TCM Prescription: Shen Shi Tong Infusion



Prescription Description
Prescription IDTCMF5504
Pinyin NameShen Shi Tong Chong Ji
Chinese Name肾石通冲剂
English NameShen Shi Tong Infusion
Function Description石淋
IndicationsStony stranguria disorder, Chronic obstructive pyelonephritis, Hematuria, Calculus of kidney, Hematuria
Disease ICD-11 Category SA90 [Stony stranguria disorder (TM1), 石淋 (TM1) ];
GB55.Z [Chronic tubulo-interstitial nephritis, unspecified, 慢性肾小管-间质肾炎,未特指的 ];
MF50.4 [Haematuria, 血尿 ];
GB70.0 [Calculus of kidney, 肾结石 ];
Human Tissues Associated with IndicationBladder, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1114 Herba glechomae longitubae 金钱草 TCMH1114
TCMH2161 Vaccaria segetalis 王不留行 TCMH2161
TCMH177 Polygonum aviculare 萹蓄 TCMH177 ITSAG3700-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1706 Dianthus superbus 瞿麦 TCMH1706 ITSAJ4556-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH780 Lygodium japonicum 海金砂 TCMH780 ITSAJ4232-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 10.5557
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 10.4134
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.97174
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, APEX1, AXL, CA2, CA9, CES1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 9.89976
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, KDR, MET, PPARA, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, XDH 9.69182
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, SLC6A4 9.05402
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, SLC6A4 9.05402
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TYR 7.96817
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TYR 7.94744
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 7.85834
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A4, SRC, TYR 7.53598
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, KCNH2, MET, SRC, TERT 7.4839
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, CDC25B, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 7.33611
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR2A 7.25579
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TOP2A, XDH 7.25579
[BP] GO:0007268 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, SLC6A2 7.10007
[BP] GO:0098916 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, SLC6A2 7.10007
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 7.0087
[BP] GO:0099536 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, SLC6A2 7.0087
[BP] GO:0099537 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, SLC6A2 7.0087
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.71269
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.71269
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.71269
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.71269
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 6.70404
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, KDR, SLC6A2, SLC6A4, SRC 6.68197
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 6.68197
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC 6.61228
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 6.55216
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 6.40865
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, HSD17B2, MET, PPARA 6.39656
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FUT7, GLO1, HTR2B, PIM1, PPARA, TYR, XDH 6.39525
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.34
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CES1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR 6.30296
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.27792
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.26615
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.26615
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, KCNH2, SLC1A1, SLC6A2 6.24009
[BP] GO:0007200 None ADRA1A, ADRA2A, DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B 6.16884
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.05198
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, SLC6A2 6.05159
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.0359
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HTR5A, RORC, SLC6A4, SRC, TYR 6.02307
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, KCNH2, MET 5.93346
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, HSD17B2 5.93336
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4 5.89035
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.75985
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, APEX1, CA2, CA9, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, GRM5, HTR5A, IGF1R, MMP2, PPARA, SLC6A4, SRC 5.67765
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AXL, CA1, CA2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC 5.65657
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC 5.61952
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 5.61625
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.57014
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TERT, TOP2A, XDH 5.51374
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TERT, TOP2A, XDH 5.43574
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, RORC 5.3503
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, CA2, DRD1, DRD2, DRD3, ESR1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 5.29845
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 5.28355
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.14957
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 5.14568
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC, TERT 5.11596
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.09175
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.09133
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, CYP1B1, DRD2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 5.04948
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.0476
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, APEX1, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HTR5A, PPARA, SLC6A4, SRC 5.03211
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, SLC6A2 5.03029
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SRC, TERT 5.00985
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.99249
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TERT, TOP2A, XDH 4.93162
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SLC6A4, SRC 4.91521
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, CYP1B1, DRD2, DRD3, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.89378
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, GRIK5, HTR1A, SLC1A1, SLC6A2, SLC6A4 4.87457
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 4.83115
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SIGMAR1, SLC6A4, SRC, TERT, TOP2A, TYR 4.77178
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 4.75417
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.66304
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, RORC, SLC6A4, SRC, TYR 4.59992
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.53173
[BP] GO:0048511 rhythmic process AXL, DRD2, DRD3, ESR1, HTR7, PPARA, RORC, SLC6A4, SRC, TOP2A 4.4798
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.47597
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, FABP3, FABP4, FUT7, MET, PPARA 4.4676
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, RORC, SRC 4.4673
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, SLC6A4 4.45331
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.45331
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.44868
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.41728
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.40331
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.39527
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.39527
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.39527
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA 4.35452
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.27072
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.27045
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, GRM1, HTR2A, HTR2B, MMP2, PPARA, SLC6A4, SRC, TERT, TYR 4.2683
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.26218
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, GRM1, GRM5, HTR2A, HTR2B, KCNH2 4.25481
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, CYP1B1, DRD2, DRD3, ESR1, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.24917
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.24917
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 4.24917
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, PPARA 4.23753
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA 4.23636
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, DRD1, DRD2, DRD3, GRM5, HTR2B, HTR5A, KDR 4.22798
[BP] GO:0032225 None DRD1, DRD2, DRD3, SLC6A4 4.21404
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA 4.2089
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A 4.17658
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.16169
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.15982
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, PPARA 4.15937
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.14494
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 4.12756
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A 4.09428
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, CYP1B1, DRD2, DRD3, ESRRA, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 4.09209
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.06288
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.0353
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.00836
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.99387
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.99387
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD17B2, HTR1A, HTR2A 3.99125
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, CA2, CA7, DRD1, DRD2, DRD3, GRM5, HTR1A, HTR2A, KCNH2, MMP9, SLC6A4 3.98938
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, GRM1, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.98125
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.95603
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.95062
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, RORC, SLC6A4, SRC 3.87384
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.86788
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.86776
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3 3.85261
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.82518
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.8251
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.79694
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.79694
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, KCNH2 3.77129
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.76485
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.76485
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SLC6A4, SRC 3.76485
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, ESRRB, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.76485
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, DRD2, DRD3, HTR2A, KCNH2, MMP9 3.76205
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, SLC6A4, SRC, TYR 3.75218
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 3.74953
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A, SLC6A4 3.74909
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.73671
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 3.73481
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.72756
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.63201
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.57707
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 3.54971
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 3.54971
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A 3.54971
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.52973
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, GRIK5, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 3.52734
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.52302
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.50914
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PPARA 3.50507
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 3.45764
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.45764
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.45764
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 3.38413
[BP] GO:0042391 None ADORA1, ADRA1A, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 3.37423
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.36457
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.35868
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.34124
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.34124
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.34124
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.33933
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 3.32503
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.30888
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, HTR2B, KCNH2, MMP12, SLC6A4, SRC, TERT 3.29089
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, HTR2A, PTPN1, SRC 3.2518
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC 3.2518
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MMP9, PTPN1, SRC, TERT, XDH 3.2518
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, GRIK5, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 3.2332
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.23253
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, CDC25B, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 3.21248
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.20391
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.19946
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.19946
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, KCNH2 3.19946
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, AXL, CA2, CYP1B1, DRD2, DRD3, ESRRB, F3, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SRC, TERT 3.19946
[BP] GO:0030814 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 3.19613
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.18167
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.157
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.15516
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, GRM3 3.15516
[BP] GO:0030802 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 3.14134
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, DRD1, DRD2, DRD3, HTR1A 3.13727
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 3.13281
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.10753
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 3.10696
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, XDH 3.10696
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT 3.10639
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.10151
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 3.09744
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.07475
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.07022
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, GRM3 3.07022
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.06757
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 3.06757
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B 3.06737
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, HTR2A, HTR2B, PTPN1, SRC 3.06489
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 3.06489
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.05162
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SLC6A4, SRC 3.05162
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC 3.05162
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, CA9, CDC25B, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 3.04556
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD17B2, TYR, XDH 3.04556
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT 3.03923
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.03895
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MET, MMP9, PTPN1, SRC, TERT, XDH 3.02346
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, GRM1, HTR2A, HTR2B, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SLC6A4, SRC, TERT, XDH 2.99561
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.99561
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, GRM3 2.99561
[BP] GO:1900371 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 2.98973
[BP] GO:0019725 cellular homeostasis ADRA1A, APEX1, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B 2.98456
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.98234
[BP] GO:0030808 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 2.97696
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.97342
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.95996
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.95996
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.94094
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 2.93167
[BP] GO:0009115 None AOX1, XDH 2.91526
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 2.9152
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC 2.90545
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KCNH2, KDR, SRC 2.90152
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, SLC6A4, SRC, TERT 2.90152
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.89438
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.89438
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.89163
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, RORC, SLC6A4 2.89146
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.87979
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, HTR2A, KCNH2, SLC1A1 2.87979
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.86701
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TOP2A 2.84164
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.83301
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.82959
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT 2.82506
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, MMP12, SLC6A4, SRC 2.82351
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 2.81689
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.81572
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.81572
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.81572
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.81572
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 2.80833
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.79249
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.7877
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.7877
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.7877
[BP] GO:0032845 None ADORA1, ADRA2A, DRD2, HTR2A, HTR2B, SRC 2.78098
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MET, PTPN1, SRC 2.76754
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A4, SRC, TERT, TOP2A, XDH 2.75705
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.75627
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.75627
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.75627
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, CA9, CDC25B, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.75399
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.7532
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.74219
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.74219
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.72354
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.71827
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.71507
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, GRM3 2.69184
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, GLO1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 2.68732
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR 2.66915
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.66915
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.66915
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A4, SRC, TERT, TOP2A, XDH 2.64714
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC, TERT, XDH 2.62999
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.62804
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.62804
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.62721
[BP] GO:0050730 None ADORA1, ADRA2A, FLT3, GRM5, HTR2A, PTPN1, SRC 2.61679
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.61491
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, DRD3, GRM1, HTR2A, KCNH2, SLC1A1 2.60203
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.59763
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.58271
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.57702
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.56857
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.5673
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.56322
[BP] GO:0099566 None GRM1, GRM5 2.54078
[BP] GO:0046110 None AOX1, XDH 2.54078
[BP] GO:0060160 None DRD2, DRD3 2.54078
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54078
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.53585
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.52175
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.52175
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MET, MMP12, PPARA, RORC, SRC, TERT, TOP2A 2.48242
[BP] GO:0007610 None DRD1, DRD2, DRD3, GRM1, GRM5, HTR1A, HTR2A, HTR2B, PPARA, SLC6A4 2.47963
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.47293
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.47293
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, XDH 2.4645
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GRM1, HTR2A, HTR2B 2.45574
[BP] GO:0055065 metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, KCNH2 2.45574
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA 2.44765
[BP] GO:0030335 positive regulation of cell migration ADRA2A, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.42037
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.41339
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.41339
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, CA9, CDC25B, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.41316
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, CA9, CDC25B, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.41188
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.40443
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.40443
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.40418
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.38798
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.3683
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.35918
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.35918
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, GRM1, HTR2A, HTR2B, PTPN1, SRC 2.35667
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.34733
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, DRD1, ESR1, FLT3, GRM5, IGF1R, MMP2, SLC6A4, SRC 2.34163
[BP] GO:2000147 positive regulation of cell motility ADRA2A, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.3218
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.30462
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.30462
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.30131
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.30131
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR 2.30082
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.2956
[BP] GO:0006145 None AOX1, XDH 2.29271
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29271
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29271
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.26996
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.26316
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.26156
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.26156
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26156
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.26082
[BP] GO:0031279 None ADRA2A, DRD2, DRD3, GRM3 2.26082
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.2524
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, GRM5, HTR2A, SLC6A4 2.25072
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR 2.24249
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.24249
[BP] GO:0051339 None ADRA2A, DRD2, DRD3, GRM3 2.24057
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.24057
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, TERT 2.23833
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 2.23833
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.23594
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.22164
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.22164
[BP] GO:0071875 None ADRA1A, ADRA2A, DRD2 2.22164
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.22164
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TOP2A 2.21877
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.21877
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, CYP1B1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.21691
[BP] GO:0045936 None ADRA2A, DRD2, DRD3, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.21626
[BP] GO:0010563 None ADRA2A, DRD2, DRD3, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.21129
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.20212
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.2
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.18116
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.18088
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.18067
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, SRC 2.1696
[BP] GO:0040017 positive regulation of locomotion ADRA2A, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.16601
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, SLC6A4 2.16586
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, MMP12, PPARA, RORC, SRC, TERT 2.15573
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.13651
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.13651
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.13651
[BP] GO:0021853 None DRD1, DRD2 2.12224
[BP] GO:0010641 None F3, SRC 2.12224
[BP] GO:0090325 None DRD2, DRD3 2.12224
[BP] GO:1904936 None DRD1, DRD2 2.12224
[BP] GO:0042321 None ADORA1, DRD2 2.12224
[BP] GO:0010513 None HTR2A, HTR2B 2.12224
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.12224
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.12224
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.12224
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.10902
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.10049
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.10049
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.09832
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.09685
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.09685
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, GRM1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.08882
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, GRM5, IGF1R, MMP2, SLC6A4, SRC 2.08169
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.06927
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.06732
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.05972
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.05972
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 2.04179
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HTR2B, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.03101
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.01724
[BP] GO:0098657 import into cell ACHE, ADORA1, AXL, DRD2, DRD3, HTR2B, SLC1A1, SLC6A2, SLC6A4 2.01566
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA4, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SLC6A2, SLC6A4 9.74143
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SLC6A2, SLC6A4 8.71523
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC 7.83342
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPI, AXL, CA12, CA14, CA2, CA4, CA9, DRD1, DRD2, DRD3, ESR1, F3, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT 7.26095
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, ADRA2A, CA2, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, SIGMAR1, SLC1A1, SRC 6.4001
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX5, ALPI, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TYR 5.09192
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPI, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTPN1, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TYR 4.76978
[CC] GO:0043005 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SLC6A2, SLC6A4, SRC 4.1653
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.82518
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.82518
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SLC6A2, SLC6A4, SRC 3.75922
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SLC6A2, SLC6A4, SRC 3.50688
[CC] GO:0044456 None ACHE, ADORA1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SLC6A4, SRC 3.45665
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.32684
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 2.86091
[CC] GO:0005783 None ADORA1, APEX1, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GRIK5, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.85375
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPI, AXL, CA12, CA14, CA4, CA9, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, TYR 2.73488
[CC] GO:0097458 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, SIGMAR1, SLC6A2, SLC6A4, SRC 2.70544
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.24074
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.21877
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, ADRA2A, ALPI, AXL, CA12, CA14, CA9, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, TYR 2.20412
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 2.01724
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 14.2226
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 13.5844
[MF] GO:0030594 None DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 13.1963
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 13.1891
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 12.8647
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 12.0676
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82336
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TOP2A, TYR, XDH 9.74143
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 9.74143
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 9.74143
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, SLC6A4 9.44388
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 9.39107
[MF] GO:0008227 None ADRA1A, ADRA2A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.90138
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.02037
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 6.77898
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.71269
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.71269
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.71269
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.71269
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.6016
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.15127
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.69518
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.63428
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, XDH 5.41671
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 5.22702
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.15831
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SLC6A4, SRC, TOP2A 5.13534
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.04948
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.04948
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.98836
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.94795
[MF] GO:0046872 metal ion binding ALOX5, ALPI, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TOP2A, TYR, XDH 4.93327
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.93162
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 4.72197
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.63569
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, F3, FLT3, FUT7, GLO1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TYR, XDH 4.5497
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 4.1653
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC 3.98831
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD17B2, TYR, XDH 3.89462
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.86776
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC 3.80344
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.76691
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 3.52302
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.32684
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6 3.07022
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.98234
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91526
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.9152
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.89438
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, RORC 2.77938
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.72431
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.66915
[MF] GO:0005330 None SLC6A2, SLC6A4 2.54078
[MF] GO:0099583 None GRM1, GRM5 2.54078
[MF] GO:0047374 None CES1, CES2 2.54078
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.47293
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.47293
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, DRD2, ESR1, ESR2, FLT3, GRIK5, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, TERT, TOP2A, TYR, XDH 2.47293
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.41339
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.38798
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.32082
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.29271
[MF] GO:0004971 None GRIA2, GRIA4 2.29271
[MF] GO:0032795 None ADORA1, ADRA2A 2.29271
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC, XDH 2.19367
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2 2.18088
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12224
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B2, XDH 2.00885


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GRIK5, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, GRM1, ADRA2A, GRM3, HTR6, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 17.4855
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A, CYP2C19, SLC6A4 9.1451
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9248
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.3581
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, GRM1 6.0947
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.085
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, HTR2A, DRD1, DRD2, GRM1 6.0497
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA, GRIA4 4.7899
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.4776
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.7972
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.4142
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7326
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.724
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, GRIA4 2.9694
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.4456
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP2C19, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPI, XDH, CES1 2.8136
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1, CYP2C19 2.9694
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 2.8979
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 2.8972
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9694
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.442
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.1502
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 2.767
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.9876
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 1.7773
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.086
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A, ADRA2A 1.7978
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 1.9957
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9991
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9355
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0024
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.6828
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.3875
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7082
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.6596
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.6451
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.613
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.4794
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.298
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9722
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7978
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9363
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.0295
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9477
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8617
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9722
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2629
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8153
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.138
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2574
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1687
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.228
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8153
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8094
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7523
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.7978
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0709
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7289
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7238
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7289
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.6312
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1648
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6863
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2381
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6153
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1988
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1988
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.2232
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2422
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.251
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2651
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2825
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2825
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2711
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.3264
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3235
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3125
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3433
Tight junction_Homo sapiens_hsa04530 SRC 0.3433
Platelet activation_Homo sapiens_hsa04611 SRC 0.367
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3508
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3863
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.367
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.367
Axon guidance_Homo sapiens_hsa04360 MET 0.3626
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3863
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.367
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.369
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4048
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4079
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4292
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4079
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4181
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4292
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4181
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4292
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4292
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4181
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4292
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4292
Peroxisome_Homo sapiens_hsa04146 XDH 0.4292
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4292
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4627
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4427
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4746
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4934
Bile secretion_Homo sapiens_hsa04976 CA2 0.4738
Glioma_Homo sapiens_hsa05214 IGF1R 0.4934
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4923
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4934
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4934
Shigellosis_Homo sapiens_hsa05131 SRC 0.4934
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5131
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6826
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.6878
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5634
Malaria_Homo sapiens_hsa05144 MET 0.5741
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6055
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5804
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5771
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6499
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8356
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5918
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6312
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.716
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6959
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7263
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7474
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7238
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.738
Folate biosynthesis_Homo sapiens_hsa00790 ALPI 0.9477
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9694
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.228


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)