TCM Prescription: Qing Nao Fu Shen Oral Liquid



Prescription Description
Prescription IDTCMF5443
Pinyin NameQing Nao Fu Shen Ye
Chinese Name清脑复神液
English NameQing Nao Fu Shen Oral Liquid
Function Description不寐, 头痛, 眩晕, 健忘
IndicationsVertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Headache, Concussion
Disease ICD-11 Category SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MB6Y [Other specified symptoms or signs involving the nervous system, 其他特指的累及神经系统的症状或体征 ];
NA07.0 [Concussion, 脑震荡 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH1142 Schizonepetae spica 荆芥穗 TCMH1142
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2573 Ziziphus jujuba var. spinosa 枣仁 TCMH2573 ITSAM943-14
TCMH1276 Nelumbo nucifera 莲子心 TCMH1276 ITSAI3109-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH2681 Caulis bambusae in taeniam 竹茹 TCMH2681
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH1275 Nelumbo nucifera 莲子 TCMH1275 ITSAI3109-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH670 Ligusticum sinense 藁本 TCMH670 ITSAP3226-14
TCMH1432 Vitex trifolia 蔓荆子 TCMH1432 ITSAO4721-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, EPHX2, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KCNH2, KDR, KIT, MAOB, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 22.2339
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CDK6, CES1, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PTAFR, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, TYR 19.0672
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD2, EGFR, EPHX2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 16.4141
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MAOB, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PTAFR, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 16.3788
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, KDR, MAOB, NR3C1, POLB, PTAFR, PTGS2, SLC6A2, SLC6A4, SRC, TOP1, TRPV1 14.9564
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, KIT, MAOB, MMP2, NR3C1, PIK3CA, POLB, PPARA, PTAFR, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 14.936
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 14.936
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5702
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5702
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 14.254
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EPHX2, FABP3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, PDE5A, PIK3CA, PIM1, PPARA, PTAFR, PTGS1, PTGS2, TBXAS1, TYR, XDH 14.1136
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 13.7964
[BP] GO:0007187 None ADORA1, ADRA2A, CHRM2, CNR1, CNR2, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 13.5816
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.3526
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.296
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM2, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 12.9937
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESRRB, F10, F2, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP1, TRPV1, TYR 12.9692
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CES1, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, EPHX2, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TRPV1, TYR 12.7104
[BP] GO:0003018 None ADORA1, ADRA2A, DRD1, EGFR, EPHX2, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SLC6A4, SRC, TEK 12.3872
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTAFR, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 12.0942
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, MAOB, NR3C1, PTAFR, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 11.9013
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD2, EGFR, EPHX2, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 11.8714
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 11.7341
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.6702
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MAOB, MMP2, NR3C1, PPARA, PTAFR, PTGS2, SLC6A4, SMAD3, SRC, TEK, TRPV1 11.6702
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F2, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 11.5457
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 11.5377
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PTGS2 11.5166
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.4698
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4698
[BP] GO:0097746 None ADORA1, ADRA2A, DRD1, EGFR, EPHX2, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SLC6A4 11.4556
[BP] GO:0035296 None ADORA1, ADRA2A, DRD1, EGFR, EPHX2, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SLC6A4 11.4556
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 11.4556
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 11.4412
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, MAOB, NR3C1, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TEK, TRPV1 11.3652
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, EPHX2, ESR1, F2, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, PIK3CA, PIK3CB, POLA1, POLB, SMAD3, SRC, TERT, TRPV1 11.3156
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 11.3039
[BP] GO:0007188 None ADORA1, ADRA2A, CHRM2, CNR1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 11.2679
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.2679
[BP] GO:0050880 None ADORA1, ADRA2A, DRD1, EGFR, EPHX2, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SLC6A4 11.1128
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 11.0927
[BP] GO:0035150 None ADORA1, ADRA2A, DRD1, EGFR, EPHX2, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SLC6A4 11.0783
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD1, DRD2, EGFR, F2, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2, TRPV1 11.0638
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, KIT, PTGS2, SLC6A4 11.0445
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, KIT, PTGS2, SLC6A4 11.0445
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8779
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CES1, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EPHX2, HMGCR, HTR1B, HTR1D, KDR, MAOB, POLB, SLC6A4, SRC 10.6749
[BP] GO:0003013 None ADORA1, ADRA2A, DRD1, EGFR, EPHX2, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SLC6A4, SRC, TEK 10.6513
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, MAOB, NR3C1, PTAFR, PTGS2, RORC, SLC6A4, SRC, TYR 10.517
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 10.517
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 10.1681
[BP] GO:0099536 None CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1, SLC6A2 10.1007
[BP] GO:0099537 None CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1, SLC6A2 10.1007
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.0893
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, EPHX2, ESR1, F2, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, TRPV1 10.0134
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.98308
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, EGFR, ESR1, F2, F3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, TEK, TERT 9.97397
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 9.90117
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, NQO2, PHF8, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.84693
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.76656
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.76656
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 9.66671
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, HTR1B, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 9.59062
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, EPHX2, NQO2, PTGS1, RORC 9.53198
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, EGFR, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.37418
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.35058
[BP] GO:0007268 None CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1, SLC6A2 9.31989
[BP] GO:0098916 None CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1, SLC6A2 9.31989
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, EGFR, F2, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MAOB, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1 9.21325
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 9.10641
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 9.04442
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.89315
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CNR1, CYP1A1, EPHX2, F2, FABP3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, RORC, SRC, TEK 8.74047
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, F2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, PTAFR, SRC 8.7001
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, GRM1, HMGCR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, POLB, PPARA, PTAFR, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 8.69926
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.69578
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, PTAFR, PTGS2, RORC, SLC6A4, SMAD3, SRC, TRPV1 8.69346
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH 8.56857
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.52959
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, EPHX2, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KCNH2, KIT, PDE5A, PIK3CA, PTAFR, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 8.52777
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.52242
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.49552
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, FABP3, GBA2, GLO1, PPARA, PTGS1, PTGS2, TBXAS1 8.46537
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 8.44069
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.42318
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.395
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.26411
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.23104
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, ESRRB, F2, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.18062
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 8.00618
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, DRD2, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, PDE5A, PIK3CB, PTPN1, SRC, TEK, XDH 7.98137
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.97581
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.93212
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.93212
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EPHX2 7.92169
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, KIT, MAOB, MMP9, PTGS2, SRC, TERT 7.92169
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, HMGCR, HTR1A, MAOB, PTAFR, TYR 7.86138
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.78403
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.78267
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.62509
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.55452
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.52344
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.50624
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.47323
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CNR1, DRD1, DRD2, F2, GPR35, GRM5, HTR1A, HTR1B, HTR2A, KCNH2, MAOB, MMP9, PTAFR, PTGS2, SLC6A4 7.43425
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM2, CNR1, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, SLC1A1, SLC6A2, TEK, TRPV1 7.35253
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, CNR1, DRD2, GPR35, HTR1B, HTR2A, KCNH2, MAOB, MMP9, PTGS2 7.34593
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, GRIK5, HTR1A, INSR, MAOB, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3, TRPV1 7.3319
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, HTR1B, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, POLA1, POLB, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A, TRPV1 7.28424
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.27292
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2, TRPV1 7.25386
[BP] GO:0007267 None ADORA1, CHRM2, CNR1, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1, SLC6A2, TEK 7.21918
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK 7.11944
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 7.11944
[BP] GO:0023052 None ADORA1, CHRM2, CNR1, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNH2, SLC1A1, SLC6A2, TEK 7.1076
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2, SLC6A4 7.08461
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 7.06918
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.05048
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 7.04897
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM2, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KCNH2, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIK3CA, PIM1, PTAFR, PTGS2, PTPRS, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 6.92548
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, SLC6A4 6.90164
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, PDE5A, PIK3CB, PTPN1, SRC, TEK, XDH 6.89242
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC, TEK 6.87873
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, DRD2, EGFR, GRM1, GRM5, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KIT, PPARA, PTGS2, SLC6A4, TRPV1 6.83058
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.80982
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, HTR1B, KCNH2, KDR, NR3C1, PTAFR, PTGS2, SRC, TRPV1 6.78436
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CES1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MAOB, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 6.75243
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, EPHX2, ESR1, F2, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 6.73284
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.71148
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2, HTR1B 6.59839
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.59354
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CB, PTPN1, SRC 6.59354
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.55413
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, F2, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 6.51973
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.51917
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 6.51515
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, HTR1B, MMP2, MMP9, PTAFR, PTGS2, TERT 6.45749
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.45376
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, NR3C1, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.41458
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, CHRM2, DRD2, EGFR, GPR35, GRM1, HCAR2, HTR2A, HTR2C, KCNH2, KIT, PDE5A, PTAFR, PTGS2, SLC1A1, SMAD3, TRPV1 6.35908
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 6.35724
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.34052
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 6.34052
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESRRB, F2, F3, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIM1, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 6.32462
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.32462
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.26122
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, ALOX12, APP, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 6.24984
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, EGFR, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 6.20371
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 6.20371
[BP] GO:0090066 None ADORA1, ADRA2A, ALOX15, DRD1, EGFR, EPHX2, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SLC6A4 6.13502
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, EGFR, F2, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 6.12981
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH 6.11929
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 6.0654
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.01168
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 5.98706
[BP] GO:0007200 None ADRA2A, CHRM2, DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B, HTR2C 5.98095
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 5.95661
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, ALPI, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.95661
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, DRD1, EGFR, ESR1, FLT3, GRM5, HTR1B, IGF1R, INSR, KIT, MMP2, NR3C1, PTAFR, PTGS2, SLC6A4, SMAD3, SRC, TRPV1 5.91045
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, MAOB, NR3C1, PTAFR, PTGS2, SRC 5.90872
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 5.89287
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, EGFR, F2, HCAR2, HTR2B, INSR, KCNH2, MMP12, PTAFR, PTGS2, SLC6A4, SMAD3, SRC, TERT, TRPV1 5.89287
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, EGFR, ESR1, HTR7, KIT, PPARA, RORC, SLC6A4, SRC, TOP1, TOP2A 5.89287
[BP] GO:0050795 None ADORA1, CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.82272
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EGFR, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 5.81017
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 5.7853
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.76942
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.76942
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 5.71452
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.63632
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 5.57753
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KIT, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.57593
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1, SMAD3, TRPV1 5.56389
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.55913
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 5.55417
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3, TRPV1 5.55211
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 5.55211
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH 5.54964
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 5.54621
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, EPHX2, HSPA1A, MAOB 5.54621
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS, TOP1 5.51509
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6, CYP3A4 5.49783
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.49369
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK 5.45187
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.44924
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.44675
[BP] GO:0006939 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, TRPV1 5.43386
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CNR1, CYP19A1, DRD2, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAOB, MMP12, PTAFR, SLC6A4, SRC, TRPV1 5.43386
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CB, PTPN1, SRC 5.40886
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, MAOB, NR3C1, PTAFR, PTGS2, SRC 5.38734
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PHF8, PIK3CA, POLB, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.37915
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD1, DRD2, EGFR, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 5.36344
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.35845
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, KIT, MAOB, MMP9, PTGS2, TERT 5.32303
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, EPHX2, F2, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 5.31703
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CNR1, CYP19A1, DRD2, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAOB, MMP12, PTAFR, SLC6A4, SRC 5.28288
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, CNR2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TERT, XDH 5.27452
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, DRD2, EGFR, GRM5, HMGCR, HTR2A, INSR, KIT, PTGS2, SLC6A4 5.27294
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, CNR2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TERT, XDH 5.24972
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC, TEK 5.23924
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.19735
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 5.17835
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.17835
[BP] GO:0014062 None HTR1A, HTR1B, MAOB, SLC6A4 5.17835
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.17835
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 5.13288
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, ESRRB, GRM3, GRM8, HTR1B, HTR1E, HTR2A, INSR, PDE5A, PPARA 5.10652
[BP] GO:0008217 None ADORA1, CNR1, DRD2, EPHX2, HSD11B2, PPARA, PTAFR, PTGS1, PTGS2, SMAD3 5.10166
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, EGFR, GRM5, HMGCR, HTR2A, INSR, KIT, PTGS2, SLC6A4 5.08964
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT, PTAFR 5.08863
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 5.02361
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, HTR1B, IGF1R, INSR, MMP2, PTAFR, PTGS2, SLC6A4, SRC, TRPV1 5.02237
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, DRD1, DRD2, EGFR, ESR1, F2, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 4.99976
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 4.98978
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, ESRRB, GRM3, GRM8, HTR1B, HTR1E, HTR2A, INSR, PDE5A, PPARA 4.98031
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 4.97037
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 4.95983
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 4.95119
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, HTR2A, MET, PIK3CA, TRPV1 4.94322
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT, PTAFR 4.86707
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.8585
[BP] GO:0051588 None DRD1, DRD2, GRIK5, HTR1A, HTR1B, HTR2C, MAOB, SLC6A4 4.75986
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.75986
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR, HMGCR 4.7375
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EPHX2, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.7289
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH 4.72552
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.71252
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 4.69664
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 4.69525
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.67455
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.67455
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, HTR1B, MMP2, MMP9, PTAFR, PTGS2, TERT 4.66469
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD1, DRD2, EPHX2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 4.66445
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4, TRPV1 4.64544
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, HTR1B, IGF1R, INSR, MMP2, PTAFR, PTGS2, SLC6A4, SRC, TRPV1 4.61705
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.56624
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.54493
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS, TOP1 4.53924
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, EPHX2, F2, KIT, PIK3CA, PIK3CB, POLB, PTAFR, PTGS1, PTGS2, TRPV1 4.53344
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.46988
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CB, PTPN1, SRC 4.46512
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.44797
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, F2, PPARA, SMAD3 4.41923
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, MAOB, NR3C1, PTAFR, PTGS2 4.37954
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2, MAOB 4.37877
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD1, DRD2, F2, HMGCR, PPARA, PTPRS, SMAD3, TEK 4.3541
[BP] GO:1900543 None ADRA2A, DRD2, GRM3, GRM8, HTR1B, HTR1E, PPARA 4.34408
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, INSR, KDR, KIT, MAOB, MMP9, PHF8, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 4.31552
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PHF8, PPARA, PTAFR, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 4.31552
[BP] GO:0045980 None ADRA2A, DRD2, GRM3, GRM8, HTR1B, HTR1E, PPARA 4.30641
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.30004
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 4.28742
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.2731
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, CHRM2, DRD2, EGFR, HTR2A, KCNH2, PDE5A, PTAFR, PTGS2, SLC1A1 4.2731
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR 4.24026
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 4.2309
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.2309
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.21479
[BP] GO:0030815 None ADRA2A, DRD2, GRM3, GRM8, HTR1B, HTR1E 4.1717
[BP] GO:0051952 None ADORA1, ADRA2A, CNR1, DRD1, DRD2, HTR1B, HTR2A 4.16688
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 4.15335
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.14387
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CB, PTPN1, SRC 4.12831
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT, PTAFR 4.12671
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, MAOB, TYR 4.09891
[BP] GO:0030800 None ADRA2A, DRD2, GRM3, GRM8, HTR1B, HTR1E 4.07758
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.06495
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.05888
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH 4.0234
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.93665
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, APP, BCL2, CNR1, DRD2, GPR35, HMGCR, HSPA1A, HTR1B, HTR2A, KCNH2, MAOB, MMP9, PTGS2 3.88531
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, F2, HCAR2, HSPA1A, KIT, MMP12, MMP2, PDE5A, PIK3CA, PIK3CB, PTAFR, PTPN1, PTPRS, SMAD3, SRC 3.884
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 3.8822
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 3.87219
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 3.87096
[BP] GO:0051967 None ADORA1, DRD2, HTR1B, HTR2A 3.87096
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.86339
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 3.85448
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.85448
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PIK3CA, PPARA, SMAD3 3.82683
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HMGCR, HTR1A, HTR2A, HTR2C 3.82683
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 3.82018
[BP] GO:0003012 None ADORA1, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PDE5A, PIK3CA, TRPV1 3.81334
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, INSR, PTGS2, SMAD3, TRPV1, XDH 3.75021
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, KIT, SRC, TEK 3.72511
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PTGS2, SMAD3, TRPV1, XDH 3.71629
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, F2, MMP12, PPARA, SMAD3, TEK 3.71179
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, POLA1, SRC, TEK, TYR 3.70905
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 3.70875
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.70875
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT, PTAFR 3.69048
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, PHF8 3.69048
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTAFR, PTGS2, SLC6A4, TEK, TRPV1, TYR 3.6679
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 3.6679
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, CYP2D6, DRD2, DUSP3, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.64978
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.64716
[BP] GO:0032225 None DRD1, DRD2, PTGS2, SLC6A4 3.64716
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 3.64716
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 3.64351
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.63655
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PTAFR 3.61516
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 3.61383
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT, PTAFR 3.57686
[BP] GO:0016311 None ALPI, ALPL, APEX1, BCL2, CA3, CDC25B, DUSP3, EPHX2, POLB, PTPN1, PTPRS 3.53735
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, HMGCR, INSR, KIT, PTGS2 3.53585
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, GRM5, HTR2A, KIT, PTPN1, SRC 3.52742
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, POLB, PTGS2, TERT 3.52742
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F2, F3, HMGCR, HTR2A, HTR2C, INSR, KDR, KIT, NUAK1, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 3.50608
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PTAFR 3.50238
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 3.50087
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.48692
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH 3.4868
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.4868
[BP] GO:0006940 None ADORA1, ADRA2A, CHRM2, KIT, PTAFR, PTGS2 3.46836
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 3.44718
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, NR3C1, PHF8, PPARA, PTAFR, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 3.44718
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.44289
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.44289
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, GRM3, GRM8, HTR1B, HTR1E, PDE5A 3.41379
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.38952
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.36962
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, PTAFR, SRC 3.36554
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTAFR, PTGS2, SLC6A4, TEK, TRPV1, TYR 3.33361
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, EGFR, HTR1B, NR3C1, PTAFR 3.33361
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, HMGCR, PTGS2, SLC6A4, TRPV1, TYR 3.33245
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR, PTGS2, SLC6A4 3.32084
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTAFR, SRC, TEK 3.32042
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EPHX2, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 3.30139
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.30128
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.30128
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, F2, GPR35, GRM1, HTR2A, HTR2B, HTR2C, TRPV1 3.28698
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA, PTAFR 3.25181
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.25059
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SLC6A4, SRC, TRPV1, TYR 3.25059
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.22963
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.22963
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.22963
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 3.22101
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS, TOP1, TOP2A 3.21721
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, F2, HMGCR, HSD11B2, HTR2A, KIT, MAOB, MMP12, PTAFR, PTGS2, SLC6A4, SMAD3, SRC, TRPV1, TYR 3.19008
[BP] GO:0034762 None ABCB1, ADRA2A, APP, BCL2, CA2, DRD1, DRD2, F2, GPR35, GRM5, KCNH2, MMP9, PTAFR 3.18578
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, DRD2, EGFR, GRM1, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.17559
[BP] GO:0030818 None ADRA2A, DRD2, GRM3, GRM8, HTR1B 3.16598
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B, TERT 3.16598
[BP] GO:0040008 regulation of growth ALOX12, APP, BCL2, CSNK2A1, DRD2, EGFR, ESR2, F2, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SLC6A4, SMAD3, TNKS2 3.16326
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2B, HTR2C, TRPV1 3.13608
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CNR1, DRD2, EGFR, F2, HCAR2, HMGCR, HTR2B, HTR2C, MMP12, PTGS2, PTPN1, SMAD3, SRC 3.12443
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, GRM1, GRM5, GRM8, HMGCR, HTR2A, INSR, KIT, PTGS2, SLC6A4, TRPV1, TYR 3.12443
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 3.12443
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 3.12443
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.12443
[BP] GO:0050995 None ADORA1, ADRA2A, CNR1, HCAR2 3.12443
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 3.12243
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4, MAOB 3.12001
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.12001
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.11986
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, PTAFR, SLC6A4, SRC, TRPV1 3.11436
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA, SMAD3, TEK 3.09818
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.09524
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.09524
[BP] GO:0030803 None ADRA2A, DRD2, GRM3, GRM8, HTR1B 3.08652
[BP] GO:0030814 None ADRA2A, DRD1, DRD2, GRM3, GRM8, HTR1B, HTR1E 3.07755
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.05649
[BP] GO:0051953 None ADORA1, ADRA2A, CNR1, DRD2 3.05649
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PTGS2, SMAD3, TEK 3.05608
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTAFR, SMAD3, SRC, TEK 3.056
[BP] GO:0050433 None ADRA2A, CNR1, DRD2, HTR1B, HTR2A 3.04779
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.04779
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, POLB, PTAFR, PTPN1, SRC, TEK 3.04645
[BP] GO:0006936 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA, TRPV1 3.02619
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.02323
[BP] GO:0008542 None APP, DRD1, DRD2, HMGCR, KIT 3.00812
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, F3, HMGCR, HTR2A, HTR2C, INSR, KDR, KIT, PDE5A, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.99291
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 2.99291
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 2.99291
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.98879
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, KIT, MMP2, MMP9, PTAFR, PTGS2, SLC6A4, SRC, TOP2A 2.97999
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 2.97219
[BP] GO:1900372 None ADRA2A, DRD2, GRM3, GRM8, HTR1B 2.97219
[BP] GO:0030809 None ADRA2A, DRD2, GRM3, GRM8, HTR1B 2.97219
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.96684
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, PTAFR 2.9637
[BP] GO:0048169 None APP, DRD2, GRM5, KIT 2.92693
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.92029
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2, SLC6A4 2.91499
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 2.90873
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.90873
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.89914
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH 2.89395
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, MMP12, PDE5A, PTPRS 2.89048
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT, PTAFR 2.88456
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, HTR2A, KIT, PTPN1, SRC 2.87555
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 2.87555
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 2.86938
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.86516
[BP] GO:0010676 None ESRRB, INSR, PPARA, PTAFR, SRC 2.86516
[BP] GO:0050994 None ADORA1, ADRA2A, CNR1, HCAR2, PPARA 2.86516
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, KIT, SRC, TEK 2.86516
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.86516
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, ALOX12, APP, AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, TUBB3 2.86516
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT 2.84924
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, EGFR, HMGCR, KIT, PTGS2, TYR 2.84657
[BP] GO:0022898 None ABCB1, ADRA2A, APP, BCL2, DRD2, GPR35, GRM5, MMP9, PTAFR 2.84403
[BP] GO:0007632 None APP, DRD1, DRD2, HMGCR, KIT 2.82948
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, F2, PTGS2, SMAD3, SRC, TERT 2.80685
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, NR3C1, PTAFR, SRC 2.80352
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C, SLC6A2 2.7949
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR1B, HTR2A, MET 2.79035
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, DRD1, EPHX2, F2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, POLB, PTAFR, PTGS1, PTGS2, SRC, TRPV1 2.7782
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, RORC, SMAD3, SRC, TRPV1 2.76251
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B, TERT 2.76106
[BP] GO:0051482 None DRD1, GPR35, GRM1, HTR2C 2.7592
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A 2.7592
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A, MAOB 2.74343
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 2.72626
[BP] GO:0043270 None ABCB1, ADORA1, ADRA2A, DRD1, DRD2, F2, KCNH2, PTAFR, SLC6A4 2.71419
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 2.70477
[BP] GO:0007623 circadian rhythm DRD2, EGFR, HTR7, PPARA, RORC, SLC6A4, TOP1 2.70477
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 2.70477
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.70477
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, EGFR, HMGCR, HSPA1A, HTR2B, HTR2C, KIT, MET, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, XDH 2.70477
[BP] GO:0007208 None HTR2A, HTR2C 2.70477
[BP] GO:0009115 None AOX1, XDH 2.70477
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.70477
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.70477
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.70477
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.70477
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.69558
[BP] GO:0032409 None ABCB1, ADRA2A, APP, BCL2, DRD2, GPR35, GRM5, MMP9, PTAFR 2.67544
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 2.67038
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.67038
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 2.66596
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, EPHX2, KIT, MET, PIK3CA, PIK3CB 2.66562
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 2.66437
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 2.66437
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.66437
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 2.66437
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.66423
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.64303
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTAFR, PTGS1, PTGS2 2.61852
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, KIT, TEK 2.61659
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A 2.61385
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.61385
[BP] GO:0019229 None ADRA2A, EGFR, HTR2A, PTAFR, PTGS2 2.6124
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, GRM3, GRM8, HTR1B 2.59555
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 2.59555
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.59129
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.58337
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.56983
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.56777
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.56736
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.56736
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.56736
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.56671
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 2.56671
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.53315
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.53315
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.53315
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.53315
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.51752
[BP] GO:0045907 None EGFR, HTR2A, PTAFR, PTGS2 2.51752
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, CNR1, DRD2, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MMP12, SRC 2.51613
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.5063
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.49412
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 2.49412
[BP] GO:0009266 None ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 2.47193
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGS2, SLC6A4, SRC 2.46932
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.46853
[BP] GO:0033604 None ADRA2A, CNR1, DRD2 2.46853
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, DRD2, GPR35, PTGS2 2.46703
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, KIT, TEK 2.43739
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.43739
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.40852
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, KIT, PTGS2 2.40852
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, PIK3CA, TNKS2 2.40843
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.3865
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.37344
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 2.35425
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.35184
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.35184
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, PDE5A, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.34945
[BP] GO:0030168 platelet activation ADRA2A, AXL, F2, PIK3CA, PIK3CB, SRC 2.34761
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, EGFR, KIT, MET, PIK3CA, PIK3CB 2.3317
[BP] GO:0031644 None ADORA1, GPR35, GRM1, HTR2C, PTAFR 2.32576
[BP] GO:1903524 None EGFR, HTR2A, PTAFR, PTGS2, SLC1A1 2.32576
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR2B, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.32576
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.31529
[BP] GO:0006937 None ADORA1, ADRA2A, CHRM2, KIT, PDE5A, PTAFR, PTGS2 2.29931
[BP] GO:0008306 None APP, DRD1, DRD2, HMGCR, KIT 2.29931
[BP] GO:0051172 None ADRA2A, APEX1, APP, AURKB, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HMGCR, HSPA1A, HTR1B, HTR1E, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.29787
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.29787
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.29787
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.29787
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.29787
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.29787
[BP] GO:0099566 None GRM1, GRM5 2.29787
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.29787
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.29787
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.29787
[BP] GO:0046110 None AOX1, XDH 2.29787
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.29787
[BP] GO:0033602 None CNR1, DRD2 2.29787
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.29787
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.29547
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.2874
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 2.2851
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD2, EGFR, ESR1, ESR2, F2, GRIK5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PHF8, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.27478
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F2, F3, FABP4, KDR, MET, PTGS2, SMAD3 2.27478
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.27173
[BP] GO:0045471 None CA3, CNR1, HMGCR, HTR1B, MAOB, POLB 2.24769
[BP] GO:0061097 None ADORA1, ADRA2A, APP, GRM5, PTPN1 2.23723
[BP] GO:0032412 None ABCB1, ADRA2A, APP, DRD2, GPR35, GRM5, MMP9, PTAFR 2.23584
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, MAOB, MMP12, PTAFR, PTGS2, SMAD3, SRC 2.23186
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 2.2281
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, HTR1B, HTR1E, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 2.2281
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.2281
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.2281
[BP] GO:0070920 None EGFR, ESR1, TERT 2.2281
[BP] GO:1903034 regulation of response to wounding ADRA2A, ALOX12, F2, F3, HMGCR, PTPRS, SMAD3 2.21456
[BP] GO:0050900 leukocyte migration CNR2, F2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.212
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, NR3C1, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.20825
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 2.204
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, EGFR, HMGCR, KIT, POLB, PTGS2, TYR 2.2008
[BP] GO:0030802 None ADRA2A, DRD1, DRD2, GRM3, GRM8, HTR1B 2.19791
[BP] GO:0060401 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 2.19266
[BP] GO:0050866 negative regulation of cell activation ALOX12, AXL, CNR1, CNR2, DUSP3, F2, PDE5A 2.1879
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD1, DRD2, F2, GPR35, HTR2A, KCNH2, PTGS2 2.1777
[BP] GO:0034765 None ABCB1, ADRA2A, APP, DRD1, DRD2, F2, GPR35, GRM5, KCNH2, MMP9, PTAFR 2.17118
[BP] GO:0090257 None ADORA1, ADRA2A, CHRM2, KIT, PDE5A, PTAFR, PTGS2, SMAD3 2.17118
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.17118
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, PTAFR, SLC6A4, SRC 2.17118
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, PTAFR, RORC, SLC6A4, SRC 2.17118
[BP] GO:0010675 None ESRRB, INSR, PPARA, PTAFR, RORC, SRC 2.16511
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.16511
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.16331
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.16189
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.16189
[BP] GO:0070201 None ACHE, ADRA2A, APP, BCL2, CNR1, DRD2, EGFR, F2, HCAR2, HMGCR, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.15574
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DRD2, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 2.14268
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HTR2A, INSR, PPARA, PTAFR, RORC, SRC 2.1384
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.13414
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.13414
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.13414
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.13414
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.12994
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.11473
[BP] GO:1903035 None ALOX12, F2, HMGCR, PTPRS, SMAD3 2.10625
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.10625
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.10141
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, DRD1, DRD2, EGFR, GRM5, HTR2B, HTR5A, KDR 2.09746
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.09584
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.09584
[BP] GO:0045936 None ADRA2A, DRD2, DUSP3, FABP4, GRM3, GRM8, HMGCR, HTR1B, HTR1E, IGF1R, PPARA, PTPN1, XDH 2.06873
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, F2, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC 2.06873
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PHF8, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.06534
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.06528
[BP] GO:0010563 None ADRA2A, DRD2, DUSP3, FABP4, GRM3, GRM8, HMGCR, HTR1B, HTR1E, IGF1R, PPARA, PTPN1, XDH 2.06432
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, APP, AXL, DRD2, HTR1B, HTR2B, SLC1A1, SLC6A2, SLC6A4, TRPV1 2.06432
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.06432
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.06432
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, MAOB, MMP12, PTAFR, PTGS2, SMAD3, SRC 2.06107
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, F2, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, MMP12, POLA1, PTAFR, SLC6A4, SMAD3, SRC, TOP1 2.05413
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.05413
[BP] GO:0070213 None TNKS, TNKS2 2.05413
[BP] GO:0006145 None AOX1, XDH 2.05413
[BP] GO:0097176 epoxide metabolic process ALOX12, EPHX2 2.05413
[BP] GO:0038171 None CNR1, CNR2 2.05413
[BP] GO:1901529 None ABCB1, PTAFR 2.05413
[BP] GO:0014063 None HTR1B, MAOB 2.05413
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.05413
[BP] GO:0014827 None HTR1D, HTR2B 2.05413
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PTAFR, PTGS2 2.05248
[BP] GO:1904063 None ADRA2A, DRD2, GPR35, KCNH2, MMP9 2.05248
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DRD2, DUSP3, ESR1, F2, HSPA1A, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PTAFR, PTPN1, PTPRS, SMAD3, SRC 2.05248
[BP] GO:1900371 None ADRA2A, DRD1, DRD2, GRM3, GRM8, HTR1B 2.0487
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.04628
[BP] GO:0042069 None DRD1, HTR1A, MAOB 2.04628
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.04628
[BP] GO:0042053 None DRD1, HTR1A, MAOB 2.04628
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.04628
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PTGS2, SRC 2.04223
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, BCL2, CNR1, CSNK2A1, DRD2, EGFR, F2, HCAR2, HMGCR, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.03816
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.03754
[BP] GO:0030808 None ADRA2A, DRD1, DRD2, GRM3, GRM8, HTR1B 2.03728
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.03633
[BP] GO:1903531 None ADORA1, ADRA2A, CNR1, DRD2, HMGCR, HTR1B, MAOB 2.02538
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.00407
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CA4, CHRM2, CNR1, CNR2, DRD1, DRD2, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TEK, TRPV1 12.2656
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DRD1, DRD2, DUSP3, EGFR, F10, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, PTAFR, PTGS2, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TEK, TRPV1 11.3665
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TEK, TRPV1 10.934
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALPI, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F10, F2, F3, FLT3, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 10.6888
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP2, PHF8, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR 9.46579
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPI, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TBXAS1, TEK, TRPV1, TYR 8.51084
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA2A, CA2, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, PTGS2, SLC1A1, SRC, TEK, TRPV1 6.36383
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC, TUBB3 5.51307
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, EGFR, F10, F2, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 5.23204
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC, TEK, TUBB3 5.12018
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC, TEK, TUBB3 4.66445
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH 4.36103
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CES1, CES2, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR4, HTR5A, INSR, KCNH2, KDR, KIT, MAOB, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 4.17423
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, PTGS1, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC, TOP1, TRPV1, TUBB3 4.09649
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, EGFR, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 3.97399
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TBXAS1, TEK, TRPV1, TYR 3.87219
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 3.57686
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.42543
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.4
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM2, CNR1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SLC6A4, SRC, TRPV1 3.4
[CC] GO:0016021 None ABCB1, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, APP, AXL, CA12, CA14, CA9, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TBXAS1, TEK, TRPV1, TYR 3.22101
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, GRIK5, HMGCR, HSPA1A, HTR5A, KDR, PTGS2, PTPN1, XDH 2.86085
[CC] GO:0097060 None CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.82344
[CC] GO:0098589 membrane region APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.76997
[CC] GO:0009330 None TOP1, TOP2A 2.70477
[CC] GO:0043235 receptor complex ADRA2A, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.46932
[CC] GO:0043204 None CNR2, DRD2, GRIK5, HTR5A, PTPRS, TOP1 2.2676
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.21456
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.1801
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH 22.2339
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, ALPI, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 19.9207
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, PTAFR, RORC, TEK, TRPV1 18.265
[MF] GO:0030594 None CHRM2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.2912
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 17.2742
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CDK6, CHRM2, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, PTAFR, RORC, TEK, TRPV1 16.4427
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 16.3788
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, PTAFR, RORC, TEK, TRPV1 16.3788
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, PTAFR, RORC, SMAD3, TEK, TRPV1 15.4172
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.6998
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.6998
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, EPHX2, F10, F2, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 14.6657
[MF] GO:0008227 None ADRA2A, CHRM2, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.6657
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5702
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5702
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.8116
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK, TRPV1 13.0421
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK, TRPV1 13.0421
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, NQO2, PHF8, PTGS1, PTGS2, TBXAS1, TYR, XDH 11.8714
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, SLC6A4 11.793
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.6702
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PHF8, TBXAS1, XDH 11.1128
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4754
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TEK, TOP1, TOP2A, TRPV1 10.1681
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.0914
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PHF8, PPARA, PTPN1, RORC, SMAD3, TNKS 9.36868
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.27362
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PHF8, PTGS1, PTGS2, TBXAS1, TYR 9.05237
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 8.93163
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 8.87933
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 8.54779
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HMGCR, HSD11B2, HSD17B1, MAOB, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 8.40862
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 8.13561
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, TBXAS1, TYR 7.99079
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 7.6195
[MF] GO:0004930 None ADORA1, ADORA3, ADRA2A, CHRM2, CNR1, CNR2, DRD1, DRD2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTAFR 7.33703
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.19847
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.11944
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4 6.97334
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4 6.42156
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 6.32637
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 6.01942
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.4344
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, NQO2, NR3C1, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TUBB3, XDH 5.17835
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 4.8585
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, PTAFR, RORC, TRPV1 4.7123
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 4.67455
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 4.37877
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, DRD2, EGFR, EPHX2, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, KIT, MAOB, MET, MMP9, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 4.30615
[MF] GO:0019899 enzyme binding ADRA2A, ALPI, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KCNH2, KIT, MET, NR3C1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A 4.30615
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 4.30486
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.30004
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, NQO2, NR3C1, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TUBB3, XDH 4.23109
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.12671
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.12671
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH 4.00266
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.91966
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TEK, TERT, TOP1 3.88531
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 3.86795
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.84068
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTAFR, PTPRS, SLC1A1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH 3.78867
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, DRD2, EPHX2, FLT3, HMGCR, KCNH2, KIT, MAOB, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.77586
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.34304
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SLC1A1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH 3.26956
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.25059
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 3.24806
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 3.06067
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH 3.04645
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH 3.04435
[MF] GO:0016788 None ACHE, ADORA1, ALPI, ALPL, APEX1, CA1, CA2, CA3, CDC25B, CES1, CES2, DUSP3, EPHX2, PDE5A, POLA1, PTPN1, PTPRS 3.00611
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 2.90873
[MF] GO:0016803 ether hydrolase activity ALOX12, ALOX15, EPHX2 2.90873
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.86938
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.81438
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.81438
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PHF8, PTGS1, PTGS2 2.76543
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.70477
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.70477
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.70477
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.70477
[MF] GO:0003845 None HSD11B1, HSD11B2 2.70477
[MF] GO:0008389 None CYP2A13, CYP2A6 2.70477
[MF] GO:0071886 None HTR2A, HTR2C 2.70477
[MF] GO:0042578 None ADORA1, ALPI, ALPL, APEX1, CA3, CDC25B, DUSP3, EPHX2, PDE5A, PTPN1, PTPRS 2.66596
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, DRD2, EGFR, EPHX2, FLT3, HMGCR, KCNH2, KIT, MAOB, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.61852
[MF] GO:0016801 None ALOX12, ALOX15, EPHX2 2.56736
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 2.46703
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.43739
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.35184
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.29787
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.29787
[MF] GO:0004949 None CNR1, CNR2 2.29787
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.29787
[MF] GO:0005330 None SLC6A2, SLC6A4 2.29787
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.29787
[MF] GO:0099583 None GRM1, GRM5 2.29787
[MF] GO:0047374 None CES1, CES2 2.29787
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.27062
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.23723
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, POLA1, PTAFR, PTPN1, SMAD3, SRC, TOP2A 2.16189
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.16189
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.16189
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, POLA1, PTAFR, PTPN1, SMAD3, SRC, TOP2A 2.14978
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.09893
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PTAFR, PTPRS, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 2.05616
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.05413
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.05413
[MF] GO:0004971 None GRIA2, GRIA4 2.05413
[MF] GO:0032795 None ADORA1, ADRA2A 2.05413
[MF] GO:0051425 None APP, INSR 2.05413
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.05413
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.04628
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.04628


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, GRIK5, PTAFR, HTR2B, HTR2C, HTR2A, NR3C1, HTR4, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4, HTR1E, GPR35, HTR1D, HTR1A, HTR1B, TRPV1, F2, HTR5A, ADRA2A 26.1341
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, ALOX12, HTR2A, PTGS2, HTR5A, HTR4, CYP2C19, PTGS1, SLC6A4, HTR6, HTR7, CYP2D6, ALOX5 22.0843
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.1881
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4, HCAR2, HTR6, PIK3CA, ADORA1, DRD1, DRD2, PPARA, GRIA4 10.7185
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.7857
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PTAFR, HTR2B, HTR2C, HTR2A, HTR5A, HTR4, GRM1, EGFR, HTR6, GRM5, HTR7, DRD1 8.1912
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, HMGCR, PTGS2, CYP3A4, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, CBR1, EPHX2, TYR, POLA1, CYP2A6, AKR1B10, TBXAS1, CYP1A2, CYP1A1, ALPL, ALPI, CES1 7.9318
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, ALOX15, TBXAS1, ALOX12, PTGS2, CYP2C19, PTGS1 8.1622
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.2779
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 8.2779
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, HTR2B, HTR2C, HTR2A, DRD1, DRD2, GRM1, EGFR 8.1233
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.6916
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.6692
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, INSR, KIT, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 6.5622
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.3474
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, KIT, BCL2, MET 5.3041
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, ALOX12, PIK3CB, TRPV1, HTR2A 5.4419
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 5.9519
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, KIT, GRM8, PIK3CB, GRM1, EGFR 5.2638
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 4.9876
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.0291
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP2D6, CYP1A2, AOX1, CYP3A4, CYP2C19 5.3669
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, PIK3CA, INSR, KIT, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.5814
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.5887
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.4108
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.4108
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 4.3927
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 4.3979
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.3086
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 3.7493
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.5379
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 3.4994
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, PTGS2, GRM1, GRIA4 3.5305
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PDE5A, PIK3CB, ADRA2A 3.2623
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 3.6821
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 3.5533
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 2.8645
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 3.4839
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.3177
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.4961
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.2906
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, DRD1, DRD2 3.971
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 4.3576
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, GRM1 3.0268
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 2.9031
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.4617
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 2.5053
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 2.533
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 2.9634
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.0944
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.4839
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.409
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 2.3662
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 2.3838
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 2.3487
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB, F2, EGFR 2.0568
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.1992
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, DRD1, DRD2, GRIA4 2.2865
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.1244
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 1.9739
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 1.9739
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, DRD1, GRIA4 2.447
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.5502
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.3516
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.5889
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.0094
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.136
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1427
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.1182
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 2.71
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 1.8083
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 1.9739
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.1622
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 1.5733
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.1807
Phagosome_Homo sapiens_hsa04145 TUBB3 0.1807
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2117
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.409
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 1.7187
Axon guidance_Homo sapiens_hsa04360 MET 0.2238
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 1.7187
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.2303
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.4135
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 2.3824
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.5733
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.2721
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.518
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, TERT, PIK3CB 1.2428
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.2157
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.2735
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.2827
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.2157
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.2965
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.2958
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 0.8271
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.4132
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.44
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 0.9397
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE5A, XDH 0.754
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 0.8945
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 0.7557
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.5164
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 0.7447
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.5239
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3131
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.311
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.5164
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.312
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.5334
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3254
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 0.7174
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.5447
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.0849
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.0541
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.2428
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.2157
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.3371
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.6621
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.3513
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.364
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.6712
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.6919
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.362
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.6919
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.7224
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.3217
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.6992
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.3756
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.7142
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.7342
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.7387
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.7476
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.3779
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 0.7731
Shigellosis_Homo sapiens_hsa05131 SRC 0.3958
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.3986
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.4752
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 0.8582
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.6505
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 3.2692
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.6505
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 0.8996
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 0.8748
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.7428
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.44
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.6254
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.4414
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.4414
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 0.9825
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 0.9296
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 3.6821
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.4704
Malaria_Homo sapiens_hsa05144 MET 0.4751
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 1.9048
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 0.9914
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.4848
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.4799
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.4848
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5036
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 1.9801
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.0923
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.528
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.5642
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.528
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.1827
DNA replication_Homo sapiens_hsa03030 POLA1 0.5563
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6082
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6533
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.2513
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.3179
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6282
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.4541
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6621
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.618
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.3275
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.3896
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.4102
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6533
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.6844
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.6417
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7062
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.7731
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.7557
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.0024
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.6183
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1556


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)