TCM Prescription: Shen Xi Dan



Prescription Description
Prescription IDTCMF5415
Pinyin NameShen Xi Dan
Chinese Name神犀丹
English NameShen Xi Dan
Function Description湿温, 暑温
IndicationsDampness and warmth disorder, Summer-heat disorder, Typhoid, Paratyphoid fevers, Sunstroke
Disease ICD-11 Category SE02 [Dampness and warmth disorder (TM1), 湿温 (TM1) ];
SE00 [Summer-heat disorder (TM1), 暑温 (TM1) ];
1A07.Z [Typhoid fever, unspecified, 伤寒，未特指的 ];
1A08 [Paratyphoid Fever, 副伤寒 ];
NF01.0 [Heat stroke, 中暑 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1714 Lonicera japonica 忍冬藤 TCMH1714 ITSAI3881-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH396 Semen sojae praeparata 淡豆豉 TCMH396
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD17B1, HSD17B2, KDR, MET, NR1H4, PPARA, PTAFR, PTGS2, SLC1A1, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, XDH 12.1147
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTAFR, PTGS2, RORC, SRC, TYR 9.41778
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FUT7, HMGCR, IDO1, NR1H4, PIM1, PPARA, PTAFR, PTGS2, SOAT1, SOAT2, TYR, XDH 9.03121
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP2, NR1H4, NR3C1, PPARA, PTAFR, PTGS2, RORC, SRC, TYR 9.03121
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 9.03121
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, NR1H4, PPARA, PTGS2, SOAT1, SOAT2 8.54541
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 8.36859
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTAFR, PTGS2, RORC, SRC, TYR 8.2603
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.17795
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.16581
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.14021
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, NR1H4, SOAT1, SOAT2 7.92215
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, DAO, DHFR, HMGCR, NR1H4, PTAFR, SOAT1, SOAT2, TYR 7.36939
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTGS2, RORC, SOAT1, SOAT2, SRC, THRA, THRB, TNKS2, TYR 7.21624
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 7.21624
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, THRA, TNKS, TNKS2, XDH 6.9024
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.9024
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 6.87263
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, THRA, TNKS, TNKS2, XDH 6.794
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.65715
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.63179
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, NR1H4, NR3C1, PTAFR, PTGS2, RORC, SRC 6.50049
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP2, MMP9, NR1H4, PTAFR, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.50049
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, MMP9, NR1H4, NR3C1, PTAFR, PTGS2, RORC, SRC 6.41792
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 6.38747
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 6.3749
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.33378
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.28267
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR1H4, NR3C1, PGR, PIM1, PPARA, RORC, SRC, THRA, THRB 6.20732
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, NR1H4, NR3C1, PTAFR, PTGS2, RORC, SRC, TYR 6.16678
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC 6.0126
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTAFR, PTGS2, PTPN1, SRC, THRA 5.99538
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, GRIK5, GRM5, GSK3B, IGF1R, MMP2, MMP9, NR1H4, NR3C1, PTAFR, PTGS2, RORC, SRC 5.90241
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, NR1H4, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.90157
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, NR1H4, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.84578
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC 5.84578
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, NR1H4, NR3C1, PPARA, PTAFR, PTGS2, SRC 5.8418
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, NR1H4, PTAFR, PTGS2, PTPN1, SRC, XDH 5.8418
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, NR1H4, PTAFR, PTGS2, PTPN1, SRC, XDH 5.8418
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, PTAFR, PTGS2, SRC, XDH 5.76537
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 5.75782
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, THRA, XDH 5.75445
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, THRA, XDH 5.66216
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GRM3, GSK3B, HMGCR, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.45798
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 5.43801
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, NR1H4, PPARA, PTGS2, RORC, SRC, THRA 5.35852
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.25258
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGS2, SOAT1, SOAT2 5.23845
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC 5.21673
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GRM3, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 5.21205
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.21205
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.21205
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.20716
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, PTGS2, PTPN1, SRC, XDH 5.19503
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.12162
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, THRA, XDH 5.1018
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GRM3, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 5.0752
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.93648
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, IGF1R, KDR, MMP2, MMP9, NR1H4, NR3C1, PTAFR, PTGS2, PTPN1, RORC, SRC 4.92281
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MET, MMP2, MMP9, NR1H4, PTAFR, PTPN1, SRC, TNKS, TNKS2 4.84602
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, GSK3B, HMGCR, MMP12, MMP9, NR1H4, PPARA, PTAFR, PTGS2, PTPN1, SRC, THRA 4.837
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, NR1H4, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, SRC, THRA, TNKS, TNKS2, XDH 4.81322
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.81151
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 4.77325
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 4.74476
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.69074
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CYP19A1, DHFR, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 4.69074
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIM1, PPARA, PTGS2, PTPRS, RORC, SOAT1, SOAT2, SRC, THRA, THRB, TNKS2, TYR 4.68053
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, NR3C1, PTAFR, PTGS2, RORC, SRC, TYR 4.67111
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 4.67067
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.66969
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MET, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2 4.63655
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 4.63638
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 4.59595
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GRM3, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 4.58895
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.48851
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.47082
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, THRA, TYR 4.46805
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PPARA, PTAFR, PTGS2, SRC, TYR 4.45783
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 4.44946
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 4.3985
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.3914
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, DAO, DHFR, HMGCR, PTAFR, TYR 4.3914
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, HMGCR, KDR, NR1H4, PTGS2, SRC, TNKS, TNKS2 4.31302
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, FLT3, GRM5, GSK3B, IGF1R, MMP2, NR1H4, NR3C1, PTAFR, PTGS2, SRC 4.25182
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, GRM5, PTPN1 4.107
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, NR1H4, PTAFR, PTGS2, SRC 4.0943
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PPARA, PTAFR, PTGS2, SRC, TYR 4.07954
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, CSNK2A1, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MMP9, PTAFR, PTGS2, PTPN1, SOAT1, SRC, XDH 4.06293
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 4.06117
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2 4.06117
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HMGCR, HSD17B1, HSD17B2, NR1H4 4.03258
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, GRM1, HMGCR, IGF1R, KDR, PTPN1, SRC, XDH 4.0299
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA, SLC1A1 4.00991
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, NR1H4, SOAT1, SOAT2, SRC 3.95814
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.95367
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 3.95367
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TNKS, XDH 3.91885
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MMP9, PTAFR, PTGS2, PTPN1, SRC, TNKS, XDH 3.90492
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, PTAFR 3.90097
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.89173
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.89028
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GRM3, GRM8, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.87163
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 3.85461
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, FLT3, NR3C1, PTAFR, PTGS2, RORC, SRC 3.82945
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, CA2, CYP1B1, GRM1, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP9, NR1H4, PIM1, PTAFR, PTGS2, PTPRS, SLC1A1, SRC, THRA, THRB, TNKS2, XDH 3.78941
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, DHFR, HMGCR, PTAFR, SOAT1, SOAT2 3.76299
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2 3.75806
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, PTPN1, SRC, TNKS 3.72922
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, PTAFR, PTGS2, SRC 3.72922
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, THRA, TNKS, TNKS2, XDH 3.68396
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, PTAFR, PTGS2, SLC1A1, THRA, THRB 3.66653
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.62355
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 3.54909
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, NR1H4, PPARA, PTGS2 3.53645
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53645
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.53292
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.53292
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.53217
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.51809
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTAFR, PTGS2, SRC 3.51809
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 3.51769
[BP] GO:0007188 None ADORA1, ADRA2A, ADRA2C, GRM1, GRM3, GRM5, GRM8 3.50507
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.49538
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.49538
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.47618
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, NR1H4, SOAT1, SOAT2 3.47618
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 3.46869
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PTAFR, PTGS2, SRC 3.4639
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.46173
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, HSD17B2, IDO1, MMP2, MMP9, PGR, PTAFR, PTGS2, SRC, THRA, THRB 3.45593
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, FABP3, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2 3.45544
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.4454
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, GRM5, PTPN1, SRC 3.4403
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 3.40363
[BP] GO:0051172 None ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GRM3, GRM8, HMGCR, IGF1R, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.39573
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.39573
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, GSK3B, IGF1R 3.39465
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.3885
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MMP9, PTAFR, PTGS2, PTPN1, SRC, XDH 3.36605
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.35846
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AR, AXL, CA2, CYP1B1, HMGCR, IDO1, KDR, MET, MMP12, MMP9, NR1H4, PIM1, PTAFR, PTGS2, SLC1A1, SRC 3.35846
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CYP1A1, CYP1B1, DHFR, FABP3, HMGCR, KDR, NR3C1, PTAFR, PTGS2, SRC 3.32846
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.29209
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, GRM5, PTPN1, SRC 3.28921
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 3.28921
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, PTAFR, PTGS2 3.24455
[BP] GO:1904645 response to amyloid-beta APP, GRM5, GSK3B, IGF1R 3.24039
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTAFR, PTGS2, SRC, THRA, TYR 3.23487
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PTAFR, PTGS2, SRC 3.23119
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 3.2227
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AR, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, XDH 3.2121
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AR, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, XDH 3.19637
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 3.18312
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, DHFR, FLT3, GRM1, GRM5, GSK3B, MET, MMP9, PTAFR, PTPN1, SRC, TNKS, XDH 3.17849
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16008
[BP] GO:0007187 None ADORA1, ADRA2A, ADRA2C, GRM1, GRM3, GRM5, GRM8 3.15663
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, DHFR, HMGCR, IDO1, PTAFR, PTGS2 3.15416
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 3.14472
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.14045
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA, SLC1A1 3.13967
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.13634
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, GSK3B, IGF1R, PPARA, PTGS2, SRC 3.118
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, NR1H4, PPARA, PTGS2, SRC 3.09736
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTAFR, PTGS2 3.08127
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTAFR, PTGS2 3.08127
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, FABP3, IGF1R, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2 3.07874
[BP] GO:0051930 None ADORA1, ADRA2C, GRM1, PTAFR 3.06634
[BP] GO:0051931 None ADORA1, ADRA2C, GRM1, PTAFR 3.06634
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 3.06186
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CBR1, CDC25B, CYP1A1, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, MET, MMP2, MMP9, PGR, PTGS2, PTPRS, RORC, SOAT1, SOAT2, SRC, THRA, THRB 3.05768
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, PTPRS, SRC, THRA, TYR 3.05471
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, AR, CYP19A1, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 3.02345
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, HMGCR, SOAT1, SOAT2 3.02023
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2 3.02023
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTAFR, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2 2.95283
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.95283
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTAFR, PTGS2 2.95283
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, HSD17B2, KDR, MMP9, PGR, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, THRA, TYR 2.95283
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.95231
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.94239
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.94239
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTAFR, PTGS2 2.94237
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTAFR, PTGS2, SRC 2.93626
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.90108
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTAFR, PTGS2, SRC 2.90108
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC 2.90108
[BP] GO:0070542 None FABP3, NR1H4, PTAFR, PTGS2, SRC 2.89227
[BP] GO:0008050 None THRA, THRB 2.87788
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.87177
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86567
[BP] GO:0003008 None ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, CYP1B1, GRM1, GRM5, GRM8, HMGCR, PTAFR, PTGS2, SOAT2, SRC, THRA, THRB, TYR 2.86376
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, GSK3B, MMP12, NR1H4, PTAFR, PTGS2, SRC 2.85998
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.84747
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTAFR, PTGS2 2.83049
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.78122
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, APP, GSK3B, HMGCR, MMP9, NR1H4, PTGS2, THRA 2.77975
[BP] GO:0032845 None ADORA1, ADRA2A, HMGCR, SRC, TNKS, TNKS2 2.77872
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.76243
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, NR3C1, PTAFR, PTGS2, SRC 2.74454
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC 2.72187
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.72001
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.67819
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, NR1H4, PTGS2, TNKS, TNKS2 2.6637
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, GRM1, PTAFR, PTGS2, SLC1A1, THRA, THRB 2.63128
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APP, AR, AURKB, CSNK2A1, CYP1B1, DHFR, FABP3, FABP4, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2 2.63128
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.62949
[BP] GO:0045986 None ADORA1, ADRA2C, PTGS2 2.61553
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.61553
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.61004
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.5948
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, AR, CSNK2A1, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 2.58696
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.58696
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, IDO1 2.58696
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.54707
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.50677
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, APP, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 2.49772
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, FABP4, HMGCR, IDO1, KDR, MET, MMP12, NR1H4, PPARA, PTGS2, PTPRS 2.49393
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, FABP4, IDO1, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, SRC 2.47858
[BP] GO:0099566 None GRM1, GRM5 2.47858
[BP] GO:0034435 None SOAT1, SOAT2 2.47858
[BP] GO:0060748 None AR, PGR 2.47858
[BP] GO:0034433 None SOAT1, SOAT2 2.47858
[BP] GO:0034434 None SOAT1, SOAT2 2.47858
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47858
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, PGR, PTGS2, SRC, THRA, THRB 2.46238
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.45186
[BP] GO:0050994 None ADORA1, ADRA2A, PPARA, THRA 2.45172
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.45106
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, PTGS2 2.45009
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TNKS 2.43103
[BP] GO:0007617 None APP, THRA, THRB 2.43103
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.42932
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.42342
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.42081
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, ADRA2C, CYP19A1, GRIK5, HMGCR, MMP12, NR1H4, PTAFR, SRC 2.39846
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, FLT3, GRM1, GRM5, PTPN1, SRC, TNKS 2.38278
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.37255
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.37255
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.35542
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, PTAFR, SRC 2.35505
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DHFR, PPARA 2.34304
[BP] GO:0071396 cellular response to lipid AR, AXL, FLT3, NR1H4, NR3C1, PTAFR, RORC, SRC 2.34304
[BP] GO:0055088 None FABP3, FABP4, NR1H4, SOAT1, SOAT2 2.34304
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 2.33482
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.32586
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.32586
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32586
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.28042
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.27319
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.26877
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, DHFR, FLT3, GRM1, GRM5, GSK3B, PTAFR, PTPN1, SRC, TNKS, XDH 2.26835
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.25735
[BP] GO:0019229 None ADRA2A, ADRA2C, PTAFR, PTGS2 2.25735
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.25479
[BP] GO:0045934 None ADRA2A, AR, AURKB, FABP4, GRM3, GRM8, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB, TNKS, TNKS2 2.25162
[BP] GO:0035625 None ADRA2A, ADRA2C 2.25162
[BP] GO:0032811 None ADRA2A, ADRA2C 2.25162
[BP] GO:0070213 None TNKS, TNKS2 2.25162
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.25162
[BP] GO:1901529 None ABCB1, PTAFR 2.25162
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25162
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.25162
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.24624
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.23705
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23705
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, NR1H4, PTGS2, SRC 2.2327
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, HMGCR 2.19896
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.19732
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.19569
[BP] GO:0010675 None GSK3B, PPARA, PTAFR, RORC, SRC 2.19569
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, NR1H4, PPARA, PTAFR, SLC1A1, SOAT1, SOAT2, SRC, THRA, TNKS, TNKS2, XDH 2.19091
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19035
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRA2A, APP, CA2, CA7, GRM5, MMP9, PTAFR, PTGS2 2.18256
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, ADRA2C, CYP19A1, GRIK5, HMGCR, MMP12, NR1H4, PTAFR, SRC 2.18256
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.1822
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, GSK3B, PGR, PPARA, RORC, SRC 2.17902
[BP] GO:0007154 None ADORA1, ADRA2C, AR, AXL, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PTGS2, SLC1A1 2.17186
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.16201
[BP] GO:0045932 None ADORA1, ADRA2C, PTGS2 2.15075
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.14867
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.14867
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.14741
[BP] GO:0042632 None FABP3, FABP4, SOAT1, SOAT2 2.14696
[BP] GO:0055092 None FABP3, FABP4, SOAT1, SOAT2 2.14696
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, IDO1, MMP12, NR1H4, PTAFR, PTGS2, PTPRS, SRC 2.14511
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.13833
[BP] GO:0030154 cell differentiation AR, AXL, CBR1, CYP1A1, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, MMP2, MMP9, PTGS2, RORC, SOAT1, SOAT2, THRA, THRB 2.13651
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, CSNK2A1, GRIK5, GSK3B, HMGCR, NR1H4, PTGS2, PTPN1, SRC, THRA 2.12595
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, GSK3B, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.11911
[BP] GO:0043086 negative regulation of catalytic activity ADRA2A, APP, CSNK2A1, FABP4, GRM3, GSK3B, HMGCR, IGF1R, MMP9, PTGS2, PTPN1, SRC 2.1191
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.11294
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CDC25B, CSNK2A1, DHFR, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MMP9, PTAFR, PTGS2, PTPN1, SRC, XDH 2.11059
[BP] GO:0007267 None ADORA1, ADRA2C, AR, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 2.10893
[BP] GO:0002237 response to molecule of bacterial origin AXL, CYP1A1, CYP1A2, IDO1, NR1H4, PTGS2, SRC 2.09519
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.08462
[BP] GO:0035624 None ADRA2A, ADRA2C 2.08318
[BP] GO:0060509 None THRA, THRB 2.08318
[BP] GO:0014060 None ADRA2A, ADRA2C 2.08318
[BP] GO:0042391 None ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.08308
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, XDH 2.08159
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, GSK3B, IGF1R, SRC 2.07937
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.07564
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, FLT3, GRM1, GRM5, PTPN1, SRC 2.07503
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, NR1H4, PPARA, PTAFR, SLC1A1, SOAT1, SOAT2, SRC, TNKS, XDH 2.07284
[BP] GO:0031644 None ADORA1, ADRA2C, GRM1, PTAFR 2.07284
[BP] GO:1903524 None ADRA2C, PTAFR, PTGS2, SLC1A1 2.07284
[BP] GO:1902532 negative regulation of intracellular signal transduction HMGCR, IGF1R, MET, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 2.0617
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, APP, AR, AURKB, CSNK2A1, CYP1B1, DHFR, FABP3, FABP4, GRM3, GRM5, GRM8, GSK3B, IGF1R, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, RORC, SOAT1, SRC, THRA, THRB, TNKS, TNKS2 2.05365
[BP] GO:1900543 None ADRA2A, GRM3, GRM8, PPARA 2.05338
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.03881
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC 2.03423
[BP] GO:0045980 None ADRA2A, GRM3, GRM8, PPARA 2.03423
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.0132
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.0132
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, GSK3B, HMGCR, IGF1R, MET, PTGS2, PTPN1, PTPRS, XDH 2.00885
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.00727
[BP] GO:0019098 None APP, THRA, THRB 2.00025
[CC] GO:0044456 None ACHE, ADORA1, ADRA2C, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, PTPRS, SRC 4.16463
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA2A, CA2, CA4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 3.89905
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SLC1A1, SOAT1, SOAT2, SRC, TNKS, TNKS2, TYR 3.77486
[CC] GO:0043005 None ADORA1, ADRA2C, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 3.60285
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1 3.55335
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AXL, CA2, CA4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTGS2, PTPRS, SLC1A1, SRC 3.39573
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.33274
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1 3.29209
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, PTPRS, SLC1A1, SRC 2.98964
[CC] GO:0098794 None ADORA1, APP, GRIA2, GRIA4, GRM3, GSK3B 2.65971
[CC] GO:0043235 receptor complex ADRA2A, APP, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, NR3C2 2.58696
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SOAT1, SOAT2, SRC, THRA, TNKS, TNKS2, TYR, XDH 2.57542
[CC] GO:0005783 None ADORA1, APP, CA4, CYP19A1, FLT3, GRIK5, HMGCR, KDR, PTGS2, PTPN1, SOAT1, SOAT2, XDH 2.39865
[CC] GO:0097458 None ADORA1, ADRA2C, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IDO1, PTGS2, PTPRS, SRC, TUBB3 2.33482
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.23712
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.20768
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.16446
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.16446
[CC] GO:0120025 None ADORA1, ADRA2C, AKR1B1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 2.16048
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.15803
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, APP, AR, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 2.05103
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, THRA, THRB, TNKS, TYR, XDH 13.8678
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SOAT1, SOAT2, SRC, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 10.9688
[MF] GO:0003707 steroid hormone receptor activity AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 8.54541
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 8.2603
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.98749
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.8198
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, THRA, THRB, TNKS 7.72036
[MF] GO:0005496 steroid binding AR, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC, SOAT1, SOAT2 7.37121
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 7.36939
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 7.12078
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, PTPRS, SOAT1, SOAT2, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 6.99371
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, HMGCR, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 6.83672
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 6.624
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, NR1H4, PGR, PPARA, RORC, THRA, THRB 6.41792
[MF] GO:0004879 nuclear receptor activity AR, NR1H4, PGR, PPARA, RORC, THRA, THRB 6.41792
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, HMGCR, HSD17B1, IDO1, PTGS2, SOAT1, SOAT2, SRC, XDH 5.8418
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, FABP3, FABP4, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, SOAT1, SOAT2 5.00086
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, THRA, THRB 4.99008
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.77325
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, THRA, THRB, TNKS, TNKS2, TYR, XDH 4.63655
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, THRA, THRB, TNKS, TNKS2, TYR, XDH 4.39613
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.08007
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 3.96148
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 3.82879
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 3.78941
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DAO, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, NR1H4, PIM1, PTAFR, PTPRS, SLC1A1, SOAT1, SOAT2, SRC, TUBB3, XDH 3.68571
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59955
[MF] GO:0004887 None NR1H4, THRA, THRB 3.55335
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.45593
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.4454
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.4454
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.39465
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR 3.33274
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR 3.33274
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.33274
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.16008
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DAO, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, NR1H4, PIM1, SLC1A1, SOAT1, SOAT2, SRC, TUBB3, XDH 3.1204
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.91155
[MF] GO:0034736 None SOAT1, SOAT2 2.87788
[MF] GO:0004772 None SOAT1, SOAT2 2.87788
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, THRA 2.75341
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.65112
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 2.62029
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.58696
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.47858
[MF] GO:0004938 None ADRA2A, ADRA2C 2.47858
[MF] GO:0099583 None GRM1, GRM5 2.47858
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC, THRA 2.45928
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43103
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43103
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.37255
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.35542
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.32586
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, SRC 2.32005
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.29063
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, THRA, THRB, TUBB3, XDH 2.26701
[MF] GO:0050662 coenzyme binding DAO, DHFR, HMGCR, HSD17B1, SOAT1, SOAT2, XDH 2.2526
[MF] GO:0004971 None GRIA2, GRIA4 2.25162
[MF] GO:0032795 None ADORA1, ADRA2A 2.25162
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.15075
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, GRM5, GSK3B, HMGCR, MET, NR3C1, PGR, PPARA, PTAFR, PTGS2, PTPN1, SRC, THRB, TNKS2 2.0677


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, THRB, THRA, GRIK5, PTAFR, NR3C1, ADRA2C, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 10.9234
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.0726
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.4447
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.9031
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, DHFR, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, IDO1 4.9788
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.6623
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 3.6678
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.7667
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 3.6678
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.6678
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.3428
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6678
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 2.945
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 2.9427
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2 3.0247
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9359
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 2.9126
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, NR1H4, HMGCR 2.9359
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.4486
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, GRM1 2.622
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.2237
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2 2.267
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, THRB, THRA, SRC 2.2202
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.9838
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.1534
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0791
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0835
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2C, ADRA2A 1.7943
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9965
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, IGF1R 1.7049
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7049
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 1.6114
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.6325
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.5527
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.5527
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3033
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.4374
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GSK3B, GRIA4 1.3914
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, GRM1 1.1064
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KDR, MET, IGF1R 1.016
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9208
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.1321
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9582
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1064
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9183
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1321
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 0.9863
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8055
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2286
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.1064
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9389
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8592
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 0.9194
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.1395
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0502
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1284
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 0.9485
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8147
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8122
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2094
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8055
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.016
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7765
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.7657
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 0.8055
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.7765
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.7994
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.7657
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7506
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7657
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.7657
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.7657
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.7373
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.7135
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.3345
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.2089
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2091
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.6842
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.6002
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2541
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.628
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2636
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2784
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2881
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2974
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2969
Influenza A_Homo sapiens_hsa05164 GSK3B 0.2974
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3252
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3303
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3303
Platelet activation_Homo sapiens_hsa04611 SRC 0.4019
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.4044
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.407
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4253
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4742
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4453
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.449
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.445
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6404
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4566
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4616
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4612
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4607
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4701
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4707
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4707
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4794
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4707
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4707
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4707
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4707
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.657
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5203
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5203
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5187
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5287
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5458
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5436
Glioma_Homo sapiens_hsa05214 IGF1R 0.5458
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5305
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5458
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.5458
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6114
Shigellosis_Homo sapiens_hsa05131 SRC 0.5458
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5458
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8035
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5527
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5799
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.5965
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5829
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5829
Malaria_Homo sapiens_hsa05144 MET 0.6002
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6002
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6002
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6002
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6194
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6282
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.6676
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 1.9104
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7022
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6619
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7022
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7373
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7657
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7409
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7657
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8147
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8049
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 0.9259
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9359


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)