TCM Prescription: Shi Xiao Pills



Prescription Description
Prescription IDTCMF5877
Pinyin NameShi Xiao Wan
Chinese Name湿消丸
English NameShi Xiao Pills
Function Description月经失调
IndicationsIrregular menstruation
Disease ICD-11 Category GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH147 Glehnia littoralis 北沙参 TCMH147 ITSAF389-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.8283
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.8283
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.1636
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.1177
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.1177
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1 10.6673
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 10.3838
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TRPV1, XDH 10.3838
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 10.2916
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 10.1963
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.67803
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TRPV1 9.64421
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.64421
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 9.62232
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.44847
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1 9.14926
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.84968
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 8.79862
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 8.76349
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 8.5452
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 8.5329
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 8.5329
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.51353
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.49073
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 8.4274
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.38796
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 8.38707
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.36325
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.27329
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.18283
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 7.86331
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TEK, TOP2A, XDH 7.84885
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.8408
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.43681
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.40644
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TRPV1 7.38352
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 7.26539
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 7.23562
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 7.15277
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.02426
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 7.00332
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 7.00332
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC, TRPV1 6.97932
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 6.94911
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.93979
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.92248
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1 6.80195
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.66562
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1B1, CYP2A13, CYP2A6 6.64817
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 6.60364
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.4853
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.48073
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 6.46639
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.4663
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC 6.4663
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.44453
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.3825
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.37999
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.36669
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.3558
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.3558
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.33425
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.32919
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 6.24566
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.2346
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.20247
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.11339
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.08045
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.08045
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.08045
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 6.07259
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 6.03116
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TRPV1 6.02576
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 6.00187
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, XDH 6.00187
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.95433
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.90027
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.88934
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.88348
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.88348
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 5.7945
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 5.76881
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.76881
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.7595
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.75008
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 5.66717
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.66717
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 5.66007
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1 5.62827
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.62827
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.6071
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.56728
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.56728
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK 5.54974
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 5.52786
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 5.47631
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TRPV1 5.46795
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 5.46057
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 5.45068
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.41683
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.3798
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 5.3449
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.31743
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.24058
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1 5.22607
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 5.21407
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 5.19837
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 5.18118
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.18118
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, EGFR, ESR1, FABP3, FLT3, PRKCE, PTGS2, RORC, SRC 5.16314
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.15814
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 5.07166
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 5.04949
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.00584
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.9296
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 4.9269
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 4.91933
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, PRKCG, RORC, SRC, TOP2A 4.91454
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 4.88036
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 4.8634
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 4.84465
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.84465
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 4.8374
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.83052
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1 4.80903
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.78866
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 4.78334
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.77402
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.7693
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 4.7693
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.7441
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 4.72473
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 4.69181
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.688
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.62165
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, PRKCD, PRKCE, SRC 4.53857
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.51992
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.49529
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 4.45282
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 4.40702
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 4.35543
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.34777
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.34517
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, PTGS2, SLC22A2, SLC22A3, SMAD3, TRPV1 4.33698
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.33698
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.33698
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.33698
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 4.28464
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 4.23767
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 4.19153
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 4.19153
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 4.18088
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TEK 4.12673
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.10096
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TOP2A 4.09407
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.05844
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 4.05844
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TOP2A 4.05095
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.03178
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, PRKCE, SRC, TRPV1 3.99229
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1B1, CYP2A13, CYP2A6 3.9888
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC 3.97972
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, EGFR, ESR1, FLT3, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK 3.96404
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.95944
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.91614
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.90106
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.8632
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.86212
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 3.86212
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1, XDH 3.85248
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.84788
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.8269
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.79772
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 3.79364
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.78944
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.78944
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 3.76951
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 3.76951
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 3.7571
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 3.7571
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.75191
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 3.75191
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.73351
[BP] GO:0051246 regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.72249
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.70366
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.6957
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.69446
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, PRKCA, PRKCE, SLC22A1 3.66308
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 3.60304
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.5672
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.54564
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.53398
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.50486
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.49575
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 3.49575
[BP] GO:0006855 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.47401
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.46243
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 3.46243
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.44745
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.43828
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.43828
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 3.43828
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 3.43828
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 3.42189
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.39491
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.39483
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 3.38568
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.38498
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.35079
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, MET, PIK3CA, PPARA, PRKCG, SMAD3 3.34753
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PRKCE, PTGS2 3.3433
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, PRKCE 3.33741
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.32066
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.26115
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.26115
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.25418
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TOP2A, TRPV1 3.23181
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.15819
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.15029
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, PTGS1, PTGS2 3.12486
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.11559
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 3.10901
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 3.10428
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 3.10428
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.10428
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 3.09325
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 3.08397
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 3.06859
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 3.05347
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 3.02581
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.02199
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 3.02082
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC 3.01171
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, GPR35, MMP9, PRKCE, PTGS2 3.01171
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 3.01171
[BP] GO:0035408 None PRKCA, PRKCB 3.01171
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.99551
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 2.98409
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BACE1, CA2, CA7, EGFR, PRKCE, PTGS2 2.98409
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BACE1, CA2, CA7, EGFR, PRKCE, PTGS2 2.98409
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 2.9798
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 2.9727
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.9678
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.9678
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, F10, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.96484
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 2.95543
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 2.94864
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.9302
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.92227
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, EGFR, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.9205
[BP] GO:0015893 None CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.9205
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.91713
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.89895
[BP] GO:0050776 regulation of immune response BCL2, DUSP3, ESR1, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.89895
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.89008
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.87977
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, NQO2, PTGS1, PTGS2, XDH 2.85684
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.85082
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC 2.83893
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, EGFR, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.83893
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK 2.83893
[BP] GO:0050730 None ADORA1, EGFR, FLT3, PRKCD, PRKCE, PTPN1, SRC 2.83209
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.83151
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 2.82963
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, PRKCE, PTGS2, SRC 2.81608
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH 2.8145
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.79259
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.7891
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.784
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.784
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.784
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.77282
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, ESR1, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.76334
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.75687
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3 2.72716
[BP] GO:0042752 None ADORA1, PPARA, PRKCG, RORC, TOP2A 2.72224
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.71338
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.71255
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP2A6, ESR1 2.67795
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.6702
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.6702
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.6702
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.6702
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.66636
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC 2.65463
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, PRKCD, PRKCE, SRC 2.65463
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.64755
[BP] GO:0090087 None ACHE, ADORA1, CA2, EGFR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.64649
[BP] GO:0010676 None INSR, PPARA, PRKCE, SRC 2.63079
[BP] GO:0050994 None ADORA1, PPARA, PRKCD, PRKCE 2.63079
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.63079
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.6251
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK 2.60215
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.59058
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.59058
[BP] GO:0051248 None CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, XDH 2.5887
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK 2.5887
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.57671
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.57671
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.57259
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.56099
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1 2.56099
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC 2.55551
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.55093
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.53454
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.49393
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.47238
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.47238
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1 2.47019
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.46035
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.44582
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, INSR, PTGS2, SRC 2.44455
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 2.44282
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.41758
[BP] GO:0002684 positive regulation of immune system process AXL, BCL2, CA2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SRC 2.41526
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 2.41224
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 2.3979
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, MET, PIK3CA, TRPV1 2.39747
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.38304
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC 2.38304
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, MMP12, PRKCE, SRC, TRPV1 2.37618
[BP] GO:1901374 None SLC22A1, SLC22A2 2.37092
[BP] GO:0015874 None SLC22A1, SLC22A2 2.37092
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.37092
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.3699
[BP] GO:0010675 None INSR, PPARA, PRKCE, RORC, SRC 2.3543
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PIK3CA, PRKCD, PRKCG, SRC 2.33658
[BP] GO:0051894 None KDR, SMAD3, TEK 2.31834
[BP] GO:0055074 calcium ion homeostasis BCL2, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.30117
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.29876
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 2.26952
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.26839
[BP] GO:1900076 regulation of cellular response to insulin stimulus PRKCB, PRKCD, PTPN1, SRC 2.25351
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.25238
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, EGFR, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.25151
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.2478
[BP] GO:0045913 None INSR, PPARA, PRKCE, SRC 2.23351
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.23182
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, IGF1R, INSR, PRKCD, SRC 2.23182
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23182
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, PRKCD, PTGS2, SMAD3, SRC 2.23182
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.23182
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.23182
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.21885
[BP] GO:0002431 Fc receptor mediated stimulatory signaling pathway PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.2059
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.2059
[BP] GO:0006928 movement of cell or subcellular component AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK 2.19658
[BP] GO:0032069 None HSPA1A, PRKCD, PTPN1 2.19035
[BP] GO:0046618 None SLC47A1, SLC47A2 2.18701
[BP] GO:0038094 Fc-gamma receptor signaling pathway PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.18081
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.16727
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.15257
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.13444
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTGS2 2.11206
[BP] GO:0045088 regulation of innate immune response ESR1, HSPA1A, MMP12, MMP2, PRKCD, PRKCE, PTPN1, SRC 2.10543
[BP] GO:0055065 metal ion homeostasis BCL2, EGFR, ESR1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.09624
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, EGFR, FABP4, MMP9, PTGS2 2.09182
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.08948
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.07528
[BP] GO:0031334 positive regulation of protein complex assembly ESR1, HSPA1A, MET, MMP1, PRKCE, SRC 2.07149
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.07065
[BP] GO:0046627 None PRKCB, PRKCD, PTPN1 2.07065
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.07065
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, PTGS2, SRC, TRPV1 2.06672
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, PIK3CB, PTGS2 2.06672
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, PIK3CA, PIK3CB, PTGS1, PTGS2 2.05941
[BP] GO:0032845 None ADORA1, BCL2, PRKCE, SRC, TRPV1 2.056
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.05172
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.04558
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.04058
[BP] GO:1901890 None KDR, SMAD3, TEK 2.04058
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.04058
[BP] GO:0070201 None ACHE, BCL2, EGFR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.03762
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.02984
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, PRKCD, PTGS2 2.02915
[BP] GO:0050678 None EGFR, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.02492
[BP] GO:1901342 regulation of vasculature development CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK, XDH 2.0178
[BP] GO:0071248 cellular response to metal ion CYP1A1, EGFR, FABP4, MMP9, PTGS2 2.01481
[BP] GO:0070542 None FABP3, PRKCE, PTGS2, SRC 2.01419
[BP] GO:0008217 None ADORA1, PPARA, PTGS1, PTGS2, SMAD3 2.00361
[BP] GO:0009888 tissue development ALPL, CYP1B1, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.00361
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, FLT3, GLO1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1 7.03665
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1 4.9296
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, SLC22A1, TEK 3.34624
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.23974
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 2.94864
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CA4, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 2.91669
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC 2.82963
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TEK, TRPV1 2.784
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, INSR, MET, PRKCG, PTGS2, SLC22A1, SRC, TEK, TRPV1 2.53554
[CC] GO:0045121 membrane raft BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.28214
[CC] GO:0098857 membrane microdomain BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.26792
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TOP2A, TRPV1, XDH 2.24668
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, BACE1, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 2.12869
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SMAD3, SRC, TOP2A, XDH 2.05773
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.04058
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, XDH 12.3163
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TEK, TOP2A, XDH 12.1226
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.7668
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1844
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 9.98518
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.84968
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.5329
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 8.36325
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.96662
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TOP2A, TRPV1, XDH 7.57763
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.49885
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TOP2A, TRPV1, XDH 7.25907
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.98859
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.94458
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.88875
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.79564
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.4663
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.45918
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.42796
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.27458
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.2346
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.21544
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 5.92221
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 5.66834
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.41291
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.38953
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6 5.2261
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.19019
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 5.12616
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 5.12513
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 5.02263
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.86169
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.82435
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.81434
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.77402
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.62165
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.33698
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.28338
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 4.07675
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.99229
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.9849
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13 3.84603
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 3.79364
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, XDH 3.72249
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, NQO2, PTGS1, PTGS2, XDH 3.68596
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.46158
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.46158
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.46158
[MF] GO:1901363 heterocyclic compound binding ADORA1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.41461
[MF] GO:0019899 enzyme binding AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP2A6, DUSP3, EGFR, ESR1, HSPA1A, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 3.25418
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.23974
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.21238
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.1828
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 3.10428
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, NQO2, PTGS1, PTGS2, SRC, XDH 3.10428
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.01171
[MF] GO:0008389 None CYP2A13, CYP2A6 3.01171
[MF] GO:0035403 None PRKCA, PRKCB 3.01171
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, NQO2 2.9678
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.90967
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1B1, CYP2A13 2.83151
[MF] GO:0015238 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.79321
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6 2.77995
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.7664
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.71338
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.71338
[MF] GO:0015307 None SLC47A1, SLC47A2 2.63079
[MF] GO:1901375 None SLC22A1, SLC22A2 2.63079
[MF] GO:0005333 None SLC22A1, SLC22A2 2.63079
[MF] GO:0005277 None SLC22A1, SLC22A2 2.63079
[MF] GO:0008513 None SLC22A1, SLC22A2 2.63079
[MF] GO:0004699 None PRKCD, PRKCE 2.63079
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.56527
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SLC22A1, SMAD3, TOP2A, TRPV1, XDH 2.44455
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.3467
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.31834
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.2749
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.23182
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 2.22558
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.21885
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 2.21551
[MF] GO:0043559 insulin binding IGF1R, INSR 2.18701
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.11345
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.10574
[MF] GO:0008519 None SLC22A1, SLC22A2, SLC22A3 2.07065
[MF] GO:0016740 transferase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 2.056
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04058
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.04058
[MF] GO:0035257 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.01481


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 10.6194
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB 9.9014
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, BCL2, MET 9.5995
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 9.9014
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PIK3CA, PRKCB, SRC, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 9.54
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7786
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 9.0715
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 9.0485
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 8.9223
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 8.9223
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 8.8847
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 8.7462
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 8.3122
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.5661
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 8.313
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 7.6629
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.3122
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 7.5619
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.9801
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 7.4156
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 6.7284
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 6.2252
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 6.0659
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 6.5452
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 5.7277
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 6.4965
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 5.9154
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 7.4156
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.9154
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 5.3648
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 5.4753
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, ALOX5, PRKCA, PTGS2, PTGS1 4.8608
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.4759
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.9458
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.8303
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.9219
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.6299
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8881
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.1913
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, PIK3CB 3.9855
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.7433
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.7277
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 5.4088
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA, EGFR 4.2047
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.0084
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.9855
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A1, CYP1B1, PTGS2 4.3439
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.6853
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.659
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.4492
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 3.3833
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PRKCA, PIK3CB, EGFR 3.3619
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 3.0349
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.687
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.7662
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.5577
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.4412
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.7867
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.9212
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.4096
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.2856
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.6562
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 4.0432
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 3.0257
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 3.1176
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 3.0764
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1921
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.8592
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4901
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A1, CYP1B1 3.4253
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 3.167
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA, PTGS2 2.9817
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.3421
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 3.0879
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.7126
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.734
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 3.0477
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3155
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3284
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.3405
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.564
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.368
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.6919
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.5896
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4097
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.5058
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.5342
Axon guidance_Homo sapiens_hsa04360 MET 0.4254
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4338
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.4429
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.468
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.501
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, FUT7, AKR1B10, ALOX5, CYP1A1, ALPL, AKR1B1, PTGS2, CYP19A1, XDH, PTGS1 2.1832
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, PRKCB, PRKCA, EGFR 2.2013
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8438
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5206
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8102
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.3873
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2013
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 1.0892
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5432
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5578
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5418
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9987
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, TRPV1 1.6247
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3165
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6849
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.9739
Peroxisome_Homo sapiens_hsa04146 XDH 0.5596
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.0421
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, PIK3CB, PPARA 2.072
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5753
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.714
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.582
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1548
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1662
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6156
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.8022
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6 0.6182
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.9404
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA 2.0741
Shigellosis_Homo sapiens_hsa05131 SRC 0.6383
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6415
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 2.0388
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.272
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 2.128
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 2.1991
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.2427
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6977
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6977
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.4173
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.4173
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.4828
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.5058
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.5058
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.4314
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7217
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.7217
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.4919
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1 1.4504
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4504
Malaria_Homo sapiens_hsa05144 MET 0.7317
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.4828
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.4429
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.7498
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A1 1.5147
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.564
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.5147
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1A1, CYP1B1, CYP19A1 2.633
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5865
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.9179
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8551
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8102
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8986
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8761
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9496
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 3.1816
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.7773
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9586
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.909
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1 1.8867
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9496
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0992
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0562
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9678
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2982
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1988
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, XDH 3.4412


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)