TCM Prescription: Shu Shen Ling Capsules



Prescription Description
Prescription IDTCMF5493
Pinyin NameShu Shen Ling Jiao Nang
Chinese Name舒神灵胶囊
English NameShu Shen Ling Capsules
Function Description绝经前后诸症
IndicationsMenopausal disorder, Menopausal and perimenopausal disorder
Disease ICD-11 Category SB95 [Menopausal disorder (TM1), 绝经前后诸症 (TM1) ];
GA30 [Menopausal or certain specified perimenopausal disorders, 绝经期或某些特指的围绝经期疾患 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH143 Albizia julibrissin 北合欢 TCMH143 ITSAK2640-14
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT330 SMO Smoothened homolog GPCR Q99835
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT837 SHH Sonic hedgehog protein Unclassified Q15465
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, SHH, TRPV1 17.3406
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, SHH 14.7735
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, MAOA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 13.0531
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A4, SMO, SRC, TRPV1, TYR 12.1798
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGES, PTGS2, RELA, RORC, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TRPV1, TYR 12.0807
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.9126
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PTGES, PTGS2, RELA, RORC, SLC6A4, SMO, SRC, TYR 11.2131
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGES, PTGS2, RELA, RORC, SLC6A4, SMO, SRC, TRPV1, TYR 11.2131
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FDPS, FUT7, GBA2, GLO1, HSD17B3, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR, XDH 11.2131
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, TNKS2, XDH 10.9761
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, TNKS2, XDH 10.9505
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A4, SMO, SRC, TRPV1, TYR 10.8639
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TOP2A, TRPV1, XDH 10.437
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 10.4232
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, RELA, SHH, SLC6A4, SMO, SRC, TERT, XDH 10.4232
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TOP2A, TRPV1, XDH 10.4048
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 10.2202
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 10.1777
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 10.1651
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TRPV1 10.0547
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TOP2A, TRPV1, XDH 9.91194
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FDPS, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 9.68854
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, PPARA, PTGS2, RELA, SLC6A4, SRC, TRPV1 9.57425
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 9.57425
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SHH, SRC, TERT 9.48336
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.28629
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, TNKS2, XDH 9.15365
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 9.14041
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, NR3C1, PPARA, PTGS2, RELA, SLC6A4, SRC, TRPV1 8.75392
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.62967
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, SHH 8.62967
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 8.45116
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RELA, RORC, SLC6A4, SMO, SRC, TRPV1 8.38349
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA, PTGES, PTGS1, PTGS2 8.31946
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 8.31946
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TOP2A, TRPV1 8.23699
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.23118
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS2, TOP2A, TYR 7.96216
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, SHH 7.92103
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TOP2A, TRPV1, TYR 7.86742
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.80795
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, NR3C1, PIM1, PPARA, RELA, RORC, SRC 7.77077
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 7.73975
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SHH, SLC6A2, SLC6A4, SMO, SRC, TNKS2, TRPV1, TYR 7.73334
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SHH, SLC6A4, SMO, SRC, TERT, TRPV1 7.64437
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.57258
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT 7.54648
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.54648
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT 7.49341
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3, SHH 7.45899
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PPARA, PTGES, PTGS1, PTGS2 7.45899
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.44026
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, GBA2, HSD17B3, MAOA, TYR 7.44026
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SMO, SRC, TRPV1 7.44026
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, TNKS2, XDH 7.41696
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA, SHH, SMO, TERT 7.39112
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.39026
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.29204
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PIK3CA, PPARA, RELA, SHH, SRC, TYR 7.25913
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.2278
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.12923
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 7.06521
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RELA, RORC, SLC6A4, SMO, SRC, TRPV1 7.02272
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, XDH 6.9662
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT 6.90047
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.89923
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.88658
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, XDH 6.8271
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2, TRPV1 6.67379
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.42601
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KCNH2, KDR, NR3C1, PTGS2, RELA, SLC6A2, SLC6A4, SRC, TRPV1 6.42432
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, RELA, SHH, SLC6A4, SMO, SRC, TERT, TNKS2, TRPV1, XDH 6.18832
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SHH, SRC, TERT 5.86671
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTGS2, RELA, SHH, SMO, SRC, TERT, TRPV1 5.80183
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6, CYP3A4 5.80183
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SHH, SRC, TERT 5.69425
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KCNH2, KDR, NR3C1, PTGS2, RELA, SRC, TRPV1 5.69141
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 5.60971
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 5.57224
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, SMO, SRC, TERT, TRPV1 5.51656
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.4585
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SHH, SMO, SRC, TYR 5.4332
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 5.4332
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES, PTGS1, PTGS2 5.39715
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SHH, SRC, TERT 5.38696
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.1962
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SHH, SRC, TERT 5.1962
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2, SHH, TERT 5.15091
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.13999
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.13999
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FDPS 5.09966
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, PTGS2, SHH, SLC6A4, SRC, TOP2A 4.92519
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.90739
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, FDPS, HSD17B3, TYR 4.85227
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, HCAR2, KCNH2, MAP2K1, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SHH, SLC6A4, SMO, SRC, TERT, TRPV1 4.82699
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.81656
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 4.80575
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, PTGS2, RELA, SRC 4.80037
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, XDH 4.78179
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.77362
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.76647
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 4.70898
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, TNKS2, XDH 4.70898
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 4.67151
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FDPS 4.63107
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1, SHH 4.60524
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, FDPS, HSD17B3, PTGES, PTGS1, PTGS2 4.59948
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, MMP12, NR3C1, PPARA, PTGS2, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 4.51476
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3, SHH 4.51476
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGES, PTGS1, PTGS2 4.44335
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.4213
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.41588
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1, SHH 4.37475
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, TNKS2, XDH 4.27219
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TNKS 4.25703
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.22254
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.22254
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.20937
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, RELA, SLC6A4, SRC 4.19281
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.19059
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MAP2K1, MET, MMP12, NR3C1, PPARA, PTGS2, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 4.10917
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.10291
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, KCNH2, MMP12, PTGS2, SHH, SLC6A4, SMO, SRC, TERT, TRPV1 4.10291
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.06627
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SHH, SRC 4.06625
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 4.02718
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMO, SRC, TERT, TNKS 4.02718
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SHH, SMO, SRC, TNKS, TNKS2, TRPV1 4.00788
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, AR, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, RELA, SLC6A4, SRC, TRPV1 3.99146
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, RELA, SRC 3.96634
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 3.96634
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC, TRPV1 3.96634
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 3.96595
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, PTGS2, SHH, SRC 3.93534
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.92229
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.91538
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3, SHH 3.9117
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, ESR1, FLT3, NR3C1, RELA, RORC, SLC6A4, SMO, SRC 3.89712
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, APP, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, XDH 3.88827
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SHH, SMO, SRC, TERT, TNKS, TRPV1, XDH 3.86798
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, MAP2K1, PTGES, PTGS2, SHH, SLC6A4, TERT, XDH 3.86798
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FDPS, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 3.83162
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSD11B2, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1 3.83162
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.83162
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.82901
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.79546
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, AR, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SHH, SRC, TERT, XDH 3.79546
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 3.77564
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 3.75879
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.74077
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.73616
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 3.70099
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.69839
[BP] GO:0050793 regulation of developmental process ADRA2C, ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, MAP2K1, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS2, TRPV1, XDH 3.69839
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.69568
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.64239
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB, TRPV1 3.64239
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMO, SRC, TNKS 3.63931
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SHH, SLC6A4, SRC, TERT, XDH 3.63828
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.63324
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SHH, SLC6A4, SRC, TERT, XDH 3.62195
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGES, PTGS1, PTGS2 3.61915
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, SHH, TYR 3.60878
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A 3.60749
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA, SHH, SMO 3.60749
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.60102
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, MAP2K1, MET, PIK3CB, PIM1, SHH, SRC, TYR 3.57804
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.55121
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, RELA, SLC6A4, TRPV1, TYR 3.52852
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TRPV1, TYR 3.52377
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SLC6A4, SRC 3.50266
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GLO1, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SHH, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.49781
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.46316
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.45436
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.44504
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.42506
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MAP2K1, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A 3.38138
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, HCAR2, MET, PIK3CA, PPARA, RELA, SHH 3.35425
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TERT, TRPV1, TYR 3.34545
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.33854
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.32949
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.3017
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.27516
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, SRC, TNKS, TNKS2, TRPV1 3.27106
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.24833
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.24833
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, ESRRB, HCAR2, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PTPN1, RELA, SHH 3.24301
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, RELA, SLC6A4, TRPV1, TYR 3.24084
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, RELA, SLC6A4, SRC, TRPV1, TYR 3.22493
[BP] GO:0051094 positive regulation of developmental process ADRA2C, ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, KDR, MAP2K1, PIM1, PTGS2, RELA, SHH, SMO, SRC, TERT 3.22493
[BP] GO:0006693 None CES2, PTGES, PTGS1, PTGS2 3.22493
[BP] GO:0006692 None CES2, PTGES, PTGS1, PTGS2 3.22493
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 3.21834
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, SHH 3.21637
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, TRPV1 3.21076
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TRPV1, TYR 3.18158
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.17984
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SHH, SMO, SRC 3.15723
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.14351
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 3.13604
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.11553
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 3.11553
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 3.10379
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CDC25B, CDK6, CES1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MAP2K1, MET, MMP2, MMP9, PTGS2, RORC, SHH, SMO, SRC, TERT, TOP2A 3.09718
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.05465
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.05062
[BP] GO:0045934 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TRPV1 3.04584
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, APP, AXL, BCL2, FLT3, FUT7, MMP9, PIK3CA, PIK3CB, RORC, SHH, SMO, SRC, TRPV1 3.02597
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 2.98933
[BP] GO:0030168 platelet activation ADRA2A, ADRA2C, AXL, PIK3CA, PIK3CB, SRC 2.93489
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MAP2K1, PTGS2, RELA, TERT 2.92739
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, SHH 2.87143
[BP] GO:0019371 None PTGES, PTGS1, PTGS2 2.87143
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, SMO, TNKS2 2.87143
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.87143
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4, MAOA 2.85752
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, SHH 2.84093
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SHH, SMO, SRC, TNKS, TNKS2, TRPV1 2.83699
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, IGF1R, MMP2, PTGS2, RELA, SLC6A4, SRC, TRPV1 2.83699
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRA2C, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.83138
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 2.81969
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, MAP3K7, RELA, SHH, SMO 2.78797
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 2.78378
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, FLT3, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.78378
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.78378
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, KDR, MAP2K1, PIM1, PTGS2, RELA, SHH, SLC6A4, SMO, SRC, TERT, XDH 2.78378
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.78378
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.78378
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.78378
[BP] GO:0009115 None AOX1, XDH 2.78378
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.78378
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.78378
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.78378
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.78267
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.78267
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, RELA, SRC 2.78267
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HSD11B2, PTGS2, RELA, SLC6A4, SRC, TRPV1, TYR 2.78013
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 2.77344
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.76668
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.74916
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.7384
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, AR, BCL2, CACNA1C, CSNK2A1, HCAR2, MMP12, PTGS2, PTPN1, SHH, SMO, SRC, TERT 2.72778
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, PTPN1 2.71582
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, ESR1, ESRRA, HCAR2, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, RELA, SHH, SRC 2.70568
[BP] GO:0051172 None ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.70568
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.70568
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.69962
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.69962
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.69962
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, CACNA1C, HCAR2, MMP12, PTGS2, PTPN1, SHH, SMO, SRC 2.69055
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.68582
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.68543
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.67338
[BP] GO:0045893 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TOP2A 2.66916
[BP] GO:1903508 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TOP2A 2.66916
[BP] GO:1902680 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TOP2A 2.66629
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, FLT3, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.65687
[BP] GO:0040007 None APP, AR, BCL2, CYP19A1, ESR1, SHH, SMO, SRC, TNKS2 2.65687
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.65045
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 2.63513
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.63513
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC, SHH 2.63513
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.63352
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, SRC 2.63343
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.61919
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, IGF1R, MMP2, PTGS2, RELA, SLC6A4, SRC, TRPV1 2.61919
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, PTGS2, SHH, SMO, SRC, TERT 2.61919
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.6113
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.6113
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, PTGS2, RELA, SLC6A4, TRPV1, TYR 2.60948
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 2.59647
[BP] GO:0045595 regulation of cell differentiation ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, ESRRA, ESRRB, KDR, MAP2K1, PPARA, PTGS2, RELA, RORC, SHH, SLC6A4, SMO, TERT, TRPV1, XDH 2.58985
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, MAOA 2.57528
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.57323
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.54656
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.54049
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.51963
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, ESR1, MET, SHH, SMO, SRC 2.51246
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MAP2K1, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.51135
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.50368
[BP] GO:0048538 thymus development BCL2, MAP2K1, SHH, TYR 2.49603
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.49603
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, ALOX12, AOX1, APEX1, APP, AR, BCL2, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, MAP3K7, NR3C1, PPARA, PTGS2, RELA, RORC, SHH, TERT, TOP2A, TYR, XDH 2.48966
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 2.48567
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.48408
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, PPARA, PTGS2, RELA, SRC, TRPV1 2.47712
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.47029
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.47029
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.47029
[BP] GO:0045986 None ADORA1, ADRA2C, PTGS2 2.47029
[BP] GO:0006633 None ALOX12, ALOX15, PTGES, PTGS1, PTGS2 2.46958
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.46958
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, KCNH2, MMP9, PTGS2 2.46035
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, FLT3, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.45801
[BP] GO:0051254 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TOP2A 2.43679
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 2.41845
[BP] GO:0007228 None SHH, SMO 2.41845
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.41845
[BP] GO:0003140 None SHH, SMO 2.41845
[BP] GO:0046110 None AOX1, XDH 2.41845
[BP] GO:0060737 prostate gland morphogenetic growth ESR1, SHH 2.41845
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41845
[BP] GO:0060769 None AR, SHH 2.41845
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.41845
[BP] GO:0060523 prostate epithelial cord elongation ESR1, SHH 2.41845
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.4155
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, MAP2K1, PIM1, TERT, TNKS, TOP2A 2.41283
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, PTGES, PTGS1, PTGS2 2.37003
[BP] GO:0048589 None APP, AR, BCL2, CYP19A1, ESR1, SHH, SMO, TNKS2 2.36517
[BP] GO:0008217 None ADORA1, AR, HSD11B2, PPARA, PTGS1, PTGS2 2.35739
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, KDR, MAP3K7, PIK3CA, PIK3CB, PPARA, SHH, SRC 2.35739
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.34677
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 2.33118
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.33118
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA 2.32545
[BP] GO:0000122 None AR, AURKB, ESR1, ESR2, ESRRA, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, TRPV1 2.32099
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.31813
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.30503
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PTGES, PTGS2, RELA, SRC, TRPV1 2.29959
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, BCL2, CDK6, CES1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MAP2K1, MMP2, MMP9, PTGS2, RORC, SHH, SMO, TOP2A 2.29226
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PTGS2, TERT 2.29226
[BP] GO:0051253 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TERT, TRPV1 2.29226
[BP] GO:0022603 regulation of anatomical structure morphogenesis ALOX12, AR, BCL2, CYP1B1, ESR1, F3, KDR, MAP2K1, PIM1, PTGS2, SHH, SMO, SRC, TERT, XDH 2.29226
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.28781
[BP] GO:0051100 negative regulation of binding AURKB, CYP2D6, MET, PPARA, SMO, TNKS 2.28101
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, PTGS2, SLC6A4, SRC 2.28101
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.23424
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.23187
[BP] GO:0048645 None AR, MAP2K1, SHH 2.22663
[BP] GO:0010628 positive regulation of gene expression APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PIK3CB, PPARA, RELA, RORC, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TOP2A 2.20991
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.20875
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, PTPN1, SRC 2.20875
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, PIK3CA, PIM1, SLC6A4, SMO, TNKS2 2.20764
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, MAP2K1, PIM1, PTGS2, SLC6A4, SRC, TERT, TNKS, TOP2A 2.20764
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.18825
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.18825
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.18209
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.17705
[BP] GO:0060740 None AR, ESR1, SHH 2.17705
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.17705
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.17705
[BP] GO:0035625 None ADRA2A, ADRA2C 2.17705
[BP] GO:0032811 None ADRA2A, ADRA2C 2.17705
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.17705
[BP] GO:0070213 None TNKS, TNKS2 2.17705
[BP] GO:0021938 None SHH, SMO 2.17705
[BP] GO:0006145 None AOX1, XDH 2.17705
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17705
[BP] GO:0060688 regulation of morphogenesis of a branching structure AR, ESR1, SHH, SMO 2.16942
[BP] GO:0030177 positive regulation of Wnt signaling pathway CSNK2A1, SHH, SRC, TERT, TNKS, TNKS2 2.16586
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SHH, SRC, TERT, XDH 2.15451
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, BCL2, CACNA1C, HCAR2, MMP12, PTGS2, PTPN1, SHH, SMO, SRC 2.1538
[BP] GO:1903507 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TRPV1 2.14563
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH 2.14563
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, MAP2K1, SHH, TYR 2.14413
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CACNA1C, KCNH2, MMP9, PTGS2, SLC6A4 2.14134
[BP] GO:1902679 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RELA, RORC, SHH, SMO, SRC, TRPV1 2.14106
[BP] GO:0010226 None FABP4, PTGS2, SHH 2.1398
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.1398
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1398
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.1398
[BP] GO:0009058 None ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, AR, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAP3K7, NR3C1, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, RELA, RORC, SLC6A4, TERT, TYR 2.1398
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.13808
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH 2.11904
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.08721
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.08721
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.08721
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.0833
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, PTPN1, SRC 2.07578
[BP] GO:0050678 None AR, CDK6, F3, KDR, MMP12, SHH, SMO, XDH 2.07578
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, GLO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PIM1, PPARA, PTGS2, RELA, RORC, SHH, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.05298
[BP] GO:0050679 None AR, F3, KDR, MMP12, SHH, SMO 2.05166
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PTGS2, TERT 2.05166
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.04888
[BP] GO:0061900 None APP, SMO, TRPV1 2.03913
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.03913
[BP] GO:0045944 None APP, AR, ESR1, ESRRA, ESRRB, MET, MMP12, NR3C1, PPARA, RELA, SHH, SMO, TERT, TNKS, TOP2A 2.02077
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.00416
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.00407
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, MAOA, PTGS2, SLC6A2, SLC6A4, TRPV1 2.00025
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, SHH, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.17443
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TRPV1, TYR 5.04805
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1, SHH 4.69414
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, ESR1, F3, FLT3, GBA2, GLO1, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TRPV1 3.83162
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, HSD17B3, KDR, MAP2K1, PTGS2, PTPN1, XDH 3.65665
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.26934
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2 3.22493
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.96898
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPN1, SHH, SLC6A2, SLC6A4, SMO, SRC, TRPV1, TYR 2.59312
[CC] GO:0043226 organelle ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.51544
[CC] GO:0045121 membrane raft APP, KDR, PTGS2, SHH, SLC6A2, SLC6A4, SMO, SRC 2.35739
[CC] GO:0098857 membrane microdomain APP, KDR, PTGS2, SHH, SLC6A2, SLC6A4, SMO, SRC 2.33982
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AR, AURKB, BCL2, CA4, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, NR3C1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.26269
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA7, CDC25B, CDK6, CES1, CSNK2A1, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, MAP2K1, MAP3K7, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTPN1, RELA, SHH, SLC6A4, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.1538
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, SHH, TNKS, TYR, XDH 18.9126
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHH, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 14.6633
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SHH, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 13.9866
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 11.2131
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SHH, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.6303
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SHH, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.4232
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.68854
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC, SHBG 9.68854
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC, SHH, TNKS 8.75451
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, XDH 8.18492
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 6.98356
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 6.84279
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.60469
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 6.57958
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 6.54796
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 6.36436
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.28227
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.20935
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, SHBG, TRPV1 6.19376
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.12753
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.12753
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 6.10925
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SMO, SRC, TOP2A, TRPV1 6.0388
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.79111
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, TYR 5.46129
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 5.4585
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MAP3K7, MET, MMP9, NQO2, PTGS2, RELA, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 4.76647
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1, SHBG 4.59519
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.59235
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.44561
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.44335
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, SMO, TRPV1 4.2743
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6, CYP3A4 4.11647
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, RORC, SMO, TRPV1 3.88827
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, SMO, TRPV1 3.83051
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 3.73616
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC 3.58366
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, SMO, TRPV1 3.54509
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRA2C, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 3.54509
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SRC 3.42857
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 3.37779
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, ADRA2C, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, RELA, SLC6A4, TERT, TOP2A, TYR, XDH 3.32949
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SRC 3.32949
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.22493
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.16747
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.13051
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.02073
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.98933
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.97726
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.87143
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.78378
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, F3, KCNH2, MET, NR3C1, PPARA, PTGS2, PTPN1, RELA, SLC6A4, SRC, TNKS2, TOP2A 2.78378
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.78378
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78378
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.78378
[MF] GO:0003845 None HSD11B1, HSD11B2 2.78378
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, ADRA2C, AOX1, AR, AXL, BCL2, FLT3, KCNH2, NQO2, PTGS2, RELA, SLC6A4, TERT, TOP2A, TYR, XDH 2.77344
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.7446
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.61189
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 2.6113
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.46958
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.41845
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41845
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.41845
[MF] GO:0004938 None ADRA2A, ADRA2C 2.41845
[MF] GO:0005330 None SLC6A2, SLC6A4 2.41845
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.41845
[MF] GO:0047374 None CES1, CES2 2.41845
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.40256
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.22663
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, RELA, SRC, TERT 2.22663
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, RELA, SRC, TOP2A, TRPV1, XDH 2.17705
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17705
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17705
[MF] GO:0032795 None ADORA1, ADRA2A 2.17705
[MF] GO:0005497 None AR, SHBG 2.17705
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17705
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SHH, SLC6A2, SLC6A4, SMO, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.15451
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1, RELA 2.13808


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, CYP2D6, ALOX5, ALOX15, ALOX12, CACNA1C, PTGS2, CYP2C19, PTGS1, SLC6A4 10.9158
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 10.9158
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, SHH, CDK6, SMO, PIK3CA, BCL2, MET 8.8918
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1B1, ALOX12, PTGS2, CYP3A4, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, FDPS, TYR, AKR1B10, CYP1A2, CYP1A1, ALPL, PTGES, CES1 8.8918
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.678
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SMO, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 7.2011
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.3944
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGES, PTGS1 6.4903
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.43
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, ESR2, RELA 6.1269
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 5.5635
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.337
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 5.3652
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, PIM1, PIK3CB, RELA 5.4916
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.5061
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 5.7726
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.3652
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.1245
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, ADORA1, CACNA1C, PIK3CB, ADRA2C, ADRA2A 5.0652
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 5.0652
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, PIK3CA, PIK3CB, MET, IGF1R 5.0727
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, AOX1, CYP3A4, CYP2C19 5.1245
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.0652
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, PIK3CA, ADORA1, CACNA1C, PIK3CB, PPARA, RELA 4.6107
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB, RELA 5.0296
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.5774
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.0627
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2, RELA 4.7265
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 4.1682
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.315
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 3.8804
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.0532
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.0652
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, PIK3CA, PIK3CB, IGF1R 4.1682
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.6084
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.7383
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.0591
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, PIK3CA, PIK3CB, RELA 4.1511
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, PIK3CA, KDR, PIK3CB, MET, RELA, IGF1R 3.4459
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, PIK3CA, PIK3CB, RELA 3.9722
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, PIK3CB, MET 4.1312
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.4459
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.4459
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.4459
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.5183
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.3355
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.3142
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA, RELA 3.2657
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 2.9654
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.1292
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.111
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 2.8536
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 2.9566
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, ESRRB, PIK3CB, IGF1R 2.8321
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6501
Influenza A_Homo sapiens_hsa05164 FDPS, MAP2K1, PIK3CA, PIK3CB, RELA 2.4692
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1, ADRA2C, ADRA2A 2.3614
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6, PIK3CA, PIK3CB 3.3142
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.4271
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.3614
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 2.9566
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB, RELA 2.2191
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, BCL2, PIK3CB 3.1637
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 2.7042
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.6501
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.6038
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2337
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.0984
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8567
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.111
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.1255
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2807
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, MAP3K7, IGF1R 2.2191
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.8758
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, RELA 2.1255
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2515
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.2476
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2607
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, TERT, PIK3CB, RELA 1.8595
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 1.9859
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0316
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, PIK3CB 2.0725
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA, RELA 1.965
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.5804
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB 1.4943
Axon guidance_Homo sapiens_hsa04360 MET 0.3453
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2806
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3782
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.3614
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, PIK3CB 1.3057
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4165
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4541
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.787
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.622
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4327
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6525
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4316
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0908
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4327
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.6602
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.443
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4443
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.1281
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7645
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4448
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.6672
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7525
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.2734
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.6347
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.7438
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4443
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8145
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.458
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4505
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4443
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4521
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.7989
Peroxisome_Homo sapiens_hsa04146 XDH 0.458
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8348
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.459
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.458
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4675
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4655
Pertussis_Homo sapiens_hsa05133 RELA 0.4791
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.9523
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4814
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9614
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 0.9485
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4814
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5017
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.0774
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0359
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.0009
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.0359
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.527
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1309
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.0774
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1913
Legionellosis_Homo sapiens_hsa05134 RELA 0.5815
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1874
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1874
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1913
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.2267
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2185
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.3614
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2398
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2836
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2836
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2351
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6078
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.2351
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6128
Malaria_Homo sapiens_hsa05144 MET 0.6178
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3088
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2892
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6256
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.622
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.4385
Basal cell carcinoma_Homo sapiens_hsa05217 SHH, SMO 1.3295
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6256
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4106
Hedgehog signaling pathway_Homo sapiens_hsa04340 SHH, SMO 1.3984
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.6714
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4717
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6803
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6803
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7277
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7857
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7647
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8024
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7484
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.7975
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7857
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7737
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8116
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7749
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8024
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7286
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6434
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8348
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9809
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8674
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9614
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9473
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0359
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3216
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1355


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)