TCM Prescription: Tong Mai Ling Tablets



Prescription Description
Prescription IDTCMF5873
Pinyin NameTong Mai Ling Pian
Chinese Name通脉灵片
English NameTong Mai Ling Tablets
Function Description胸痹, 真心痛
IndicationsTrue heart pain disorder, Chest pain
Disease ICD-11 Category SA20 [True heart pain disorder (TM1), 真心痛 (TM1) ];
MD30.Z [Chest pain, unspecified, 胸痛，未特指的 ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, MIF, PPARA, PTGES 9.77063
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, NR3C1, PGR, PIM1, PPARA, RELA, RORC, SRC 9.71155
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MIF, MMP12, MMP2, MMP9, PGR, PIM1, PTGES, RELA, SLC6A4, SRC, TERT, XDH 9.57077
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 9.22058
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TYR, XDH 9.15621
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 8.55142
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FUT7, HSD17B3, MIF, PIM1, PPARA, PTGES, TYR, XDH 7.70202
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, APP, AR, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARA, PTGES, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 7.70086
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 7.61266
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TYR, XDH 7.25531
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, PTGES, RELA, RORC, SLC6A4, SRC, TYR 7.19416
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGES, RELA, RORC, SLC6A4, SRC, TYR 7.19416
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 7.11602
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC, TYR 7.03896
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 6.66292
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 6.64172
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.60478
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, MAOA, MET, MIF, PPARA, SLC6A2, SLC6A4, SRC, TERT, XDH 6.5045
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, PTGES, RELA, RORC, SLC6A4, SRC, TYR 6.44426
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, PTGES, RELA, RORC, SLC6A4, SRC, TYR 6.33382
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, RELA, SRC, TERT 6.19508
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.09149
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TYR, XDH 6.01051
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TYR, XDH 5.92169
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 5.92169
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGES 5.90991
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.74324
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGES 5.68935
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.56912
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, RELA, RORC, SLC6A4, SRC, TERT 5.48044
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, XDH 5.43766
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MIF, PTPN1, RELA, SRC, XDH 5.41561
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PTGES 5.3864
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, RELA, SLC6A4, SRC 5.3864
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 5.37471
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 5.35776
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CACNA1C, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, RELA, RORC, SLC6A4, SRC, TERT, TYR 5.35776
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, RELA, SLC6A4, SRC 5.33273
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.31641
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, RELA, TERT 5.29855
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.2277
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 5.18369
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NR3C1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 5.13977
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 5.06213
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SRC, TERT, XDH 5.01105
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.97315
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.95513
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.94035
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT 4.90963
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NR3C1, PTPN1, RELA, RORC, SLC6A4, SRC, TERT 4.8443
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 4.8443
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MET, MIF, PPARA, PTGES 4.8443
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MIF, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 4.833
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PTPN1, RELA, SRC, XDH 4.79388
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 4.74856
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.7428
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SRC, TERT, XDH 4.73442
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, RELA, SRC, TERT 4.72436
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PTPN1, RELA, SRC, TERT, XDH 4.68365
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SLC6A2, SLC6A4, SRC, TYR 4.66168
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.61775
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGES 4.6111
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 4.45995
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, PPARA, PTPN1, RELA, SRC, TERT, XDH 4.41646
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.32851
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 4.32851
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.32529
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MMP9, PGR, PIM1, PPARA, RELA, RORC, SRC, TYR 4.26788
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RELA, RORC, SLC6A4, SRC 4.25276
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, APP, CES1, CYP19A1, CYP1A1, CYP1B1, HSD17B3, MAOA, TYR 4.18493
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, XDH 4.18083
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, RELA, SRC, TERT 4.10657
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.07229
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.06372
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RELA, RORC, SLC6A4, SRC 4.00903
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC 3.93669
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC 3.90394
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CACNA1C, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.90394
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.90394
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MIF, PTGES 3.88424
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 3.84111
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.74361
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA2, CACNA1C, CYP1B1, ESR1, ESRRA, ESRRB, F3, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, RELA, SLC6A4, SRC, TERT, XDH 3.70751
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PTGES 3.65632
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.62026
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, CA2, CYP1B1, ESRRB, F3, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, RELA, SRC, TERT 3.56219
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 3.5572
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, XDH 3.54322
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, XDH 3.54322
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, XDH 3.54322
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.54322
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FLT3, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, XDH 3.43457
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, ESR1, ESR2, F3, FLT3, MAP2K1, MAP3K7, MET, MIF, MMP9, PTPN1, RELA, SRC, TERT, XDH 3.38809
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SLC6A4, SRC 3.38809
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 3.37997
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 3.36845
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 3.36667
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 3.28765
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MAP2K1, MET, MIF, PIM1, SRC, TYR 3.23475
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.23475
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT 3.19366
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT 3.1399
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTPN1, SRC, XDH 3.13435
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.12787
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.12696
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, PGR, SLC6A4, SRC 3.11744
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT 3.1063
[BP] GO:0071396 cellular response to lipid AR, AXL, ESR1, FLT3, NR3C1, RELA, RORC, SLC6A4, SRC 3.10611
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SRC, TERT, XDH 3.10318
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.10277
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.09068
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, ESR1, FLT3, IGF1R, MMP2, NR3C1, RELA, SLC6A4, SRC 3.08956
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.08145
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, XDH 3.04647
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.01442
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.99349
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SRC, TERT 2.96564
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KCNH2, KDR, NR3C1, RELA, SRC 2.95995
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PGR, PPARA, RORC, SLC6A4, SRC 2.94297
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.91864
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.90759
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, PGR, SRC 2.89174
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.87918
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.86149
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA 2.86149
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, MIF, MMP9, PTPN1, RELA, SRC, TERT 2.84618
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGES, TYR 2.84618
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, RELA, SRC, TERT, XDH 2.8263
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, NR3C1, RELA, SLC6A2, SLC6A4, SRC 2.82115
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80852
[BP] GO:0010629 None APP, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, KDR, MAP2K1, MIF, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT, XDH 2.80852
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT 2.80852
[BP] GO:0009115 None AOX1, XDH 2.80518
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, RELA, SRC, XDH 2.79507
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, KDR, RELA, SLC6A4, SRC 2.77011
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.73992
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71942
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, SRC, TERT, XDH 2.69748
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 2.64687
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MAOA 2.64687
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, TERT 2.6449
[BP] GO:0050730 None ADORA1, ADRA2A, APP, FLT3, MIF, PTPN1, SRC 2.63565
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, MIF, MMP12, PPARA, RELA 2.58934
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, XDH 2.58528
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, KCNH2, MAP2K1, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 2.58497
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.56644
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56644
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.56644
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.53449
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, XDH 2.53274
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.48867
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 2.47364
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGES, TYR 2.46347
[BP] GO:0045893 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT 2.42439
[BP] GO:1903508 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT 2.42439
[BP] GO:1902680 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT 2.42276
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, KCNH2, MIF, MMP12, SLC6A4, SRC, TERT 2.40705
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGES, TYR 2.40705
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, MIF, PTPN1, SRC 2.40705
[BP] GO:0060748 None AR, PGR 2.40705
[BP] GO:0046110 None AOX1, XDH 2.40705
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40705
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.40705
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.40161
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.39984
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 2.39124
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TERT, XDH 2.38439
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.38387
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, MAP2K1, PTGES, SLC6A4, TERT, XDH 2.37978
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.37525
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.35841
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, RELA, SRC 2.35841
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.32782
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC 2.32782
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.32751
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.32134
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, KDR, MIF, SRC 2.30998
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.29762
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, MMP2, PPARA, RELA, SLC6A4, SRC, TERT, TYR 2.27984
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, MIF, SLC6A4, SRC, TERT 2.27984
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.27984
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2C19, MAOA 2.27699
[BP] GO:0051254 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PGR, PPARA, RELA, RORC, SRC, TERT 2.24075
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.24075
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.24075
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, CACNA1C, KCNH2, MIF, MMP9, SLC6A4 2.23949
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.23167
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.23167
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.20938
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MAP2K1, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SRC, TERT, XDH 2.20938
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.19823
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.19064
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.19031
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19031
[BP] GO:0006145 None AOX1, XDH 2.19031
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.19031
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.19031
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 2.19031
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.17006
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SLC6A4, SRC, TYR 2.14778
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.1473
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1473
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.13617
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.13617
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESR1, F3, FLT3, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, XDH 2.12014
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, XDH 2.11798
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, FLT3, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.11798
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, IGF1R, MET, MIF, MMP9, PTPN1, RELA, SRC, XDH 2.10037
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PTPN1, RELA, SRC 2.09419
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.0744
[BP] GO:0006693 None CES2, MIF, PTGES 2.05989
[BP] GO:0006692 None CES2, MIF, PTGES 2.05989
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HSD17B3 2.05209
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, MAP3K7, MMP12, MMP2, PPARA, PTPN1, RELA, SRC 2.04087
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.0196
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.01242
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.01236
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.01236
[BP] GO:0010641 None F3, SRC 2.01236
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.00464
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.00464
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGES, PTPN1, RELA, SLC6A4, SRC, TERT, TYR, XDH 3.53172
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.36845
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, HSD11B1, HSD17B2, HSD17B3, NR3C2, PTGES, PTPN1 2.32782
[CC] GO:0005783 None ADORA1, APP, CA4, CES1, CES2, CYP19A1, FLT3, HSD17B3, KDR, MAP2K1, PTPN1, XDH 1.99892
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, F3, KCNH2, MET, MIF, SLC6A2 1.97894
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TYR, XDH 15.8368
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 10.0496
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 10.0496
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 9.71155
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTGES, PTPN1, SRC, TERT, TYR, XDH 8.28651
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC 8.01252
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.91112
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.91112
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.89003
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.33305
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 6.33305
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 6.01105
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 5.95087
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 4.94088
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.833
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.79388
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.62566
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 4.50994
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MAP3K7, MET, MIF, MMP9, PGR, RELA, SLC6A4, TERT, TYR, XDH 4.35336
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.1425
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SRC 4.07229
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.06712
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.93667
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.90394
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 3.88731
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, SHBG 3.88424
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SRC 3.7875
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, PTGES, SRC, XDH 3.62611
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.62611
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59913
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.40796
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.36667
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.36667
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.31167
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.2474
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.23721
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.19366
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.15059
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, ESR1, ESR2, ESRRB, F3, KCNH2, MET, MIF, NR3C1, PGR, PPARA, PTPN1, RELA, SLC6A4, SRC 3.1063
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.01442
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SLC6A4, SRC 2.95656
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.88668
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 2.86149
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RELA, RORC 2.82115
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.80518
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RELA, RORC 2.695
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.625
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.58614
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1, RELA 2.45642
[MF] GO:0005330 None SLC6A2, SLC6A4 2.40705
[MF] GO:0047374 None CES1, CES2 2.40705
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ALDH2, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SLC6A4, SRC, TERT, XDH 2.35604
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.32751
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.29762
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.29762
[MF] GO:0001077 None AR, ESR1, ESRRA, NR3C1, PGR, PPARA, RELA 2.27699
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TERT 2.25284
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.19031
[MF] GO:0032795 None ADORA1, ADRA2A 2.19031
[MF] GO:0005497 None AR, SHBG 2.19031
[MF] GO:0001012 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RELA, RORC 2.15366
[MF] GO:0000977 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RELA, RORC 2.15366
[MF] GO:0043565 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, NR3C2, PGR, PPARA, RELA, RORC, TERT 2.14335
[MF] GO:0000982 None AR, ESR1, ESRRA, NR3C1, PGR, PPARA, RELA, RORC 2.11798
[MF] GO:0001228 None AR, ESR1, ESRRA, ESRRB, NR3C1, PGR, PPARA, RELA 2.05562
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01236


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 8.655
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6043
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.655
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 6.6388
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, TYR, CYP2C19, CYP19A1, HSD11B1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, PTGES, CES1 5.9731
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, CACNA1C, CYP2C19, SLC6A4 5.4202
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.971
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.2389
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.1632
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.6419
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MMP1, MMP2, MMP9, MET, RELA, IGF1R 3.8931
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 4.0668
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 4.0068
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP2C19 3.8931
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.2513
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP2C19 2.9792
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, RELA, IGF1R 2.6407
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C, ADRA2A 2.6362
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9322
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9792
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.6362
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3, RELA 2.5261
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PGR, CDC25B, IGF1R 2.5411
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.5261
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, MMP9, MET, CDC25B 2.432
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.432
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, ADORA1, CACNA1C, PPARA, RELA 2.4042
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, IGF1R 2.3891
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.3311
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.2275
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, PGR, IGF1R 2.3206
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.3342
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, MMP9, RELA 2.1404
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.1023
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.6407
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2113
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.4331
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.2292
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.1404
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, KDR, MET, RELA, IGF1R 1.6631
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.1023
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19, PTGES 2.2025
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1544
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1404
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 1.7131
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 1.8019
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6949
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.6631
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.7097
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.6694
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4443
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.6054
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA 1.4528
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.6054
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.4804
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1, ADRA2A 1.367
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.4366
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.3393
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA 1.1686
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2508
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.2438
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9197
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.8351
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 0.9197
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.8356
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.8598
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3329
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8356
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9197
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.3284
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.8993
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.8598
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.8742
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.8351
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9197
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0416
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8108
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.3866
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7929
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.731
HTLV-I infection_Homo sapiens_hsa05166 TERT, RELA 0.5484
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.3933
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.7293
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7293
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.637
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.0852
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6562
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7565
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.1324
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4125
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4368
Axon guidance_Homo sapiens_hsa04360 MET 0.431
Platelet activation_Homo sapiens_hsa04611 SRC 0.4399
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.2965
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.2508
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3655
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1324
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.2508
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3277
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.1324
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4612
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2965
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.2965
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.2965
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.265
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4915
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2088
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2508
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4995
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4995
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2965
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4995
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5084
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.506
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4999
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2897
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5049
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.2965
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.506
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4995
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5137
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5151
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5151
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3573
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5255
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5151
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2965
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.265
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5209
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5209
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5151
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.5209
Peroxisome_Homo sapiens_hsa04146 XDH 0.5255
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5259
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5343
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5255
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5324
Pertussis_Homo sapiens_hsa05133 RELA 0.5462
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5484
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4443
Bile secretion_Homo sapiens_hsa04976 CA2 0.555
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4528
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5685
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.4395
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5484
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5857
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5711
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5857
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1 0.5916
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.6284
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6478
Legionellosis_Homo sapiens_hsa05134 RELA 0.6321
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7557
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6478
Malaria_Homo sapiens_hsa05144 MET 0.6613
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.776
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6664
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6712
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7131
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.7293
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6942
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7587
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9481
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7293
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7293
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.813
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8351
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8008
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.9205
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8008
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.813
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8351
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.1509
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8069
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8351
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8351
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9322
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2965


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)