TCM Prescription: Rou Kou Si Shen Pills



Prescription Description
Prescription IDTCMF5608
Pinyin NameRou Kou Si Shen Wan
Chinese Name肉蔻四神丸
English NameRou Kou Si Shen Pills
Function Description腹泻, 腹痛, 腹泻, 五更泻
IndicationsAbdominal pain disorder, Diarrhea
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
ME05.1 [Diarrhoea, 腹泻 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1741 Myristica fragrans 肉豆蔻 TCMH1741 GENG137-13, GBVH1657-11
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT48 SCN5A Sodium channel protein type V alpha subunit Ion channel Q14524
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT601 F2 Thrombin Unclassified P00734
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1312 Enterococcus durans
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRB2, AKR1B1, ALPL, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PPARG, RORC, SMAD3, SRC, TEK, TOP1, TYR 12.5888
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.5888
[BP] GO:0010033 response to organic substance ADRB2, AKR1B1, ALPL, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PPARG, RORC, SMAD3, SRC, TEK, TYR 11.9047
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, ALPL, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PPARG, RORC, SRC, TEK, TYR 11.8453
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8453
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, TBXAS1, TYR, XDH 10.9579
[BP] GO:0010647 positive regulation of cell communication ADRB1, ADRB2, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F2, FLT3, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 10.7119
[BP] GO:0023056 positive regulation of signaling ADRB1, ADRB2, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F2, FLT3, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 10.6842
[BP] GO:0010646 regulation of cell communication ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 10.3341
[BP] GO:0023051 regulation of signaling ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 10.1691
[BP] GO:0065008 regulation of biological quality ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, F10, F2, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, INSR, KDR, MET, MTNR1B, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, PPARG, SMAD3, SRC, TEK, XDH 9.81647
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 9.71751
[BP] GO:1902531 regulation of intracellular signal transduction ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, F10, F2, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TEK, XDH 9.6167
[BP] GO:0044237 cellular metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 9.19661
[BP] GO:0008152 metabolic process ACHE, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 9.03252
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRB1, ADRB2, AKR1B1, AXL, CYP1B1, DRD2, EGFR, F10, F2, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 9.02841
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, HSP90AB1, OPRK1, OPRM1, PDE3A, PPARG, RORC, SRC, TEK, TYR 9.02444
[BP] GO:0009719 response to endogenous stimulus ADRB2, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PPARG, SMAD3, SRC, TEK 9.00599
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 8.96163
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRB1, ADRB2, CDC25B, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 8.81975
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRB1, ADRB2, CDC25B, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 8.81975
[BP] GO:0009967 positive regulation of signal transduction ADRB1, ADRB2, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F2, FLT3, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 8.79476
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, ESR1, HTR7, MTNR1A, MTNR1B, OPRK1, OPRM1, PPARA, PPARG, RORC, SRC, TOP1 8.70929
[BP] GO:0048518 positive regulation of biological process ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 8.23459
[BP] GO:0032501 multicellular organismal process ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRB, F10, F2, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 8.22763
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, ADRB1, ADRB2, CA2, DRD1, DRD2, ESR1, F2, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, INSR, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PPARG, SIGMAR1, SRC 8.18559
[BP] GO:0042493 response to drug AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, OPRK1, OPRM1, PDE3A, PPARG, SRC, TOP1 8.15212
[BP] GO:0019220 regulation of phosphate metabolic process ADRB1, ADRB2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.13768
[BP] GO:0009628 response to abiotic stimulus ADRB1, ADRB2, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, MMP2, OPRD1, OPRK1, OPRM1, PPARA, PPARG, SMAD3, SRC, TEK, TYR 8.13257
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F2, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRM1, PIM1, PPARG, SMAD3, SRC, TEK, XDH 8.07942
[BP] GO:0051174 regulation of phosphorus metabolic process ADRB1, ADRB2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.07685
[BP] GO:0050896 response to stimulus ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, ALPL, AURKB, AXL, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, F10, F2, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TYR 7.91789
[BP] GO:0048584 positive regulation of response to stimulus ADRB1, ADRB2, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, ESRRA, F10, F2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP2, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 7.76422
[BP] GO:0042592 homeostatic process ADRB1, ADRB2, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, PPARG, SMAD3, SRC 7.73926
[BP] GO:0007187 None ADRB1, ADRB2, DRD1, DRD2, HTR1A, HTR6, HTR7, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1 7.72554
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARG, RORC, SMAD3, SRC 7.64201
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ADRB2, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F2, GPR35, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 7.49138
[BP] GO:0007165 signal transduction ADORA3, ADRB1, ADRB2, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK 7.44303
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PDE3A, PPARA, PPARG, TBXAS1 7.36353
[BP] GO:0003018 None ADRB1, ADRB2, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PDE3A, SRC, TEK 7.30326
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARG, RORC, SMAD3, SRC 7.30289
[BP] GO:0048583 regulation of response to stimulus ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 7.20741
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PPARG, SRC, TEK, TYR 7.1567
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, OPRD1, OPRK1, OPRM1 7.08742
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PPARG, SRC, TEK 7.06724
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.85858
[BP] GO:0009966 regulation of signal transduction ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 6.83139
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, OPRK1, OPRM1, PPARG, RORC, SRC, TYR 6.75428
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARG 6.65738
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PPARG, SRC, TEK, TYR 6.65383
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 6.57971
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, OPRK1, PDE3B, PPARA, PPARG, SRC, TEK 6.57971
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7 6.57971
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7 6.57971
[BP] GO:0031325 positive regulation of cellular metabolic process ADRB1, ADRB2, AURKB, CDC25B, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.48658
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, TEK, TOP1, XDH 6.42418
[BP] GO:0051049 regulation of transport ACHE, ADRB2, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, F2, GPR35, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, INSR, MMP12, MMP9, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PPARG, PTPN1, SMAD3, SRC 6.32397
[BP] GO:0042325 regulation of phosphorylation ADRB2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, TEK, XDH 6.28645
[BP] GO:0003013 None ADRB1, ADRB2, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PDE3A, SRC, TEK 6.21902
[BP] GO:0009893 positive regulation of metabolic process ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.15643
[BP] GO:0042327 positive regulation of phosphorylation ADRB2, CDC25B, DRD2, EGFR, ESRRB, F2, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 6.14983
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, TEK, TOP1, XDH 6.01047
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, ADRB2, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PPARA, PPARG, RORC, SMAD3, SRC 5.96114
[BP] GO:0009987 cellular process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 5.95439
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 5.95439
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, HSP90AB1, OPRM1, PDE3A, PPARG, RORC, SRC 5.79098
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, PPARG, SMAD3 5.75558
[BP] GO:0001934 positive regulation of protein phosphorylation ADRB2, CDC25B, DRD2, EGFR, F2, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.7443
[BP] GO:0001932 regulation of protein phosphorylation ADRB2, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.71324
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.6755
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, MTNR1B, OPRK1 5.67288
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADRB2, AKR1B1, ALPL, AOX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, HSP90AA1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, SENP6, SMAD3, SRC, TEK, TOP1, TYR, XDH 5.6691
[BP] GO:0043410 positive regulation of MAPK cascade ADRB2, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.66194
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, F2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PDE3B, PPARA, PPARG, RORC, SRC, TEK 5.65743
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PDE3A, PPARA, PPARG, TBXAS1 5.64296
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRB2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PPARG, PTPN1, SMAD3, SRC, XDH 5.64296
[BP] GO:0023057 negative regulation of signaling ACHE, ADRB2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PPARG, PTPN1, SMAD3, SRC, XDH 5.62149
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.58914
[BP] GO:0031399 regulation of protein modification process ADRB2, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.58914
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.58914
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.58914
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK, TYR 5.58914
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 5.57565
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.54496
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F2, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 5.53819
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD17B1, HSD17B2 5.51025
[BP] GO:0065009 regulation of molecular function ADORA3, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, OPRD1, OPRM1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 5.4553
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRB2, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.42738
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.41146
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARG, PTPN1, RORC, SMAD3, SRC 5.38
[BP] GO:0043408 regulation of MAPK cascade ADRB2, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.37249
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARG 5.36945
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 5.36945
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.33543
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.25065
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CA3, CYP1A1, CYP1B1, DRD1, DRD2, HSP90AA1, KDR, OPRD1, OPRK1, SRC 5.22463
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 5.20732
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD1, DRD2, F2, HTR2A, HTR2B, HTR2C, KDR, SRC 5.20194
[BP] GO:0007188 None ADRB1, ADRB2, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.18925
[BP] GO:0051247 positive regulation of protein metabolic process ADRB2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F2, FLT3, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 5.16033
[BP] GO:0032502 developmental process ACHE, ADRB1, ADRB2, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B2, HSP90AB1, HTR2A, HTR2B, INSR, KDR, MET, MMP2, MMP9, PDE3A, PDE3B, PIM1, PPARA, PPARG, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 5.138
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.11088
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, OPRM1, PTPN1, SRC, TEK 5.11088
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, OPRK1, PDE3A, PDE3B, PPARG, RORC, SRC 5.11088
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.10588
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRB1, ADRB2, AXL, CA2, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F2, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARG, SMAD3, SRC, TEK, XDH 5.10588
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PPARA, PPARG, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 5.0797
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, OPRM1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 5.07303
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PPARG, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 5.06686
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, ADRB2, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PPARG, RORC, SMAD3, SRC 5.01693
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRB2, CDC25B, DRD2, EGFR, ESR1, F2, FLT3, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 5.01348
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PTPN1, SMAD3, SRC, TEK 4.99081
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.93394
[BP] GO:0097746 None ADRB1, ADRB2, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.84754
[BP] GO:0035296 None ADRB1, ADRB2, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.84754
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PPARG, RORC, SRC 4.81648
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG, TBXAS1 4.81627
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 4.78501
[BP] GO:0080134 regulation of response to stress CYP19A1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, OPRK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.76188
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, F2, OPRM1, PPARA, SMAD3 4.7457
[BP] GO:0051338 regulation of transferase activity ADRB2, AURKB, CDC25B, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PPARG, PTPN1, SRC, TEK 4.72103
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, ADRB2, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC 4.72091
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC, SRC 4.71709
[BP] GO:0050880 None ADRB1, ADRB2, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.66834
[BP] GO:0035150 None ADRB1, ADRB2, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.64552
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 4.62607
[BP] GO:0044093 positive regulation of molecular function ADRB1, ADRB2, AURKB, CDC25B, DRD2, EGFR, ESR1, ESR2, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, OPRD1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.62309
[BP] GO:0007623 circadian rhythm DRD2, EGFR, HTR7, MTNR1A, MTNR1B, PPARA, RORC, TOP1 4.58066
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PDE3A, PIM1, PPARG, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 4.56906
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.56358
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PPARG, SRC 4.50676
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, F2, HTR2A, HTR2B, HTR2C, KDR, OPRK1, SRC 4.50627
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRB2, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PPARG, PTPN1, SRC 4.49448
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, HSP90AA1, HSP90AB1, HTR1A, INSR, SMAD3 4.49055
[BP] GO:0044238 primary metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 4.479
[BP] GO:0001659 None ADRB1, ADRB2, DRD1, DRD2, HTR2A 4.479
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ADRB2, AXL, CA2, CYP1B1, DRD2, EGFR, ESRRB, F2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, OPRM1, PDE3A, PIM1, PPARG, SMAD3, SRC, TEK 4.44564
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, HTR2A, HTR2B, HTR2C, KDR, OPRM1, SRC, TEK 4.44564
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PDE3A, PIM1, PTPN1, SMAD3, SRC, TEK 4.43756
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 4.35156
[BP] GO:0006950 response to stress ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AXL, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2C, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 4.32319
[BP] GO:0030334 regulation of cell migration ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 4.31477
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.29296
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, F2, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SENP6, SRC, TEK, TOP1 4.29201
[BP] GO:0031401 positive regulation of protein modification process ADRB2, CDC25B, DRD2, EGFR, F2, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 4.28495
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PPARG, SMAD3, SRC 4.26701
[BP] GO:0051347 positive regulation of transferase activity ADRB2, AURKB, CDC25B, DRD2, EGFR, F2, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 4.25316
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.23533
[BP] GO:0032268 regulation of cellular protein metabolic process ADRB2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.23025
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.22592
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, F2, FABP4, HSP90AB1, HSPA1A, MMP12, MMP2, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 4.22592
[BP] GO:0040012 regulation of locomotion ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, OPRK1, PPARG, SMAD3, SRC, TEK 4.22071
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 4.21133
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, FABP3, IGF1R, INSR, OPRK1, PDE3B, PPARA, PPARG, SRC, TEK 4.20601
[BP] GO:0071704 organic substance metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 4.19841
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PPARG, SRC 4.19841
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, PPARG, TBXAS1, TYR, XDH 4.19744
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, PDE3A 4.19398
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.16853
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.1625
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, MTNR1A, OPRK1, OPRM1, PDE3A, PPARG, SRC 4.15791
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.13044
[BP] GO:0048585 negative regulation of response to stimulus ADRB2, CYP19A1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.12553
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, EGFR, HSPA1A 4.06319
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.02968
[BP] GO:0007268 None DRD1, DRD2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1 4.0295
[BP] GO:0098916 None DRD1, DRD2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1 4.0295
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, HSP90AB1, RORC 4.0272
[BP] GO:2000145 regulation of cell motility ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 4.00852
[BP] GO:0007267 None ADRB1, ADRB2, DRD1, DRD2, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, TEK 4.00852
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC, SRC 4.00211
[BP] GO:0007610 None DRD1, DRD2, EGFR, HTR1A, HTR2A, HTR2B, HTR2C, INSR, MTNR1A, OPRD1, OPRK1, OPRM1, PPARA 3.97179
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 3.96885
[BP] GO:0099536 None DRD1, DRD2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1 3.95373
[BP] GO:0099537 None DRD1, DRD2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1 3.95373
[BP] GO:0048871 multicellular organismal homeostasis ADRB1, ADRB2, AKR1B1, DRD1, DRD2, HTR2A, MET 3.94345
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.94345
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.94345
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, F2, MMP12, PPARA, PPARG, SMAD3, TEK 3.94164
[BP] GO:0033674 positive regulation of kinase activity ADRB2, CDC25B, DRD2, EGFR, F2, FLT3, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 3.91578
[BP] GO:1900542 None ADRB1, DRD1, DRD2, ESRRB, HTR2A, INSR, MTNR1A, OPRM1, PPARA 3.91427
[BP] GO:0007193 None DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 3.90624
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 3.90624
[BP] GO:0019932 second-messenger-mediated signaling ADRB1, ADRB2, DRD1, DRD2, EGFR, HTR2B, KDR, OPRM1, PDE3A 3.90624
[BP] GO:0043085 positive regulation of catalytic activity ADRB1, ADRB2, AURKB, CDC25B, DRD2, EGFR, ESR1, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, INSR, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 3.87929
[BP] GO:0043549 regulation of kinase activity ADRB2, CDC25B, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK 3.86618
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, HTR2A, HTR2B, HTR2C, OPRM1, PPARA, PPARG 3.86435
[BP] GO:0051050 positive regulation of transport ACHE, ADRB2, AXL, CA2, CYP19A1, DRD1, DRD2, EGFR, F2, HSP90AB1, HTR2B, INSR, MMP12, OPRK1, PPARG, SMAD3, SRC 3.8247
[BP] GO:0006140 None ADRB1, DRD1, DRD2, ESRRB, HTR2A, INSR, MTNR1A, OPRM1, PPARA 3.8247
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, PDE3A 3.80219
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.77433
[BP] GO:0007154 None ADRB1, ADRB2, AXL, DRD1, DRD2, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, PPARG, TEK 3.75108
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, FABP3, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.72483
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.72272
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.69115
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, OPRK1, SMAD3, SRC, TEK 3.69115
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.68606
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR2B, HTR7 3.64322
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, EGFR, ESR1, F2, FABP4, KDR, MET, MMP12, OPRM1, PPARA, PPARG, SMAD3, TEK 3.63837
[BP] GO:0050793 regulation of developmental process ADRB1, ADRB2, AXL, CA2, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F2, HSP90AB1, HTR2A, HTR2C, INSR, KDR, NUAK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK, XDH 3.63492
[BP] GO:0042698 ovulation cycle AXL, EGFR, OPRK1, OPRM1 3.62427
[BP] GO:0051270 regulation of cellular component movement ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 3.61784
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.60958
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 3.60852
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.57783
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 3.57025
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, INSR, PDE3A, PPARG, SRC 3.54438
[BP] GO:0023052 None ADRB1, ADRB2, DRD1, DRD2, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, TEK 3.54112
[BP] GO:0032868 None FABP3, INSR, OPRK1, PDE3B, PPARA, PPARG, SRC 3.53967
[BP] GO:0051246 regulation of protein metabolic process ADRB2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 3.53554
[BP] GO:0030534 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 3.52218
[BP] GO:0019933 None ADRB1, ADRB2, DRD1, DRD2, OPRM1, PDE3A 3.50875
[BP] GO:0051098 regulation of binding ADRB2, AURKB, CYP2D6, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC 3.5012
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.49736
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.4882
[BP] GO:0043269 regulation of ion transport ADRB2, CA2, CA7, DRD1, DRD2, F2, GPR35, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 3.4882
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.46039
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIM1, PPARA, PPARG, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 3.4592
[BP] GO:0044057 None ADORA3, ADRB1, ADRB2, DRD2, EGFR, GPR35, HTR2A, HTR2C, OPRD1, OPRK1, OPRM1, SMAD3 3.45869
[BP] GO:0009410 None DRD1, DRD2, EGFR, HSP90AB1, OPRK1, OPRM1, PPARG 3.41551
[BP] GO:0007631 None DRD1, DRD2, HTR2C, OPRD1, OPRK1, OPRM1 3.41385
[BP] GO:0009187 None HTR2B, HTR2C, PDE10A, PDE3A, PDE3B 3.38777
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.35353
[BP] GO:0009266 None ADRB1, ADRB2, HSP90AA1, HSPA1A, HTR2A, HTR2B, PPARG 3.34453
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 3.34453
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, HSP90AB1, KDR, OPRM1, SRC 3.34083
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.31796
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.31228
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.30821
[BP] GO:0019935 None ADRB1, ADRB2, DRD1, DRD2, OPRM1, PDE3A 3.29812
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27898
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27898
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27898
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.27898
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.26197
[BP] GO:0070482 response to oxygen levels CYP1A1, DRD2, MMP2, OPRD1, PPARA, PPARG, SMAD3, SRC, TEK 3.24707
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.22997
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 3.18739
[BP] GO:0042310 None HTR1A, HTR2A, HTR2B, HTR7 3.18739
[BP] GO:0044236 multicellular organism metabolic process ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9 3.17225
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADRB2, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HTR2A 3.14224
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADRB2, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HTR2A 3.14224
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.14065
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.13134
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.13134
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11425
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, OPRD1, OPRK1, OPRM1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.07407
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG, TBXAS1 3.06716
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.0308
[BP] GO:0042596 None ADRB1, DRD1, HTR1A, HTR2C 3.0308
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2B, HTR2C 3.0308
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, EGFR, HTR1A, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, OPRK1, OPRM1, SRC 3.01501
[BP] GO:0045859 regulation of protein kinase activity ADRB2, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 3.00558
[BP] GO:0003008 None ADRB1, ADRB2, AKR1B1, CYP1B1, DRD1, DRD2, EGFR, HTR1A, HTR2A, HTR2B, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TEK, TYR 2.99539
[BP] GO:1900544 None ADRB1, DRD1, ESRRB, HTR2A, INSR, MTNR1A 2.99529
[BP] GO:0045981 None ADRB1, DRD1, ESRRB, HTR2A, INSR, MTNR1A 2.99529
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, F2, PPARA, PPARG, SMAD3, TEK 2.99529
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 2.99125
[BP] GO:0051094 positive regulation of developmental process ADRB2, AXL, CA2, CYP1B1, DRD2, ESRRB, HSP90AB1, HTR2A, HTR2C, INSR, KDR, OPRM1, PDE3A, PIM1, PPARG, SMAD3, SRC, TEK 2.99125
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.99125
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.99125
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 2.99125
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.96917
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process ADRB2, AURKB, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, RORC, SMAD3, SRC 2.96635
[BP] GO:0035556 intracellular signal transduction ADRB1, ADRB2, AKR1B1, AXL, CYP1B1, DRD1, DRD2, EGFR, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, OPRM1, PDE3A, PTPN1, SRC, TEK 2.96635
[BP] GO:0031644 None GPR35, HTR2C, OPRD1, OPRK1, OPRM1 2.94035
[BP] GO:0009894 regulation of catabolic process ADRB2, CSNK2A1, EGFR, ESRRB, HSP90AB1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PDE3B, PPARA, PTPN1, SMAD3 2.94035
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.92502
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C 2.91317
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRB2, DUSP3, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 2.90198
[BP] GO:0090087 None ACHE, CA2, DRD2, EGFR, F2, HSP90AB1, HTR2B, HTR2C, MMP12, MTNR1B, OPRM1, PTPN1, SMAD3, SRC 2.89056
[BP] GO:0050806 positive regulation of synaptic transmission ADRB2, CA2, CA7, DRD1, DRD2, EGFR 2.88897
[BP] GO:0007189 None ADRB1, ADRB2, DRD1, DRD2, OPRM1 2.88897
[BP] GO:0031635 None OPRK1, OPRM1 2.88405
[BP] GO:0007208 None HTR2A, HTR2C 2.88405
[BP] GO:0009115 None AOX1, XDH 2.88405
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 2.88282
[BP] GO:1901575 None ACHE, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.87756
[BP] GO:0043627 response to estrogen CA2, ESR1, OPRK1, PPARG, TEK 2.87221
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 2.86548
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.86167
[BP] GO:0045860 positive regulation of protein kinase activity ADRB2, CDC25B, DRD2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC 2.83668
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, XDH 2.83126
[BP] GO:0065007 biological regulation ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP1, XDH 2.82981
[BP] GO:0007190 None ADORA3, ADRB1, ADRB2, DRD1 2.82462
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PDE3B, PTPN1, SRC, XDH 2.81832
[BP] GO:0009968 negative regulation of signal transduction ADRB2, DRD2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, PPARG, PTPN1, SMAD3, SRC, XDH 2.81059
[BP] GO:0001666 response to hypoxia CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 2.80779
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80559
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.80154
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 2.79545
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, NUAK1, OPRD1, OPRK1, OPRM1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.77706
[BP] GO:0046883 regulation of hormone secretion CYP19A1, DRD2, EGFR, HTR1A, HTR2A, HTR2C, MTNR1B, OPRK1 2.76624
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, TYR 2.75148
[BP] GO:0097756 None HTR1A, HTR2A, HTR2B, HTR7 2.74427
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.74408
[BP] GO:0051046 None ACHE, CYP19A1, DRD2, EGFR, HTR1A, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, OPRK1, OPRM1, SRC 2.74408
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.73128
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 2.7266
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71869
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.71869
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRB2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC 2.70257
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 2.69903
[BP] GO:0009892 negative regulation of metabolic process AURKB, CSNK2A1, CYP2D6, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRM1, PDE3B, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, XDH 2.67339
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, TYR 2.66365
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 2.66365
[BP] GO:0045776 None ADRB1, ADRB2, DRD2, PPARA 2.63345
[BP] GO:0043434 None FABP3, INSR, OPRK1, PDE3B, PPARA, PPARG, SRC, TEK 2.61827
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD1, DRD2, F2, PPARA, PPARG, SMAD3, TEK 2.60949
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, OPRD1, OPRM1, PDE3A, SMAD3, SRC 2.60949
[BP] GO:0040008 regulation of growth ADRB1, ADRB2, CSNK2A1, DRD2, EGFR, ESR2, F2, HSPA1A, INSR, PIM1, PPARG, SMAD3 2.60365
[BP] GO:0051128 regulation of cellular component organization ADRB2, AURKB, AXL, CSNK2A1, DRD2, EGFR, ESR1, ESR2, F2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, OPRD1, PDE3A, PPARG, PTPN1, SENP6, SMAD3, SRC, TEK 2.60365
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.60365
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 2.60365
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, HSP90AB1, MET, MMP9, PPARA, SRC 2.60365
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.60365
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 2.60184
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, IGF1R, INSR, PDE3B, PPARG, SRC 2.56815
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP1, XDH 2.56649
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56339
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.56339
[BP] GO:0090066 None ADRB1, ADRB2, DRD1, EGFR, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR7 2.56295
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, HSP90AB1, INSR, SRC 2.54698
[BP] GO:1904062 None ADRB2, DRD1, DRD2, F2, GPR35, MMP9, OPRK1, OPRM1 2.54443
[BP] GO:0060359 None DRD1, DRD2, HSP90AB1, OPRK1, OPRM1 2.54443
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.54209
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.54209
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.5251
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC 2.5199
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.51606
[BP] GO:0009409 None ADRB1, ADRB2, HSP90AA1, PPARG 2.51038
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.49635
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, HSP90AA1, HSPA1A, PDE10A, PDE3A, PDE3B, SRC, XDH 2.49494
[BP] GO:0046110 None AOX1, XDH 2.49255
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49255
[BP] GO:0002025 None ADRB1, ADRB2 2.49255
[BP] GO:0043279 None DRD2, HSP90AB1, OPRK1, OPRM1, PPARG 2.49128
[BP] GO:0006874 cellular calcium ion homeostasis DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.47898
[BP] GO:0008217 None ADRB1, ADRB2, DRD2, PPARA, PPARG, SMAD3 2.47821
[BP] GO:0006873 cellular ion homeostasis CA2, CA7, DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.43465
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.43189
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.43189
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PPARG, SMAD3, TEK 2.4245
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.41887
[BP] GO:0051234 None ACHE, ADRB2, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, F10, F2, FABP3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, MMP12, MMP9, OPRD1, OPRM1, PPARA, PPARG, SIGMAR1, SRC, XDH 2.40859
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PDE3A, PIM1, SENP6, SMAD3, SRC 2.40567
[BP] GO:0019538 protein metabolic process ACHE, ADRB2, ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, HSP90AA1, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SENP6, SMAD3, SRC, TEK, TOP1 2.40036
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.39445
[BP] GO:0097755 None ADRB1, ADRB2, DRD1, EGFR 2.39099
[BP] GO:0055074 calcium ion homeostasis DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.39099
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, AURKB, AXL, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK 2.3898
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, F2 2.38853
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.37989
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR, PDE3A 2.37989
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.37547
[BP] GO:0072503 cellular divalent inorganic cation homeostasis DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.35699
[BP] GO:0006807 nitrogen compound metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALPL, AOX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SMAD3, SRC, TEK, TOP1, TYR, XDH 2.34605
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.3346
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.3346
[BP] GO:0051179 None ACHE, ADRB2, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, ESR1, F10, F2, FABP3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, MMP12, MMP9, OPRD1, OPRM1, PPARA, PPARG, SIGMAR1, SRC, XDH 2.33404
[BP] GO:0051336 regulation of hydrolase activity ADRB1, CSNK2A1, DRD2, EGFR, ESR1, HSP90AB1, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, XDH 2.32733
[BP] GO:0071880 None ADRB1, ADRB2, DRD2 2.31306
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.27775
[BP] GO:0033555 multicellular organismal response to stress ADRB1, DRD1, HTR1A, HTR2C 2.27775
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.27775
[BP] GO:0010564 regulation of cell cycle process AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PDE3A, SENP6 2.27623
[BP] GO:0006810 None ACHE, ADRB2, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, F2, FABP3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, MMP12, MMP9, OPRD1, OPRM1, PPARA, PPARG, SIGMAR1, SRC, XDH 2.2619
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, SRC 2.25066
[BP] GO:0032922 None DRD2, PPARA, RORC, TOP1 2.25023
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A, TYR 2.24276
[BP] GO:0001959 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.24276
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.24022
[BP] GO:0007198 None HTR1A, HTR7 2.24022
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.24022
[BP] GO:0006145 None AOX1, XDH 2.24022
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.24022
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24022
[BP] GO:0044267 cellular protein metabolic process ADRB2, ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, HSP90AA1, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SENP6, SMAD3, SRC, TEK, TOP1 2.23508
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ADRB2, ALPL, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, HTR2B, KDR, MET, MMP2, MMP9, PDE3A, PPARG, RORC, SMAD3, SRC, TEK 2.2265
[BP] GO:0043949 None ADRB1, PDE10A, PDE3B 2.21032
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.21032
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.21032
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, OPRD1, PDE3A, SMAD3, SRC 2.20957
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.20957
[BP] GO:0072347 None DRD2, HSP90AB1, OPRK1, OPRM1 2.20957
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.20957
[BP] GO:0050678 None EGFR, HTR2B, KDR, MMP12, PPARG, SMAD3, TEK, XDH 2.19932
[BP] GO:0072521 None AOX1, HSPA1A, HTR2B, HTR2C, PDE10A, PDE3A, PDE3B, XDH 2.19209
[BP] GO:0045088 regulation of innate immune response DRD2, ESR1, HSP90AB1, HSPA1A, MMP12, MMP2, PPARG, PTPN1, SRC 2.17964
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PPARG, TBXAS1, TYR 2.16976
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HTR2A, INSR, PPARA, RORC, SRC 2.16973
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.16973
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA3, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 2.16894
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1626
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.16079
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD1, DRD2, EGFR, HTR2A 2.16079
[BP] GO:0060759 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.16054
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, F2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.12444
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PPARG, SRC 2.12299
[BP] GO:0051894 None KDR, SMAD3, TEK 2.1173
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.1173
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.1173
[BP] GO:0032098 None HTR2C, OPRM1, PPARA 2.1173
[BP] GO:0071875 None ADRB1, ADRB2, DRD2 2.1173
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1173
[BP] GO:0007626 None DRD1, DRD2, HTR2C, OPRD1, OPRK1, OPRM1 2.11664
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.11561
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.10795
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.10641
[BP] GO:0034762 None ADRB2, CA2, DRD1, DRD2, F2, GPR35, MMP9, OPRK1, OPRM1 2.0944
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B 2.0924
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, OPRK1, PTPN1, XDH 2.08745
[BP] GO:0042311 None ADRB1, ADRB2, DRD1 2.07251
[BP] GO:0055065 metal ion homeostasis DRD1, DRD2, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.07212
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.07212
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.07192
[BP] GO:0021853 None DRD1, DRD2 2.07063
[BP] GO:1904936 None DRD1, DRD2 2.07063
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.07063
[BP] GO:0010891 None PPARA, PPARG 2.07063
[BP] GO:0009896 positive regulation of catabolic process ADRB2, CSNK2A1, ESRRB, HSPA1A, HTR2A, INSR, KDR, PPARA, PTPN1 2.06718
[BP] GO:0009895 negative regulation of catabolic process EGFR, HSP90AB1, HTR2B, MET, PDE3B, PPARA, SMAD3 2.06136
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, DRD1, DRD2, HTR2A 2.05867
[BP] GO:0050795 None DRD2, HTR1A, HTR2A, HTR2B 2.05867
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C 2.05867
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.05867
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C 2.05867
[BP] GO:0008150 biological_process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 2.0581
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AXL, CYP1A1, DRD1, EGFR, ESR1, MTNR1A, OPRK1, OPRM1, SRC 2.05774
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.05774
[BP] GO:0030802 None ADRB1, DRD1, DRD2, MTNR1A, OPRM1 2.04885
[BP] GO:1903393 None KDR, SMAD3, TEK 2.0427
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.039
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRB1, ADRB2, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, OPRD1, OPRM1, PIM1, PPARA, PPARG, RORC, SMAD3, SRC 2.03725
[BP] GO:0010959 None ADRB2, DRD1, DRD2, F2, GPR35, HTR2A, OPRD1, OPRK1 2.03667
[BP] GO:0045598 None HTR2A, HTR2C, PPARG, RORC, SMAD3 2.03667
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, OPRD1 2.03667
[BP] GO:0002791 None ACHE, DRD2, EGFR, HTR2B, HTR2C, MMP12, MTNR1B, OPRM1, SRC 2.03217
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HTR2B, MMP12, OPRK1, SRC 2.03107
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, OPRK1, PPARG, RORC, SRC 2.03107
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.02305
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.02044
[BP] GO:0051223 None ACHE, DRD2, EGFR, F2, HSP90AB1, HTR2B, MMP12, MTNR1B, OPRM1, PTPN1, SMAD3, SRC 2.01523
[BP] GO:0043467 regulation of generation of precursor metabolites and energy ESRRB, HTR2A, INSR, OPRK1, PPARA 2.00955
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRB1, ADRB2, AXL, BACE1, CA4, DRD1, DRD2, F10, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 7.74085
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRB1, ADRB2, AXL, BACE1, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 6.79501
[CC] GO:0044459 plasma membrane part ADORA3, ADRB1, ADRB2, AXL, BACE1, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, F10, F2, FLT3, GPR35, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TEK 6.78196
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F10, F2, FLT3, GPR35, HSP90AA1, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PIM1, PTPN1, SMAD3, SRC, TEK 4.73179
[CC] GO:0044425 membrane part ACHE, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, GPR35, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SIGMAR1, SRC, TBXAS1, TEK, TYR 4.54975
[CC] GO:0016020 membrane ACHE, ADORA3, ADRB1, ADRB2, ALOX5, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, EGFR, ESR1, F10, F2, FLT3, FUT7, GPR35, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TYR 3.98363
[CC] GO:0031253 None CA4, CA9, DRD1, DRD2, HSP90AA1, HSP90AB1, INSR, OPRD1, OPRM1, SRC 3.78091
[CC] GO:0098590 plasma membrane region ADRB2, CA2, CA4, CA9, DRD1, DRD2, EGFR, HSP90AA1, HSP90AB1, HTR2A, INSR, MET, OPRD1, OPRM1, SIGMAR1, SRC, TEK 3.74779
[CC] GO:0045121 membrane raft BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.22749
[CC] GO:0098857 membrane microdomain BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.2052
[CC] GO:0032590 None INSR, OPRD1, OPRM1 2.71869
[CC] GO:0098589 membrane region BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 2.67608
[CC] GO:0044444 cytoplasmic part ACHE, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BACE1, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, INSR, KDR, MMP2, MMP9, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARG, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TOP1, TYR, XDH 2.4332
[CC] GO:0044432 endoplasmic reticulum part BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, F10, F2, FLT3, HSD17B2, PTPN1, SIGMAR1, TBXAS1 2.42388
[CC] GO:0031224 None ACHE, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, CA12, CA14, CA4, CA9, DRD1, DRD2, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, TBXAS1, TEK, TYR 2.30093
[CC] GO:0043204 None DRD2, OPRK1, OPRM1, PDE10A, TOP1 2.09275
[CC] GO:0016323 basolateral plasma membrane CA2, CA4, CA9, EGFR, HSP90AB1, TEK 2.05446
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.5135
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 17.6467
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 15.1162
[MF] GO:0038023 signaling receptor activity ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PPARG, RORC, SIGMAR1, TEK 12.5888
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6352
[MF] GO:0004872 receptor activity ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PPARG, RORC, SIGMAR1, TEK 11.3102
[MF] GO:0060089 molecular transducer activity ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PPARG, RORC, SIGMAR1, TEK 10.9579
[MF] GO:0004871 signal transducer activity ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PPARG, RORC, SIGMAR1, SMAD3, TEK 10.9579
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 10.7119
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3341
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PIM1, PPARA, PPARG, SIGMAR1, SRC, TEK, TOP1 9.49245
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F2, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TBXAS1, TEK, TOP1, TYR, XDH 9.02444
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PPARG, PTPN1, RORC, SMAD3 9.00526
[MF] GO:0008227 None ADRB1, ADRB2, DRD2, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7 8.56355
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PPARG, SIGMAR1, TEK 8.44477
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PPARG, SIGMAR1, TEK 8.44477
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.01619
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, XDH 7.17653
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, OPRM1 6.88428
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.87237
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 6.78618
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.65383
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.63101
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR2C, HTR7 6.63101
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR2C, HTR7 6.63101
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7 6.57971
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7 6.57971
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR2B, HTR2C, HTR7 6.41504
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 6.41504
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, OPRM1 6.35348
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 6.2247
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 6.2247
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.17073
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 5.79312
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 5.70281
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.6691
[MF] GO:0004930 None ADORA3, ADRB1, ADRB2, DRD1, DRD2, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PPARG, SIGMAR1 5.61349
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.58914
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 5.58914
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.33543
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 5.20732
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.08618
[MF] GO:0044877 macromolecular complex binding ACHE, ADRB2, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.88057
[MF] GO:0032403 protein complex binding ACHE, ADRB2, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.82804
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR2C, HTR7 4.7457
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.61387
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.48286
[MF] GO:0042277 peptide binding ACHE, ADRB2, BACE1, HSP90AB1, IGF1R, INSR, OPRD1, OPRK1, OPRM1, PPARG 4.31477
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.29201
[MF] GO:0033218 amide binding ACHE, ADRB2, BACE1, HSP90AB1, IGF1R, INSR, OPRD1, OPRK1, OPRM1, PPARG 3.90624
[MF] GO:1901338 None ADRB1, ADRB2, DRD1, DRD2 3.77433
[MF] GO:0097159 organic cyclic compound binding ADRB1, ADRB2, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, NUAK1, PDE10A, PDE3A, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 3.77433
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, SRC, TBXAS1, XDH 3.73053
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A 3.65456
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.63492
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.63305
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.24789
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.22997
[MF] GO:0005488 binding ACHE, ADRB1, ADRB2, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 3.06384
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, HSD17B1, PPARA, PPARG, RORC 3.05013
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.88405
[MF] GO:0004119 None PDE3A, PDE3B 2.88405
[MF] GO:0008389 None CYP2A13, CYP2A6 2.88405
[MF] GO:0071886 None HTR2A, HTR2C 2.88405
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F2, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SENP6, SRC, TEK, TOP1 2.84491
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.71869
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 2.65366
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.63345
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP1 2.57942
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.56815
[MF] GO:0004935 None ADRB1, ADRB2, DRD2 2.56339
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP1 2.54922
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 2.54443
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.5251
[MF] GO:0019899 enzyme binding ADRB1, ADRB2, AURKB, BACE1, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, MET, PDE3B, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 2.51582
[MF] GO:0008502 None MTNR1A, MTNR1B 2.49255
[MF] GO:0004939 None ADRB1, ADRB2 2.49255
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, PPARG, SRC, TEK, TOP1, XDH 2.40684
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CSNK2A1, EGFR, F10, F2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, PPARG, SRC, TEK, TOP1, XDH 2.3898
[MF] GO:0001965 None HTR2A, HTR2B, OPRM1 2.37547
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 2.27775
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24022
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, PPARG, TOP1 2.23594
[MF] GO:0003674 molecular_function ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PPARG, PTPN1, RORC, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 2.22401
[MF] GO:0042802 identical protein binding ACHE, ADRB2, AOX1, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, SMAD3, TYR, XDH 2.22389
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.21032
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.19817
[MF] GO:0001540 amyloid-beta binding ACHE, ADRB2, BACE1, INSR 2.13409
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.1173
[MF] GO:1901363 heterocyclic compound binding AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PDE10A, PDE3A, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 2.07251
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.07251
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP1, XDH 2.07212
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.07212
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP1, XDH 2.07203
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.07063
[MF] GO:0043559 insulin binding IGF1R, INSR 2.07063
[MF] GO:0051380 None ADRB1, ADRB2 2.07063
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, PDE3B, PTPN1, SMAD3, SRC 2.05313
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, INSR, KDR, SMAD3 2.00955
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.00397


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.8784
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, GPR35, HTR2B, HTR1A, OPRK1, HTR2C, ADRB1, OPRM1, HTR2A, ADRB2, F2, HTR6, MTNR1A, HTR7, MTNR1B, ADORA3, DRD1, DRD2 13.7115
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, OPRM1, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.9825
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7064
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3927
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, ADRB1, HTR2A, DRD1, DRD2, EGFR 6.8639
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2C, HTR2A 6.0994
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, ADRB1, HTR2A, ADRB2, DRD1, EGFR 5.6826
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PDE3B, PDE3A, HTR1A, ADRB1, ADRB2, DRD1, DRD2, PPARA 5.4086
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, SMAD3, HSP90AB1, FLT3, MMP1, MMP2, PPARG, MMP9, MET, EGFR, IGF1R 4.786
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.427
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, ADRB2, MET, EGFR, IGF1R, HSPA1A 4.63
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.4843
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.9512
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.3865
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9169
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, INSR, PDE3B, PDE3A, ADRB1, ADRB2 4.1084
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, PDE3B, ADRB1, ADRB2 4.3738
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.3554
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, HSP90AB1, INSR, KDR, TEK, MET, EGFR, IGF1R 3.0843
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 3.9706
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, PDE3A, OPRM1, DRD1 3.4478
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PDE3B, CDC25B, IGF1R 3.3302
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 3.6465
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 2.7484
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.6659
Renin secretion_Homo sapiens_hsa04924 PDE3B, PDE3A, ADRB1, ADRB2 2.9682
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, EGFR, IGF1R 2.4803
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, HTR2A 2.3371
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9578
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1 2.8729
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.2701
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.0468
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.0468
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.2466
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.9252
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9252
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 1.5887
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8356
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.8851
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8289
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5887
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.4984
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8778
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.5656
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4344
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 1.7673
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, IGF1R 1.3016
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1763
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1763
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR, PDE3B 1.1878
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.1763
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1486
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, HSPA1A 1.0678
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 0.8658
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7331
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1637
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7469
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7469
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9255
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 0.8462
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3 0.7399
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.7469
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 0.8814
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7265
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.7144
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2182
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRB2 0.9169
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.2317
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2376
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7042
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2456
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7036
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2375
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2475
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9169
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.2564
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6955
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2812
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6972
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6955
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, ADRB2 0.6751
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.6899
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9978
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6469
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.524
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5753
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6698
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3195
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1763
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6469
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3213
Axon guidance_Homo sapiens_hsa04360 MET 0.3307
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1486
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.338
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2 0.994
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1229
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.369
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.369
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.117
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3848
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3919
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3917
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4033
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4029
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.1763
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4075
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4171
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4171
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4278
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1229
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1676
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1 0.4158
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.427
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4165
Peroxisome_Homo sapiens_hsa04146 XDH 0.4278
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2601
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4642
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.1478
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4627
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4726
Bile secretion_Homo sapiens_hsa04976 CA2 0.471
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4873
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4853
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3016
Shigellosis_Homo sapiens_hsa05131 SRC 0.4895
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5123
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5036
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5311
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5342
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5519
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5887
Malaria_Homo sapiens_hsa05144 MET 0.5711
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5753
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5753
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5753
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.498
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5558
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4828
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6411
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6698
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7042
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7144
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7802
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6955
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7042
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7042
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7151
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6996
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7144
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9512
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9169
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1763


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)