TCM Prescription: Xi Shang Le Ding



Prescription Description
Prescription IDTCMF5740
Pinyin NameXi Shang Le Ding
Chinese Name息伤乐酊
English NameXi Shang Le Ding
Function Description跌打损伤, 痹病
IndicationsArthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2348 Sanguis draconis 血竭 TCMH2348
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH2124 Speranskia tuberculata 透骨草 TCMH2124
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH2329 Realgar 雄黄 TCMH2329
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7367
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7367
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SOAT1, SOAT2, TBXAS1 13.157
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, SOAT1, SOAT2, SRC, XDH 12.4954
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, IDO1, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCD, PTGS2, RORC, SRC 11.6379
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCD, PTGS2, RORC, SRC 11.3461
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HTR2B, HTR2C, IDO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, SOAT1, SOAT2, TBXAS1, XDH 11.0622
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR5A, IDO1, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PRKCD, PTGS2, RORC, SRC 10.1367
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IDO1, PTGS2, RORC, SRC 9.60639
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 9.29046
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD11B2, HSD17B1, SOAT1, SOAT2 9.27745
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.8
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 8.53541
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, RORC, SOAT1, SOAT2, SRC 8.51916
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SOAT1, SOAT2, TBXAS1 8.28201
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 8.28201
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.91388
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CXCL8, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 7.72079
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PRKCD, PTGS2, SRC 7.69495
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 7.67153
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 7.64067
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SRC 7.34704
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PRKCD, PTGS2, SRC 7.31839
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.21309
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, TBXAS1, XDH 7.18822
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, POLA1, POLB, SOAT1, SOAT2, SRC 7.12834
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 7.07156
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.00339
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC 6.96587
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SRC 6.96587
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC 6.8931
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82796
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TBXAS1, XDH 6.81546
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, PRKCD, SRC 6.77153
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 6.74472
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PRKCD, PTGS2, SRC 6.7416
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.65008
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SOAT1, SRC, XDH 6.65008
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CXCL8, CYP1B1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IDO1, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.55929
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PTGS2, SRC 6.40159
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 6.39191
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.38831
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.38274
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PTGS2, RORC, SRC 6.36845
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.36845
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SRC, XDH 6.34055
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 6.32967
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.27977
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.23844
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CNR1, CNR2, CXCL8, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 6.22096
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.16254
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC 6.11839
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, PTPN1, SRC 5.924
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PRKCD, PTGS2, RORC, SRC 5.92269
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.86394
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PRKCD, PTGS2, RORC, SRC 5.8605
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.85447
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SRC, XDH 5.76099
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCD, PTGS2, RORC, SOAT1, SOAT2, SRC 5.6632
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2C 5.6632
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.65538
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SOAT1, SRC, XDH 5.6105
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC 5.53595
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1B1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC 5.46197
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.45146
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TBXAS1, XDH 5.44908
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SOAT1, SOAT2 5.44637
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 5.43685
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.39789
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 5.35539
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, PTPN1, SRC 5.31031
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 5.30564
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.25949
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.25122
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.25122
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 5.23836
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 5.23836
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 5.19746
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 5.1909
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARA, PTGS1, PTGS2, TBXAS1 5.15218
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 5.13754
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1 5.11333
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.08183
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.05996
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CXCL8, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, IDO1, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, SRC 5.01484
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLA1, POLB, PRKCD, PTGS2, PTPN1, RORC, SRC 4.96354
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, SOAT1, SOAT2 4.95301
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.77011
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 4.71965
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 4.71529
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.69306
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CNR1, CNR2, CSNK2A1, CXCL8, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCD, PTPN1, RORC, SRC 4.61293
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.57508
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 4.56206
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.54855
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 4.54855
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PTGS1, PTGS2 4.52116
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCD, PTGS2, PTPN1, SRC, XDH 4.51192
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 4.51192
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 4.4971
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 4.48967
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4666
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.43157
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.43157
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 4.3592
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC 4.33573
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.26909
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC 4.26585
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCD, PTGS2, PTPN1, SRC, XDH 4.18563
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.09923
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SOAT1, SRC, XDH 4.09667
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, PRKCD, PTPN1, SRC, XDH 4.08443
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTPN1, SRC, XDH 4.08443
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 4.06432
[BP] GO:0016477 cell migration AXL, CNR2, CXCL8, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 4.06339
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PRKCD, PTGS1, PTGS2, SRC 3.9552
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, CXCL8, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 3.92076
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.85575
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PRKCD, PTGS2, RORC, SRC 3.85575
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TBXAS1, XDH 3.84004
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.84004
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PRKCD, PTGS2, SRC 3.81876
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, CXCL8, HTR1A, HTR2C, PIK3CA, PIK3CB, POLB, PRKCD, PTGS1, PTGS2, SRC 3.81654
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, POLB, PPARA, PTGS2, SRC 3.81046
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.80403
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, POLA1, PRKCD, SRC 3.79755
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.79514
[BP] GO:0090066 None ADORA1, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PRKCD, PTGS2 3.71003
[BP] GO:0040011 locomotion AXL, CNR2, CXCL8, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 3.70633
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SRC, XDH 3.70633
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CXCL8, CYP19A1, ESR1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PRKCD, PTGS2 3.69164
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PRKCD, PTGS2, PTPN1, SRC 3.66817
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC 3.65054
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.63772
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.63772
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.63772
[BP] GO:0048870 cell motility AXL, CNR2, CXCL8, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 3.61674
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.60701
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.57121
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.57121
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, KDR, PIK3CA, POLB, PPARA, SRC 3.57121
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.56968
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PRKCD, PTGS2 3.55033
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCD, SRC 3.52356
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PRKCD, PTGS2, SRC 3.48462
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB, PRKCD, PTGS2 3.45566
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.45566
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.44101
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.43055
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PRKCD, PTGS2 3.39642
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1 3.38156
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.38156
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.38156
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.38156
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.38156
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.38046
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CXCL8, CYP19A1, ESR1, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.35253
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 3.3422
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SOAT2, SRC 3.33768
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1 3.29686
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.29674
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.28662
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TBXAS1, XDH 3.17807
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, PIK3CB, PRKCD, PTPN1, SRC 3.1779
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1779
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, CXCL8, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.17643
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, CXCL8, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.16055
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, PPARA, PTGS2 3.15115
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.14597
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, SRC 3.14596
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, HTR1D, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.14152
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SRC, XDH 3.12657
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.12221
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.12019
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PRKCD, PTGS2, SRC 3.10924
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 3.1092
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.09312
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.08629
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.08272
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 3.07431
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.07431
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 3.0676
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 3.06423
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.0397
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC 3.00175
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.00174
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.98917
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.98736
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SOAT1, SRC, XDH 2.98714
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CNR1, CNR2, CXCL8, CYP19A1, ESR1, IGF1R, MET, MMP12, MMP9, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 2.98714
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TBXAS1, XDH 2.97949
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 2.96652
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.9574
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, MMP12, PRKCD, PTGS2, SRC 2.94954
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KDR, PRKCD, PTGS2, SRC 2.92896
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, PPARA, RORC, SRC 2.91196
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HTR5A, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SRC 2.90786
[BP] GO:0007208 None HTR2A, HTR2C 2.90786
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1 2.90255
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.89051
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.84676
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.84676
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, ESR1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SOAT1, SRC, XDH 2.84538
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PRKCD, PTGS2 2.84273
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CXCL8, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, SRC 2.84181
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1 2.82799
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SOAT1, SRC, XDH 2.81933
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80054
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.80054
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, XDH 2.80021
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, MMP12, PRKCD, PTGS2, SRC 2.79862
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC 2.79338
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.76951
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.72917
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.71421
[BP] GO:0007154 None ADORA1, AXL, BCL2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 2.67182
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.65636
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 2.6376
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.6376
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6376
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.6376
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, PRKCD, PTPN1, SRC 2.62228
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.61849
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.59723
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.59723
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SOAT1, SRC, XDH 2.59723
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.57754
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.5679
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.56674
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP1B1, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 2.52622
[BP] GO:0034433 None SOAT1, SOAT2 2.49784
[BP] GO:0034434 None SOAT1, SOAT2 2.49784
[BP] GO:0034435 None SOAT1, SOAT2 2.49784
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49784
[BP] GO:0046890 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.47884
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCD, PTPN1 2.47884
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.46075
[BP] GO:0050994 None ADORA1, CNR1, PPARA, PRKCD 2.46075
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.43977
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.43977
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.43977
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CXCL8, CYP1B1, IDO1, KDR, PIK3CA, PIK3CB, PPARA, PRKCD, SRC 2.43977
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PRKCD 2.43151
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, IDO1, MMP2, MMP9, PTGS2, SRC 2.4284
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.42586
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.42153
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.41755
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, IDO1 2.40958
[BP] GO:0001525 angiogenesis CXCL8, CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.38487
[BP] GO:0031623 None ACHE, CXCL8, HTR1B, HTR2B 2.38211
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.37847
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CXCL8, CYP1B1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, PIK3CA, PIK3CB, POLB, PRKCD, PTPN1, SRC 2.37847
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, CXCL8, ESR1, FLT3, HTR1B, IGF1R, MMP2, PRKCD, PTGS2, SRC 2.37531
[BP] GO:0050900 leukocyte migration CNR2, CXCL8, FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.36917
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.3666
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CNR1, HTR2B, HTR2C, MMP12, PRKCD, PTGS2, PTPN1, SRC 2.36221
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, HTR2A, HTR2B, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC 2.3604
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCD, SRC 2.34581
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.34581
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.34538
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.33387
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA 2.32845
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCD, PTGS2, PTPN1, RORC, SRC, XDH 2.32836
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, PIK3CB, PTPN1, SRC 2.3207
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, CXCL8, FLT3, FUT7, MMP9, PIK3CA, PIK3CB, PRKCD, RORC, SRC 2.30697
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, HSD11B2, HTR2A, IDO1, MMP12, PRKCD, PTGS2, SRC 2.29431
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.28281
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.28042
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PRKCD 2.26837
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.26837
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.26837
[BP] GO:0038171 None CNR1, CNR2 2.25393
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25393
[BP] GO:0014827 None HTR1D, HTR2B 2.25393
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.23865
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.23348
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23348
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA 2.22689
[BP] GO:0006066 None AKR1B1, AKR1B10, ALDH2, APP, CYP1B1, SOAT1, SOAT2 2.22023
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD 2.19728
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, CXCL8, FABP4, IDO1, KDR, MET, PTGS2 2.19591
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.18778
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.18778
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18778
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.18778
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.18752
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.17602
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, XDH 2.15787
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.15133
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.14923
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.13123
[BP] GO:0042632 None FABP3, FABP4, SOAT1, SOAT2 2.13123
[BP] GO:0055092 None FABP3, FABP4, SOAT1, SOAT2 2.13123
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, CNR1, CXCL8, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCD, SRC 2.13123
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, XDH 2.13123
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1 2.11767
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, PIK3CB, PRKCD, PTPN1, SRC 2.08901
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, SOAT1, SOAT2 2.08901
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.08901
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, HTR1B, IGF1R, MMP2, PRKCD, PTGS2, SRC 2.07583
[BP] GO:0071502 None HTR1B, HTR2B 2.07034
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.06676
[BP] GO:0007267 None ADORA1, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.06676
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PRKCD, SRC 2.06676
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SRC, XDH 2.05326
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.02293
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.01806
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.01776
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.01594
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.01594
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, IDO1, MMP12 2.00793
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.32139
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS1, PTGS2, PTPN1, SOAT1, SOAT2, SRC, TBXAS1 5.13175
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.01484
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SOAT1, SOAT2, SRC, TBXAS1 4.95175
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCD, PTPN1, SRC 4.4971
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, SRC 3.81248
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, HSD11B1, HSD11B2, PTGS1, PTGS2, PTPN1, SOAT1, SOAT2, TBXAS1 3.15115
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, PTGS1, PTGS2, SOAT1, SOAT2, TBXAS1 3.01759
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, HTR5A, KDR, PRKCD, PTGS2, PTPN1, SOAT1, SOAT2, XDH 2.91997
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7367
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7367
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.6162
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.6162
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.3151
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TBXAS1, XDH 13.5789
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.3509
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, XDH 11.6453
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.0747
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, IDO1, NQO2, POLA1, PTGS1, PTGS2, SOAT1, SOAT2, SRC, TBXAS1, XDH 10.586
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1367
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, XDH 9.74741
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.65475
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.42213
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCD, PTGS1, PTGS2, PTPN1, SOAT1, SOAT2, SRC, TBXAS1, XDH 9.01464
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, PTGS1, PTGS2, SRC, TBXAS1 8.73052
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, TBXAS1, XDH 8.63247
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, PTGS1, PTGS2, SRC, TBXAS1 8.42813
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.71922
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.65008
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.65008
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 6.40159
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.27108
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, SRC 6.01623
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 5.65538
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 5.54489
[MF] GO:0097159 organic cyclic compound binding ADORA1, ALDH2, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TBXAS1, XDH 5.53782
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 5.33358
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.28047
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.11889
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.11889
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.92097
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 4.90232
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.83431
[MF] GO:1901363 heterocyclic compound binding ADORA1, ALDH2, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, XDH 4.71529
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, IDO1, NQO2, XDH 4.4971
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, XDH 4.38879
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 4.20081
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.09667
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.94755
[MF] GO:0005496 steroid binding ESR1, HSD11B2, HSD17B1, RORC, SOAT1, SOAT2 3.86234
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.85251
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.48191
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.4246
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.35499
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.17807
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.08002
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.91997
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, XDH 2.90786
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.90786
[MF] GO:0034736 None SOAT1, SOAT2 2.90786
[MF] GO:0004772 None SOAT1, SOAT2 2.90786
[MF] GO:0003845 None HSD11B1, HSD11B2 2.90786
[MF] GO:0008389 None CYP2A13, CYP2A6 2.90786
[MF] GO:0071886 None HTR2A, HTR2C 2.90786
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.70613
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.69242
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCD, SOAT1, SOAT2, SRC, XDH 2.63429
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCD, SRC 2.63429
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCD, SRC 2.5134
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.49784
[MF] GO:0004949 None CNR1, CNR2 2.49784
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, SRC 2.47884
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, SOAT1, SOAT2 2.40871
[MF] GO:0050662 coenzyme binding ALDH2, HSD11B2, HSD17B1, NQO2, SOAT1, SOAT2, XDH 2.24362
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1 2.21201
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.20266
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, SRC 2.18288
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1 2.05718


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 18.479
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 11.0887
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.5447
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0877
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 7.0036
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.1734
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.9055
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PRKCD, HTR2B, HTR2C, PIK3CB, HTR2A 5.8867
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, TBXAS1, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.8867
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.9055
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 CXCL8, PIK3CA, MMP2, PRKCD, BCL2, PIM1, PIK3CB 5.8867
Pathways in cancer_Homo sapiens_hsa05200 CXCL8, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.5151
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1 5.8867
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.2486
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4557
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.3994
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, CYP1B1, IDO1 5.3989
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.5439
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9 5.37
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.1111
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 4.0067
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 4.5309
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.9923
Hepatitis B_Homo sapiens_hsa05161 CXCL8, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.9355
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1914
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCD, PIK3CB, PPARA 3.4641
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.2773
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.2965
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 3.0122
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4349
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.2034
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.1325
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.1219
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.9201
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.8486
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1674
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.8726
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0122
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.7203
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, PIK3CA, SRC, PRKCD, PIK3CB 2.614
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.6702
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.8567
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.5722
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, BCL2, PTGS2 2.7899
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.658
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5781
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.2977
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4984
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.4984
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.4794
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4984
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PIK3CA, PIK3CB, PPARA 2.3302
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, PIK3CA, PIK3CB, PPARA 2.1908
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.1363
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.1363
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.0629
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.8303
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.8184
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD 1.9446
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9931
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCD, PIK3CB 1.9245
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5358
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.2929
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9234
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2085
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2977
Amoebiasis_Homo sapiens_hsa05146 CXCL8, PIK3CA, PIK3CB 1.8604
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.5561
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.6385
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3225
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5724
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8, PIK3CA, PIK3CB 1.8184
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5379
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 CXCL8, PIK3CA, PIK3CB 1.8303
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2962
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.5414
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3213
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET 1.5126
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2808
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.5414
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3213
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.3692
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.5358
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8, PIK3CA, PIK3CB 1.5245
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3718
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCD, PIK3CB 2.5781
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5022
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET 2.2507
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1456
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.412
Axon guidance_Homo sapiens_hsa04360 MET 0.4065
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2929
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.412
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB 0.9743
Influenza A_Homo sapiens_hsa05164 CXCL8, PIK3CA, PIK3CB 1.3441
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7371
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD 0.4177
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.7899
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7326
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8877
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9003
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4617
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4728
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4892
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4883
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.502
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5085
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5085
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0869
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.5112
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0683
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5072
Peroxisome_Homo sapiens_hsa04146 XDH 0.5214
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.0869
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1023
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1 1.1565
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5607
Pertussis_Homo sapiens_hsa05133 CXCL8 0.5564
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5585
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5704
Bile secretion_Homo sapiens_hsa04976 CA2 0.5682
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.5704
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.8567
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5924
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.581
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3178
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3178
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5896
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6142
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3536
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3317
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.631
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3734
Legionellosis_Homo sapiens_hsa05134 CXCL8 0.6419
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.3462
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4418
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.3813
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6605
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6649
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.6696
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5358
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6876
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.4936
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.6826
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.5561
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6062
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.7104
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5933
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7387
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7857
DNA replication_Homo sapiens_hsa03030 POLA1 0.7778
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8283
Base excision repair_Homo sapiens_hsa03410 POLB 0.8063
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9038
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8283
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9234
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8601
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8827
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8348
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8745
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8745
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0892
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.9048
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 2.1908
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1076
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3329


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)