TCM Prescription: Shi Er Wen Jing Pills



Prescription Description
Prescription IDTCMF5909
Pinyin NameShi Er Wen Jing Wan
Chinese Name十二温经丸
English NameShi Er Wen Jing Pills
Function Description月经失调, 痛经, 不孕
IndicationsDysmenorrhea disorder, Infertility disorder, Infertility, Dysmenorrhea, Irregular menstruation
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
SC22 [Infertility disorder (TM1), 不孕 (TM1) ];
GA31 [Female infertility, 女性不孕症 ];
GA34.3 [Dysmenorrhoea, 痛经 ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus, Liver, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4529
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5962
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, GLO1, HTR2B, HTR2C, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 10.1235
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 9.50234
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.30041
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.28261
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.92215
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR2B, HTR2C, KDR, MAOA, MET, MTNR1B, PPARA, SRC, TNKS, TNKS2, TRPV1, XDH 7.52643
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTGES, SRC, TRPV1, TYR 7.44488
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 6.97131
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGES, SRC, TYR 6.77934
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, NQO2, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 6.75899
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, HTR2A, HTR2B, HTR2C, KDR, SRC, TNKS, TNKS2, TRPV1 6.59244
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP2, MMP9, PPARA, PTGES, SRC, TRPV1, TYR 6.37149
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR2C, MTNR1B 6.24561
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, TRPV1, XDH 6.19473
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.17098
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.14717
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, TRPV1, XDH 6.14717
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.0821
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 6.05071
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTGES, SRC, TRPV1, TYR 6.01235
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, PTGES, SRC, TRPV1, TYR 5.92319
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.89763
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC, TRPV1 5.7663
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 5.72487
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2, TRPV1 5.6779
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, TRPV1, XDH 5.60661
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 5.5343
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 5.5343
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 5.50146
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.19684
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.19684
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 5.1875
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.08819
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, SRC 5.07588
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TRPV1 5.03292
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PTGES, SRC, XDH 5.03292
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.01073
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGES, TBXAS1 4.43495
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 4.4232
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.38597
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PTPN1, SRC, XDH 4.37877
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.35458
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 4.35458
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.3383
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES, TBXAS1 4.24466
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.24466
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.1868
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.15837
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TOP2A, TYR 4.13365
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PPARA, PTGES, TBXAS1 4.13365
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.03141
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.01158
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.97311
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, SRC 3.91022
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.88814
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.87698
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.85132
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, MTNR1B, SRC, TRPV1 3.80687
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1B, PPARA, PTPN1, SRC, TRPV1 3.75963
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.74431
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, MTNR1B, PTPN1, SRC, TNKS, TNKS2, XDH 3.71442
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.67288
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.6222
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1 3.58907
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, SRC 3.56404
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, MTNR1A, MTNR1B, PPARA, SRC, TOP2A 3.5167
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, MTNR1B, PTPN1, SRC, TNKS, TNKS2, XDH 3.46758
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TRPV1, TYR 3.42392
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.4034
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.4034
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.4034
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.39669
[BP] GO:0007210 None HTR2A, HTR2B, HTR2C, HTR6 3.39669
[BP] GO:0098664 None HTR2A, HTR2B, HTR2C, HTR6 3.39669
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.30075
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP2, MMP9, PPARA, PTGES, PTPN1, SRC, TOP2A, TRPV1, TYR 3.29513
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.22975
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP2, MMP9, SRC, XDH 3.20122
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.17594
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.17594
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.14686
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TBXAS1, TYR 3.12712
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.08742
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.07453
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1A, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.01447
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.96626
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.96626
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.9563
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.94476
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.84416
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.84202
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TRPV1 2.82254
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.79529
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.7791
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TRPV1 2.76974
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.7607
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC, TRPV1 2.73195
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, SRC, TRPV1 2.72837
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, MTNR1B, TRPV1 2.72837
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TBXAS1, TYR 2.7108
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.70643
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1A, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.68882
[BP] GO:0007208 None HTR2A, HTR2C 2.68882
[BP] GO:0009115 None AOX1, XDH 2.68882
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.67579
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TBXAS1, TYR 2.66267
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PTPN1, SRC, XDH 2.66267
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PTPN1, SRC, XDH 2.66267
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1A, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.63979
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD17B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.61153
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.59676
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.53162
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.51151
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.51151
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR2A, HTR2B, MMP2, PPARA, SRC, TRPV1, TYR 2.51039
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, TRPV1 2.48093
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, TRPV1 2.48093
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, PPARA, TRPV1 2.45789
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, MAOA, TYR 2.45434
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.44274
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.3906
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.3906
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.37178
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.35759
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MTNR1A, PPARA, SRC, TNKS, TNKS2, TOP2A, TRPV1 2.35102
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.30394
[BP] GO:0046110 None AOX1, XDH 2.30237
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30237
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.30237
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, MTNR1A, SRC, TOP2A 2.28813
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.28813
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES 2.27772
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.25715
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.25715
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.25617
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, PPARA, SRC, TRPV1 2.21303
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, SRC, TRPV1 2.1978
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.18815
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.15934
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, TRPV1 2.14628
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.11577
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PPARA, PTPN1, SRC, XDH 2.09945
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2 2.0994
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.09773
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.08996
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.08996
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.07519
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PPARA, PTPN1, SRC, XDH 2.06681
[BP] GO:0070213 None TNKS, TNKS2 2.06573
[BP] GO:0006145 None AOX1, XDH 2.06573
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06573
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.06573
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.06103
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, TRPV1 2.05387
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTPN1, SRC, XDH 2.05387
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.05387
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.0239
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.01506
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.00417
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MTNR1A, PPARA, SRC, TNKS, TNKS2, TOP2A, TRPV1 2.00417
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, SRC, TOP2A, TRPV1 2.00417
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C 2.0005
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.0005
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, TRPV1 2.0005
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR 3.34001
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, TBXAS1 2.49937
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 2.41297
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, KDR, MAOA, MMP2, MMP9, NQO2, PIM1, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.39448
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPN1, SRC, TBXAS1, TRPV1, TYR 2.34003
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, TBXAS1 2.30394
[CC] GO:0031233 None CA4, F10, F3 2.19649
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 17.2177
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.9341
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.8494
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, PIM1, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 11.8494
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.755
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5962
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR2A, HTR2B, HTR2C, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.1065
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, TNKS 8.54768
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 8.46541
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.15804
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.8139
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.35918
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.34757
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.77512
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH 5.72065
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.03292
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 4.97176
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.92437
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.72606
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.68406
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIM1, PPARA, SRC, TOP2A, TRPV1 4.64321
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 4.5518
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.35458
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 4.1868
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.71442
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.63907
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 3.58907
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.56404
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.56404
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, TRPV1 3.46223
[MF] GO:0004993 None HTR2A, HTR2B, HTR2C, HTR6 3.39669
[MF] GO:0099589 None HTR2A, HTR2B, HTR2C, HTR6 3.39669
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.22857
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.20604
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.17594
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.14686
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.10661
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.96626
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.8532
[MF] GO:0043176 None HTR2A, HTR2B, HTR2C 2.84579
[MF] GO:0051378 None HTR2A, HTR2B, HTR2C 2.84579
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.70931
[MF] GO:0099528 None HTR2A, HTR2B, HTR2C, HTR6 2.70643
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.68882
[MF] GO:0003845 None HSD11B1, HSD11B2 2.68882
[MF] GO:0008389 None CYP2A13, CYP2A6 2.68882
[MF] GO:0071886 None HTR2A, HTR2C 2.68882
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 2.63685
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 2.63685
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, MTNR1A, NQO2 2.60488
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.57469
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.51039
[MF] GO:0008502 None MTNR1A, MTNR1B 2.30237
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.28813
[MF] GO:0042165 neurotransmitter binding ACHE, HTR2A, HTR2B, HTR2C 2.28013
[MF] GO:0008227 None HTR2A, HTR2B, HTR2C, HTR6 2.14628
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.14294
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.06573


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.1639
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.5571
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.5324
Metabolic pathways_Homo sapiens_hsa01100 MAOA, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.5522
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.0731
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.0844
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, MTNR1A, MTNR1B, ADORA3, HTR2B, ADORA1, HTR2C, TRPV1, HTR2A 4.8864
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.9867
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, MAOA, ALOX5, HTR2B, HTR2C, HTR2A 4.2869
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.9245
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9901
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, TRPV1, HTR2A 3.5085
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.5085
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.0569
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.767
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.0569
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.0612
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1 3.0569
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.4821
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0569
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.6904
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.2691
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9412
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR2B, HTR2C, HTR2A 1.6914
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9165
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGES 2.0522
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9151
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6914
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.7073
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, PPARA 1.5787
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.4828
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.5126
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2601
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4296
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1754
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2015
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9059
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1975
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1395
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1721
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9416
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9322
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9059
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 0.9144
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1242
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9602
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1795
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0202
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8468
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8821
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9234
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0114
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8529
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0187
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1212
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8136
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8136
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8265
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8265
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8265
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.752
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8083
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7479
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.744
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3421
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6552
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6315
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5825
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5791
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.212
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.616
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2569
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2935
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3024
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3118
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3004
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2934
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3446
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3299
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3563
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3413
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3563
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3549
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3667
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3667
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3768
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3768
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3809
Axon guidance_Homo sapiens_hsa04360 MET 0.372
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.3702
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4077
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4345
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4345
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4546
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4458
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4456
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4538
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4455
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4541
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4546
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4546
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5787
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5126
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4543
Peroxisome_Homo sapiens_hsa04146 XDH 0.4645
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5046
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5035
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5123
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5223
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5223
Bile secretion_Homo sapiens_hsa04976 CA2 0.511
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5223
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5207
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5137
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5223
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5327
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5245
Shigellosis_Homo sapiens_hsa05131 SRC 0.5223
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8013
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.555
Malaria_Homo sapiens_hsa05144 MET 0.5842
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.5842
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.586
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5825
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5825
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5842
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.586
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6354
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6354
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6354
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7124
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6923
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7342
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7342
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7506
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7467
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7719
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8529
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8468
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9059
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1711


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)