TCM Prescription: Qing Jin Ning Fei Pills



Prescription Description
Prescription IDTCMF5333
Pinyin NameQing Jin Ning Fei Wan
Chinese Name清金宁肺丸
English NameQing Jin Ning Fei Pills
Function Description咳嗽, 喘病
IndicationsDyspnea
Disease ICD-11 Category MD11.5 [Dyspnoea, 呼吸困难 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH552 Rhizoma pinelliae preparata 法半夏 TCMH552
TCMH925 Exocarpium citri grandis 化橘红 TCMH925
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1444 Datura metel 曼陀罗叶 TCMH1444 ITSAM3639-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1090 Brassica juncea 芥子 TCMH1090 ITSAJ4546-14
TCMH710 Trichosanthes kirilowii maxim 瓜蒌子 TCMH710 ITSAO4359-14
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH2596 Fritillaria verticillata 浙贝母 TCMH2596
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1223 Tussilago farfara 款冬花 TCMH1223 ITSAH4326-14
TCMH46 Stemona tuberosa 百部 TCMH46 GBVC4204-11, GBVC4202-11
TCMH72 Bletilla striata 白芨 TCMH72 ITSAJ4380-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 11.4866
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1, TYR 10.8205
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PPARA, TRPV1 9.80636
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, RORC, SRC, TRPV1, TYR 9.55888
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, RORC, SRC, TYR 9.13881
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.8374
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.98221
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TRPV1, TYR 7.95138
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1, TYR 7.95138
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 7.71364
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, RORC, SRC, TRPV1, TYR 7.39771
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 7.35777
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 7.34403
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8 6.92344
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.88978
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 6.7174
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.55016
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRM1, GRM3, GRM5, GRM8 6.42609
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, MIF, PIM1, PPARA, TYR, XDH 6.30082
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 6.27509
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.19688
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.19688
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, XDH 6.09493
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8 5.99308
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8 5.99308
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.82489
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.75352
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, PPARA, SRC, TRPV1 5.70352
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.65546
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, RORC, SRC, TRPV1 5.64895
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 5.5817
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.51234
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 5.49466
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.46594
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.44275
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.44275
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 5.43498
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.41569
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, TRPV1 5.14603
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR 5.129
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.12329
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.12329
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 5.09391
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.08637
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 5.08637
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.07927
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, KDR, MIF, SRC, TNKS, TNKS2, TRPV1 4.96821
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TRPV1, TYR 4.95701
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.92643
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 4.91979
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 4.91485
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.88597
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.85293
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, TYR 4.75337
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC, TRPV1 4.69249
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.69249
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, GRIK5, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TRPV1 4.69249
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 4.60296
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, GRM1, GRM3, GRM5, GRM8 4.57574
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.49853
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, NR3C1, SRC, TRPV1 4.47919
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.47323
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MET, MIF, PPARA 4.46633
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 4.43414
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.39959
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TRPV1 4.38324
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 4.37428
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.36593
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.36593
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.3631
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TRPV1 4.36258
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF 4.3589
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 4.34943
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.34301
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.34001
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.33951
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.2437
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 4.2437
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.14082
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.09336
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.07662
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, GRM1, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SRC, TNKS2, TRPV1, XDH 4.03294
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.01949
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 4.01949
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.99807
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.99029
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 3.97049
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.97022
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.96676
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 3.95624
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 3.94235
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC 3.92046
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.85516
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.83395
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, F3, FLT3, GRM1, KDR, MET, MIF, PTPN1, SRC, XDH 3.78513
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 3.77743
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.76316
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.75836
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC, TRPV1 3.75528
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.74958
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.74163
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 3.72901
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC 3.72901
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 3.68562
[BP] GO:0032845 None ADORA1, BCL2, MIF, SRC, TNKS, TNKS2, TRPV1 3.6356
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.61172
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.59113
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.57643
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.57643
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.52338
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.50703
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 3.50396
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 3.47903
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 3.45053
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CDK6, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 3.4241
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.40601
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.38468
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.38054
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.37244
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.34787
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 3.34528
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 3.33911
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.32799
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, KDR, SRC 3.30699
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 3.24341
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRM1, IGF1R, KDR, MET, MIF, MMP9, PTPN1, SRC, XDH 3.22973
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.21306
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.21306
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.18619
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC 3.17571
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CHRM3, CNR1, CYP1B1, ESRRB, F3, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SRC, TRPV1 3.17095
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, ESRRB, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.13249
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.08652
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.08652
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.04727
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 3.02962
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 2.98737
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, SRC, TRPV1 2.9799
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA 2.91429
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.86703
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.86528
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CNR1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC 2.85709
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF 2.83672
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, SRC, TRPV1 2.8002
[BP] GO:0009115 None AOX1, XDH 2.8002
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.8002
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.8002
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.8002
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.79996
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MIF, MMP9, PTPN1, SRC, TNKS, XDH 2.79511
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.78554
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.78554
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78301
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.77843
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.77843
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.76468
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, MIF, PPARA 2.76073
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.76073
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.76073
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.76046
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.69925
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TRPV1, XDH 2.67958
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CNR1, CNR2, CYP1B1, GRM1, GRM5, GRM8, HSD11B2, SRC, TRPV1, TYR 2.67958
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, GRIK5, GRM5, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TRPV1 2.65218
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 2.63401
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, MIF, MMP12 2.55273
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, GRM1, KDR, MIF, PTPN1, SRC, XDH 2.54623
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.53719
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.53719
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, GRM1, HSD11B2, MMP2, PPARA, SRC, TRPV1, TYR 2.52047
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.51932
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, ESR1, GRM1, GRM3, GRM5, GRM8, SRC 2.50613
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, MIF, PTPN1, SRC 2.50613
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9 2.4908
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.48975
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.47029
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.42428
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.41134
[BP] GO:0099566 None GRM1, GRM5 2.41134
[BP] GO:0046110 None AOX1, XDH 2.41134
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41134
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.41134
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 2.40687
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, SRC, TRPV1, TYR 2.38739
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.37066
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.3496
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.33722
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC 2.32229
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.30968
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.30234
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.30234
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.29006
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SRC 2.28926
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.28926
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.27476
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.27476
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.24907
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.23698
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.2363
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, MIF, MMP12, MMP2, PTPN1, SRC 2.23471
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC 2.22925
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.22038
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.18657
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.18657
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.1847
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.1847
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.1847
[BP] GO:0070213 None TNKS, TNKS2 2.17575
[BP] GO:0006145 None AOX1, XDH 2.17575
[BP] GO:0038171 None CNR1, CNR2 2.17575
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17575
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17575
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.17427
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC 2.16352
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14959
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.14038
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.13577
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.13071
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.11977
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.11314
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, GRM1, IGF1R, KDR, MIF, PTPN1, SRC, XDH 2.10563
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.10562
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MET, MIF, MMP9, PTPN1, SRC, TNKS, XDH 2.09081
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08707
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CNR1, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.08313
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC 2.06816
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06789
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.06789
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SRC 2.06259
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, MIF, PIM1, PPARA, TYR 2.06168
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CHRM1, CNR1, GRM5, MIF, MMP9 2.04721
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.04278
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.01984
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.01984
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 2.01432
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.01325
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.01325
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.01273
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 2.01273
[BP] GO:0046541 None CHRM1, CHRM3 2.01151
[BP] GO:0043696 None CDK6, ESRRB 2.01151
[BP] GO:0043697 None CDK6, ESRRB 2.01151
[BP] GO:0010641 None F3, SRC 2.01151
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.01151
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.01151
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.01049
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PTPN1, SRC, TNKS 2.00384
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 7.10361
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 6.30082
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 6.15373
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 5.65546
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TRPV1 5.23654
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TRPV1, TYR 4.81706
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 4.77399
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC, TRPV1 4.57574
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 4.49853
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.46714
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 4.13855
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TRPV1, TYR 3.69859
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.92435
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.84731
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.84731
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, CNR1, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 2.83657
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, CNR1, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 2.83657
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.68382
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 2.63332
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 2.38739
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.24014
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.13577
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.10697
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 15.6448
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 10.1568
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.60135
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 9.56078
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 9.1586
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 8.2166
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.90376
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 7.735
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 7.30548
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 7.20024
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, TNKS 6.72509
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.50433
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 6.33209
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.19688
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 6.09493
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 6.09493
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.01228
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.91316
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.83074
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TRPV1, TYR, XDH 5.77141
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 5.5817
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.22853
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.09391
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.97347
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.97347
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TRPV1, TYR, XDH 4.93717
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.8798
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.80998
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 4.06026
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.96352
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.84225
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.54598
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.32799
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.24341
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.21578
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.21441
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.16828
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.0572
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.02986
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.89387
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.8002
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.8002
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8002
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.8002
[MF] GO:0003845 None HSD11B1, HSD11B2 2.8002
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.76468
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, SRC, XDH 2.73422
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 2.69028
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.60357
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.51932
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.47419
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41134
[MF] GO:0004949 None CNR1, CNR2 2.41134
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.41134
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.41134
[MF] GO:0099583 None GRM1, GRM5 2.41134
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.3496
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.3496
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.27476
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.2363
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.21718
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17575
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17575
[MF] GO:0004971 None GRIA2, GRIA4 2.17575
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17575
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.08707
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.06789
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.01984
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8 2.01432
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.01151
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01151


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, GRM3, GRM5, CNR2, CNR1, ADORA3, GRM8, ADORA1, GRIA4 13.3743
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 10.3389
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9197
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.5535
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.4542
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.7994
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 4.1237
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.3556
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.7883
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.8706
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8706
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, GRM1, GRIA4 3.3896
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.2317
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.7433
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7433
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.0215
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 3.0425
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7321
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.0215
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, MET, IGF1R 2.7277
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.0425
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.4703
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0215
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.2626
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.1937
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12 2.3182
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.1812
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0193
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.0193
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1324
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0403
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.105
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9996
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9935
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7506
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.0193
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.6714
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.7701
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7277
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3059
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4694
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9374
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2317
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9547
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0013
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9905
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0429
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8413
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2619
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9638
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9718
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1883
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2317
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.1202
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2557
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9374
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9055
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0216
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.1786
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9801
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1786
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9718
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0852
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8677
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8677
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7937
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8677
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8173
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2051
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8413
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2357
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.777
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5812
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7875
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6801
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1739
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6449
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5756
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1463
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2793
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2859
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2981
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3075
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2858
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3075
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3373
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3226
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.334
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3492
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3216
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3492
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3477
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.3458
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3598
Platelet activation_Homo sapiens_hsa04611 SRC 0.377
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3783
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.377
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.377
Axon guidance_Homo sapiens_hsa04360 MET 0.3721
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4052
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4322
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4319
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4563
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4475
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4471
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4563
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4558
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4563
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4563
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4563
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4563
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4563
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3891
Peroxisome_Homo sapiens_hsa04146 XDH 0.4568
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4563
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4972
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4713
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4872
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5092
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5237
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5237
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5237
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5107
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5237
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5237
Shigellosis_Homo sapiens_hsa05131 SRC 0.5237
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5237
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5588
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6906
Malaria_Homo sapiens_hsa05144 MET 0.5983
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5661
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6061
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6021
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.656
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6061
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6672
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8864
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7513
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7693
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7937
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.76
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7875
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9133
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9007
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9718
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0215
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2317


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)