TCM Prescription: Shu Le Re Yunji



Prescription Description
Prescription IDTCMF5460
Pinyin NameShu Le Re Yunji
Chinese Name舒乐热熨剂
English NameShu Le Re Yunji
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH296 Radix aconiti 川乌 TCMH296
TCMH27 Oleum eucalypti 按油 TCMH27
TCMH1063 Curcuma longa 姜黄 TCMH1063 ITSAP2805-14
TCMH1090 Brassica juncea 芥子 TCMH1090 ITSAJ4546-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH191 Mentha haplocalyx 薄荷油 TCMH191 HM595443
TCMH2027 Oleum terebinthinae 松节油 TCMH2027
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT962 ENPP2 Autotaxin Hydrolase Q13822


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MET, MIF, PPARA, PRKCD, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 11.4866
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA, PTGES, PTGS1, PTGS2 10.5282
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PRKCD, PTGES, PTGS2, SMAD3, SRC, TEK, TYR 10.1342
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PRKCD, PTGES, PTGS2, SRC, TEK, TYR 10.1342
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CXCL8, CYP1B1, EGFR, ERBB2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 10.1342
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 10.1227
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 10.1227
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 9.61397
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, PTGS1, PTGS2 9.60609
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 9.50885
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, EGFR, ERBB2, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK 9.43198
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, PTGS1, PTGS2 9.36954
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.27097
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2 9.08016
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PRKCD, PTGES, PTGS2, SMAD3, SRC, TEK, TYR 8.81536
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.21069
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 8.1523
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AXL, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, PTGS2, SRC, TEK, XDH 7.96102
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PRKCD, PTGS2, SRC, TEK, XDH 7.93557
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSPA1A, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR, XDH 7.80784
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, PTGS1, PTGS2 7.80784
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PRKCD, PTGS2, SMAD3, SRC 7.67732
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1B1, EGFR, ERBB2, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK 7.58667
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PPARA, PTGES, PTGS1, PTGS2 7.31038
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2 7.14841
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, CXCL8, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, PRKCD, PTGS2, SMAD3, SRC 7.11515
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CACNA1C, CXCL8, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 7.08315
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 7.08315
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, APP, AR, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 7.05181
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, CXCL8, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PRKCD, SMAD3, SRC, TEK 7.04969
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 7.03793
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2 7.03755
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AR, AXL, CSNK2A1, CXCL8, CYP1B1, EGFR, ERBB2, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 7.02013
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, APP, AR, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 7.02013
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2 7.01828
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, PTGES, PTGS2, SRC, TYR 6.93943
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.93943
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGES, PTGS2, SRC 6.93943
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 6.93943
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 6.9348
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 6.92654
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 6.90756
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.86591
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK 6.7657
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, PRKCD, PTGS2, SRC, TEK 6.71242
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 6.71056
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, PTGS2, SMAD3, SRC, TEK 6.60511
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 6.56672
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PRKCD, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 6.52383
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, PRKCD, PTGS2, SMAD3, SRC 6.49544
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 6.45717
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CXCL8, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK 6.37847
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 6.33177
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 6.22636
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 6.22636
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, PTGES, PTGS2, SRC, TEK, TYR 6.16936
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR 6.13694
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 6.06173
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, TYR 6.01534
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTGS2, SMAD3, SRC, TEK 5.96767
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CXCL8, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PRKCD, PTGS2, SRC 5.95565
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.86568
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR, XDH 5.84322
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, APP, AR, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 5.83105
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, APP, AR, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 5.83105
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, APP, AR, AURKB, CSNK2A1, CXCL8, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 5.77991
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.74474
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.74474
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, CXCL8, EGFR, ERBB2, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PRKCD, PTGS2, SMAD3, SRC 5.74474
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, MAOA, PTGS1, PTGS2, TYR, XDH 5.70539
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, KDR, MIF, PRKCD, SRC, TEK, XDH 5.4537
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.44519
[BP] GO:0030335 positive regulation of cell migration APP, CXCL8, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.44078
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 5.40585
[BP] GO:2000147 positive regulation of cell motility APP, CXCL8, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.28029
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.24445
[BP] GO:0051272 positive regulation of cellular component movement APP, CXCL8, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.16153
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AR, AXL, CA2, CACNA1C, CXCL8, CYP1B1, EGFR, ERBB2, F3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCD, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 5.16153
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC 5.11649
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2 5.08833
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, EGFR, ERBB2, F3, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 5.05794
[BP] GO:0040017 positive regulation of locomotion APP, CXCL8, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.01292
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CXCL8, CYP1B1, DUSP3, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 5.01246
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, TYR 4.97007
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AR, AXL, CA2, CXCL8, CYP1B1, EGFR, F3, HCAR2, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SLC1A1, SMAD3, SRC, TEK 4.94705
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, MIF, PRKCD, SRC 4.80959
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, ERBB2, FLT3, GRM1, INSR, KDR, MIF, SRC, TEK, XDH 4.80923
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, PRKCD, PTGS2, SMAD3, SRC 4.79006
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 4.78144
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 4.7089
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SRC, TEK, XDH 4.68904
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 4.65431
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, INSR, MET, SRC, TEK, XDH 4.63561
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PGR, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 4.63561
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, INSR, MET, SRC, TEK 4.62318
[BP] GO:0001516 None MIF, PTGES, PTGS1, PTGS2 4.60805
[BP] GO:0046457 None MIF, PTGES, PTGS1, PTGS2 4.60805
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PRKCD, PTGS2, SRC, TEK, XDH 4.47269
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.47269
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.45899
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SRC, TEK, XDH 4.457
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ERBB2, FLT3, MET, MIF, PIM1, PRKCD, SRC, TEK, TYR 4.457
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, PTGS2, SRC, TEK, TYR 4.457
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SRC, TEK, XDH 4.42777
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS2, SMAD3, SRC, TEK, XDH 4.39453
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 4.38291
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 4.35654
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGES, PTGS1, PTGS2 4.31914
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CXCL8, CYP19A1, EGFR, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, PRKCD, PTGS2, SMAD3, TEK 4.30981
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR, XDH 4.26578
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, CXCL8, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, SMAD3, SRC, XDH 4.25513
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, CXCL8, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, SMAD3, SRC, XDH 4.23734
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, PTGS2, SRC 4.18496
[BP] GO:0071363 cellular response to growth factor stimulus APP, CXCL8, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC 4.15431
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 4.12646
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PTGS2, SRC, TEK 4.12308
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.08652
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, PTGS2, SRC, TEK, TYR 4.07771
[BP] GO:0050678 None AR, EGFR, ERBB2, F3, KDR, MMP12, PGR, SMAD3, TEK, XDH 4.05446
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1, HSD17B2 4.05446
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.05446
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 4.05382
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, MAOA, PTGS2, SLC1A1, SMAD3 4.03616
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 4.0329
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 4.02436
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PRKCD, PTGS2, SRC, TEK, XDH 4.0124
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CXCL8, CYP19A1, DUSP3, EGFR, ERBB2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 3.98231
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF, PRKCD 3.969
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, ERBB2, HCAR2, INSR, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 3.9594
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, APP, AR, AURKB, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 3.9594
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PRKCD, PTGES, PTGS2, SMAD3, SRC, TEK, XDH 3.95098
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PRKCD, SRC, TEK 3.93422
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.93084
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 3.88553
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 3.88063
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.86861
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, PTGS2, SRC 3.86133
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 3.80966
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.79119
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TYR, XDH 3.77561
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH 3.76422
[BP] GO:0032103 positive regulation of response to external stimulus CXCL8, EGFR, F3, FABP4, KDR, MET, MIF, PTGS2, SMAD3 3.76394
[BP] GO:0070848 response to growth factor APP, CXCL8, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC 3.76394
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PRKCD, PTGS2, SRC, TEK 3.74636
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, MIF, PTGES, PTGS1, PTGS2 3.73921
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, PRKCD, PTGS2, SRC 3.73257
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PRKCD, SRC, TEK 3.70513
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, APP, AR, AURKB, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 3.66409
[BP] GO:0008217 None ADORA1, ADRB1, AR, PPARA, PTGS1, PTGS2, SMAD3 3.64947
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.63012
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PRKCD, SRC 3.61586
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60674
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.58566
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, EGFR, HCAR2, KDR, MIF, PTGS2, SRC 3.57661
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, APP, AR, AURKB, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, XDH 3.57661
[BP] GO:0050927 None CXCL8, F3, KDR, SMAD3 3.54331
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 3.53217
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.50187
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 3.49063
[BP] GO:0050926 None CXCL8, F3, KDR, SMAD3 3.48699
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.48699
[BP] GO:0006693 None MIF, PTGES, PTGS1, PTGS2 3.48699
[BP] GO:0006692 None MIF, PTGES, PTGS1, PTGS2 3.48699
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC 3.46688
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CXCL8, CYP1B1, ERBB2, FABP3, HSPA1A, PTGES, PTGS2, SMAD3, XDH 3.46621
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, MIF, PRKCD, SRC 3.44575
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, APP, AR, AURKB, CSNK2A1, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 3.44035
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK 3.43819
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PRKCD, PTGS2, SRC, TEK, XDH 3.43539
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.43361
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 3.43361
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.39799
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, PTGS2, SRC, TEK, XDH 3.39003
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.38815
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, MIF, PRKCD, SRC 3.38738
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.38241
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES, PTGS2 3.36643
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 3.35711
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH 3.35711
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, SRC 3.34119
[BP] GO:0006636 unsaturated fatty acid biosynthetic process MIF, PTGES, PTGS1, PTGS2 3.3318
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.32914
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 3.30726
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.29311
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.28505
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, EGFR, GPR35, GRM1, HCAR2, PTGS2, SLC1A1, SMAD3 3.28099
[BP] GO:0050679 None AR, EGFR, ERBB2, F3, KDR, MMP12, TEK 3.27241
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, PTGS1 3.27104
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.25096
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.22944
[BP] GO:0007154 None ADORA1, ADRB1, AR, AXL, CACNA1C, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PTGS2, SLC1A1, TEK 3.22321
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, EGFR, HSPA1A, MAOA 3.22321
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC 3.22321
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 3.22321
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.21323
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21323
[BP] GO:0050920 regulation of chemotaxis CXCL8, CYP19A1, F3, KDR, MET, MIF, SMAD3 3.18235
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MIF, PRKCD, SMAD3, SRC, TEK, XDH 3.17093
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC 3.15829
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR, XDH 3.15772
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.15772
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.15384
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, PTGS2, SRC, TEK, XDH 3.13512
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SRC, TEK 3.13115
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 3.12468
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, SRC 3.11077
[BP] GO:0033674 positive regulation of kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PRKCD, SRC, TEK 3.1086
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.1086
[BP] GO:0019371 None PTGES, PTGS1, PTGS2 3.1086
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.09447
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.09447
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.08661
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 3.05853
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK 3.03948
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, ERBB2, KDR, MIF, SRC, TEK 3.01197
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.01197
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.01197
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC 3.01197
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, SRC 3.01197
[BP] GO:0009968 negative regulation of signal transduction AR, CXCL8, DUSP3, EGFR, ERBB2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, SMAD3, SRC, XDH 3.01197
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.99302
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, CYP2D6, DUSP3, EGFR, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC, XDH 2.99302
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.99302
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR, XDH 2.98652
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PRKCD, SRC, TEK 2.96343
[BP] GO:1901570 None ALOX5, MIF, PTGES, PTGS1, PTGS2 2.92086
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, PRKCD, SRC 2.91451
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91157
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.90536
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.90353
[BP] GO:0023052 None ADORA1, ADRB1, AR, CACNA1C, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1, TEK 2.89751
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 2.8842
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, PRKCD, SRC 2.8842
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.88344
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 2.86269
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.83526
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.83526
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, CACNA1C, CXCL8, CYP1B1, EGFR, ERBB2, GRM5, IGF1R, INSR, KDR, MET, MIF, NUAK1, PRKCD, SRC, TEK 2.83032
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 2.81829
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK 2.81829
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.81829
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CACNA1C, GPR35, GRM5, MIF, MMP9, PRKCD, PTGS2 2.74945
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.73786
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, PRKCD, PTGS2, SRC 2.6927
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, CSNK2A1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 2.65164
[BP] GO:0045766 positive regulation of angiogenesis CXCL8, CYP1B1, F3, KDR, PTGS2, TEK 2.64637
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PRKCD, SRC 2.64637
[BP] GO:0007267 None ADORA1, ADRB1, AR, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1, TEK 2.64351
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, NR3C1, PTGS2, SRC 2.63604
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, PTGS2, SRC, TEK 2.63604
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, SRC, XDH 2.63051
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 2.62449
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.62449
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 2.61567
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 2.61567
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTGS2, SRC 2.60751
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.59243
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.571
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 2.55495
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, PRKCD, PTGS2, SMAD3 2.54792
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, CACNA1C, CSNK2A1, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 2.53923
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.53075
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, SMAD3, SRC, TEK 2.52571
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PTGS2, XDH 2.52571
[BP] GO:0099566 None GRM1, GRM5 2.52571
[BP] GO:0060748 None AR, PGR 2.52571
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52571
[BP] GO:0002520 None CACNA1C, SMAD3 2.52571
[BP] GO:1904591 positive regulation of protein import APP, EGFR, PRKCD, PTGS2, SMAD3 2.52162
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.52162
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.52162
[BP] GO:1901342 regulation of vasculature development CXCL8, CYP1B1, ERBB2, F3, KDR, PTGS2, TEK, XDH 2.52076
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.50855
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.50855
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.50855
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.50855
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, SRC 2.49317
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.48458
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD 2.48458
[BP] GO:0051223 None ACHE, APP, CACNA1C, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 2.48249
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.4797
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC 2.45986
[BP] GO:0048870 cell motility AXL, CXCL8, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 2.45865
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3 2.43756
[BP] GO:0030155 regulation of cell adhesion CXCL8, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PPARA, PRKCD, SMAD3, SRC, TEK 2.43756
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.4368
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.43573
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.43573
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.42924
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 2.42097
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MIF, MMP12, SRC 2.40812
[BP] GO:1904018 positive regulation of vasculature development CXCL8, CYP1B1, F3, KDR, PTGS2, TEK 2.40599
[BP] GO:0035295 tube development AKR1B1, AR, CXCL8, CYP1A1, EGFR, SMAD3 2.40599
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, PPARA, SRC 2.40599
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD, SRC 2.39772
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, SRC 2.37781
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.35878
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.35735
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.35735
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, EGFR, ERBB2, F3, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, TYR, XDH 2.34707
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CXCL8, CYP1B1, EGFR, ERBB2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PRKCD, PTGS2, SRC, TEK 2.32431
[BP] GO:0019722 calcium-mediated signaling CACNA1C, CXCL8, EGFR, GRM5, KDR 2.31367
[BP] GO:0007187 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.31039
[BP] GO:0070201 None ACHE, APP, CACNA1C, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 2.30067
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.30015
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.30015
[BP] GO:0001775 cell activation ALOX5, APP, AXL, CXCL8, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PRKCD, SMAD3, SRC 2.2952
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.28525
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28525
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.27951
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.25883
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25761
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC 2.23481
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD 2.21171
[BP] GO:0043434 None FABP3, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 2.21086
[BP] GO:0051894 None KDR, SMAD3, TEK 2.21086
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21086
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, MIF, PPARA, PRKCD, SMAD3, TEK 2.2043
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CYP19A1, EGFR, HSD17B2, INSR, PGR, PTGS2, SRC 2.19235
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.17878
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PRKCD, PTGS2, SMAD3, SRC 2.16861
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.16861
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, KDR, MIF, SRC, TEK 2.16591
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC 2.1638
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, EGFR, PTGS2, SLC1A1 2.15574
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, GRIK5, HCAR2, MMP9, PRKCD, PTGS2, SMAD3, SRC, XDH 2.15398
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 2.13207
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.12932
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, GRIK5, HCAR2, MMP9, PRKCD, PTGS2, SMAD3, SRC, XDH 2.12348
[BP] GO:1903393 None KDR, SMAD3, TEK 2.12074
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC 2.10258
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.10146
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AR, AXL, CYP1A1, EGFR, ERBB2, FABP4, FLT3, FUT7, KDR, MET, MIF, MMP2, MMP9, PGR, PRKCD, PTGS2, SMAD3, SRC, TEK 2.1006
[BP] GO:0010641 None F3, SRC 2.09936
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 2.09293
[BP] GO:0050921 positive regulation of chemotaxis CXCL8, F3, KDR, MET, SMAD3 2.09293
[BP] GO:0003013 None ADORA1, ADRB1, EGFR, PTGS2, SRC, TEK 2.09066
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.08876
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.0848
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CSNK2A1, CXCL8, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PTGS2, SMAD3, SRC 2.07079
[BP] GO:1903524 None ADRB1, EGFR, PTGS2, SLC1A1 2.07064
[BP] GO:0045765 regulation of angiogenesis CXCL8, CYP1B1, ERBB2, F3, KDR, PTGS2, TEK 2.07039
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.06659
[BP] GO:0052548 None APP, CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.06349
[BP] GO:0050873 None ADRB1, FABP4, PTGS2 2.04553
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, PRKCD, SRC 2.04333
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTGS2, SRC 2.03687
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, SRC 2.01568
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.00909
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.00631
[BP] GO:0051336 regulation of hydrolase activity ADRB1, APP, CSNK2A1, EGFR, ERBB2, F3, HSPA1A, MMP9, NUAK1, PRKCD, PTGS2, SMAD3, SRC, XDH 2.00069
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MMP2, NR3C2, PGR, PIM1, PRKCD, PTGES, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TYR 6.50377
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK 5.86999
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, APP, AXL, CA2, CA4, CA9, CACNA1C, DUSP3, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTGS2, SLC1A1, SRC, TEK 5.23429
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, NR3C2, PTGES, PTGS1, PTGS2, SLC1A1, SRC, TEK, TYR 5.16153
[CC] GO:0043235 receptor complex APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, NR3C2, SMAD3 5.02014
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCD, SLC1A1, SMAD3, SRC, TEK 4.98687
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CA4, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.05446
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, GRIA2, HSD11B1, HSD17B2, NR3C2, PTGES, PTGS1, PTGS2 3.56647
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.47066
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.36078
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.22321
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2, TEK 3.13619
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, FLT3, GRIA2, HSD11B1, HSD17B2, NR3C2, PTGES, PTGS1, PTGS2 3.13441
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.99689
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.99689
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.91157
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, ERBB2, HSPA1A, PRKCD, PTGES, SRC, TYR 2.53861
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.24061
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.21171
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTGES, PTGS1, PTGS2, SMAD3, SRC, TYR, XDH 2.19225
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.13911
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.0953
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.0848
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, SMAD3, TYR, XDH 11.4866
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.77745
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TYR, XDH 9.08016
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, TEK 9.02014
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 8.58686
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCD, PTGES, PTGS1, PTGS2, SRC, TEK, TYR, XDH 8.45066
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.19035
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.09758
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, TEK 7.96102
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SMAD3, TEK 7.80784
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 7.80784
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, TEK 7.73135
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.34093
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 7.15659
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.08315
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.93943
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, MAOA, PTGS1, PTGS2, TYR, XDH 6.91725
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR 6.75454
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK 6.335
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK 6.335
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.25387
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.01534
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.52627
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.41125
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.3263
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCD, SRC, TEK 5.30888
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR 5.24445
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SRC, TEK 5.19407
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.08665
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, PTGES, PTGS1, PTGS2, SRC, XDH 5.05762
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGS1, PTGS2, SLC1A1, SMAD3, TYR, XDH 4.94098
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, SMAD3 4.82209
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCD, PTGS1, PTGS2, SLC1A1, SMAD3, TYR, XDH 4.68442
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.47654
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.30567
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SRC, TEK 3.88834
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA 3.44433
[MF] GO:0019899 enzyme binding ADRB1, APP, AR, AURKB, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ERBB2, F3, GRM5, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK 3.22321
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.15819
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SRC, TEK 3.15819
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, SMAD3 3.13619
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 3.1086
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 3.01197
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.93282
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93282
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.91818
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR 2.79436
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 2.70762
[MF] GO:0099583 None GRM1, GRM5 2.52571
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.47083
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.47083
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.44035
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 2.43668
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.37984
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, PTGES, SLC1A1, SRC, TEK, XDH 2.29767
[MF] GO:0004971 None GRIA2, GRIA4 2.28525
[MF] GO:0051425 None APP, INSR 2.28525
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.22553
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.21171
[MF] GO:0043559 insulin binding IGF1R, INSR 2.09936
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SLC1A1, SRC, TEK, XDH 2.0953
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.0848
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, EGFR, ERBB2, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PGR, PTGS2, SMAD3, TYR, XDH 2.0848
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCD, SRC, TEK 2.06755
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.00631
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.00631


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.7206
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7206
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 8.0041
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.8041
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 7.8069
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, ADRB1, NR3C1, GRM1, GRIA4 7.8041
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, CXCL8, FLT3, MMP1, MMP2, ERBB2, PTGS2, MMP9, MET, EGFR, IGF1R 6.2738
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.2682
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.6119
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, GRM1, EGFR, HSPA1A 5.8614
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1, PTGS2, PTGS1 5.9735
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.307
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, CYP2D6, ALOX5, CACNA1C, PTGS2, PTGS1 5.527
Metabolic pathways_Homo sapiens_hsa01100 MAOA, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.1373
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 4.963
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, CXCL8, MMP2, PRKCD, PIM1, F3 4.6782
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, CXCL8, INSR, GRM8, GRM1, EGFR 4.9027
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, PTGS2, GRM1, GRIA4 4.6782
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 4.2741
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 4.0652
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.9311
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD, CACNA1C, EGFR 3.7696
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 3.3987
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.8225
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, TEK, EGFR, IGF1R 3.5274
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.1859
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 3.1859
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.9961
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, GRIA4 3.1859
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.1859
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.9311
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGES, PTGS1 3.2582
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.1542
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.1859
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C 2.7411
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET, EGFR 3.1859
Prostate cancer_Homo sapiens_hsa05215 AR, ERBB2, EGFR, IGF1R 2.8055
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2 3.1859
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.6035
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.2014
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1859
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, GRIA4 2.2524
Hepatitis B_Homo sapiens_hsa05161 SMAD3, CXCL8, SRC, MMP9 2.1351
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, PTGS2, EGFR 2.0272
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET, EGFR 1.9987
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.2322
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2014
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2435
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.8925
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.8074
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1114
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.2014
Insulin resistance_Homo sapiens_hsa04931 INSR, PRKCD, PPARA 1.6702
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, HSPA1A 1.4297
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, ERBB2, EGFR 2.186
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1, TEK 1.8586
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.547
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, PTGS2 1.8262
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA, EGFR 1.4685
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.4297
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, INSR, PPARA 1.3689
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.1967
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCD, CACNA1C 2.4963
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC, PRKCD 1.1522
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA 2.4802
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2021
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2621
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2771
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2871
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2945
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3042
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9205
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2945
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2945
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5849
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 0.9183
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5541
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8069
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 0.9996
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.8697
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3227
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3302
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD 0.9996
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8778
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8814
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7918
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, CXCL8 0.9586
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0171
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7918
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8814
Influenza A_Homo sapiens_hsa05164 CXCL8, HSPA1A 0.6712
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C 0.7701
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.862
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6919
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3587
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3683
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD, CACNA1C 0.8778
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.0992
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.3888
Axon guidance_Homo sapiens_hsa04360 MET 0.3835
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0459
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0584
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD 0.3973
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4003
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.4349
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4493
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.4493
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4493
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4493
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1431
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4568
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.4616
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4559
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4665
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4686
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.472
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4686
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.472
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.472
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4927
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4686
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.472
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4753
Peroxisome_Homo sapiens_hsa04146 XDH 0.4726
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4675
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4927
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4927
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4932
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4828
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4726
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4814
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4927
Pertussis_Homo sapiens_hsa05133 CXCL8 0.4909
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4844
Bile secretion_Homo sapiens_hsa04976 CA2 0.4927
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.4932
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2784
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5085
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4927
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, MIF, TYR 2.8608
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5109
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5253
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.2784
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.3722
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3689
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.5541
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4215
Legionellosis_Homo sapiens_hsa05134 CXCL8, HSPA1A 1.3812
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3462
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.4527
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5869
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5909
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4928
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.6115
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5967
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6722
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7185
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8066
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8005
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.764
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6702
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7585
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7833
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8069
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8005
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9987
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8324
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.2014
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.196
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0036


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)