TCM Prescription: Wei Huo Ling Tablets



Prescription Description
Prescription IDTCMF5650
Pinyin NameWei Huo Ling Pian
Chinese Name胃活灵片
English NameWei Huo Ling Tablets
Function Description腹胀, 腹痛
IndicationsAbdominal pain disorder, Dyspepsia, Enteritis
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH907 Piper nigrum 胡椒 TCMH907 ITSAA3189-14
TCMH2693 Fructus gleditsiae abnormalis 猪牙皂 TCMH2693
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH29 Croton tiglium 巴豆霜 TCMH29 ITSAJ4152-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT642 ADRA1D Alpha-1d adrenergic receptor GPCR P25100
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT650 ADRA1B Alpha-1b adrenergic receptor GPCR P35368
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRNA3, CHRNA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, HTR2C, INSR, KCNH2, KDR, MET, MIF, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 16.1002
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TEK, TYR 14.0913
[BP] GO:0010033 response to organic substance ADRA1A, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TEK, TYR 13.8426
[BP] GO:0010647 positive regulation of cell communication ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.8787
[BP] GO:0023056 positive regulation of signaling ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.8787
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, APEX1, AXL, BCL2, CA9, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, PRKCB, PRKCD, PRKCE, RORC, SRC, TEK, TYR 12.4005
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 11.885
[BP] GO:0009967 positive regulation of signal transduction ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.5361
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA9, CHRNA3, CHRNA7, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HTR2C, KCNH2, KDR, POLB, PRKCD, PRKCE, PRKCG, SRC 11.3164
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 11.3164
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CHRNA7, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, MIF, PRKCA, PRKCB, PRKCE, PTPN1, SRC, TEK, XDH 10.6802
[BP] GO:0048584 positive regulation of response to stimulus ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CHRNA7, CNR1, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.6568
[BP] GO:1902531 regulation of intracellular signal transduction ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 10.3783
[BP] GO:0042592 homeostatic process ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CHRNA7, CNR1, EGFR, FABP3, FABP4, FLT3, GPR35, HTR2C, INSR, KCNH2, MET, POLA1, POLB, PRKCB, PRKCE, SMAD3, SRC 10.1745
[BP] GO:0010646 regulation of cell communication ACHE, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.166
[BP] GO:0023051 regulation of signaling ACHE, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.0198
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADRA1A, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 9.38341
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CHRNA7, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 9.13613
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.91373
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRB2, AKR1B1, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, SMAD3, SRC, TEK 8.91373
[BP] GO:0044237 cellular metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 8.69455
[BP] GO:0032502 developmental process ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PRKCA, PRKCD, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 8.47513
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 8.47513
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADRB2, APEX1, AXL, BCL2, CA2, CA7, CHRNA3, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK 8.45812
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, PRKCD, PRKCE, SRC, TEK 8.44563
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.39598
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 8.39598
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 8.24147
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TNKS, XDH 8.17477
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FABP3, FLT3, HTR2C, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 8.08527
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FABP3, FLT3, HTR2C, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 8.08527
[BP] GO:0019220 regulation of phosphate metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 7.93163
[BP] GO:0032501 multicellular organismal process ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, AXL, BCL2, CHRNA3, CHRNA7, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, HSD17B2, HTR2C, IGF1R, INSR, KCNH2, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, PRKCG, RORC, SMAD3, SRC, TEK, TNKS2, TYR 7.9239
[BP] GO:0043408 regulation of MAPK cascade ADRA1A, ADRA1B, ADRB2, CHRNA7, DUSP3, EGFR, FLT3, HTR2C, IGF1R, INSR, KDR, MIF, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 7.9239
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 7.89145
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, APEX1, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TEK, TYR 7.87243
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.81897
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TNKS, XDH 7.7923
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA1B, ADRA1D, AKR1B1, BCL2, CA12, CA2, CA7, CHRNA7, CNR1, EGFR, FABP3, FABP4, GPR35, HTR2C, INSR, KCNH2, MET, PRKCB, PRKCE, SMAD3 7.7024
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, HTR2C, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 7.69451
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 7.6051
[BP] GO:0008152 metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 7.58661
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, APEX1, CHRNA7, CNR1, CNR2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TEK, TYR 7.58661
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A 7.43294
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA1A, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 7.43294
[BP] GO:0043410 positive regulation of MAPK cascade ADRA1A, ADRA1B, ADRB2, CHRNA7, EGFR, FLT3, HTR2C, INSR, KDR, MIF, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 7.42809
[BP] GO:0042327 positive regulation of phosphorylation ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, HTR2C, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 7.40571
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTPN1, RORC, SMAD3, SRC, TOP2A 7.29288
[BP] GO:0031399 regulation of protein modification process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, XDH 7.15863
[BP] GO:0042325 regulation of phosphorylation ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 7.15863
[BP] GO:0001932 regulation of protein phosphorylation ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 7.15419
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 7.07176
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 7.07176
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KCNH2, KDR, MET, MIF, NUAK1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 7.04729
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.94854
[BP] GO:0008283 cell proliferation ABCB1, ACHE, ADRA1B, ADRA1D, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, MIF, PIM1, POLA1, PRKCD, SRC, TEK, TYR 6.88804
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, BCL2, CHRNA7, CNR1, CNR2, CYP1A1, CYP1B1, KDR, POLB, PRKCD, PRKCE, SRC 6.88804
[BP] GO:0009966 regulation of signal transduction ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.8606
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADRB2, AXL, BCL2, CA2, CA7, CHRNA3, CNR1, CYP19A1, EGFR, GPR35, HSPA1A, HTR2C, INSR, KCNH2, MIF, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC 6.76059
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, SRC 6.57402
[BP] GO:0007165 signal transduction ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 6.53575
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.53575
[BP] GO:0065009 regulation of molecular function ABCB1, ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 6.53575
[BP] GO:0042127 regulation of cell proliferation ADRA1A, ADRA1D, AKR1B1, BCL2, CDC25B, CHRNA7, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PIM1, PRKCA, SMAD3, SRC, TEK, XDH 6.50655
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, PRKCE, RORC, SRC, TYR 6.32021
[BP] GO:0014070 response to organic cyclic compound APEX1, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PRKCE, PRKCG, RORC, SRC, TEK, TYR 6.28042
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7, CNR1, CNR2, PRKCE 6.22272
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 6.22272
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, SRC 6.20925
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.18772
[BP] GO:0050790 regulation of catalytic activity ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 6.16718
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA1A, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR2C, IGF1R, KCNH2, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 6.16669
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, HTR2C, MIF, PIM1, PPARA, TBXAS1, TYR, XDH 6.14134
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.14004
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADRB2, AKR1B1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 6.0596
[BP] GO:0080134 regulation of response to stress ABCB1, CNR1, CNR2, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MIF, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 6.0596
[BP] GO:0031401 positive regulation of protein modification process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, HTR2C, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 6.05903
[BP] GO:0050801 ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA12, CA2, CA7, CHRNA7, EGFR, FABP3, GPR35, HTR2C, KCNH2, PRKCB, PRKCE, SMAD3 5.97423
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.96415
[BP] GO:0051247 positive regulation of protein metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, EGFR, FLT3, HSPA1A, HTR2C, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 5.96415
[BP] GO:0030334 regulation of cell migration APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.96415
[BP] GO:0051239 regulation of multicellular organismal process ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, BCL2, CA2, CHRM2, CHRNA3, CHRNA7, CNR1, CYP1B1, EGFR, GPR35, HSPA1A, HTR2C, INSR, KCNH2, KDR, MET, MIF, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS2, XDH 5.9168
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FABP3, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.88235
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.83254
[BP] GO:0044238 primary metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.78427
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CHRNA3, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HSD17B1, HSD17B2, HTR2C, PRKCA, PRKCE 5.7671
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, CHRNA7, DUSP3, EGFR, HTR2C, KDR, MIF, PRKCA, PTPN1, SRC, TEK 5.7671
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, HSPA1A, HTR2C, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 5.74115
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.74115
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, BCL2, CA2, CHRNA7, CNR1, CYP1B1, EGFR, HSPA1A, KDR, MET, MIF, MMP9, PIM1, PRKCA, PRKCB, PRKCE, SMAD3, SRC, TEK 5.73192
[BP] GO:0009893 positive regulation of metabolic process ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.67265
[BP] GO:0044092 negative regulation of molecular function ADRB2, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TNKS 5.62343
[BP] GO:0006950 response to stress ACHE, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CHRNA7, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, HTR2C, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 5.61387
[BP] GO:2000145 regulation of cell motility APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.61387
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.58647
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.55565
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, PRKCD, SRC, TEK 5.55565
[BP] GO:0070482 response to oxygen levels BCL2, CHRNA7, CYP1A1, MMP2, POLB, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 5.54673
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.52954
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA12, CA2, CA7, CHRNA7, EGFR, GPR35, HTR2C, KCNH2, PRKCB, PRKCE, SMAD3 5.43036
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.42947
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, HSPA1A, INSR, MET, MIF, MMP9, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.4283
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, TBXAS1 5.42257
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADRA1A, ADRB2, CA2, CA7, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, PRKCE 5.42046
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADRA1A, ADRB2, CA2, CA7, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, PRKCE 5.42046
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.39021
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PRKCB, PRKCD, PRKCE, RORC, SMAD3, SRC 5.37998
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2C, PPARA, PRKCD, PRKCE, SRC, TEK 5.37493
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.31715
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, EGFR, HTR2C, KDR, MIF, PRKCE, SRC, TNKS, TNKS2 5.27733
[BP] GO:0008284 positive regulation of cell proliferation ADRA1D, AKR1B1, BCL2, CDC25B, CHRNA7, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MIF, MMP2, MMP9, PIM1, PRKCA, TEK 5.21933
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.20799
[BP] GO:0009628 response to abiotic stimulus ADRB2, AKR1B1, AURKB, BCL2, CA2, CHRNA7, CYP1A1, EGFR, HSPA1A, MMP2, POLB, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK, TYR 5.20799
[BP] GO:0040012 regulation of locomotion APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.18954
[BP] GO:0051270 regulation of cellular component movement APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.17152
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.16234
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.0967
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK 5.06166
[BP] GO:0009894 regulation of catabolic process ADRB2, APEX1, BCL2, CNR1, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.04714
[BP] GO:0001666 response to hypoxia BCL2, CHRNA7, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 5.04526
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 5.04526
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, CHRNA7, EGFR, HTR2C, KDR, MIF, PRKCA, SRC, TEK 4.99096
[BP] GO:0071704 organic substance metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.96503
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, AURKB, AXL, BCL2, CNR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 4.96503
[BP] GO:0036293 response to decreased oxygen levels BCL2, CHRNA7, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 4.93555
[BP] GO:0010638 positive regulation of organelle organization ADRB2, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 4.8981
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 4.87452
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, APEX1, CHRNA7, FABP3, IGF1R, INSR, PPARA, PRKCD, SRC, TEK 4.86125
[BP] GO:0055080 cation homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA2, CA7, CHRNA7, EGFR, GPR35, HTR2C, KCNH2, PRKCB, PRKCE, SMAD3 4.7978
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC 4.79315
[BP] GO:0019222 regulation of metabolic process ACHE, ADRA1A, ADRA1B, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.75206
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KCNH2, KDR, PRKCD, PRKCE, SRC 4.74941
[BP] GO:0044267 cellular protein metabolic process ADRB2, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.74941
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.74886
[BP] GO:0048585 negative regulation of response to stimulus ADRA1A, ADRB2, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP9, PPARA, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 4.74886
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7, PRKCE 4.72314
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HTR2C, PPARA, PRKCD, PRKCE, RORC, SRC, TEK 4.71856
[BP] GO:0006464 cellular protein modification process ADRB2, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.67603
[BP] GO:0036211 protein modification process ADRB2, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.67603
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, APEX1, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, PRKCB, PRKCD, PRKCE, RORC, SRC 4.67583
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, PRKCA, PRKCE, SRC 4.64372
[BP] GO:0006940 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3 4.63034
[BP] GO:0009987 cellular process ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.61814
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.61814
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.61814
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS, TOP2A 4.61296
[BP] GO:0001994 None ADRA1A, ADRA1B, ADRA1D 4.5923
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.5923
[BP] GO:0030168 platelet activation AXL, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.58144
[BP] GO:0051338 regulation of transferase activity ADRB2, AURKB, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC, TEK, TNKS 4.51985
[BP] GO:0007568 aging ADRA1A, APEX1, AURKB, BCL2, CNR1, CYP1A1, MIF, POLB, PRKCD 4.51689
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 4.51052
[BP] GO:0007166 cell surface receptor signaling pathway ADRB2, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 4.48615
[BP] GO:0080090 regulation of primary metabolic process ADRA1A, ADRA1B, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.48615
[BP] GO:0051128 regulation of cellular component organization ADRB2, AURKB, AXL, BCL2, CHRNA3, CHRNA7, CNR1, CSNK2A1, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.47963
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA1A, ADRB2, BCL2, CNR2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 4.46933
[BP] GO:0043085 positive regulation of catalytic activity ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, HSPA1A, INSR, MIF, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.46405
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA1A, ADRB2, BCL2, CNR2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 4.4551
[BP] GO:0051347 positive regulation of transferase activity ADRB2, AURKB, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, INSR, MIF, PRKCD, PTPN1, SRC, TEK, TNKS 4.44318
[BP] GO:0043412 macromolecule modification ADRB2, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.42427
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADRA1A, ADRA1B, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.42385
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, PRKCD, SRC, TEK 4.42385
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PRKCA, PRKCE, SMAD3, SRC, TNKS, TOP2A 4.40782
[BP] GO:0042391 None ADRA1A, ADRB2, BCL2, CHRNA3, CHRNA7, CNR1, CNR2, GPR35, KCNH2, KDR, SRC 4.39028
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 4.36411
[BP] GO:0050806 positive regulation of synaptic transmission ADRA1A, ADRB2, CA2, CA7, CHRNA7, EGFR, PRKCE 4.34163
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.3127
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC, TEK 4.24969
[BP] GO:0051246 regulation of protein metabolic process ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 4.2457
[BP] GO:0043269 regulation of ion transport ABCB1, ADRB2, BCL2, CA2, CA7, CHRNA3, CNR1, GPR35, KCNH2, MIF, MMP9, PRKCD, PRKCE 4.2457
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 4.23853
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.22693
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, EGFR, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 4.2217
[BP] GO:0019538 protein metabolic process ACHE, ADRB2, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.19241
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DUSP3, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTPN1, SRC, XDH 4.18136
[BP] GO:0044057 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3, EGFR, GPR35, HTR2C, KCNH2, PRKCA, SMAD3 4.16951
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA, TBXAS1 4.15911
[BP] GO:0043405 regulation of MAP kinase activity CHRNA7, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC 4.14556
[BP] GO:0043549 regulation of kinase activity ADRB2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC, TEK 4.13303
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.11656
[BP] GO:0051098 regulation of binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TNKS 4.11656
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 4.04945
[BP] GO:0071880 None ADRA1A, ADRA1B, ADRA1D, ADRB2 4.04686
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.01743
[BP] GO:0050794 regulation of cellular process ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.99832
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADRA1A, ADRA1B, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.98986
[BP] GO:0055065 metal ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, EGFR, GPR35, HTR2C, KCNH2, PRKCB, PRKCE, SMAD3 3.97828
[BP] GO:0033674 positive regulation of kinase activity ADRB2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, INSR, MIF, PRKCD, PTPN1, SRC, TEK 3.95516
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADRA1A, ADRA1B, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.94469
[BP] GO:0048856 anatomical structure development ACHE, ADRA1A, ADRA1B, ADRA1D, AKR1B1, AXL, BCL2, CA2, CHRM2, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.94303
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.94303
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.91678
[BP] GO:0032845 None BCL2, HTR2C, MIF, PRKCE, SRC, TNKS, TNKS2 3.90081
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, PRKCG, RORC, SRC, TOP2A 3.87792
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 3.85787
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, EGFR, FABP4, KDR, MET, MIF, PPARA, PRKCA, PRKCD, PRKCG, SMAD3, TEK 3.84019
[BP] GO:0019725 cellular homeostasis ADRA1A, ADRA1B, ADRA1D, APEX1, BCL2, CA2, CA7, CHRNA7, GPR35, HTR2C, POLA1, PRKCB, PRKCE, SMAD3 3.82247
[BP] GO:0030003 cellular cation homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA2, CA7, CHRNA7, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 3.82026
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, EGFR, FABP4, HSPA1A, MMP2, PPARA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK 3.81944
[BP] GO:0045859 regulation of protein kinase activity ADRB2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC 3.80825
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 3.80522
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.75914
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.75812
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 3.75812
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.75812
[BP] GO:0071875 None ADRA1A, ADRA1B, ADRA1D, ADRB2 3.75812
[BP] GO:0009892 negative regulation of metabolic process APEX1, AURKB, BCL2, CHRNA7, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 3.754
[BP] GO:0006873 cellular ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA2, CA7, CHRNA7, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 3.72731
[BP] GO:0003018 None ADRA1A, ADRA1B, ADRA1D, ADRB2, EGFR, SRC, TEK 3.71581
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.66203
[BP] GO:0055074 calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 3.64787
[BP] GO:0090257 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3, PRKCA, SMAD3 3.63717
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 3.60227
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.5982
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRB2, CHRNA7, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC 3.53687
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.53105
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADRB2, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, KCNH2, MIF, PRKCD, PRKCE, SMAD3, SRC 3.52892
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.51671
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.51671
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.50412
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PRKCD, PRKCE, PTPN1, SRC, TOP2A 3.48894
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, SMAD3, XDH 3.48894
[BP] GO:0045860 positive regulation of protein kinase activity ADRB2, CDC25B, CHRNA3, CHRNA7, EGFR, FLT3, INSR, MIF, PRKCD, PTPN1, SRC 3.45975
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.43573
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.37257
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.30682
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.30682
[BP] GO:0007187 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CNR1, CNR2 3.28121
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA2, CA7, CHRNA7, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 3.2489
[BP] GO:0045907 None ADRA1A, ADRA1B, ADRA1D, EGFR 3.23557
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.23497
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, FABP3, HTR2C, KCNH2, PPARA, PRKCB, PRKCE 3.2265
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.18013
[BP] GO:0031329 regulation of cellular catabolic process ADRB2, APEX1, BCL2, CNR1, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.17705
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.15866
[BP] GO:0050793 regulation of developmental process ADRB2, AXL, BCL2, CA2, CHRNA3, CHRNA7, CNR1, CYP1B1, EGFR, HTR2C, INSR, KDR, MIF, NUAK1, PIM1, PPARA, PRKCA, PRKCB, RORC, SMAD3, SRC, TEK, TNKS2, XDH 3.14084
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRB2, BCL2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 3.13562
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, APEX1, EGFR, FLT3, IGF1R, INSR, MMP2, PRKCD, PRKCE, SMAD3, SRC 3.07484
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.07339
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, KDR, MET, MIF, PRKCA, SMAD3 3.05877
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CHRNA7, CNR1, CSNK2A1, DUSP3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 3.05051
[BP] GO:0033043 regulation of organelle organization ADRB2, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.03693
[BP] GO:0003013 None ADRA1A, ADRA1B, ADRA1D, ADRB2, EGFR, SRC, TEK 2.99199
[BP] GO:0035408 None PRKCA, PRKCB 2.99199
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.99199
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97169
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, APEX1, IGF1R, INSR, PRKCD, SRC 2.96025
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2C, KDR, PRKCE, SRC 2.96025
[BP] GO:0044070 regulation of anion transport ABCB1, CA2, CA7, MIF, PRKCD 2.94947
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, GPR35, HTR2C, PRKCB, PRKCE, SMAD3 2.93202
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, GPR35, KCNH2, MMP9, PRKCE 2.91755
[BP] GO:0003008 None ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, BCL2, CHRNA7, CNR1, CNR2, CYP1B1, EGFR, INSR, KCNH2, PRKCG, SRC, TEK, TYR 2.91446
[BP] GO:0006807 nitrogen compound metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.9046
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.90361
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, FABP4, PPARA, PRKCD, SMAD3, TEK 2.90361
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, TBXAS1 2.89923
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, MIF, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3 2.89124
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, PRKCE, TNKS 2.88595
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC, TEK 2.88343
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 2.87751
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, SRC 2.85078
[BP] GO:0051248 None CHRNA7, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MIF, MMP9, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, XDH 2.8475
[BP] GO:0007200 None ADRA1A, ADRA1B, ADRA1D, CHRM2, HTR2C 2.84533
[BP] GO:0051094 positive regulation of developmental process ADRB2, AXL, BCL2, CA2, CHRNA7, CNR1, CYP1B1, HTR2C, INSR, KDR, PIM1, PRKCA, PRKCB, SMAD3, SRC, TEK 2.83741
[BP] GO:0060359 None CHRNA3, CHRNA7, CNR1, PRKCE, PRKCG 2.82379
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, SMAD3, XDH 2.77774
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, TNKS, TNKS2 2.7559
[BP] GO:0032147 activation of protein kinase activity ADRB2, CHRNA3, CHRNA7, EGFR, INSR, PRKCD, PTPN1, SRC 2.73264
[BP] GO:0045766 positive regulation of angiogenesis CHRNA7, CYP1B1, KDR, PRKCA, PRKCB, TEK 2.7256
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.71879
[BP] GO:0051100 negative regulation of binding ADRB2, AURKB, MET, PPARA, PRKCD, TNKS 2.71355
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 2.71355
[BP] GO:0050730 None EGFR, FLT3, MIF, PRKCD, PRKCE, PTPN1, SRC 2.70271
[BP] GO:0007188 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CNR1 2.70033
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.68295
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.67172
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, SRC 2.66622
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.64928
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.64928
[BP] GO:0006937 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3 2.63325
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.6271
[BP] GO:0032091 negative regulation of protein binding ADRB2, AURKB, MET, PPARA, PRKCD 2.6215
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PRKCG, PTPN1, XDH 2.6194
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, SRC 2.61026
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.59364
[BP] GO:0032409 None ABCB1, ADRB2, BCL2, GPR35, MMP9, PRKCD, PRKCE 2.59364
[BP] GO:0007610 None BCL2, CHRNA3, CHRNA7, CNR1, EGFR, HTR2C, INSR, PPARA, PRKCE, PRKCG 2.58683
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.58524
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58524
[BP] GO:1905144 None CHRNA3, CHRNA7 2.58524
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.5793
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.5793
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.5793
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.5793
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.56949
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.56949
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.56269
[BP] GO:0010676 None INSR, PPARA, PRKCE, SRC 2.55372
[BP] GO:0050994 None CNR1, PPARA, PRKCD, PRKCE 2.55372
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.54693
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.53181
[BP] GO:0098900 None ADRA1A, CNR1, CNR2, GPR35 2.52541
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.52541
[BP] GO:0031348 negative regulation of defense response CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 2.52315
[BP] GO:0009896 positive regulation of catabolic process ADRB2, CSNK2A1, HSPA1A, INSR, KDR, PPARA, PRKCD, PRKCE, PTPN1 2.51182
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.49882
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.49882
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.49882
[BP] GO:1904018 positive regulation of vasculature development CHRNA7, CYP1B1, KDR, PRKCA, PRKCB, TEK 2.47286
[BP] GO:0002682 regulation of immune system process AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, HSPA1A, MIF, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.45964
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRB2, CHRNA7, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.45231
[BP] GO:0090087 None ACHE, CA2, CNR1, EGFR, HTR2C, MIF, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.4438
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC 2.4363
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.42518
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.42499
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41482
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41435
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, EGFR, MET, PPARA, PRKCG, SMAD3 2.40978
[BP] GO:0046883 regulation of hormone secretion CHRNA3, CNR1, CYP19A1, EGFR, HTR2C, PRKCA, PRKCE 2.40978
[BP] GO:0043406 positive regulation of MAP kinase activity CHRNA7, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.40052
[BP] GO:0051172 None APEX1, AURKB, CHRNA7, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.38851
[BP] GO:0023052 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3, CNR1, HTR2C, KCNH2, PRKCG, TEK 2.38743
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.36517
[BP] GO:0001503 ossification BCL2, EGFR, MMP2, MMP9, TEK 2.36517
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.36517
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.36361
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.36361
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.35004
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP9, PRKCD, SRC, TEK 2.3487
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.34622
[BP] GO:0019229 None ADRA1A, ADRA1B, ADRA1D, EGFR 2.34622
[BP] GO:0070213 None TNKS, TNKS2 2.34097
[BP] GO:0038171 None CNR1, CNR2 2.34097
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34097
[BP] GO:0016043 cellular component organization ABCB1, ACHE, ADRB2, APEX1, AURKB, AXL, BCL2, CDC25B, CHRM2, CHRNA3, CHRNA7, CNR1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TOP2A 2.33888
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, KDR, PRKCE, SMAD3, SRC, TEK 2.33468
[BP] GO:0095500 None CHRM2, CHRNA3, CHRNA7 2.32064
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32064
[BP] GO:1903831 None CHRM2, CHRNA3, CHRNA7 2.32064
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PPARA, TBXAS1 2.30965
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PRKCD, SRC, TEK 2.28742
[BP] GO:0071840 cellular component organization or biogenesis ABCB1, ACHE, ADRB2, APEX1, AURKB, AXL, BCL2, CDC25B, CHRM2, CHRNA3, CHRNA7, CNR1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TOP2A 2.28568
[BP] GO:0032102 negative regulation of response to external stimulus CNR2, CYP19A1, MIF, PPARA, PRKCD, SMAD3, TEK 2.27973
[BP] GO:0051894 None KDR, SMAD3, TEK 2.26989
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26989
[BP] GO:0010675 None INSR, PPARA, PRKCE, RORC, SRC 2.26889
[BP] GO:0044089 positive regulation of cellular component biogenesis HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.26889
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.25663
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.25663
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC 2.25066
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, ADRA1B, ADRA1D, GPR35, HTR2C, PRKCE, SMAD3 2.23032
[BP] GO:0097746 None ADRA1A, ADRA1B, ADRA1D, ADRB2, EGFR 2.22506
[BP] GO:0035296 None ADRA1A, ADRA1B, ADRA1D, ADRB2, EGFR 2.22506
[BP] GO:0007154 None ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, BCL2, CHRM2, CHRNA3, CNR1, HTR2C, PRKCG, TEK 2.21367
[BP] GO:0048869 cellular developmental process ACHE, ADRB2, AXL, BCL2, CDC25B, CHRNA7, CYP1A1, EGFR, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, PRKCD, RORC, SMAD3, SRC, TEK, TOP2A 2.2126
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.19627
[BP] GO:1900076 regulation of cellular response to insulin stimulus PRKCB, PRKCD, PTPN1, SRC 2.18779
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.1802
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.1802
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1802
[BP] GO:0045913 None INSR, PPARA, PRKCE, SRC 2.16755
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP9, PRKCD, SRC, TEK 2.15276
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.15276
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.14833
[BP] GO:0007267 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3, CNR1, HTR2C, PRKCG, TEK 2.14833
[BP] GO:0032069 None HSPA1A, PRKCD, PTPN1 2.13976
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.13976
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CHRNA7, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.13194
[BP] GO:1903524 None ADRA1A, ADRA1B, ADRA1D, EGFR 2.12903
[BP] GO:0050880 None ADRA1A, ADRA1B, ADRA1D, ADRB2, EGFR 2.11863
[BP] GO:0035150 None ADRA1A, ADRA1B, ADRA1D, ADRB2, EGFR 2.10516
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.10142
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.09829
[BP] GO:0007189 None ADRA1A, ADRA1B, ADRA1D, ADRB2 2.08715
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 2.07665
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.06636
[BP] GO:0097061 None CHRNA7, IGF1R, INSR 2.05942
[BP] GO:0042310 None ADRA1A, ADRA1B, ADRA1D 2.05942
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 2.03977
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A 2.03869
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP9, PRKCD, SRC, TEK 2.02711
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1 2.02388
[BP] GO:0099173 None CHRNA7, IGF1R, INSR 2.02388
[BP] GO:0046627 None PRKCB, PRKCD, PTPN1 2.02388
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.02388
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.02388
[BP] GO:1904645 response to amyloid-beta ADRB2, CHRNA7, IGF1R 2.02388
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP2, PRKCD, PRKCE, SRC 2.02044
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.01444
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.01444
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.01421
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.01421
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.01421
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.01421
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, EGFR, F10, FLT3, GLO1, GPR35, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK 5.62343
[CC] GO:0098590 plasma membrane region ABCB1, ADRA1A, ADRA1B, ADRB2, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR1, EGFR, INSR, MET, PRKCG, SRC, TEK 4.69283
[CC] GO:0016020 membrane ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX5, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, FUT7, GLO1, GPR35, HSD17B2, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR 4.68584
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, KCNH2, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 4.67946
[CC] GO:0045121 membrane raft ADRA1A, ADRA1B, CHRNA3, CHRNA7, CNR1, EGFR, INSR, KDR, SRC, TEK 4.63034
[CC] GO:0098857 membrane microdomain ADRA1A, ADRA1B, CHRNA3, CHRNA7, CNR1, EGFR, INSR, KDR, SRC, TEK 4.61814
[CC] GO:0044459 plasma membrane part ABCB1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, DUSP3, EGFR, F10, FLT3, GPR35, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, PRKCG, SRC, TEK 4.4551
[CC] GO:0098589 membrane region ADRA1A, ADRA1B, CHRNA3, CHRNA7, CNR1, EGFR, INSR, KDR, SRC, TEK 4.0035
[CC] GO:0044853 plasma membrane raft ADRA1A, ADRA1B, CHRNA3, CHRNA7, INSR, SRC 3.90081
[CC] GO:0031226 intrinsic component of plasma membrane ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CA4, CHRM2, CNR1, CNR2, F10, FLT3, GPR35, HTR2C, IGF1R, INSR, KDR, MET, TEK 3.15866
[CC] GO:0044444 cytoplasmic part ACHE, ADRA1A, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MIF, MMP2, MMP9, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 2.85078
[CC] GO:0005887 integral component of plasma membrane ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CNR1, CNR2, FLT3, GPR35, HTR2C, IGF1R, INSR, KDR, MET, TEK 2.36286
[CC] GO:0031965 None ADRA1A, ADRA1B, ALOX5, BCL2, EGFR, SMAD3, TNKS 2.20706
[CC] GO:0005901 caveola ADRA1A, ADRA1B, INSR, SRC 2.10699
[CC] GO:0044425 membrane part ABCB1, ACHE, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GPR35, HSD17B2, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, PRKCG, PTPN1, SRC, TBXAS1, TEK, TYR 2.02711
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01421
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 12.4304
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 12.4211
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 11.8814
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 11.7311
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.166
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.47513
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 8.12144
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, GLO1, HTR2C, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 7.8938
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.40571
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.40571
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.25245
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.84447
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.65225
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 6.40082
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.32021
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.27669
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 6.22272
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.11315
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, GLO1, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 5.96732
[MF] GO:0038023 signaling receptor activity ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, FLT3, GPR35, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 5.85986
[MF] GO:0004871 signal transducer activity ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, FLT3, GPR35, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK 5.56363
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.38245
[MF] GO:0042562 hormone binding ACHE, CHRNA3, CHRNA7, EGFR, HSD17B1, IGF1R, INSR 5.20799
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.1339
[MF] GO:0004937 None ADRA1A, ADRA1B, ADRA1D 5.06745
[MF] GO:0004872 receptor activity ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, FLT3, GPR35, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 5.05542
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.92209
[MF] GO:0019899 enzyme binding ADRB2, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, HSPA1A, KCNH2, MET, MIF, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 4.92044
[MF] GO:0008227 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, HTR2C 4.91438
[MF] GO:0060089 molecular transducer activity ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, FLT3, GPR35, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.8523
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.79733
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.66436
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.62758
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 4.62758
[MF] GO:0099600 transmembrane receptor activity ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, FLT3, GPR35, HTR2C, IGF1R, INSR, KDR, MET, TEK 4.61296
[MF] GO:0004888 transmembrane signaling receptor activity ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, FLT3, GPR35, HTR2C, IGF1R, INSR, KDR, MET, TEK 4.61296
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.5923
[MF] GO:0004935 None ADRA1A, ADRA1B, ADRA1D, ADRB2 4.41187
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.38474
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.19241
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 4.17601
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 4.17418
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.16606
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 4.16017
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.10808
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.00354
[MF] GO:0004936 None ADRA1A, ADRA1B, ADRA1D 3.99494
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 3.71581
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.56327
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.44691
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.44691
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.42266
[MF] GO:0044877 macromolecular complex binding ACHE, ADRB2, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.4164
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.38171
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.37257
[MF] GO:0043168 anion binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 3.3359
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 3.18013
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.18013
[MF] GO:0016740 transferase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TNKS2 3.17178
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.15866
[MF] GO:0032403 protein complex binding ACHE, ADRB2, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 3.12829
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 3.07339
[MF] GO:0035403 None PRKCA, PRKCB 2.99199
[MF] GO:0097367 carbohydrate derivative binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.96025
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, POLA1, SRC, TBXAS1, XDH 2.94611
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.64928
[MF] GO:0042166 None ACHE, CHRNA3, CHRNA7 2.64928
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.59439
[MF] GO:0015464 None CHRM2, CHRNA3, CHRNA7 2.58524
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.58524
[MF] GO:0004949 None CNR1, CNR2 2.58524
[MF] GO:0004699 None PRKCD, PRKCE 2.58524
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.5793
[MF] GO:0042165 neurotransmitter binding ACHE, CHRNA3, CHRNA7, HTR2C 2.55372
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.38734
[MF] GO:0001540 amyloid-beta binding ACHE, ADRB2, CHRNA7, INSR 2.34622
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.34097
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.34097
[MF] GO:0042802 identical protein binding ACHE, ADRB2, BCL2, CHRNA7, CSNK2A1, EGFR, FLT3, IGF1R, KCNH2, KDR, MET, MIF, MMP9, SMAD3, TOP2A, TYR, XDH 2.18355
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.15276
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15276
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.14499
[MF] GO:0070405 ammonium ion binding ACHE, CHRNA3, CHRNA7, HTR2C 2.06636
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.06636
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.05942
[MF] GO:0055131 None HSPA1A, KCNH2 2.01421
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01421


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.9727
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.6028
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, PRKCB, CHRNA7, HTR2C, ADRA1D, PRKCA, ADRB2, ADRA1B, ADRA1A, EGFR 8.4129
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, CNR1, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 7.8952
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.8952
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, ABCB1, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B 7.5309
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA 7.0941
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, KDR, PRKCA, MMP9, MET, EGFR, IGF1R 7.0941
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRNA3, PRKCB, CHRNA7, BCL2, PRKCA 6.9147
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRNA3, CNR2, GPR35, CNR1, CHRNA7, HTR2C, ADRA1D, ADRB2, ADRA1B, ADRA1A 6.9944
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.3118
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, BCL2, PRKCA, MMP9, MET, EGFR, IGF1R 6.4893
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, INSR, BCL2, PRKCA, TEK, EGFR, IGF1R 7.0941
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, ADRA1D, PRKCA, ADRA1B, ADRA1A 6.6817
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, SRC, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 6.1658
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, SRC, PRKCE, PRKCD, HTR2C, PRKCA 6.086
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.7846
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, ADRA1D, PRKCA, ADRB2, ADRA1B, ADRA1A 6.3227
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PRKCB, SRC, BCL2, PRKCA, MMP9 5.0357
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 5.0445
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 5.1186
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, EGFR, HSPA1A 4.8671
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, HTR2C, PRKCA, EGFR 5.1104
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, PRKCA, TEK, MET, EGFR, IGF1R 4.5102
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB2, MET, EGFR, IGF1R, HSPA1A 4.4815
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, INSR, PRKCE, PRKCD, PPARA 4.6576
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4105
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, SRC, KDR, PRKCA 4.6576
Glioma_Homo sapiens_hsa05214 PRKCG, PRKCB, PRKCA, EGFR, IGF1R 4.5513
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1D, PRKCA, ADRB2, ADRA1B, ADRA1A 3.9978
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.6486
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR, PRKCE, ADRA1D, ADRB2, ADRA1B, ADRA1A 3.7279
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, SRC, PRKCA, EGFR 4.0023
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.8881
Chemical carcinogenesis_Homo sapiens_hsa05204 CHRNA7, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1138
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, ALOX5, HTR2C, PRKCA 3.5485
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 3.1754
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, PRKCE, BCL2, PRKCA 3.4391
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, MMP2, PRKCA, MMP9 3.4629
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 3.1549
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, SRC, PRKCA, EGFR 2.967
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PRKCB, PRKCA, EGFR 3.5784
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.4832
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.1897
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.0662
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PRKCB, INSR, PRKCA 4.1163
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.2028
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.7683
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA, EGFR 2.7678
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2777
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.9543
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA 2.7678
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.8274
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, SRC, PRKCA 2.5372
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3666
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9759
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.9817
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5002
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2988
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 1.9666
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.9314
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, PRKCA, EGFR 1.512
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.0319
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3556
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.7552
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 1.5817
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.3852
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 1.8857
Apoptosis_Homo sapiens_hsa04210 BCL2 0.382
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.6661
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2 1.9458
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.1917
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3939
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.6249
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3184
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 1.9048
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.1378
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7196
Influenza A_Homo sapiens_hsa05164 PRKCB, PRKCA, HSPA1A 1.3321
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2412
Axon guidance_Homo sapiens_hsa04360 MET 0.4094
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.2936
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.288
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.288
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4176
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADRB2, PPARA 1.2037
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, SRC, PRKCD 1.2631
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADRB2 2.4648
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7575
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8713
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5522
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7392
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8668
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7948
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6611
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8834
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4537
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9397
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8236
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8576
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7347
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.9481
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4683
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9314
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4675
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.476
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.3059
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4953
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.2412
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2761
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0945
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.2412
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5177
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5293
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1229
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5163
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5233
Peroxisome_Homo sapiens_hsa04146 XDH 0.5309
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1487
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5675
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.5675
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5465
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5675
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5522
Leishmaniasis_Homo sapiens_hsa05140 PRKCB 0.5675
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5717
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5797
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.249
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5882
Renin secretion_Homo sapiens_hsa04924 ADRB2 0.594
Shigellosis_Homo sapiens_hsa05131 SRC 0.5911
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA 2.6649
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCE, PRKCD 2.6457
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3656
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3341
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6498
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6623
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6498
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3736
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4074
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4623
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.667
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.667
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8321
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.9792
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4388
Malaria_Homo sapiens_hsa05144 MET 0.6763
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.4074
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.7069
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7126
Nicotine addiction_Homo sapiens_hsa05033 CHRNA7 0.7409
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7815
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7409
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6203
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8236
DNA replication_Homo sapiens_hsa03030 POLA1 0.7734
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8668
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9241
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8713
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8303
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.8196
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.942
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8851
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.8642
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8008
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8668
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1062
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0258
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2665


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)