TCM Prescription: Sheng Ji Bie Jia Pills



Prescription Description
Prescription IDTCMF5839
Pinyin NameSheng Ji Bie Jia Wan
Chinese Name圣济鳖甲丸
English NameSheng Ji Bie Jia Pills
Function Description症积
IndicationsDyspepsia
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH238 Dichroa febrifuga 常山 TCMH238 ITSAJ4406-14
TCMH216 Fructus tsaoko 草果 TCMH216 GQ118666
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT827 NQO1 Quinone reductase 1) Oxidoreductase P15559
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, IDO1, MPO, NQO1, PTGS2, RORC, SRC, TYR 10.2631
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.08854
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, KDR, MET, NQO1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 9.08854
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MPO, NQO1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 8.7517
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IDO1, IGF1R, MPO, NQO1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 8.7517
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MPO, NQO1, PIK3CA, PPARA, PTGS2, RORC, SRC, TOP1, TYR 8.16367
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, IDO1, MPO, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 7.95901
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MPO, NQO1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 7.6031
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GPR35, HCAR2, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.59502
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GPR35, HCAR2, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.58492
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MPO, NQO1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 7.52603
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, NQO1, NQO2, PTGS1, PTGS2, TYR, XDH 7.34857
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.9303
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IDO1, IGF1R, KDR, MPO, NQO1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 6.83077
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.5036
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.3637
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MPO, NQO1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 6.14552
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.10829
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, NQO1, PTGS2, RORC, SRC, TYR 6.10796
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.10099
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F10, FLT3, GPR35, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.03097
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MPO, NQO1, PIK3CA, PIM1, PTGS2, PTPN1, SRC 5.9507
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.9507
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GPR35, HCAR2, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 5.9507
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.94969
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GPR35, HCAR2, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 5.84198
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MPO, NQO1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TNKS2, TYR 5.84185
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, NQO1, PTGS2, SRC 5.82061
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.68761
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MPO, NQO1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP1, TYR 5.59164
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MPO, NQO1, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 5.55699
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, GPR35, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.48633
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MPO, NQO1, PIK3CA, PIM1, PTGS2, PTPN1, SRC 5.2877
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, KDR, NQO1, PTGS2, SRC, TOP1 5.2877
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO, NQO1 5.21079
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FLT3, GPR35, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, NQO1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.17073
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, GPR35, IGF1R, MET, NQO1, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.0406
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 5.0406
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NQO1, PPARA, PTGS2, SRC 5.0406
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, NQO1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.9489
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, GPR35, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.91468
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F10, FABP4, FLT3, GPR35, HTR6, IDO1, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.89079
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.84022
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MPO, NQO1, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 4.83487
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.83487
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 4.83487
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.83487
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.75233
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.66909
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.66909
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, FABP4, HSD17B2, IDO1, IGF1R, MET, MPO, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP1, TYR 4.66431
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, KDR, NQO1, SRC 4.65149
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO1, NQO2, PTGS1, RORC 4.52757
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 4.46416
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.44252
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36769
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.31761
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PPARA, PTPRS, SRC, TYR 4.29509
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FABP4, FLT3, GPR35, HTR6, IDO1, IGF1R, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.27617
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.23483
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.12982
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 4.11703
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS1, PTGS2 3.95818
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, NQO1, PPARA, PTGS2, SRC 3.87818
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 3.70923
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NQO1, PIK3CA, PTGS2, RORC, SRC 3.67523
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GPR35, HCAR2, IDO1, IGF1R, KDR, MET, MPO, NQO1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.6573
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GPR35, IDO1, IGF1R, KDR, MET, MPO, NQO1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.6573
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.61314
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO, NQO1 3.58835
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.57465
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, GPR35, MET, PIK3CA, PIK3CB, SRC 3.55626
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, GPR35, HCAR2, IGF1R, KDR, MET, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.54791
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 3.54791
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, MPO, NQO1, PTGS2, SRC, TYR 3.51495
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, PIK3CA, PTGS2, RORC, SRC 3.51495
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, NQO1, SRC 3.48183
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS, TOP1 3.46228
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MPO, NQO1, PTGS1, PTGS2, SRC 3.43774
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 3.41635
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 3.33359
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MPO, NQO1, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 3.23984
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IDO1, IGF1R, KDR, PIM1, PTGS1, PTGS2, SRC, XDH 3.20341
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 3.17359
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.16889
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS, TOP1 3.16889
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.16738
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.13765
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP1 3.13103
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.12748
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12748
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2 3.07856
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.00542
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, GPR35, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.00542
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC, XDH 3.00174
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, MPO, NQO1, PTGS2, SRC, TYR 2.96247
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.96247
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.91349
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.91316
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, FLT3, GPR35, IGF1R, MET, NQO1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, XDH 2.9052
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, KDR, MET, PPARA, PTGS2, PTPRS 2.9052
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, NQO1 2.9052
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2, PTPN1, PTPRS, SRC 2.89768
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, NQO1, PTGS2 2.85451
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, NQO1, PTGS2 2.84547
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8334
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, GPR35, MET, PIK3CA, PIK3CB 2.8334
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.81324
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, MPO, NQO1, PTGS2 2.80846
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC 2.80846
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.80846
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.77973
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76002
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, IDO1, MPO, PTGS1, PTGS2 2.75693
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, IGF1R, MET, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 2.71166
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.68483
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.65982
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NQO1, PIK3CA, PTGS2, PTPN1, RORC, SRC 2.64908
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 2.60903
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.60903
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60903
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.60903
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, NQO1, PTGS2 2.55948
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.53647
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, NQO1, SRC 2.53647
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, MET, PIK3CA, PPARA 2.51764
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, HCAR2, IDO1, PIK3CA, PIK3CB, PTPN1, PTPRS, SRC 2.51764
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP1 2.51764
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.49149
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, HCAR2, IDO1, NQO1, PIK3CB, PTGS2, SRC, XDH 2.486
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, FABP4, FLT3, IGF1R, NQO1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 2.48533
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.48533
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.46875
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, NQO1, SRC 2.46737
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.46737
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, HCAR2, IDO1, NQO1, PIK3CB, PTGS2, SRC, XDH 2.46737
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, NQO1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC 2.42599
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.42599
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.42599
[BP] GO:1904880 response to hydrogen sulfide KDR, NQO1 2.42599
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.42366
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTPN1, SRC 2.41266
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, NQO1, PTGS2, SRC, TYR 2.39732
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.39176
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NQO1, PTGS2, SRC 2.37635
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, PTGS2, SRC 2.37367
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, NQO1, PTGS2, TYR 2.35009
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.33343
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.32483
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32483
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.31394
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, NQO1 2.30468
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, NQO1 2.29214
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.29214
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FLT3, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.29138
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FLT3, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.29138
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.28447
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.28447
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.284
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, IDO1, PTPRS 2.27371
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.27281
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, HCAR2, IDO1, NQO1, PIK3CB, PTGS2, SRC, XDH 2.26394
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, PTGS2 2.24534
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, PTGS2 2.24534
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.23936
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23936
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, PTGS2 2.23936
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23936
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, MPO, PIK3CB, SRC, XDH 2.23713
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 2.23554
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.22875
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.21215
[BP] GO:0070213 None TNKS, TNKS2 2.21215
[BP] GO:0038171 None CNR1, CNR2 2.21215
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21215
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, IGF1R, NQO1, PPARA, PTGS2, SRC, TYR 2.20647
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, PTGS2, SRC 2.19894
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, GPR35, HCAR2, PIK3CB, PPARA, PTGS2, PTPN1, SRC 2.18827
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CNR1, CNR2, CYP19A1, ESR1, IGF1R, MET, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 2.18827
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, KDR, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.1496
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.14238
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.13543
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, PTGS2, SRC 2.13009
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.11645
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, NQO1, PTGS2, SRC 2.1087
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, MPO, NQO1, PPARA, PTGS2, SRC, TYR 2.10274
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.07551
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, GPR35, PTGS2 2.05385
[BP] GO:2000108 None HCAR2, IDO1, PIK3CB 2.03463
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.03463
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.03463
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.02474
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.01976
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.01446
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR 3.15975
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F10, FLT3, GPR35, HCAR2, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SRC 3.00308
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TYR 2.73097
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, KDR, MPO, NQO1, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.35328
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM2, CNR1, CNR2, F10, FLT3, GPR35, HTR6, IGF1R, KDR, MET, PTPRS 2.23311
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, F10, FLT3, GPR35, HTR6, IGF1R, KDR, MET, PTGS2, PTPRS, SRC 2.18827
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MPO, NQO1, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 10.3566
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.89502
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, NQO1, NQO2, PTGS1, PTGS2, TYR, XDH 8.5858
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 8.11542
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, NQO2, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 7.73119
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC 6.47302
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.32498
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC 6.23872
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.58601
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1 5.26494
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, MPO, NQO2, PTGS1, PTGS2, SRC, XDH 4.78451
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.69727
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63184
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.63171
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.48183
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.47221
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.47221
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, IDO1, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.43518
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.42174
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.41635
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.32048
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, IDO1, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.16738
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.00542
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.00542
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.97925
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, GPR35, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 2.9692
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.9052
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TOP1 2.89922
[MF] GO:0043168 anion binding ABCB1, ALOX15, AURKB, AXL, CSNK2A1, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TOP1, TUBB3, XDH 2.89768
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.7984
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, NQO2, PPARA, PTPN1, RORC, TNKS 2.7984
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.77914
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.69969
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.68483
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.60546
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.46737
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, GPR35, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 2.4636
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.42599
[MF] GO:0004949 None CNR1, CNR2 2.42599
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, GPR35, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 2.33343
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.31765
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TUBB3, XDH 2.23554
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, GPR35, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 2.07551
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.07551


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.6509
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2042
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.9876
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.2787
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9876
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.4939
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.4939
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, PIK3CA, ADORA1, PIK3CB, PPARA 4.3067
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, KDR, PIK3CB, MET, ESR1, IGF1R 4.3067
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.3067
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 4.29
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MET, CDC25B 4.29
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3067
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.6398
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CNR2, GPR35, CNR1, ADORA3, ADORA1 3.6398
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.1909
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, ALOX15, PTGS2, PTGS1 3.6398
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1219
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6062
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.249
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.5415
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.2934
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.372
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.2889
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, BCL2, PIK3CB, PTGS2, MET, IGF1R 2.9094
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2839
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.0316
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, BCL2, PIM1, PIK3CB 2.8765
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0739
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.8996
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2227
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, PIK3CB, ESR1 2.8965
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.857
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.776
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.5418
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.6696
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6265
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6696
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB 2.3914
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.3015
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.3015
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.2226
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.3914
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, MPO, IGF1R 2.1221
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3995
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.9918
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4289
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.9255
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9918
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3914
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.1111
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0326
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0374
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2 1.8952
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.3452
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7022
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.8047
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7093
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7791
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7093
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6803
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7022
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6826
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6332
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.6757
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6212
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3409
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4292
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2557
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3501
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3633
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3737
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.117
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4295
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6396
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9674
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9901
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6 0.8428
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0078
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0206
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4711
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8557
Axon guidance_Homo sapiens_hsa04360 MET 0.4656
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4711
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8471
Phagosome_Homo sapiens_hsa04145 TUBB3, MPO 0.9296
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1969
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1969
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2435
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1829
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1767
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2068
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, PIK3CB 1.1022
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1829
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.1969
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5402
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5394
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.553
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5522
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.2779
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5661
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5661
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5691
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5691
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5682
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4508
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4185
Peroxisome_Homo sapiens_hsa04146 XDH 0.5849
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4185
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.6005
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4646
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4292
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6243
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6223
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.4292
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6373
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4508
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5319
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4717
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6396
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.656
Shigellosis_Homo sapiens_hsa05131 SRC 0.656
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.656
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6772
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5777
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5403
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6278
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.7082
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7022
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6767
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7347
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7934
Malaria_Homo sapiens_hsa05144 MET 0.7474
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7605
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7655
Bladder cancer_Homo sapiens_hsa05219 SRC 0.8049
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7799
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9735
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9918
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8557
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9255
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8474
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8557
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8969
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1369
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9539
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9062
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9423
Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 NQO1 1.2471
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.181
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.249


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)