TCM Prescription: Xia Xiao Pills



Prescription Description
Prescription IDTCMF5867
Pinyin NameXia Xiao Wan
Chinese Name下消丸
English NameXia Xiao Pills
Function Description遗精, 遗尿
IndicationsEnuresis disorder, Involuntary ejaculation disorder, Enuresis
Disease ICD-11 Category SB02 [Enuresis disorder (TM1), 遗尿 (TM1) ];
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
6C00 [Enuresis, 遗尿症 ];
Human Tissues Associated with IndicationKidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1275 Nelumbo nucifera 莲子 TCMH1275 ITSAI3109-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1663 Semen euryales 芡实 TCMH1663
TCMH1274 Stamen nelumbinis 莲须 TCMH1274
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 13.8357
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 13.7074
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 12.8074
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, FABP3, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 11.1986
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.6673
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GLO1, HMGCR, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.87557
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TYR 9.68454
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 9.33824
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 9.31403
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 8.83793
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.83793
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.83365
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.81844
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.81844
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.81844
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.41423
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.31352
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 8.27494
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.18469
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 8.14823
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TEK, TYR 8.11816
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.02132
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.96513
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 7.80978
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 7.80749
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.80749
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 7.76193
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 7.73762
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 7.73762
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.72985
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR 7.71762
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.59354
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.57501
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.53473
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 7.12591
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 7.08305
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.94806
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, FLT3, HMGCR, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 6.9011
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FABP4, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TYR 6.84084
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.82844
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR 6.71862
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.66287
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.57682
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 6.56935
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 6.46803
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD2, DUSP3, EGFR, ESR1, FLT3, FUT7, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 6.42596
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.42596
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.35766
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.30899
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.08037
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.08037
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A 6.0003
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.0003
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.88594
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 5.86542
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.8571
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.80996
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 5.79559
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, CDC25B, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.76477
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, EGFR, ESR1, PPARA, RORC, SRC, TOP1, TOP2A 5.70791
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, CDC25B, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.70791
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 5.52884
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, CDC25B, DRD2, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.52594
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, CDC25B, DRD2, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.52594
[BP] GO:0032879 regulation of localization ACHE, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, EGFR, GPR35, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.41053
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.3824
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.31988
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 5.24748
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.20485
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.18953
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.13431
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.13188
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, FDPS, HMGCR, HTR1A, TYR 5.10544
[BP] GO:0080134 regulation of response to stress APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.07272
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A 5.07272
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.06533
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD2, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 5.04343
[BP] GO:0001934 positive regulation of protein phosphorylation APP, BCL2, CDC25B, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.03607
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 5.016
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.93212
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, EGFR, FABP3, HMGCR, KDR, PTGS2, SRC, TOP1 4.91169
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.90816
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.90816
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.86096
[BP] GO:0001932 regulation of protein phosphorylation APP, BCL2, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.83331
[BP] GO:0042327 positive regulation of phosphorylation APP, BCL2, CDC25B, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.8037
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.8037
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.79504
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.79504
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.77943
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.76718
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.7487
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD2, EGFR, HMGCR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 4.7394
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.73638
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.73638
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.68986
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.67361
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.66193
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 4.65442
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.64796
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.62989
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.61916
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.61916
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DRD2, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.58139
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.57306
[BP] GO:0048583 regulation of response to stimulus AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.54624
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.50088
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.49125
[BP] GO:0031399 regulation of protein modification process APP, BCL2, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.48198
[BP] GO:0051247 positive regulation of protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.47623
[BP] GO:0065009 regulation of molecular function APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.44682
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, HMGCR, KDR, SRC 4.43156
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.4199
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.4199
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CYP19A1, DRD2, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.4199
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2 4.41325
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.35817
[BP] GO:0043408 regulation of MAPK cascade APP, DRD2, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.35339
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.34106
[BP] GO:0043410 positive regulation of MAPK cascade APP, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.31797
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, PPARA 4.29363
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 4.28136
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.28136
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.26972
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS, HMGCR 4.25999
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, BCL2, CDC25B, DRD2, EGFR, ESR1, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.24834
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.24502
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.24502
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.20623
[BP] GO:0051049 regulation of transport ACHE, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, EGFR, GPR35, HMGCR, HSPA1A, HTR1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 4.18805
[BP] GO:0009893 positive regulation of metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.13876
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.11365
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.10945
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.10945
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.05471
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 4.0264
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 4.01888
[BP] GO:0006950 response to stress ACHE, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 4.01699
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.9839
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FDPS, FLT3, HMGCR, PPARA, PTGS2, RORC, SRC, TEK 3.9774
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TOP2A 3.9774
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.94221
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.93172
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC 3.90097
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.8958
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 3.89516
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.84002
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD2, EGFR, HMGCR, KDR, PIK3CB, PTGS2, SRC 3.82856
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGS1, PTGS2, TBXAS1 3.79555
[BP] GO:0031401 positive regulation of protein modification process APP, BCL2, CDC25B, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.79168
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.79168
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.70512
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.69807
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.66237
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.60459
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.60205
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS 3.5168
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.49548
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.49075
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.4876
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.48471
[BP] GO:0044093 positive regulation of molecular function APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 3.47872
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP1, TOP2A 3.45646
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 3.39304
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.38502
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.38502
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.38152
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.36077
[BP] GO:0019222 regulation of metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 3.35992
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.35992
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.35944
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, EGFR, HTR1A, INSR, PTGS2, SMAD3 3.35592
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, PPARA 3.34004
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD2, EGFR, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.30613
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 3.2733
[BP] GO:0032268 regulation of cellular protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.27144
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 3.2701
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.26851
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD2, EGFR, PTGS2 3.26773
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26195
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 3.26195
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.23441
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 3.21943
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.21372
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.20166
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.20023
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.20012
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 3.16915
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 3.15727
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, DRD2, EGFR, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 3.14273
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, DRD2, EGFR, HMGCR, KDR, SRC, TEK 3.14273
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 3.09363
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.09319
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 3.09319
[BP] GO:0080090 regulation of primary metabolic process APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.06333
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD2, EGFR, HMGCR, PTGS2, TYR 3.06333
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.06071
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, HTR1A, TYR 3.05434
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.04426
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 3.00779
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 2.99178
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.95832
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.94743
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94743
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.93126
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.93056
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.92404
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, DRD2, EGFR, PTGS2 2.92404
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, DRD2, EGFR, PTGS2 2.92404
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, DUSP3, ESR1, ESR2, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.92189
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR 2.91307
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.90349
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.90349
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 2.89361
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.86579
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.85355
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FLT3, FUT7, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 2.84495
[BP] GO:0006644 phospholipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, FDPS, MET, PIK3CA, PIK3CB 2.83439
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.83127
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.83127
[BP] GO:0019637 organophosphate metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, FDPS, HMGCR, HSPA1A, MET, PIK3CA, PIK3CB, PTGS2, XDH 2.82785
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TOP2A 2.82448
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, EGFR, PIK3CB, PTGS2 2.81981
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.80382
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.78307
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, EGFR, ESR1, GPR35, PIK3CB, SMAD3 2.78123
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, HSPA1A 2.76609
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 2.76333
[BP] GO:0003018 None EGFR, HMGCR, HTR1A, PTGS2, SRC, TEK 2.76333
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.75
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH 2.74864
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, DRD2, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SMAD3 2.72565
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.72237
[BP] GO:0009894 regulation of catabolic process APEX1, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 2.71663
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.71663
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.71663
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.71518
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.71518
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.71446
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.70882
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, PTGS2, SRC, TYR 2.68575
[BP] GO:0033674 positive regulation of kinase activity CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.65402
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.64601
[BP] GO:0051246 regulation of protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.64601
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB 2.64331
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.64226
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 2.62063
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.60749
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.60749
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.60749
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.60749
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 2.5897
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.5897
[BP] GO:0031323 regulation of cellular metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.58551
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.58346
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.57354
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.56681
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.56286
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56247
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.55676
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.53519
[BP] GO:0051050 positive regulation of transport ACHE, APP, AXL, BCL2, CA2, CYP19A1, DRD2, EGFR, INSR, MMP12, PTGS2, SMAD3, SRC 2.52306
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.52306
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.52022
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.5177
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.51129
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.51129
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.50735
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.49498
[BP] GO:0051171 regulation of nitrogen compound metabolic process APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.48919
[BP] GO:0032922 None DRD2, PPARA, RORC, TOP1 2.48631
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.46063
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, HTR1A 2.4399
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP4, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.43691
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.43144
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.43144
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, EGFR, HSPA1A, INSR 2.41433
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.41421
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.41279
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41279
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, INSR 2.37915
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.37457
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MMP2, MMP9, PTGS2, RORC, SMAD3, TOP2A 2.35834
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.35661
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD2, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TOP2A 2.34837
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK 2.3472
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.34363
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.33428
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, DRD2, EGFR, ESR1, INSR, MET, MMP2, SMAD3, SRC, TEK 2.32593
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.32399
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.31554
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31554
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.31554
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.31554
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31554
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.31123
[BP] GO:0016311 None ALPI, ALPL, APEX1, BCL2, CDC25B, DUSP3, PTPN1 2.30627
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.28384
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, FDPS, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.27111
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.27059
[BP] GO:0051894 None KDR, SMAD3, TEK 2.27059
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.27059
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27059
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.25242
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, GPR35, PTGS2 2.25242
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD2, EGFR, ESR1, GPR35, PIK3CB, SMAD3 2.25166
[BP] GO:0003013 None EGFR, HMGCR, HTR1A, PTGS2, SRC, TEK 2.2102
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.2102
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, PIK3CA 2.21015
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, FDPS, HMGCR 2.20913
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, MMP12, PTGS2, SMAD3, SRC 2.20837
[BP] GO:0032989 cellular component morphogenesis APP, AXL, BCL2, DRD2, EGFR, MET, SRC, TEK 2.20798
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.20787
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.20702
[BP] GO:0002682 regulation of immune system process APP, AXL, BCL2, CA2, CYP19A1, DRD2, DUSP3, ESR1, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.2068
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, SRC 2.19083
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, KDR, SRC 2.19083
[BP] GO:1903393 None KDR, SMAD3, TEK 2.19083
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC 2.19083
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, TEK, TYR 2.19083
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.19083
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, PTGS2, SRC, TYR 2.19051
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.17925
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.16549
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.15627
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.15294
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, EGFR, FDPS, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC, TOP1 2.15229
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD2, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A 2.15163
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD2, ESR1, GPR35, PIK3CA, PIK3CB, SMAD3 2.15059
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD2, ESR1, GPR35, PIK3CA, PIK3CB, SMAD3 2.15016
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.14141
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.13486
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.13486
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.13486
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.12441
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.12441
[BP] GO:0007623 circadian rhythm DRD2, EGFR, PPARA, RORC, TOP1 2.12441
[BP] GO:0007612 None APP, DRD2, HMGCR, INSR, PTGS2 2.12441
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD2, EGFR, ESR1, GPR35, PIK3CB, SMAD3 2.12185
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.12116
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.10945
[BP] GO:0032147 activation of protein kinase activity DRD2, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.10329
[BP] GO:0030100 regulation of endocytosis APP, AXL, DRD2, PIK3CB, PTPN1, SRC 2.10268
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD2, EGFR, HMGCR, PTGS2, TYR 2.10073
[BP] GO:0007610 None APP, BCL2, DRD2, EGFR, HMGCR, HTR1A, INSR, PPARA, PTGS2 2.10054
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTGS2 2.09131
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.08704
[BP] GO:0051239 regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, DRD2, EGFR, ESR1, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.08599
[BP] GO:0043271 negative regulation of ion transport BCL2, DRD2, GPR35, MMP9, PTGS2 2.06733
[BP] GO:0051248 None APP, CSNK2A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.06111
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.05581
[BP] GO:0090087 None ACHE, APP, CA2, DRD2, EGFR, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.05568
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, HMGCR, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK 2.05334
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.05237
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.05237
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.05237
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.05237
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.02521
[BP] GO:0065007 biological regulation ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, GPR35, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 2.02521
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, EGFR, ESR1, HMGCR, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.02285
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD2, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TOP2A 2.02285
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02285
[BP] GO:1990535 None APP, INSR 2.02285
[BP] GO:1901890 None KDR, SMAD3, TEK 2.02285
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.02285
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.02285
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.02285
[BP] GO:0070201 None ACHE, APP, BCL2, DRD2, EGFR, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.02012
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, TEK, TYR 2.02012
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, FDPS, HMGCR, PTGS1, PTGS2 2.01628
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.01408
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, PTGS2 2.01343
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TOP1, TOP2A, TYR, XDH 3.39787
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.98663
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.96697
[CC] GO:0009330 None TOP1, TOP2A 2.94743
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 2.92404
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP1, TOP2A, TYR, XDH 2.76513
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.51199
[CC] GO:0016020 membrane ACHE, ALOX5, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, FLT3, FUT7, GLO1, GPR35, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TEK, TYR 2.27853
[CC] GO:0005886 plasma membrane ACHE, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD2, EGFR, ESR1, FLT3, GLO1, GPR35, HTR1A, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK 2.26165
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, TBXAS1 2.17543
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CYP19A1, FLT3, HMGCR, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.10248
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.02285
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 15.0622
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 15.0622
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 14.9648
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 12.3617
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 8.18469
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.18469
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.11623
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, FDPS, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TYR, XDH 8.11623
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.80865
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.49885
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP1, TOP2A 7.12766
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.71374
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TYR, XDH 6.63607
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 6.32591
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 5.48634
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 5.29946
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.27193
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.24703
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 5.07272
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.04343
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.93212
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.86658
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.73638
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, TBXAS1, XDH 4.53268
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.3789
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.07471
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.03163
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SMAD3, TOP2A, TYR, XDH 3.89516
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.79168
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.77127
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.62826
[MF] GO:0097159 organic cyclic compound binding APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, ESR1, ESR2, FDPS, FLT3, HMGCR, HSD17B1, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, XDH 3.57876
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.56839
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.56839
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.55432
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, XDH 3.45646
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, XDH 3.40724
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, XDH 3.406
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.38152
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 3.34004
[MF] GO:1901363 heterocyclic compound binding APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, FDPS, FLT3, HMGCR, HSD17B1, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, XDH 3.34004
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.26195
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 3.22272
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, XDH 3.20012
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 3.19702
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK, TOP1 3.19702
[MF] GO:0019899 enzyme binding ALPI, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 3.1955
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.94743
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.94743
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.76513
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.64601
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.64601
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.49498
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.37915
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 2.3472
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.3384
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.31554
[MF] GO:0051425 None APP, INSR 2.31554
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.29383
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 2.24847
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.22995
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 2.21479
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 2.21015
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.19083
[MF] GO:0038023 signaling receptor activity AXL, DRD2, EGFR, ESR1, ESR2, FLT3, GPR35, HTR1A, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.18579
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.17925
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.15229
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.15059
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15059
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, DRD2, FLT3, HMGCR, NQO2, PTGS2, SMAD3, TOP2A, TYR, XDH 2.12441
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.12116
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.09265
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.08704
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.08704
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02285
[MF] GO:0004035 alkaline phosphatase activity ALPI, ALPL 2.02285
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.02285


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.0245
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.1963
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.4208
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.0754
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.1752
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 7.0801
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 6.8904
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 6.6
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.3594
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 6.1375
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.9378
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.1774
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.8539
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.957
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.8309
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3546
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.6101
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.2501
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.6548
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.6101
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, TBXAS1, PTGS2, PTGS1 4.6428
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.433
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.5387
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.4215
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.1056
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.321
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6906
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.0364
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.4095
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.6407
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, HTR1A, PTGS2, PTGS1 3.6024
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.5174
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.4742
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 3.4528
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6024
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.0339
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.4407
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.4847
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.4263
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 3.0246
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.9059
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.8649
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.683
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0339
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.6402
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1767
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.684
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, HTR1A, PIK3CB, DRD2, PPARA 2.6611
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.362
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6216
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6216
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.4288
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.4573
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.3742
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.4011
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.3657
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.3038
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.2453
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB, HSPA1A 2.1045
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.073
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.8542
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6207
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3, PIK3CA, PIK3CB 1.6087
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5799
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9727
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0454
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6078
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.942
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.2733
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7683
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3228
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3155
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3212
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5535
Alcoholism_Homo sapiens_hsa05034 DRD2 0.3212
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.9176
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, BCL2, PIK3CB 1.7683
Gap junction_Homo sapiens_hsa04540 SRC, DRD2, EGFR 2.0744
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, INSR, PIK3CB 1.4299
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3649
Parkinson's disease_Homo sapiens_hsa05012 DRD2 0.3868
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0248
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR1A, DRD2 0.9547
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2381
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4035
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3721
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.5354
Axon guidance_Homo sapiens_hsa04360 MET 0.4162
Dopaminergic synapse_Homo sapiens_hsa04728 DRD2 0.4138
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4245
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3348
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9034
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9212
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8063
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8983
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.934
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7734
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.6216
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9727
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.8069
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3484
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4915
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4915
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.502
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4915
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5011
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0881
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0987
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.683
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5242
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1249
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5242
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5367
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5354
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1731
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1365
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.523
Peroxisome_Homo sapiens_hsa04146 XDH 0.5367
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1946
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.9055
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5727
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5588
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5707
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5855
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5879
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3479
Shigellosis_Homo sapiens_hsa05131 SRC 0.6077
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3917
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6354
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3658
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8821
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.3658
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.475
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4238
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6664
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4238
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.484
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6929
Malaria_Homo sapiens_hsa05144 MET 0.7055
Cocaine addiction_Homo sapiens_hsa05030 DRD2 0.7055
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7153
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7206
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6782
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8136
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7734
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8523
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8136
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8983
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8303
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8726
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9727
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9027
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8623
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9337
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8499
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8983
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1645
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.1967
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.518
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3066


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)