TCM Prescription: Tiao Jing Huo Xue Tablets



Prescription Description
Prescription IDTCMF5628
Pinyin NameTiao Jing Huo Xue Pian
Chinese Name调经活血片
English NameTiao Jing Huo Xue Tablets
Function Description月经失调, 痛经
IndicationsDysmenorrhea disorder, Dysmenorrhea, Irregular menstruation
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA34.3 [Dysmenorrhoea, 痛经 ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH2578 Lycopi Herba 泽兰 TCMH2578
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 12.6267
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 12.6267
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 12.4776
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, PIM1, PPARA, TYR, XDH 11.5147
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 11.3507
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0102
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, INSR, KCNH2, KDR, MET, MTNR1B, PPARA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.8897
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1268
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.0909
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 10.0909
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.0909
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.0587
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.0091
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 9.84645
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 9.77949
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 9.53697
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 9.2089
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 9.20553
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, MTNR1B, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 9.13056
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 8.94545
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 8.94545
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TEK, TYR 8.88219
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 8.76503
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.56697
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC, TEK 8.42563
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, HSD17B1, HSD17B2 8.38935
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, MTNR1B, SMAD3, SRC, TERT 8.3301
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.28334
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.28334
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.28334
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, IGF1R, INSR, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK 8.26428
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HTR5A, RORC, SLC6A4, SRC, TEK, TYR 8.25419
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 8.07879
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, MTNR1B, SMAD3 7.83797
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 7.83797
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B 7.72801
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 7.59659
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK, TERT 7.57186
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA 7.51005
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.44769
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MMP12, MMP9, MTNR1B, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TERT 7.44585
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.37652
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 7.37652
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 7.37652
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 7.34353
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, INSR, PPARA, SLC6A4, SRC, TEK 7.3264
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, MTNR1B 7.29314
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, ALOX15, APP, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, PTPN1, SRC, TEK, XDH 7.27271
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC, TEK 7.25022
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 7.07498
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 7.07498
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 7.07498
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.05557
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA 6.97373
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC, TEK 6.94798
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.94798
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.89205
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.85339
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.83959
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.83565
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 6.80309
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, MTNR1A, MTNR1B, PPARA, RORC, SLC6A4, SRC 6.79632
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 6.67833
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.65743
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, HTR2C, KCNH2, KDR, SLC6A2, SLC6A4, SRC 6.65208
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 6.63351
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, RORC, SRC, TEK 6.53936
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.40085
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, EGFR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 6.38809
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SMAD3, SRC, TERT 6.34571
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 6.27162
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.24446
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 6.22385
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, RORC 6.22007
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.22007
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 6.20927
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, APP, CA2, DRD1, DRD2, DRD3, ESR1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, INSR, MTNR1A, MTNR1B, SIGMAR1, SRC 6.20708
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 6.20708
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC, TERT 6.18846
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR2C, KDR, SRC 6.18776
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.1507
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.13006
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.12786
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.0976
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.08793
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.08275
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, KDR, SRC 6.05884
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, RORC, SLC6A4, SRC, TYR 6.05839
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 6.05839
[BP] GO:0007200 None ADRA1A, ADRA2A, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 5.92074
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.91939
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, APP, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 5.91939
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 5.91097
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.87315
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.85801
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SIGMAR1, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.8286
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK 5.77612
[BP] GO:0050801 ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, SMAD3 5.75869
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 5.66668
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, MTNR1A, MTNR1B, PPARA, RORC, SLC6A4 5.65437
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, KCNH2, MMP12, SLC6A4, SMAD3, SRC, TERT 5.65423
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.63968
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.63968
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A, SLC6A4 5.63968
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A, SLC6A4 5.63968
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, XDH 5.6086
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, XDH 5.6086
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.48878
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 5.4438
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.42869
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, SLC6A2, SLC6A4, SMAD3 5.39372
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, SMAD3 5.23549
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 5.21558
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA 5.21009
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.1898
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, ALOX15, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.16458
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.12944
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.11147
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.0944
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.08657
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.07656
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, XDH 5.07656
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 5.0691
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.0128
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.98972
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 4.94691
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.9417
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.9417
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT 4.9417
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 4.9417
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SLC6A4, SRC 4.93106
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR 4.93082
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, HTR2C, KCNH2, PPARA, SLC6A2, SLC6A4 4.93066
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, SRC, TEK 4.8852
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.78916
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SLC6A4, SMAD3, SRC 4.78379
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 4.75188
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.74546
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.71749
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.68695
[BP] GO:0055080 cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, SMAD3 4.6428
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.61956
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 4.61183
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.56508
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.55875
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SLC6A4, SRC 4.54854
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 4.52581
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, DRD2, DRD3, GPR35, HTR2A, KCNH2, MMP9 4.46852
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 4.45417
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.44888
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.42036
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SLC6A4, SRC 4.41864
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.41795
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.40321
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 4.39966
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.3919
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.39117
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, HTR2C, MTNR1B 4.37607
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 4.37081
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.36489
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT 4.33557
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HTR5A, INSR, KDR, MMP9, PIM1, PPARA, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 4.33009
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.32618
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PPARA, RORC, SMAD3, SRC, TERT 4.31392
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 4.28665
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, SLC6A4 4.28519
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.28519
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 4.27359
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.26685
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.25207
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.21621
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.19261
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 4.18663
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 4.16801
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.163
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.15259
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.13819
[BP] GO:0032225 None DRD1, DRD2, DRD3, SLC6A4 4.13819
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, HTR2C, KCNH2, SMAD3 4.1149
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A, KCNH2, MMP9, SLC6A4 4.11298
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, APP, AURKB, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.0496
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.04377
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, DRD2, DRD3, EGFR, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, PTPN1, SMAD3, SRC 4.03828
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.02613
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 3.9812
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, ALOX15, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 3.97979
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, SRC 3.9561
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 3.94895
[BP] GO:0007610 None APP, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, HTR2C, INSR, MTNR1A, PPARA, SLC6A4 3.94468
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, RORC, SMAD3, SRC, TERT 3.91564
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, SMAD3 3.90379
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, MTNR1A, PPARA 3.8921
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A 3.8921
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.8793
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.86213
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.85775
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SLC6A4, SRC 3.85456
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 3.83404
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK 3.81836
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, APP, AURKB, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.81766
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, MTNR1A, PPARA 3.80271
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.79619
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 3.79348
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.79339
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.79163
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.77738
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, TYR 3.7711
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.7588
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.75716
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.75123
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, TERT 3.72242
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.71235
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.71065
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.70653
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.70064
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.7006
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.68816
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TERT 3.65154
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.65092
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.60609
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 3.60609
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.58367
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.58133
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 3.57195
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 3.52661
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, HTR2C, SLC6A4 3.5254
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK 3.51964
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR2C, HTR6, HTR7, KCNH2, MTNR1B, SLC6A2, TEK 3.5085
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.50191
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.48792
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.48792
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, HTR7, INSR, KCNH2, SLC6A4, SRC, TEK, TYR 3.45252
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.44072
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 3.44061
[BP] GO:0032845 None ADORA1, ADRA2A, DRD2, HTR2A, HTR2B, HTR2C, SRC 3.44061
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, SLC6A4 3.4377
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.43168
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.41513
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.40934
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.40934
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PTPN1, SRC, TEK 3.40114
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 3.33528
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC6A2, TEK 3.3335
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.28972
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.28972
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.28972
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, TYR 3.28843
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27273
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27273
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27273
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27273
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 3.27273
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.25684
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.25684
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.223
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 3.223
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC6A2 3.223
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC6A2 3.223
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, TYR 3.20978
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SLC6A4, SRC 3.17538
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.16367
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.16099
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.15207
[BP] GO:0099536 None DRD1, DRD2, DRD3, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC6A2 3.15002
[BP] GO:0099537 None DRD1, DRD2, DRD3, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC6A2 3.15002
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.13146
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.12883
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 3.10218
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, HTR2A, PTPN1, SRC 3.09228
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.08695
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.08695
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.07801
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.07504
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, SLC6A4 3.04475
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.03821
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HSPA1A, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, XDH 3.03821
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.03821
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.01596
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2C19, CYP2D6 3.01235
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.01235
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.01041
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.00746
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.99619
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 2.99619
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.99619
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SLC6A4, SMAD3, SRC 2.99331
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 2.98119
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.93813
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, EGFR, ESR1, F10, FABP3, HSPA1A, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.91421
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.90419
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C 2.89999
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.89871
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.89871
[BP] GO:0007208 None HTR2A, HTR2C 2.89359
[BP] GO:0009115 None AOX1, XDH 2.89359
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 2.89359
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 2.88871
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, SLC6A4 2.83385
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.82893
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.81854
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.81753
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.81659
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.8118
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80857
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.80857
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.80857
[BP] GO:0050708 None ACHE, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, MTNR1B, SRC 2.79781
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.79781
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 2.79781
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.75135
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 2.74938
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.74855
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.73991
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.71773
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71773
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.71773
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.71773
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.7042
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.67836
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT 2.63433
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SLC6A4, SRC 2.63398
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.63383
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.63151
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.63151
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.63151
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.63092
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.63092
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, FABP3, HSPA1A, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, XDH 2.62468
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.62285
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.61293
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, MTNR1A, SLC6A4, SRC 2.59758
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.59758
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.59758
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 2.59512
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.59369
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC6A2, TEK 2.59369
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.59171
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.58725
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.57435
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 2.57337
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KCNH2, KDR, SRC 2.57082
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, HTR2C, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 2.56923
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56679
[BP] GO:0070920 None EGFR, ESR1, TERT 2.56679
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 2.54785
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.54574
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, EGFR, HTR2A, KCNH2 2.54574
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.53759
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.53759
[BP] GO:1904062 None ADRA2A, APP, DRD1, DRD2, DRD3, GPR35, KCNH2, MMP9 2.52748
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.51629
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.51347
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.4959
[BP] GO:0046110 None AOX1, XDH 2.4959
[BP] GO:0060160 None DRD2, DRD3 2.4959
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4959
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.48022
[BP] GO:0051223 None ACHE, ADRA2A, APP, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, MTNR1B, PTPN1, SMAD3, SRC 2.47953
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.47953
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA, SMAD3 2.46692
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.46007
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.44622
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.43919
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.43418
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.43418
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, MTNR1B, PTPN1, SMAD3, SRC, TERT 2.42314
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.38205
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.38006
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.36678
[BP] GO:0007617 None APP, DRD1, MTNR1A 2.36678
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.36678
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SLC6A4, SMAD3, SRC, TERT 2.3629
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.35397
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SLC6A4, SRC 2.35167
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.34713
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.32715
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.32426
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.32426
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2C, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.3233
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, CYP1B1, DRD2, FABP3, HSPA1A, SLC6A4, SMAD3, TERT, XDH 2.32237
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.31606
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, APP, DRD2, DRD3, GPR35, HSPA1A, HTR2A, KCNH2, MMP9 2.31496
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.31175
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.31175
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.3001
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.29289
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PTPN1, SMAD3, SRC, XDH 2.2844
[BP] GO:0070201 None ACHE, ADRA2A, APP, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, MTNR1B, PTPN1, SMAD3, SRC 2.28295
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.28127
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.27554
[BP] GO:0033555 multicellular organismal response to stress DRD1, HTR1A, HTR2C, SLC6A2 2.27554
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.27554
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.25632
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.25632
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.2479
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.2479
[BP] GO:0006145 None AOX1, XDH 2.24402
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.24402
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24402
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.24015
[BP] GO:0007613 None DRD1, DRD2, HTR2A, INSR, SLC6A4 2.23464
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 2.23361
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.22778
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.22778
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.21007
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.21007
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.21007
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.21007
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, APP, AXL, DRD2, DRD3, HTR2B, SLC6A2, SLC6A4 2.20527
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.20395
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.20395
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, CBR1, CDC25B, CES1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, HTR2B, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT 2.19267
[BP] GO:0050678 None EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 2.18075
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.18075
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, HTR2A, PTPN1, SRC 2.16789
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.16031
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.16031
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16031
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HTR2A, INSR, PPARA, RORC, SRC 2.15852
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.15852
[BP] GO:0050679 None EGFR, F3, HTR2B, KDR, MMP12, TEK 2.14583
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SLC6A4, SRC 2.13932
[BP] GO:0019229 None ADRA1A, ADRA2A, EGFR, HTR2A 2.12819
[BP] GO:0051894 None KDR, SMAD3, TEK 2.11054
[BP] GO:0071875 None ADRA1A, ADRA2A, DRD2 2.11054
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.11054
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, HTR2C 2.10895
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.10447
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.07935
[BP] GO:1900544 None DRD1, ESRRB, HTR2A, INSR, MTNR1A 2.0775
[BP] GO:0045981 None DRD1, ESRRB, HTR2A, INSR, MTNR1A 2.0775
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.0775
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.0763
[BP] GO:0034762 None ADRA2A, APP, CA2, DRD1, DRD2, DRD3, GPR35, KCNH2, MMP9 2.06732
[BP] GO:0050927 None F3, KDR, SMAD3 2.06458
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.06458
[BP] GO:0021853 None DRD1, DRD2 2.06458
[BP] GO:0010641 None F3, SRC 2.06458
[BP] GO:0090325 None DRD2, DRD3 2.06458
[BP] GO:0007598 None F10, F3 2.06458
[BP] GO:1904936 None DRD1, DRD2 2.06458
[BP] GO:0042321 None ADORA1, DRD2 2.06458
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.04307
[BP] GO:0051094 positive regulation of developmental process APP, AXL, CA2, CYP1B1, DRD2, ESRRB, F3, HTR2A, HTR2C, INSR, KDR, PIM1, SMAD3, SRC, TEK, TERT 2.04166
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C 2.04155
[BP] GO:0040008 regulation of growth APP, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SLC6A4, SMAD3 2.04155
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, HTR2A, INSR, KDR, PPARA, PTPN1 2.03746
[BP] GO:0050926 None F3, KDR, SMAD3 2.02852
[BP] GO:1903393 None KDR, SMAD3, TEK 2.02852
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.02852
[BP] GO:0030802 None ADRA2A, DRD1, DRD2, DRD3, MTNR1A 2.02852
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, DRD1, EGFR, ESR1, MTNR1A, SLC6A4, SRC 2.02317
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.02272
[BP] GO:0010959 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, GPR35, HTR2A, KCNH2 2.00343
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.00292
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC6A2, SLC6A4, TEK 9.69575
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC6A2, SLC6A4, TEK 8.08341
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC6A2, SLC6A4, SRC, TEK 7.83797
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 7.0117
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MTNR1A, MTNR1B, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TEK, TYR 4.94772
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 4.63534
[CC] GO:0045121 membrane raft ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 4.00104
[CC] GO:0098857 membrane microdomain ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 3.97979
[CC] GO:0098589 membrane region ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 3.37503
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, EGFR, F10, FLT3, HSD17B2, PTPN1, SIGMAR1 2.83943
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.81682
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, ADRA2A, CA2, CA4, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, SIGMAR1, SRC, TEK 2.62075
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, APP, AXL, CA12, CA14, CA4, CA9, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC6A2, SLC6A4, TEK, TYR 2.49379
[CC] GO:0031233 None CA4, F10, F3 2.31175
[CC] GO:0005783 None ADORA1, APP, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, HSPA1A, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.28295
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, F3, KCNH2, MET, SLC6A2, TEK 2.06458
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 17.1471
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.0347
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 13.7616
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1, TEK 13.2035
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1, TEK 11.8654
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1, TEK 11.5147
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1, SMAD3, TEK 11.5147
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 11.0821
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, SLC6A4 10.3397
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.0909
[MF] GO:0008227 None ADRA1A, ADRA2A, DRD2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 10.0091
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, TEK 9.0625
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, TEK 9.0625
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.94545
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TERT, TYR, XDH 8.88219
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.68191
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.68191
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 8.29152
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.28334
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.28334
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SLC6A4, SRC, TEK 8.15923
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.05603
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 7.54181
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 7.44806
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 6.95589
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.94798
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 6.84646
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.72226
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 6.70736
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.49679
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.20708
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 6.10992
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 5.94524
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, SRC 5.86175
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.77591
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.65437
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B, SIGMAR1 5.62522
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, SRC 5.62167
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 5.21009
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.9026
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.9026
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.85498
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.80442
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.7111
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.45665
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, SRC, XDH 4.41507
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.80271
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.79441
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.77738
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A 3.65215
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.62707
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH 3.58367
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ALDH2, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.56624
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.25684
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.12883
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, PPARA, RORC 3.02792
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.01041
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.89871
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89359
[MF] GO:0008389 None CYP2A13, CYP2A6 2.89359
[MF] GO:0071886 None HTR2A, HTR2C 2.89359
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.80857
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 2.63958
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, SMAD3, TERT, TYR, XDH 2.59171
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.56679
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.4959
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.4959
[MF] GO:0008502 None MTNR1A, MTNR1B 2.4959
[MF] GO:0005330 None SLC6A2, SLC6A4 2.4959
[MF] GO:0047374 None CES1, CES2 2.4959
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 2.49379
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.31175
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24402
[MF] GO:0032795 None ADORA1, ADRA2A 2.24402
[MF] GO:0051425 None APP, INSR 2.24402
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 2.23361
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, KCNH2, MET, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK 2.19336
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06458
[MF] GO:0043559 insulin binding IGF1R, INSR 2.06458
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.06458
[MF] GO:1901363 heterocyclic compound binding ADORA1, ALDH2, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.03097
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.02852


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.2184
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX15, HTR2B, HTR1A, HTR2C, HTR2A, HTR5A, CYP2C19, SLC6A4, HTR6, HTR7, CYP2D6, ALOX5 12.6299
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR2B, HTR1A, HTR2C, HTR2A, HTR5A, ADRA1A, ADRA2A, HTR6, MTNR1A, HTR7, MTNR1B, ADORA3, ADORA1, DRD1, DRD2, DRD3 12.5127
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.6556
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3424
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.0054
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 5.6289
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A, DRD1, DRD2, EGFR 5.6146
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19 5.7185
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.3489
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP2C19, CYP19A1, CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.6647
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.4326
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.4364
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.3388
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9367
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9136
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.5735
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 3.8897
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.2551
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9223
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 2.6107
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, CYP2C19 2.9223
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.3715
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.8611
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A, ADRA2A 2.2895
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.2453
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, HTR2A 2.2798
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7786
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.2275
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 1.9987
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 1.9987
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 1.7932
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.8965
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.0096
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8965
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8108
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.8601
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8041
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5271
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 1.9825
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5611
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8529
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.3849
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.2449
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.224
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1242
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1258
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.1242
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0878
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.4992
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.7481
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 0.856
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.8626
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8153
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.6951
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8348
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.6951
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.6951
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 0.8327
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.6904
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8533
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8557
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.6757
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6521
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9337
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6521
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6521
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.0633
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6521
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.0927
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6496
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9303
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1249
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6496
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.5984
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6205
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.6444
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2181
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.058
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2404
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.5984
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2489
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2548
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5363
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2485
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.4905
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2489
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2403
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2548
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.4688
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2785
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.2857
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.4078
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3137
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0633
Platelet activation_Homo sapiens_hsa04611 SRC 0.3353
Axon guidance_Homo sapiens_hsa04360 MET 0.3279
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3353
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3373
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3601
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3601
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.376
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3829
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3829
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3829
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.2245
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3915
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3909
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.3957
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.224
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4078
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4126
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4078
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4117
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4078
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4078
Peroxisome_Homo sapiens_hsa04146 XDH 0.4126
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4454
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4329
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4439
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4537
Bile secretion_Homo sapiens_hsa04976 CA2 0.4521
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4664
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4664
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4688
Shigellosis_Homo sapiens_hsa05131 SRC 0.4667
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4817
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.4731
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4664
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5002
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5032
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5207
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5207
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5611
Malaria_Homo sapiens_hsa05144 MET 0.5317
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.5278
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5363
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5355
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.46
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.596
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5571
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5264
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6216
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.5904
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6688
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6521
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6521
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7696
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.6521
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6688
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6521
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6688
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.6688
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.6904
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9412
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.856
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1258


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)