TCM Prescription: Fu Ke Yang Kun Pills



Prescription Description
Prescription IDTCMF544
Pinyin NameFu Ke Yang Kun Wan 
Chinese Name妇科养坤丸
English NameFu Ke Yang Kun Pills
Function Description月经失调, 痛经, 闭经
IndicationsAmenorrhea disorder, Dysmenorrhea disorder, Irregular menstruation
Disease ICD-11 Category SB94 [Amenorrhea disorder (TM1), 闭经 (TM1) ];
SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1432 Vitex trifolia 蔓荆子 TCMH1432 ITSAO4721-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 10.995
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 10.995
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6927
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES 10.6597
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.182
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.1683
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TYR 10.1331
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.0207
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PTGES, RELA, RORC, SRC, TYR 9.69837
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR7, KDR, MAOA, MET, PPARA, SRC, TNKS, TNKS2, XDH 9.69837
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GBA2, HSD17B3, HTR2B, PIM1, PPARA, PTGES, TYR, XDH 9.41328
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, RELA, SRC, XDH 9.232
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TYR 9.232
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, PTGES, RELA, RORC, SRC, TYR 9.15454
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, PTGES, RELA, RORC, SRC, TYR 8.94372
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.61242
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 8.59902
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 8.24001
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 8.14157
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 7.78686
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 7.78686
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 7.62999
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 7.51974
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, DRD1, DRD2, DRD3, HCAR2, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 7.51419
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HSD17B3, HTR1A, MAOA, TYR 7.43179
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RELA, RORC, SIGMAR1, SRC, TNKS2, TYR 7.38277
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, PTPRS, RELA, SRC, TYR 7.35265
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 7.35265
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A 7.11705
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.00945
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 7.00776
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, TNKS2, TYR 7.00369
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, XDH 6.95625
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGES, RELA, SRC 6.86239
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, MAP2K1, MMP9, PIM1, PPARA, PTPRS, RELA, RORC, SIGMAR1, SRC, TYR 6.79292
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, RELA 6.75902
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, MMP2, PPARA, RELA, SRC 6.73396
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 6.71435
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.68594
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 6.65316
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.56491
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, KDR, RELA, SRC 6.55183
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 6.55183
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.53656
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 6.51277
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, PPARA, RELA, SRC 6.51277
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51277
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51277
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 6.14352
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 6.12425
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TYR 5.77089
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, SRC 5.74377
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 5.56228
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES 5.53701
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, AR, DRD2, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 5.53701
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGES 5.51539
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.50434
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.45246
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.45246
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SIGMAR1, SRC, TNKS, TNKS2 5.32368
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 5.32004
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 5.32004
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.27719
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.23272
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 5.22575
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.11426
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.11426
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SIGMAR1, SRC, XDH 4.91069
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SRC, XDH 4.89637
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.83655
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.78748
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.77143
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, ESRRB, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.70687
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 4.70618
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, MAOA 4.6055
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.54975
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 4.53069
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, AR, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 4.53059
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 4.51772
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 4.49374
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 4.48626
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.45069
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.44614
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 4.44476
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 4.42516
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SRC, XDH 4.42342
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 4.4189
[BP] GO:0035265 organ growth ADRA1A, AR, BCL2, CYP19A1, ESR1 4.39693
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.36103
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGES 4.32616
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F3, HCAR2, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, RELA, SRC 4.29871
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, HTR2A, HTR2B, KDR, MAP2K1, SRC 4.29871
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, RELA, SRC 4.29871
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 4.27936
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.27565
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.23495
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.23495
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.14624
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.13496
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RELA, RORC, SRC 4.1053
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, HTR2A, HTR2B, KDR, MAP2K1, PTPN1, SRC 4.10401
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.0771
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.07145
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.06558
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.05596
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, MMP2, PPARA, RELA, SRC, TYR 4.05479
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HCAR2, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTPRS, RELA, SRC, TNKS2, XDH 4.03095
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, MET, SRC 3.99501
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA, RORC, SRC 3.98989
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RELA, RORC, SRC 3.98989
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, AR, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, RELA, SRC, XDH 3.98773
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TNKS, XDH 3.97976
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, RORC, SRC 3.92958
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.91918
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 3.90463
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, HCAR2, TNKS, TNKS2 3.88588
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TYR, XDH 3.88588
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.88123
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.87524
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, XDH 3.80551
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.80551
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 3.80138
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 3.80138
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, XDH 3.79562
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, MET 3.79562
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 3.77353
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC 3.7593
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2 3.75659
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SRC, TNKS, TNKS2 3.75131
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 3.73402
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.73296
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.73296
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.73296
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MAP2K1, MET, PIM1, SRC, TYR 3.70651
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.70651
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.70651
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 3.70402
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 3.66451
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.65564
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, RELA, SRC 3.63244
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGES 3.62242
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B 3.60555
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, RELA, SRC, XDH 3.58822
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.5869
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MAP2K1, MMP12, MMP9, PPARA, PTPN1, SRC 3.58554
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.54737
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.5277
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTPRS, RELA 3.52058
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 3.48304
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 3.47491
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, XDH 3.44843
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 3.37693
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SRC, TNKS, TNKS2 3.36722
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.35602
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR1A, HTR2A, MMP9 3.35602
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.34947
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, RELA, SRC, XDH 3.34415
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 3.3339
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 3.30965
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SRC 3.29865
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SIGMAR1, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 3.28643
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.28187
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.28187
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.27749
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.27315
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.25776
[BP] GO:0008217 None ADORA1, ADRA1A, AR, DRD2, DRD3, HSD11B2, PPARA 3.25026
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 3.24144
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.19119
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.14041
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, RELA, SRC 3.13069
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.1287
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.12302
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SRC 3.12236
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 3.10734
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 3.10196
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.0971
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 3.0971
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, RELA, RORC, SRC 3.09501
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TNKS, XDH 3.07552
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.07552
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, RELA, SRC, TYR 3.05521
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.03862
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.02082
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 3.02082
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.00825
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, SRC 3.00825
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.00825
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.00825
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 2.99922
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 2.99922
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 2.97736
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CACNA1C, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 2.95032
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 2.95032
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.94305
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PTPN1, RELA, RORC, SRC 2.92566
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.91818
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 2.91336
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, RORC 2.91066
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.90417
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.89377
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.89377
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.88508
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.88028
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC 2.8596
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.84475
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.83854
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 2.80731
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, SRC 2.79977
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CDK6, CYP1B1, DRD2, FABP3, MAP2K1, PTGES, XDH 2.79519
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.79423
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 2.78634
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, DRD1, DRD2, DRD3, ESR1, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 2.78634
[BP] GO:0009115 None AOX1, XDH 2.78089
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.75895
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 2.75851
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.75705
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, RELA, SRC, TYR 2.7521
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.72547
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.71856
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.70388
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.70388
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.70388
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.70388
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.70164
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 2.70164
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.69736
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC 2.69736
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 2.69533
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.68988
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TNKS 2.67339
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, SRC 2.66141
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.64796
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.63084
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR2B, MMP12, SRC 2.62849
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.62407
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.62407
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.62407
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 2.62387
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.61684
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.60639
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.59399
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.58128
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HTR2B, KDR, MAP2K1, MET, MMP2, MMP9, PTPRS, RORC, SRC 2.58035
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.54128
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.54128
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.52587
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.5122
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.5122
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.5122
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.5055
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TNKS 2.4962
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, RELA, SRC 2.4962
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, HTR2A, MMP9 2.49223
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.49002
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.47684
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.47684
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.47684
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, RELA, TYR 2.47443
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.46862
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SRC, TNKS, TNKS2 2.44326
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.43315
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, ESR1, ESRRA, HCAR2, MAP3K7, MMP12, MMP2, PTPN1, PTPRS, RELA, SRC 2.42855
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 2.41864
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.41864
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.40535
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.40535
[BP] GO:0046110 None AOX1, XDH 2.39946
[BP] GO:0060160 None DRD2, DRD3 2.39946
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39946
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.39843
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, MAP3K7, MMP12, MMP2, PPARA, PTPN1, PTPRS, RELA, SRC 2.39543
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC 2.38553
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, HTR2B, MMP12, SRC 2.38015
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.37015
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.35991
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 2.35572
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.34418
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.34418
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, SRC, TNKS, XDH 2.34187
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA 2.33824
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.33183
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.32089
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.29996
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.27953
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.27953
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.26591
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, DRD2, DRD3, PIM1, PTPRS, TNKS2 2.24716
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, AR, BCL2, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, XDH 2.2463
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CYP1A1, HTR2A, MAP2K1, RELA 2.2419
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.22905
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.21994
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.21415
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.21415
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.15797
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 2.15565
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.15565
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.15565
[BP] GO:0070213 None TNKS, TNKS2 2.14308
[BP] GO:0006145 None AOX1, XDH 2.14308
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14308
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, SRC 2.14068
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.13618
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC 2.11316
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.11316
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.11316
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.11296
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.07851
[BP] GO:0045088 regulation of innate immune response DRD2, ESR1, MAP3K7, MMP12, MMP2, PTPN1, PTPRS, RELA, SRC 2.07851
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.0593
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0593
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.05906
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.05906
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.05906
[BP] GO:0040007 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, SRC, TNKS2 2.04513
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.03282
[BP] GO:0007154 None ADORA1, ADRA1A, AR, AXL, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.02718
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, RELA, SRC 2.02217
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B 2.01829
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA 2.01829
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, HTR2B, MMP12, SRC 2.01829
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.01588
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.01588
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.01357
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.0072
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.0072
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.00589
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, PTPRS, SIGMAR1, SRC, TNKS, TNKS2, TYR 5.25363
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS, SIGMAR1 4.57955
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, GBA2, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, PTPRS, SRC 4.23371
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1, SIGMAR1 3.78383
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, PTGES, PTPN1, PTPRS, SIGMAR1, SRC, TYR 3.71383
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, SIGMAR1 3.35602
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS, SIGMAR1 3.30209
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.28187
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR5A, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, PTPN1, PTPRS, RELA, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 3.27315
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS, SIGMAR1, SRC 3.18635
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HSD17B3, HTR5A, KDR, MAP2K1, PTPN1, SIGMAR1, XDH 2.71747
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, HTR2A, HTR5A, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SIGMAR1, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.68417
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, HTR2A, HTR5A, HTR6, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SIGMAR1, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.58035
[CC] GO:0031233 None CA4, F10, F3 2.21994
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 17.3456
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.0857
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 15.1162
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGES, PTPN1, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 10.0335
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.97485
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 9.95034
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.78331
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.0435
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 8.0435
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.79734
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.51974
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 7.48592
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 7.01445
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.00776
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC, SHBG 7.00369
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, PPARA, RORC, SIGMAR1 6.88936
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CDK6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 6.86239
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.59326
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.55692
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 6.55183
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.55183
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.55183
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51277
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51277
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.26741
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.13703
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.13703
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SIGMAR1, SRC 5.6502
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.58191
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.49534
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.49515
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.44959
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.32966
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 4.9158
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, SHBG 4.83655
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.80929
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.58679
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.58125
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.58125
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.45069
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.39693
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B2, HSD17B1, PTGES, SRC, XDH 4.29792
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.15068
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.07145
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 3.95465
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 3.95465
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.05126
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.78673
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.78634
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78089
[MF] GO:0003845 None HSD11B1, HSD11B2 2.78089
[MF] GO:0008389 None CYP2A13, CYP2A6 2.78089
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.70388
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.6333
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SRC 2.52587
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 2.52403
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.5122
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.51056
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SRC, TUBB3, XDH 2.49002
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.48197
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SRC 2.36707
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.21994
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.14308
[MF] GO:0005497 None AR, SHBG 2.14308
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SHBG, SIGMAR1, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.12664
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.09657


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.2029
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX15, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A, HTR6, HTR7, CYP2D6, ALOX5 12.6291
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 9.6098
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.0702
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 7.2662
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, HTR2A, DRD1, HTR5A, DRD2, ADRA1A, DRD3 6.9578
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, MAP2K1, ADORA1, HTR1A, CACNA1C, DRD1, DRD2, PPARA, RELA 6.2928
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.7781
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, TUBB3, HTR2B, HTR2A, DRD1, DRD2 5.6275
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.7781
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, RELA, IGF1R 4.7662
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, CACNA1C, HTR2A, DRD1, HTR5A, ADRA1A 4.768
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.8732
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.4329
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.8732
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.2714
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.1717
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.8713
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 3.8233
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, MMP9, RELA 3.4161
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1 3.8928
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.4161
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.1901
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 2.8955
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.0702
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 2.8005
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, DRD2, MET, IGF1R 2.7122
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD1, DRD2, DRD3 2.8005
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, KDR, MET, RELA, IGF1R 2.569
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2, RELA 3.2942
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGES 2.9442
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, CDK6, KDR, BCL2, MET, RELA, IGF1R 2.4147
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 2.8005
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.8955
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C, ADRA1A 2.3846
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.4431
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8099
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.1972
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.2607
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.2866
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.4192
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.2016
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.1095
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 1.9237
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.7268
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.5844
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 1.9255
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 1.9948
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 1.9237
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.4584
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 1.8353
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.5496
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, DRD1 1.9237
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.5496
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 1.9237
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.6609
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.4779
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.4935
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.4584
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 1.914
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.3662
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.3729
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.2212
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.3469
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C, ADRA1A 1.3662
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.2817
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.2178
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2017
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, ADRA1A, IGF1R 1.3469
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C, ADRA1A 1.2017
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1605
HTLV-I infection_Homo sapiens_hsa05166 RELA 0.1637
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.1605
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2609
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2702
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.58
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0742
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2954
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0462
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.3136
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 0.9678
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.0391
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7545
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3314
Axon guidance_Homo sapiens_hsa04360 MET 0.3485
Platelet activation_Homo sapiens_hsa04611 SRC 0.3592
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.5151
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.7467
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7282
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7749
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.6085
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3791
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6293
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.7331
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7331
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.7467
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8033
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.6921
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7282
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4077
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4152
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4152
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4152
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4238
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.426
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.9179
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4226
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4152
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4238
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.435
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.435
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.435
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 0.957
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 0.9957
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.435
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9735
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4377
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.435
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4391
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C 1.0275
Peroxisome_Homo sapiens_hsa04146 XDH 0.445
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.991
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4482
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.1014
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.445
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4592
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0584
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2178
Pertussis_Homo sapiens_hsa05133 RELA 0.4706
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4728
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1207
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.1014
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.2178
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0529
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4728
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1605
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.4954
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.1945
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.158
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.158
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1142
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.1734
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4928
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1207
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2145
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.1605
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2017
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1605
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5151
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5151
Legionellosis_Homo sapiens_hsa05134 RELA 0.5638
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5638
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.5795
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3469
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.584
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5885
Malaria_Homo sapiens_hsa05144 MET 0.5933
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.5983
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6003
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5983
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6059
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6003
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6165
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6546
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6269
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5661
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4935
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6478
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.6921
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8732
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7433
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7545
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.73
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8013
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7433
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7625
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7331
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7545
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7878
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9179
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8993
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9809
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2145


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)