TCM Prescription: Sha Guo Pills



Prescription Description
Prescription IDTCMF5406
Pinyin NameSha Guo Wan
Chinese Name砂锅丸
English NameSha Guo Pills
Function Description血劳, 月经不调, 带下病
IndicationsLeukorrhea disorder
Disease ICD-11 Category SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH823 Semen juglandis 核桃仁 TCMH823
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
TCMH2568 Ferrosi sulfas 皂矾 TCMH2568
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TEK, TYR 14.326
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, RORC, SRC, TEK, TYR 12.4692
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 12.3061
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TEK, TYR 12.2277
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7082
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 10.8846
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8692
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 10.8595
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 10.8354
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 10.1322
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 10.0948
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 10.0807
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FLT3, PRKCE, PRKCG, RORC, SRC, TEK, TYR 9.6758
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, IDO1, PIM1, PPARA, TYR, XDH 9.66267
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.58364
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 9.40539
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK, XDH 9.15287
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 9.07561
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B2, MET, PPARA 9.03832
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 8.90003
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 8.48489
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 8.40029
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 8.37812
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, SMAD3, SRC, TEK 8.28281
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 8.26955
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, SRC 8.03187
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK 8.03187
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PRKCA, SMAD3, SRC, TEK, XDH 7.92405
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 7.87249
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 7.84212
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.84212
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 7.69105
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, XDH 7.69105
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TEK, TYR 7.66188
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PRKCA, PRKCB, PRKCE, PTPN1, SRC, TEK, XDH 7.56567
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 7.56409
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PRKCB, PRKCD, PRKCE, RORC, SMAD3, SRC 7.47462
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 7.4234
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, IDO1, INSR, KDR, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 7.39803
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.32464
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, XDH 7.28751
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TEK, TYR 7.16939
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 7.15927
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PRKCD, SRC 7.14272
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 7.11346
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.11316
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.11002
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 7.10906
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC 7.09797
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, PRKCD, PRKCE, SRC 6.9566
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PRKCD, PRKCE, SRC, TEK 6.93308
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PRKCB, PRKCD, PRKCE, PTPN1, RORC, SMAD3, SRC, TOP2A 6.84681
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 6.82125
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.80202
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 6.80202
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.7797
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 6.74474
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 6.73464
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, IDO1, KDR, MET, PPARA, PRKCA, PRKCD, PRKCG, SMAD3, TEK 6.73457
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PRKCB, PRKCE, SMAD3, SRC 6.71731
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 6.70464
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, IDO1 6.48903
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, IDO1, PRKCE, RORC, SRC, TYR 6.42738
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, PRKCG, RORC, SMAD3, SRC, TEK, TYR 6.42645
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCD, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.35601
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, KDR, PRKCD, PRKCE, PRKCG, SRC 6.3183
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 6.31013
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.25613
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD11B1, HSD17B2 6.22542
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA 6.21206
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.20326
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, DRD5, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PRKCB, PRKCD, PRKCE, RORC, SRC 6.19572
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.18522
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 6.10144
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 6.10144
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 6.07252
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.02559
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B2, IDO1, TYR, XDH 5.94352
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.88371
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.85353
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.85353
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.85353
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD17B2, PRKCA, PRKCE 5.8516
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GLO1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.83663
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH 5.82048
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.81876
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.81743
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.80379
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 5.79289
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 5.77298
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 5.76858
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 5.71635
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, PRKCG, RORC, SRC, TOP2A 5.71174
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC 5.69694
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.67485
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PRKCB, PRKCE, SMAD3 5.65506
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PRKCD, PRKCE, RORC, SRC, TEK 5.65249
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.60724
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC 5.55462
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA 5.55129
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.54406
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.52548
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.52009
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 5.45757
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 5.39286
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.39019
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 5.3523
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.32646
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, TEK 5.32038
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, IDO1, PPARA 5.32038
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK, TYR 5.30888
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, IDO1, MMP2, MMP9, NUAK1, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 5.25149
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.23812
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP2, PPARA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK 5.23692
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK 5.13108
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 5.09284
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 5.09112
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, DRD2, EGFR, FLT3, INSR, KDR, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 5.02284
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA, PRKCB, PRKCD 5.01273
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 4.98377
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 4.97682
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.93772
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, RORC, SRC 4.8841
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PRKCG, RORC, TOP2A 4.8721
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, KDR, PRKCE, SRC 4.86045
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, XDH 4.85633
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, PRKCD, PRKCE, SRC 4.78765
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.74935
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2, PRKCE 4.74022
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.68893
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 4.67707
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.65449
[BP] GO:0030168 platelet activation AXL, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.56138
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, PRKCB, PRKCE, SMAD3 4.56072
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, PRKCE 4.55939
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, PRKCE 4.55939
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.55122
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.54954
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 4.53925
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, KDR, PRKCE, SRC 4.53734
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.49114
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, DRD1, DRD5, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PRKCD, PRKCE, SMAD3, SRC 4.47693
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3, PRKCE 4.46004
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 4.44841
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 4.41424
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.3967
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MMP9, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.38097
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 4.34733
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, PRKCE 4.32511
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, XDH 4.30036
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.29017
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, SRC, TEK 4.28588
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.27464
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC, TEK 4.24281
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.2396
[BP] GO:0018209 peptidyl-serine modification AURKB, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.2396
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B2 4.22396
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 4.21554
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTPN1, SRC, XDH 4.19465
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 4.16755
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.15674
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, IDO1, PIM1, PPARA, TYR 4.09183
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.05996
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, IDO1, KDR, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCE, SMAD3, SRC, TEK 4.04985
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.04985
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, PRKCB, PRKCE, SMAD3 4.02978
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK 4.02628
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.01945
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.99592
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 3.98314
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 3.97728
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD5, PRKCE, PRKCG 3.95412
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK 3.93033
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, PRKCD, SMAD3, TEK 3.9282
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TOP2A 3.9258
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA 3.88292
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.85713
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR, PRKCE, PRKCG 3.8467
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, SMAD3, SRC, TOP2A 3.82597
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD, PRKCE 3.79752
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.73552
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.70419
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.68019
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PRKCD, SMAD3, TEK 3.67781
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 3.66052
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.64029
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.63683
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, PRKCD, SRC 3.618
[BP] GO:0072347 None DRD2, DRD3, DRD5, PRKCE, PRKCG 3.6169
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, IDO1, PIM1, PPARA, TYR 3.6169
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.58673
[BP] GO:0001775 cell activation ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC 3.56239
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.56239
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.56239
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, PRKCD, PRKCE, SMAD3, SRC 3.54276
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, IDO1, PIM1, PPARA, TYR 3.53358
[BP] GO:0051128 regulation of cellular component organization ALOX15, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.52434
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP1, MMP2, MMP9, SRC, XDH 3.52434
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CYP19A1, DRD2, DUSP3, ESR1, HCAR2, HSPA1A, IDO1, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 3.51496
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.51496
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK, XDH 3.50869
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 3.49934
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD, SRC 3.49934
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.49934
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.49934
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, TYR 3.47108
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, PRKCD, SMAD3, TEK 3.45049
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, PRKCB, PRKCE, SMAD3 3.44264
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, PRKCB, PRKCE, SMAD3 3.4232
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5 3.41088
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, MET, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TOP2A 3.38439
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.38439
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, RORC 3.38439
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 3.37854
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 3.37334
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.36888
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, PRKCD, SRC 3.36888
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, SMAD3 3.31839
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC 3.31839
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 3.29997
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3, PRKCE 3.29997
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.29521
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.29521
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29521
[BP] GO:0043278 None DRD2, DRD3, PRKCE, PRKCG 3.28322
[BP] GO:0014072 None DRD2, DRD3, PRKCE, PRKCG 3.28322
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, PPARA, PRKCB, PRKCE 3.2802
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.2802
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, PRKCD, SRC, TEK, TYR 3.2802
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, PRKCD, SRC, TEK 3.2471
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.21937
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.19619
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.18872
[BP] GO:0009968 negative regulation of signal transduction DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 3.18229
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, PRKCG 3.15076
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.14837
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 3.13209
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, PRKCE 3.13209
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9, PRKCE 3.127
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, KDR, PRKCA, SRC, TEK 3.11547
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 3.09119
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, IDO1, KDR, MET, PRKCA, SMAD3 3.08241
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, HSD17B2, IDO1, INSR, MMP2, MMP9, SRC, TOP2A 3.08109
[BP] GO:0042060 None ALOX15, DRD5, EGFR, PPARA, SMAD3 3.07965
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD2, DRD3, EGFR, HCAR2, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC 3.07645
[BP] GO:0007190 None ADORA3, DRD1, DRD5, PRKCA 3.06903
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 3.06903
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, TYR 3.05934
[BP] GO:0006873 cellular ion homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 3.05277
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.04738
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 3.02766
[BP] GO:0046960 None DRD1, DRD5 2.99961
[BP] GO:0035408 None PRKCA, PRKCB 2.99961
[BP] GO:0006874 cellular calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 2.99528
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, PRKCE, SRC 2.99331
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.99331
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.99331
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.99331
[BP] GO:0032410 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.95648
[BP] GO:1904063 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.95648
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, MMP9, PRKCE 2.95382
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC 2.94153
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.93625
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC, TEK 2.91798
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC, TEK 2.9132
[BP] GO:0055074 calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 2.91145
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.90955
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.90955
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.90955
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.90955
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.87906
[BP] GO:0072503 cellular divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 2.8759
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F3, MET, PRKCA, PRKCD, PRKCE, XDH 2.86004
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.85622
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.85622
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.85517
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, PPARA, SMAD3 2.83989
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, SMAD3, XDH 2.81154
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCE, SRC 2.81154
[BP] GO:0043279 None DRD2, DRD3, DRD5, PRKCE, PRKCG 2.79042
[BP] GO:0045761 None DRD2, DRD3, DRD5, PRKCA 2.78695
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.78695
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC, TEK 2.77325
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, TEK 2.7726
[BP] GO:0003018 None ADORA1, DRD1, DRD5, EGFR, SRC, TEK 2.75799
[BP] GO:0050730 None ADORA1, EGFR, FLT3, PRKCD, PRKCE, PTPN1, SRC 2.75473
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.75473
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75473
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.75473
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 2.74879
[BP] GO:0034766 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.7418
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD5, INSR, PPARA, PRKCA 2.72465
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, SRC 2.72465
[BP] GO:0007611 None DRD1, DRD2, DRD3, DRD5, EGFR, INSR, PRKCG 2.71511
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HSPA1A, IGF1R, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, XDH 2.66907
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.66619
[BP] GO:0030817 None DRD1, DRD2, DRD3, DRD5, PRKCA 2.66619
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 2.66619
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, KDR, MET, PPARA, PRKCD, RORC, SMAD3, SRC, TOP2A 2.6626
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD5, INSR, PPARA, PRKCA 2.65591
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.65215
[BP] GO:0007610 None DRD1, DRD2, DRD3, DRD5, EGFR, IDO1, INSR, PPARA, PRKCE, PRKCG 2.65215
[BP] GO:0034763 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.631
[BP] GO:0055065 metal ion homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, PRKCB, PRKCE, SMAD3 2.62217
[BP] GO:0019725 cellular homeostasis APEX1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 2.62217
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.61705
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.61705
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.61705
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.61705
[BP] GO:0060160 None DRD2, DRD3 2.61632
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61632
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC 2.61629
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PRKCD, PTPN1, SRC, TEK 2.61413
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 2.60431
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PRKCD, SMAD3, XDH 2.59024
[BP] GO:0010676 None INSR, PPARA, PRKCE, SRC 2.58955
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CBR1, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PRKCD, RORC, SMAD3, SRC, TEK, TOP2A 2.58955
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, FABP4, HSPA1A, IGF1R, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, XDH 2.57279
[BP] GO:0051098 regulation of binding AURKB, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC 2.56808
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, PRKCD, PRKCE, SRC 2.56808
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.56474
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.55527
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, KDR, PRKCE, SMAD3, TEK 2.53412
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.53372
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.53372
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, PRKCE, SRC 2.53296
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, PRKCA, PRKCE, SRC 2.52477
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, TEK 2.52206
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.52206
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PRKCD, PTPN1, SRC, TEK 2.51844
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.51069
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.5103
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.5103
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC 2.48842
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MET, PPARA, PRKCG, SMAD3 2.46212
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, PRKCA, PRKCE 2.46212
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.45674
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.4515
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, PRKCD, SRC, TEK 2.41343
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.4039
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.4039
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.39881
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.39652
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.39652
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, FUT7, GLO1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.37888
[BP] GO:0030814 None DRD1, DRD2, DRD3, DRD5, PRKCA 2.37888
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, KDR, PRKCE, SMAD3, SRC, TEK 2.37448
[BP] GO:0045936 None DRD2, DRD3, DUSP3, FABP4, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.37244
[BP] GO:0010563 None DRD2, DRD3, DUSP3, FABP4, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.36777
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.36777
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36777
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B2 2.36326
[BP] GO:0031279 None DRD2, DRD3, DRD5, PRKCA 2.36326
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PRKCE 2.36326
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.3546
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.35393
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35393
[BP] GO:0051339 None DRD2, DRD3, DRD5, PRKCA 2.34243
[BP] GO:0030802 None DRD1, DRD2, DRD3, DRD5, PRKCA 2.34243
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PRKCD, SRC, TEK 2.34243
[BP] GO:0006875 cellular metal ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PRKCB, PRKCE, SMAD3 2.33431
[BP] GO:0010675 None INSR, PPARA, PRKCE, RORC, SRC 2.31079
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.30787
[BP] GO:0051495 positive regulation of cytoskeleton organization ALOX15, HSPA1A, MET, PRKCE, SMAD3, TEK 2.30787
[BP] GO:0051894 None KDR, SMAD3, TEK 2.30787
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.30787
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30787
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, MET, PPARA, PRKCD, RORC, SMAD3, SRC, TOP2A 2.30787
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, HCAR2, IDO1, MMP9, PRKCD, SMAD3, SRC, TOP2A, XDH 2.30637
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, DRD1, DRD2, DRD3, GPR35, MMP9, PRKCD, PRKCE 2.30145
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, HCAR2, IDO1, MMP9, PRKCD, SMAD3, SRC, TOP2A, XDH 2.27325
[BP] GO:0050927 None F3, KDR, SMAD3 2.25909
[BP] GO:0046887 positive regulation of hormone secretion CYP19A1, DRD2, EGFR, HCAR2, PRKCE 2.25554
[BP] GO:0044087 regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 2.2532
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PRKCD, PTPN1, SRC 2.22973
[BP] GO:1900076 regulation of cellular response to insulin stimulus PRKCB, PRKCD, PTPN1, SRC 2.22943
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.22943
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP9, PRKCD, SRC, TEK 2.22686
[BP] GO:0050776 regulation of immune response ALOX15, DRD2, DUSP3, ESR1, HSPA1A, IDO1, MMP2, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.22686
[BP] GO:0043086 negative regulation of catalytic activity CSNK2A1, DRD2, DRD3, DRD5, DUSP3, FABP4, IGF1R, MMP9, PRKCA, PRKCD, PTPN1, SRC 2.22275
[BP] GO:0043254 regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCD, PRKCE, SRC 2.22227
[BP] GO:0050926 None F3, KDR, SMAD3 2.21909
[BP] GO:1903393 None KDR, SMAD3, TEK 2.21909
[BP] GO:0045913 None INSR, PPARA, PRKCE, SRC 2.21263
[BP] GO:0035304 regulation of protein dephosphorylation ADORA1, DRD2, NUAK1, PRKCD 2.21263
[BP] GO:0003013 None ADORA1, DRD1, DRD5, EGFR, SRC, TEK 2.21204
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, PRKCD, SRC 2.21204
[BP] GO:1900371 None DRD1, DRD2, DRD3, DRD5, PRKCA 2.20685
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.20232
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.19562
[BP] GO:0030808 None DRD1, DRD2, DRD3, DRD5, PRKCA 2.19562
[BP] GO:0021853 None DRD1, DRD2 2.19562
[BP] GO:0010641 None F3, SRC 2.19562
[BP] GO:0090325 None DRD2, DRD3 2.19562
[BP] GO:1904936 None DRD1, DRD2 2.19562
[BP] GO:0042321 None ADORA1, DRD2 2.19562
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, IGF1R, INSR, PRKCD, SRC 2.18927
[BP] GO:0032069 None HSPA1A, PRKCD, PTPN1 2.18617
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PRKCD, PTPN1, SRC 2.1853
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.16919
[BP] GO:0001936 None F3, KDR, PRKCA, TEK, XDH 2.15977
[BP] GO:1900543 None DRD2, DRD3, PPARA, PRKCA 2.1593
[BP] GO:0008306 None DRD1, DRD2, DRD3, DRD5 2.1593
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, DRD3, EGFR, GPR35, HCAR2, PRKCA, SMAD3 2.15816
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.14426
[BP] GO:0007189 None DRD1, DRD2, DRD3, DRD5 2.1392
[BP] GO:0045980 None DRD2, DRD3, PPARA, PRKCA 2.1392
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC 2.1214
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, INSR 2.1214
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TOP2A 2.114
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTPN1, XDH 2.11397
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, PRKCD, SRC, TEK 2.10823
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, PRKCD, PRKCE, PTPN1, SRC, TOP2A 2.10823
[BP] GO:0051223 None ACHE, DRD2, DRD3, EGFR, HCAR2, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.10137
[BP] GO:0030100 regulation of endocytosis ALOX15, AXL, DRD2, PRKCG, PTPN1, SRC 2.08506
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP2, PRKCD, PRKCE, SRC 2.08297
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, INSR, PRKCD, PTPN1, SRC 2.07458
[BP] GO:0046627 None PRKCB, PRKCD, PTPN1 2.06712
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.06712
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.06712
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3 2.06276
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.06276
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.06276
[BP] GO:0010942 positive regulation of cell death CYP1B1, F3, HCAR2, IDO1, MMP9, PRKCD, SMAD3, SRC, TOP2A, XDH 2.06171
[BP] GO:0050708 None ACHE, DRD2, DRD3, EGFR, HCAR2, PRKCA, PRKCE, SRC 2.05462
[BP] GO:0030799 None DRD1, DRD2, DRD3, DRD5, PRKCA 2.05462
[BP] GO:0021843 None DRD1, DRD2 2.05462
[BP] GO:0021830 None DRD1, DRD2 2.05462
[BP] GO:0021826 None DRD1, DRD2 2.05462
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.05462
[BP] GO:0046958 None DRD1, DRD5 2.05462
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.05462
[BP] GO:0045088 regulation of innate immune response DRD2, ESR1, HSPA1A, MMP2, PRKCD, PRKCE, PTPN1, SRC 2.04984
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.04462
[BP] GO:0061041 regulation of wound healing F3, PRKCA, PRKCD, PRKCE, SMAD3 2.04462
[BP] GO:0046649 lymphocyte activation AXL, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.04462
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, IDO1, XDH 2.04462
[BP] GO:0042220 None DRD2, DRD3, DRD5 2.04462
[BP] GO:1901890 None KDR, SMAD3, TEK 2.04462
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.04462
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.04462
[BP] GO:0045744 None DRD2, DRD3, MET 2.04462
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.04199
[BP] GO:0018107 peptidyl-threonine phosphorylation CSNK2A1, PRKCA, PRKCB, PRKCD 2.03883
[BP] GO:2000026 regulation of multicellular organismal development AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, IDO1, INSR, KDR, PIM1, PRKCA, PRKCB, SMAD3, SRC, TEK, XDH 2.02136
[BP] GO:0007194 None DRD2, DRD3, PRKCA 2.00863
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.00863
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.00863
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK 4.93055
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TYR 3.66052
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TOP2A, TYR, XDH 3.52434
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR 3.31839
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC 2.77813
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, APEX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TOP2A, TYR, XDH 2.7435
[CC] GO:0005783 None ADORA1, APEX1, CA4, CYP19A1, CYP2D6, FLT3, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTPN1, XDH 2.53296
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TOP2A, TYR, XDH 2.51184
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.39608
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD1, DRD2, DRD5, EGFR, INSR, MET, PRKCG, SRC, TEK 2.38806
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.26325
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PRKCG, SRC, TEK 2.24363
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.05462
[CC] GO:0097730 None DRD1, DRD2, DRD5 2.00863
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TYR, XDH 18.3821
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.9341
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 15.6879
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TOP2A, TYR, XDH 14.6371
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, GLO1, IDO1, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 11.3568
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 11.0561
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0561
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8692
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 9.71229
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.44528
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.41753
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, GLO1, IDO1, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 8.40029
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.7798
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.4234
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B2, IDO1, TYR, XDH 7.13045
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 7.08325
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 6.80154
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.73457
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.73457
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, IDO1, SRC 6.42714
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.35601
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.20137
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, IDO1, SRC 6.19572
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.1821
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.17035
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.50299
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.35067
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.25953
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK 5.09149
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.87024
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.73099
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.73099
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.61836
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.55939
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.559
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.35887
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.29166
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.15674
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.11392
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 4.01945
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 3.93225
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.46978
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.46978
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.44264
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.42268
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 3.25004
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.1829
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 3.17982
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.17982
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5 3.17581
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 3.16685
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 3.11547
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 3.07677
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B2, XDH 3.01719
[MF] GO:0019899 enzyme binding AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F3, HSPA1A, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TOP2A 2.99961
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.99961
[MF] GO:0008389 None CYP2A13, CYP2A6 2.99961
[MF] GO:0035403 None PRKCA, PRKCB 2.99961
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.99446
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, IDO1, SRC, XDH 2.99331
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 2.98358
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.96272
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.95648
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.85517
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 2.77957
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.77892
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, XDH 2.77892
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.67995
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.66619
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.66619
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.63592
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 2.61632
[MF] GO:0004699 None PRKCD, PRKCE 2.61632
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.50915
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.4515
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.4039
[MF] GO:0001588 None DRD1, DRD5 2.36777
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.36777
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B2 2.34243
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1 2.21909
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.19562
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.19562
[MF] GO:0043559 insulin binding IGF1R, INSR 2.19562
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1 2.18617
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.10576
[MF] GO:0004064 arylesterase activity CA1, CA2 2.05462
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.04462


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.0957
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, EGFR, IGF1R 7.9706
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, KDR, PRKCA, TEK, DRD2, MET, EGFR, IGF1R 7.9706
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 7.9706
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.9706
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7652
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PRKCB, MMP2, PRKCE, PRKCD, PIM1, PRKCA, F3 7.1227
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.1342
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, MMP9, MET, EGFR, IGF1R 5.6089
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA, DRD1, DRD2, EGFR 6.2323
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.7371
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.4015
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B 5.7528
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, INSR, PRKCA, TEK, EGFR, IGF1R 5.8362
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9634
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA, DRD1, DRD2, DRD3, DRD5 5.3428
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, SRC, KDR, PRKCA, MET, EGFR, IGF1R 5.169
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 5.0694
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.9
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 5.169
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3756
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, INSR, PRKCE, PRKCD, PPARA 4.6676
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, CYP2D6, ALOX5, ALOX15, PRKCA 4.6167
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 4.27
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, SRC, KDR, PRKCA 4.6676
Glioma_Homo sapiens_hsa05214 PRKCG, PRKCB, PRKCA, EGFR, IGF1R 4.5741
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, ADORA3, PRKCE, ADORA1, PRKCA 4.4764
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PRKCB, SRC, PRKCA, MMP9 4.0621
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.7086
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6776
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, SRC, PRKCA, EGFR 4.0545
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, PRKCB, PRKCA, DRD1, EGFR, DRD5 3.6457
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA, DRD1 3.9727
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.9393
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, DRD1, DRD2, DRD3, DRD5 3.5427
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, DRD2, PPARA, DRD5 3.4675
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, SRC, PRKCA, ESR1 3.5427
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.5178
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, MMP2, PRKCA, MMP9 3.5427
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 3.0733
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 3.2197
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, SRC, PRKCA, EGFR 3.0299
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PRKCB, PRKCA, EGFR 3.6457
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PRKCB, INSR, PRKCA 4.1499
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.5427
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA, IDO1 4.3112
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.1253
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.2596
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.9027
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1196
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.8167
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PRKCB, PRKCA 2.6686
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA, DRD1 3.4095
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA, EGFR 2.808
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 3.012
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.8758
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3986
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3688
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, PRKCE, ADORA1 2.1169
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0184
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2089
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.516
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2697
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2976
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3075
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3174
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, PRKCA, EGFR 1.5237
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3067
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 1.5884
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.336
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3436
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PRKCA 0.3516
Influenza A_Homo sapiens_hsa05164 PRKCB, PRKCA, HSPA1A 1.3311
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.9578
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.7765
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3818
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, SRC, PRKCD 1.2623
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6496
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.4124
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 2.0202
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 1.9122
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8639
Platelet activation_Homo sapiens_hsa04611 SRC 0.4053
Axon guidance_Homo sapiens_hsa04360 MET 0.3972
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 1.9314
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6264
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD 0.4082
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4053
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8554
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.0705
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8564
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8765
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7199
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9245
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8184
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA 1.9108
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4357
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2683
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8554
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3524
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3152
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9245
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4921
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4527
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9535
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.257
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4603
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.3273
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.091
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4794
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1149
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5016
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1445
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3398
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3031
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5157
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB 1.1189
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1401
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5003
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.2683
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.2913
Peroxisome_Homo sapiens_hsa04146 XDH 0.5171
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5561
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.5561
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5325
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5391
Leishmaniasis_Homo sapiens_hsa05140 PRKCB 0.5561
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.3853
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5596
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5675
Bile secretion_Homo sapiens_hsa04976 CA2 0.5574
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2442
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5758
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.581
Shigellosis_Homo sapiens_hsa05131 SRC 0.5784
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5901
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3645
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCE, PRKCD 2.6731
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.63
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6453
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.63
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3722
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6496
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4698
Malaria_Homo sapiens_hsa05144 MET 0.6586
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4462
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.6891
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5797
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7796
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7293
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6221
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8564
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8184
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7796
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7964
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8604
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9458
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8245
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8564
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9638
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8173
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9108
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1341
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3428
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0913


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)