, DRD3, EGFR, ESR1, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, PIM1, RELA, TEK 6.23354
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, EGFR, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, MTNR1A, SMAD3, SRC, TEK, XDH 6.23354
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, EGFR, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, MTNR1A, SMAD3, SRC, TEK, XDH 6.23354
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PPARA, RELA, SMAD3, SRC, TEK, XDH 6.22387
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, SRC 6.18167
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 6.13886
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP12, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, XDH 6.13886
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESRRB, F2, F3, FABP4, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TYR 6.06723
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, SRC, TEK, XDH 6.01407
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 5.98965
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.97198
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 5.91497
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.91467
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, XDH 5.85165
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, MTNR1A, PPARA, RELA, SMAD3, SRC, TOP2A 5.85165
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.77781
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, BCL2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 5.77781
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, PIM1, RELA, SMAD3, SRC, TEK 5.7435
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, ESR1, F2, FABP3, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 5.63295
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, DRD3, EGFR, F2, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, MAP2K1, MMP12, MTNR1B, PPARA, SMAD3, SRC 5.63244
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, NUAK1, SMAD3, SRC, TEK, XDH 5.61261
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 5.52157
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 5.43095
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, SRC, TOP2A 5.34607
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PPARA, RELA, SMAD3 5.32505
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TYR 5.20535
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, XDH 5.18836
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.18836
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 5.1881
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 5.17834
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA 5.11317
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 5.07681
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, RELA, SMAD3, TYR 4.9984
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, RELA, SMAD3, TEK 4.98947
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 4.95933
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, RELA, SRC, TEK, TYR 4.95509
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, EGFR, ESRRB, F2, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, SRC, TEK, XDH 4.87922
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, RELA, SMAD3, SRC, TEK, XDH 4.87635
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.87591
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, BCL2, CNR1, CNR2, CYP19A1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, PPARA, RELA, SMAD3, SRC, TEK, XDH 4.87591
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, XDH 4.85835
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, PPARA, RELA, SMAD3, SRC, TEK, TYR 4.80555
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.80555
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PPARA, SRC, TEK, XDH 4.79996
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MAP2K1, MET, MMP12, MTNR1A, PPARA, RELA, SMAD3, SRC, TOP2A 4.79996
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.79465
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MAP3K7, MMP12, PPARA, RELA, SMAD3, SRC, TEK 4.78536
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC, TEK 4.74563
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PPARA, RELA, SMAD3 4.72607
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.69984
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, SRC 4.67522
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, RELA, SRC 4.64003
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 4.63575
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CNR1, DRD3, EGFR, F2, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, SMAD3, SRC 4.62643
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, RELA, SMAD3, SRC, XDH 4.62643
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, RELA, SMAD3, SRC, XDH 4.60767
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC, TEK 4.58871
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, RELA, SRC, TEK, TYR 4.57372
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 4.57323
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.5654
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.56305
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH 4.53787
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, EGFR, F2, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, SRC, TEK, XDH 4.49457
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.48141
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42743
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.42212
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, DRD3, EGFR, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, SRC 4.39496
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, EGFR, ESR1, ESR2, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, MET, RELA, SMAD3, SRC, TEK, XDH 4.39496
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, RELA, SRC 4.39496
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, RELA, SRC 4.39496
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, RELA, SMAD3, SRC 4.35337
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 4.34507
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD3, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, GLO1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.3436
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, RELA, SMAD3, SRC 4.32662
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MAP2K1, MET, PIM1, SRC, TEK, TYR 4.30559
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, BCL2, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, RELA, SRC, TEK, XDH 4.30559
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD3, EGFR, HTR2A 4.28189
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD3, EGFR, HTR2A 4.28189
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TOP2A 4.27793
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.27793
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F2, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK, TOP2A 4.25694
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA, SMAD3, TEK 4.24801
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.24524
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.234
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, SRC, TEK, XDH 4.22032
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, F2, MMP12, PPARA, SMAD3, TEK 4.22032
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, RELA, SRC 4.16777
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.16711
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HTR2A, HTR2C, INSR, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK 4.16068
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, EGFR, ESR1, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, SMAD3, SRC, TEK, XDH 4.1561
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.15607
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, XDH 4.14427
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.14098
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, DRD3, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SRC 4.14098
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.13191
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.12405
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, HTR2C, INSR, KDR, MAP2K1, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, XDH 4.11465
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 4.1141
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, F2, PPARA, SMAD3 4.1094
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.09869
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CNR1, CNR2, DRD3, ESR1, F2, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, INSR, MTNR1A, MTNR1B, SRC 4.06174
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, RELA, SMAD3, SRC, TOP2A 4.04014
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 4.01345
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, HSD17B3, MAOA, TYR 3.9908
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MAP2K1, MET, MMP12, MTNR1A, PPARA, RELA, SMAD3, SRC, TOP2A 3.97995
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.95438
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2, HTR2A, HTR2C, MTNR1B 3.87224
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, RELA, SRC 3.86971
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, SRC 3.86284
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.84776
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, DRD3, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SRC 3.80962
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD3, EGFR, F2, HCAR2, HTR2B, INSR, MMP12, SMAD3, SRC 3.80711
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, RELA, SRC, TEK 3.79317
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, SRC, TEK 3.79317
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, SRC 3.77456
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, MTNR1A, SRC, TOP2A 3.76165
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.74555
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, RELA, SRC 3.71121
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.68309
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TOP2A 3.65965
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.65337
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.647
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.64366
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.61044
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60712
[BP] GO:0007210 None HTR2A, HTR2B, HTR2C, HTR6 3.60712
[BP] GO:0098664 None HTR2A, HTR2B, HTR2C, HTR6 3.60712
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, HSPA1A, HTR2C, MAP2K1, MAP3K7, NUAK1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A 3.60209
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 3.55804
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.55804
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, SRC, TEK 3.55733
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 3.54866
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, RELA, SRC 3.53426
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.51835
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, RELA, SRC 3.51372
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.51352
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, EGFR, ESR1, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, SMAD3, SRC, TEK, XDH 3.51041
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CNR1, CSNK2A1, DRD3, EGFR, F2, HCAR2, HTR2B, MMP12, MTNR1B, SMAD3, SRC 3.49943
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49236
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49236
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49236
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49236
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, SRC 3.45486
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD3, EGFR, F2, HCAR2 3.45486
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, MAP3K7, PIM1, RELA 3.45289
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD3, FABP3, HTR2A, HTR2B, HTR2C, PPARA 3.44544
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, CNR1, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, SMAD3, SRC, TEK 3.43583
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.42368
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, RELA, SMAD3, SRC, TEK, XDH 3.41973
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.40163
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, RELA 3.39694
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.37456
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.3705
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F2, F3, INSR, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK, XDH 3.3705
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.33734
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CNR1, DRD3, EGFR, F2, HCAR2, HTR2B, MMP12, MTNR1B, SMAD3, SRC 3.32001
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, INSR, SMAD3, XDH 3.30832
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, SRC 3.29537
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, BCL2, EGFR, F2, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MAP2K1, MAP3K7, SRC, TEK, XDH 3.28219
[BP] GO:0050795 None ADORA1, CNR1, DRD3, HTR2A, HTR2B 3.28219
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.2707
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, PIM1, PPARA, RELA, SMAD3, SRC, TOP2A 3.22579
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, TEK 3.22032
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.20468
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 3.19201
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 3.19201
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, RELA, SRC 3.17841
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 3.16641
[BP] GO:0050708 None ACHE, CACNA1C, CNR1, DRD3, EGFR, HCAR2, HTR2B, MMP12, MTNR1B, SRC 3.16107
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD3, EGFR, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, RELA, SRC, TEK 3.12446
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, F2, HCAR2, HSPA1A, MAP3K7, MMP12, RELA, SMAD3, SRC 3.12446
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, EGFR, HSPA1A, MAOA 3.12446
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.12446
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.12446
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.12446
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.12399
[BP] GO:0007187 None ADORA1, CNR1, CNR2, DRD3, HTR6, MTNR1A, MTNR1B 3.11546
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.09266
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, DRD3, EGFR, F2, HTR2A, MMP12, PTGES, RELA, SMAD3, SRC, TYR 3.07569
[BP] GO:0007610 None APP, BCL2, CNR1, DRD3, EGFR, HTR2A, HTR2B, HTR2C, INSR, MTNR1A, PPARA 3.04648
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 3.01626
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, SRC 3.01144
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, DRD3, EGFR, ESR2, F2, HSPA1A, INSR, PIM1, SMAD3 3.01016
[BP] GO:0033674 positive regulation of kinase activity ADORA1, EGFR, F2, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, SRC, TEK 2.99586
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 2.99288
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.98685
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.98114
[BP] GO:0051223 None ACHE, APP, CACNA1C, CNR1, DRD3, EGFR, F2, HCAR2, HTR2B, MMP12, MTNR1B, SMAD3, SRC 2.9288
[BP] GO:0007208 None HTR2A, HTR2C 2.92843
[BP] GO:0009115 None AOX1, XDH 2.92843
[BP] GO:0018958 None AKR1B1, BCL2, DRD3, MAOA, TYR 2.92175
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, SRC, TOP2A 2.91641
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.91624
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, SRC 2.90091
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89386
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 2.89386
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD3, F2, PPARA, SMAD3, TEK 2.89386
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F2, F3, FABP4, KDR, MET, SMAD3 2.89386
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, XDH 2.87168
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, RELA, SRC 2.86456
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, EGFR, ESR1, HTR2B, INSR, MET, RELA, SMAD3, SRC, TEK 2.86088
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CYP1A1, DRD3, DUSP3, EGFR, INSR, SRC 2.85781
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, EGFR, ESR1, FLT3, IGF1R, INSR, RELA, SMAD3, SRC 2.85379
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.84406
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, EGFR, F2, FLT3, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, SRC, TEK 2.84399
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.84069
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, RELA, TYR 2.84069
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.82556
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, RELA, SMAD3, SRC, TEK, XDH 2.82475
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, RELA, SRC 2.81956
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, F2, MMP12, PTGES, RELA, SMAD3, SRC 2.81856
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.81504
[BP] GO:0051254 None APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TOP2A 2.8027
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD3, GPR35, HTR2A 2.79583
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.77669
[BP] GO:0045776 None ADORA1, CNR1, DRD3, PPARA 2.77592
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.77592
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, FABP3, HSPA1A, MAP2K1, PTGES, SMAD3, XDH 2.75709
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CYP1A1, DRD3, DUSP3, INSR 2.75709
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC 2.75709
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 2.74681
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.73745
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 2.73644
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.70885
[BP] GO:0008217 None ADORA1, AR, CNR1, DRD3, PPARA, SMAD3 2.67991
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGES 2.67786
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, SMAD3, XDH 2.67702
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6573
[BP] GO:0070920 None EGFR, ESR1, MAP2K1 2.6573
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, F2, MMP12, PTGES, RELA, SMAD3, SRC 2.6568
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CNR1, DRD3, F2, GPR35, HTR2A 2.65191
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CNR1, CNR2, GPR35, KDR, SRC 2.64706
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, DRD3, EGFR, F2, HSPA1A, HTR2A, INSR, KDR, MAP2K1, MET, MMP12, RELA, SMAD3, SRC 2.64292
[BP] GO:0003018 None ADORA1, EGFR, HTR2A, HTR2B, SRC, TEK 2.59607
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, DRD3, EGFR, ESRRA, ESRRB, F2, HTR2A, HTR2C, KDR, MAP2K1, PPARA, RELA, SMAD3, XDH 2.58176
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, PIM1, PPARA, RELA, SMAD3, SRC, TOP2A 2.5699
[BP] GO:0051591 None APEX1, APP, RELA, TEK, TYR 2.55615
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, F2, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.55615
[BP] GO:0045893 None APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TOP2A 2.55102
[BP] GO:1903508 None APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TOP2A 2.55102
[BP] GO:1902680 None APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC, TOP2A 2.54836
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, RELA, SRC, XDH 2.54744
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.54744
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, PTGES 2.54744
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES 2.54566
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.54566
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CACNA1C, CNR1, DRD3, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, TEK 2.54566
[BP] GO:0044057 None ADORA1, ADORA3, CACNA1C, DRD3, EGFR, GPR35, HCAR2, HTR2A, HTR2C, SMAD3 2.54566
[BP] GO:0033590 None EGFR, RELA 2.54566
[BP] GO:0046110 None AOX1, XDH 2.54566
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54566
[BP] GO:0002520 None CACNA1C, SMAD3 2.54566
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.54498
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGES, RELA, SRC 2.53508
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.53312
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, RELA, SRC 2.51389
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.49858
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.46959
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.46959
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.46959
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.46877
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.46877
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, HSPA1A, MAP3K7, RELA 2.46642
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.46642
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, MAP2K1, TEK, TYR 2.45724
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.4504
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, RELA, SRC 2.4504
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MMP12, SRC, TEK 2.4504
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.4504
[BP] GO:0098900 None CACNA1C, CNR1, CNR2, GPR35 2.4479
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, RELA, SRC, TYR 2.44088
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES 2.43495
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration CACNA1C, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C 2.42232
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.42232
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES 2.42232
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.42232
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.39195
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.3826
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PPARA 2.37835
[BP] GO:0032870 cellular response to hormone stimulus APEX1, AR, EGFR, ESR1, FLT3, INSR, RELA, SRC 2.37283
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, EGFR, ESR1, MTNR1A, SRC 2.37225
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, RELA, SMAD3, SRC, XDH 2.36761
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.36175
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, INSR, MAOA, SMAD3 2.36175
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, HTR2B, MMP12, SRC 2.36175
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3, PTGES 2.36112
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MAP2K1, MMP12, SRC, TEK 2.35522
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.34768
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, SMAD3, SRC, TEK 2.32794
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.32678
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.30976
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.30976
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.30976
[BP] GO:0006145 None AOX1, XDH 2.30703
[BP] GO:0038171 None CNR1, CNR2 2.30703
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30703
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.30703
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, HTR2A 2.30703
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.30703
[BP] GO:0051282 None CACNA1C, F2, HTR2A, HTR2B, HTR2C 2.30513
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26635
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.26461
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, DRD3, DUSP3, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, HTR2B, IGF1R, MET, MMP12, PPARA, RELA, SMAD3, SRC, XDH 2.26447
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.23853
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MAP3K7, MET, RELA, SMAD3, SRC, TEK 2.23853
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.23343
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B 2.23343
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CNR1, DRD3, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, TEK 2.22338
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD3, EGFR, HTR2A, INSR 2.22338
[BP] GO:0051894 None KDR, SMAD3, TEK 2.22223
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.22223
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.22223
[BP] GO:0045685 None APP, DRD3, F2, RELA 2.21204
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR2A 2.1882
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C 2.1882
[BP] GO:0060402 None CACNA1C, HTR2A, HTR2B, HTR2C 2.1882
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.18434
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, RELA, TYR 2.18061
[BP] GO:0050927 None F3, KDR, SMAD3 2.17525
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, RELA, SRC, TEK 2.17525
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP12, SRC, TEK 2.17355
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.16936
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, F2, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.15629
[BP] GO:0023014 signal transduction by protein phosphorylation EGFR, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MET, TEK 2.15007
[BP] GO:0051128 regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, SMAD3, SRC, TEK, TOP2A 2.14901
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.14736
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13379
[BP] GO:0050926 None F3, KDR, SMAD3 2.13379
[BP] GO:1903393 None KDR, SMAD3, TEK 2.13379
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.132
[BP] GO:0006110 None ESRRB, HTR2A, INSR, PPARA 2.12974
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.12974
[BP] GO:0010641 None F3, SRC 2.12974
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD3, EGFR, RELA, TYR 2.1262
[BP] GO:0042180 None AKR1B1, CYP19A1, GLO1, HSD17B3 2.08601
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.07516
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, F2, SMAD3, SRC 2.06739
[BP] GO:0046683 response to organophosphorus APEX1, APP, RELA, TEK, TYR 2.06739
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.06739
[BP] GO:0003013 None ADORA1, EGFR, HTR2A, HTR2B, SRC, TEK 2.06739
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, PPARA, SRC 2.06739
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.06064
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.05656
[BP] GO:0014059 None CNR1, DRD3, HTR2A 2.05656
[BP] GO:0070371 None HTR2B, KDR, MAP2K1 2.05656
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.05582
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES 2.04166
[BP] GO:0001817 regulation of cytokine production AXL, CYP1B1, F2, HSPA1A, HTR2B, MAP3K7, MMP12, RELA, SMAD3, SRC 2.04166
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, RELA, SRC 2.04166
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HSPA1A, HTR2B, MAP3K7, MMP12, RELA, SMAD3, SRC 2.04166
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, RELA, TYR 2.03279
[BP] GO:0001936 None F3, HTR2B, KDR, TEK, XDH 2.03279
[BP] GO:0007267 None ADORA1, AR, CNR1, DRD3, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, TEK 2.00336
[BP] GO:0032989 cellular component morphogenesis APP, AR, AXL, BCL2, EGFR, MET, SRC, TEK 2.00336
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, DRD3, EGFR, ESR1, F2, F3, FLT3, GLO1, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MTNR1A, MTNR1B, PIM1, SMAD3, SRC, TEK 5.43095
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CNR1, CNR2, DRD3, F3, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK 4.95509
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, DRD3, DUSP3, EGFR, F2, F3, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SRC, TEK 4.3811
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CNR1, CNR2, DRD3, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK 4.12405
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, F2, F3, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MTNR1A, MTNR1B, PIM1, PTGES, SMAD3, SRC, TEK, TYR 4.10391
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.48913
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, SRC, TEK, TYR 3.22639
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.77096
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.75709
[CC] GO:0098589 membrane region APP, CNR1, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.30703
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.25301
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B3, HSPA1A, HTR2A, HTR6, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MMP12, NUAK1, PIM1, PPARA, RELA, SHBG, SMAD3, SRC, TOP2A, TYR, XDH 2.16936
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MMP12, NUAK1, PIM1, PPARA, RELA, SHBG, SMAD3, SRC, TOP2A, TYR, XDH 2.11698
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, CYP3A4, DRD3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, TEK, TYR 2.10102
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.1192
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP12, PIM1, PPARA, SMAD3, TYR, XDH 13.2127
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 13.0124
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2272
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1869
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MTNR1A, MTNR1B, PPARA, SMAD3, TEK 10.3932
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK 10.3409
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 9.33651
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK 9.16433
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK 8.86366
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 8.12778
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F2, F3, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PTGES, SRC, TEK, TOP2A, TYR, XDH 7.70692
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, HTR2A, HTR2B, HTR2C, MAP3K7, MMP12, NUAK1, PIM1, PPARA, SMAD3, TOP2A, TYR, XDH 7.56926
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.15575
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP12, PPARA, SMAD3 6.73757
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.42421
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, SHBG 6.23354
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, SHBG 6.21056
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 6.06113
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK 6.05613
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK 6.05613
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.18836
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MAP3K7, MMP12, NUAK1, PIM1, PPARA, SMAD3, TOP2A, TYR, XDH 5.13797
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.05154
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.05154
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.99541
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.95509
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.6398
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 4.48789
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.39415
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, RELA, SMAD3, SRC 4.28243
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD17B1, PPARA, SHBG 4.16777
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.16068
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, PPARA, RELA, SMAD3, SRC 4.11931
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.93534
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.74897
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.61044
[MF] GO:0004993 None HTR2A, HTR2B, HTR2C, HTR6 3.60712
[MF] GO:0099589 None HTR2A, HTR2B, HTR2C, HTR6 3.60712
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.33855
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.33855
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTGES, RELA, SRC, TEK, TOP2A, XDH 3.33091
[MF] GO:0043176 None HTR2A, HTR2B, HTR2C 3.09266
[MF] GO:0051378 None HTR2A, HTR2B, HTR2C 3.09266
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 3.09044
[MF] GO:0070405 ammonium ion binding ACHE, DRD3, HTR2A, HTR2B, HTR2C 3.03934
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.01144
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.98685
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MTNR1A, NUAK1, PIM1, PPARA, RELA, SHBG, SMAD3, SRC, TEK, TOP2A, XDH 2.97345
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.92843
[MF] GO:0071886 None HTR2A, HTR2C 2.92843
[MF] GO:0099528 None HTR2A, HTR2B, HTR2C, HTR6 2.91624
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD17B1, HSD17B2, HSD17B3, XDH 2.86456
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.83943
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, PTGES, SRC, XDH 2.76184
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, RELA, SMAD3, SRC 2.75872
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.59607
[MF] GO:0008502 None MTNR1A, MTNR1B 2.54566
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.54566
[MF] GO:0004949 None CNR1, CNR2 2.54566
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, DRD3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MTNR1A, MTNR1B 2.5443
[MF] GO:0042165 neurotransmitter binding ACHE, HTR2A, HTR2B, HTR2C 2.46959
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.37181
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MAP3K7, MET, RELA, SMAD3, TOP2A, TYR, XDH 2.36977
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.36977
[MF] GO:0030594 None DRD3, HTR2A, HTR2B, HTR2C, HTR6 2.35704
[MF] GO:0008227 None HTR2A, HTR2B, HTR2C, HTR6 2.34768
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30703
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.30703
[MF] GO:0005497 None AR, SHBG 2.30703
[MF] GO:0051425 None APP, INSR 2.30703
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.30703
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.30703
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.27841
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.24833
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP2A, XDH 2.17355
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.12974
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12974
[MF] GO:0043559 insulin binding IGF1R, INSR 2.12974
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD17B1, HSD17B2, HSD17B3 2.09388
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.06739
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, MET, PPARA, RELA, SMAD3, SRC, TEK, TOP2A 2.04104
[MF] GO:0016229 steroid dehydrogenase activity HSD17B1, HSD17B2, HSD17B3 2.01906
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.01906


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.4157
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7617
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR2B, HTR2C, HTR2A, F2, HTR6, MTNR1A, CNR2, CNR1, MTNR1B, ADORA3, ADORA1, DRD3 8.521
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 8.521
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 7.762
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, MAP2K1, MAOA, ALOX5, HTR2B, HTR2C, CACNA1C, HTR2A 7.762
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, CNR1, INSR, KDR, TEK, MET, EGFR, IGF1R 5.4269
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, INSR, BCL2, TEK, EGFR, RELA, IGF1R 5.4269
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, EGFR, RELA, IGF1R 4.6417
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.0029
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 4.359
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2C, HTR2A, EGFR 4.6417
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, ESR1, EGFR, ESR2, HSPA1A 4.4079
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, INSR, KDR, BCL2, TEK, MET, EGFR, RELA, IGF1R 3.9957
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.813
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, KDR, MET, ESR1, EGFR, IGF1R 3.8083
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 3.9401
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, SMAD3, FLT3, BCL2, MET, EGFR, RELA, IGF1R 3.6267
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, EGFR, IGF1R 3.8083
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, TYR, CYP3A4, CYP19A1, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 3.672
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1, F3, RELA 3.3719
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, HSPA1A 3.2639
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.2483
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR2B, HTR2C, CACNA1C, HTR2A, EGFR 3.2483
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA, HSPA1A 3.1432
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.2483
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 3.1251
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, EGFR, RELA 3.0795
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, SRC, BCL2, RELA 2.8642
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, INSR, EGFR, IGF1R 3.0282
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET, EGFR 3.0687
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.0901
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.068
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, EGFR, IGF1R 3.0282
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, INSR, ADORA1, CACNA1C 2.6515
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP3A4 3.0605
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, CACNA1C, EGFR 2.6824
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, HTR2A 2.6019
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.4089
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, BCL2, PIM1, CYP1B1, MET, EGFR 2.3519
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.0034
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA, HSPA1A 2.3291
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.6572
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 2.8327
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA, HSPA1A 2.1455
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, ESRRB, IGF1R 2.0951
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 1.9519
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, RELA, IGF1R 1.7809
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.1795
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC, F2, EGFR 1.5815
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC, EGFR 1.823
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, RELA 2.0147
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2779
Glioma_Homo sapiens_hsa05214 MAP2K1, EGFR, IGF1R 2.1345
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, RELA, IGF1R 1.758
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.6507
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6413
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1455
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B, CACNA1C 1.7523
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, BCL2 2.168
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA, RELA 1.6148
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MAP3K7, RELA 1.6103
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.5265
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.5402
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.5038
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, MAP3K7, IGF1R 1.5003
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.4503
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD3 1.466
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.4049
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.0764
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR, RELA 1.4476
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3672
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.3939
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, INSR, EGFR 1.3833
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA, RELA 1.3546
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.318
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2983
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, EGFR 2.6267
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3391
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA, HSPA1A 1.2532
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3771
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3771
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2436
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, RELA 0.5011
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2094
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.398
Axon guidance_Homo sapiens_hsa04360 MET 0.3924
Platelet activation_Homo sapiens_hsa04611 SRC 0.401
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7226
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6202
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.2032
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4216
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1, INSR 0.8245
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8245
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6927
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7226
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.7964
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4614
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4624
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4755
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4743
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4806
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9144
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4859
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, IGF1R 1.0451
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.4872
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4873
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0334
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4872
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4978
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4962
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 1.0333
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, RELA 1.0147
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4931
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4946
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4872
Peroxisome_Homo sapiens_hsa04146 XDH 0.4978
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.7886
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4985
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C 1.0333
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4978
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5068
Pertussis_Homo sapiens_hsa05133 RELA 0.5158
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5088
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5178
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5178
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1205
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5439
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, RELA 1.1345
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.2436
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2032
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.256
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.2901
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2436
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.564
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2901
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.1972
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3347
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2967
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2824
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.256
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, EGFR 1.4049
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2532
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, EGFR 1.3672
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RELA 1.2934
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2934
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5923
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.3759
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3618
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.3177
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.4503
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4443
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.643
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6478
Malaria_Homo sapiens_hsa05144 MET 0.6527
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4684
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6629
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6578
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.6413
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7226
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.8202
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7734
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.721
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.721
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8049
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8156
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7964
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7474
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7794
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7886
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9431
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8156
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8428
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8309
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8726
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0091
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0685
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.068
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3347


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)