TCM Prescription: Qing Gan Tablets



Prescription Description
Prescription IDTCMF5210
Pinyin NameQing Gan Pian
Chinese Name清肝片
English NameQing Gan Tablets
Function Description胁痛, 黄疸
IndicationsHypochondrium pain disorder, Jaundice disorder, Jaundice
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PTGS2, SRC, TYR 11.1848
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, PTGS2, SRC, TYR 10.5071
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 10.5071
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, PTGS2, SRC, TYR 10.3288
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.3288
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PTGS2 10.1736
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, SRC, TYR 9.24232
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 8.359
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 8.35469
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, SRC, TYR 8.35469
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, PTGS2, SRC, TNKS, TNKS2, XDH 8.28872
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, KIT, MMP2, PTGS2, SRC 8.19325
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 8.15199
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, GBA2, IDO1, PIM1, PTGS2, TYR, XDH 8.09542
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.02561
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 8.00599
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.87819
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 7.74286
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.69653
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.67556
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, PTGS2, SRC, TNKS2, TYR 7.66997
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 7.57783
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.32926
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PTGS2, SRC 7.21805
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.14453
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.99796
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 6.99499
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.94902
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, GSK3B, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, PTGS2, SRC, TYR 6.74111
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 6.5096
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.42298
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, SRC 6.21116
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, SRC, TYR 6.21116
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.21116
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.18725
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 6.18644
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 6.15687
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.11992
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, PTGS2, SRC 6.08462
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 6.01256
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2 5.58481
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 5.47483
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, MMP1, MMP2, MMP9, SRC, XDH 5.45715
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, SRC, TNKS2, TYR 5.42513
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, KIT, MMP2, MMP9, PTGS2, SRC 5.37026
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, PTPN1, SRC 5.32784
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 5.29283
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 5.1921
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.10243
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.09364
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, F3, FLT3, KDR, KIT, MET, PTGS2, PTPN1, SRC, XDH 5.08973
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.0819
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, PTPN1, SRC, TYR 5.0819
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 5.04406
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC 5.03449
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.99292
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.96577
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.92656
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2 4.92656
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DHFR, GBA2, TYR 4.90705
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.84718
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.83372
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DHFR, ESR1, F3, FLT3, FUT7, GBA2, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.77668
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.77519
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.76197
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.54227
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.54217
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 4.50552
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, KIT, MET, PTGS2 4.44959
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, PTGS2, SRC, TNKS, TNKS2 4.37357
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 4.28737
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 4.26386
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 4.26386
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DHFR, FABP3, HSD11B2, KDR, PTGS2, SRC 4.22267
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.21181
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 4.21181
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.14692
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 4.14692
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CDK6, CYP1B1, ESR1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, SRC 4.12538
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 4.02196
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.98138
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.9572
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.89571
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.82663
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 3.81936
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.80988
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.80137
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS2, SRC 3.76026
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.75304
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.73868
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.73699
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DHFR, ESR1, F3, FABP4, GSK3B, IDO1, IGF1R, MET, MMP2, PTGS2, PTPN1, SRC, XDH 3.70351
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 3.69953
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.69489
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, KDR, KIT, MET, MMP2, MMP9, PTGS2, SRC 3.67525
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.64885
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.60619
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.60338
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.60338
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.60338
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.59716
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.58932
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, ESR1, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.56611
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.56056
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.49904
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.49751
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MMP9, PTGS2, PTPN1, SRC, TNKS, XDH 3.48807
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, IDO1 3.4698
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.45709
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.42655
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, XDH 3.41911
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PTGS2, SRC, TYR 3.4
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, ESR2, F3, FLT3, GSK3B, KIT, MET, MMP9, PTPN1, SRC, TNKS, XDH 3.4
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, SRC 3.3601
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.32432
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 3.31158
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, SRC, XDH 3.2861
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 3.24042
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1 3.23808
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.21588
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.21277
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.21277
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.21277
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC 3.18065
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TNKS2, XDH 3.16072
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 3.13014
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PTGS2, SRC, TYR 3.10017
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.09847
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SRC, TYR 3.09441
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, ESR1, FLT3, GSK3B, IGF1R, KIT, MMP2, PTGS2, SRC 3.09441
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.08251
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, SRC 3.04254
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, ESRRB, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.02841
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.00537
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.00165
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, KIT, MMP2, PTGS2, SRC, TYR 2.97053
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B2, IDO1, KIT, MMP2, MMP9, PTGS2, PTPN1, SRC 2.95749
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.95749
[BP] GO:0016488 None AKR1B10, AKR1C3 2.95749
[BP] GO:0016487 None AKR1B10, AKR1C3 2.95749
[BP] GO:0016107 None AKR1B10, AKR1C3 2.95749
[BP] GO:0009115 None AOX1, XDH 2.95749
[BP] GO:0006714 None AKR1B10, AKR1C3 2.95749
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, SRC, TNKS 2.95749
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PIM1, PTGS2, TYR 2.95749
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.94132
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.93135
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, GSK3B, IDO1, SRC, XDH 2.92838
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, HSD11B2, IGF1R, PTGS2, SRC 2.91393
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.91265
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.89505
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC, TNKS 2.88078
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, DHFR, PTGS2, XDH 2.84279
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.81643
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.81643
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PTGS2 2.81275
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PTGS2, SRC 2.81275
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, GSK3B, IDO1, MMP9, PTGS2, SRC, XDH 2.81275
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.81275
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.80064
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.79252
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, IDO1, MMP9, PTGS2, SRC, XDH 2.78853
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.78312
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, SRC 2.77929
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.75728
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.74484
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, KIT, PTPN1, SRC, TNKS, XDH 2.73576
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.72835
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.7095
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GSK3B, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.69757
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.69611
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.69611
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.68154
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.67721
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, PTGS2, SRC 2.62937
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.61413
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, GSK3B, KIT, SRC 2.61369
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PIM1, PTGS2, TYR 2.60907
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.60633
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.60472
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.60197
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2 2.59994
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.59563
[BP] GO:0046110 None AOX1, XDH 2.58447
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58447
[BP] GO:0016095 None AKR1B10, AKR1C3 2.58447
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.58447
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.57024
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.57024
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, IDO1, MMP9, PTGS2, SRC, XDH 2.57024
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PIM1, PTGS2, TYR 2.56012
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.55104
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.53825
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS2 2.53682
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.53682
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.51644
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.51644
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.51644
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.51644
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.51189
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.51189
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 2.50656
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 2.50656
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, GSK3B, IDO1, KDR, KIT, PIM1, PTGS2, SRC, XDH 2.50177
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PTGS2, SRC 2.49543
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.48228
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.47801
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.46874
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.46874
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.46654
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.46141
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, ESR1, F3, FLT3, GSK3B, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.45123
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC 2.44309
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.43685
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.41688
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41688
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.41087
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.40403
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, IGF1R, KIT, PTPN1, SRC, TNKS 2.4017
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, IDO1, PTGS2, XDH 2.4017
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.38489
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.37758
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37295
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CYP19A1, CYP1A1, DHFR, IDO1, PTGS2 2.36382
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.36247
[BP] GO:0070213 None TNKS, TNKS2 2.36247
[BP] GO:0006145 None AOX1, XDH 2.36247
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36247
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, FLT3 2.32991
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, HSD11B2, IDO1, KIT, PTGS2, SRC, TYR 2.29679
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, PTGS2, TNKS, TNKS2 2.29679
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.28955
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.28657
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.27393
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.26884
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, IDO1, XDH 2.26527
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AXL, BCL2, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GSK3B, KDR, KIT, MMP2, MMP9, PTGS2 2.25902
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, PTPN1, SRC 2.25808
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.24851
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.24851
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, IDO1, KDR, KIT, PIM1, PTGS2, SRC, TNKS2, XDH 2.2485
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.23653
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.21576
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, SRC 2.20149
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.20149
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.18358
[BP] GO:0043696 None CDK6, ESRRB 2.18358
[BP] GO:0043697 None CDK6, ESRRB 2.18358
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.18358
[BP] GO:0010641 None F3, SRC 2.18358
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.18358
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, IDO1, KDR, KIT, PIM1, PTGS2, SRC 2.18082
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.17565
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, GSK3B, TNKS 2.17328
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.17328
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, GSK3B, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.16223
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.15453
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.14347
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.14347
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.14347
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.14347
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.14159
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.12542
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.11321
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, MMP9 2.10957
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.10957
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, FLT3, FUT7, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, SRC, TNKS, TNKS2 2.10957
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.09296
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, ESR1, ESR2, GSK3B, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.09003
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.07866
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, GSK3B, TNKS 2.05944
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, ESR1, ESR2, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, PTPN1, SRC, TNKS, TNKS2 2.05818
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, CYP19A1, DHFR, TYR 2.0571
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.0571
[BP] GO:0046113 None AOX1, XDH 2.0571
[BP] GO:0016115 None AKR1B10, AKR1C3 2.0571
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP2, MMP9 2.05377
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.05377
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9 2.04339
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DHFR, GSK3B, IGF1R, MET, PTGS2, PTPN1, XDH 2.03252
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, GSK3B, SRC, TNKS 2.02938
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.01966
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, KDR, KIT, PTPN1, SRC, XDH 2.0139
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TYR 2.00993
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.00993
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.62759
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR 2.21487
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.10957
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS2, PTPN1 2.10957
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, KDR, PTGS2, PTPN1, XDH 2.10775
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.0571
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 12.6607
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PTPN1, TNKS, TYR, XDH 11.7911
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4054
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 9.98848
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 8.35469
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.72577
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.72577
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.88082
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 5.32784
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PTPN1, TNKS 5.26189
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.1921
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B2, HSD17B1, IDO1, PTGS2, SRC, XDH 5.13709
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.0819
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 5.017
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.98595
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.70258
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.50552
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.4363
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.30172
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.2754
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.24881
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 4.02238
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 4.02196
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.9572
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.94523
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.87628
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.75304
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.69716
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.64911
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.61175
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.45579
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.27642
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.95749
[MF] GO:0045550 None AKR1B10, AKR1C3 2.95749
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.95749
[MF] GO:0003845 None HSD11B1, HSD11B2 2.95749
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.90879
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.78887
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.78887
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.69582
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, TYR, XDH 2.68253
[MF] GO:0047718 None AKR1B10, AKR1C3 2.58447
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.53825
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1 2.51115
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.41229
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.36247
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.28657
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.28657
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.24851
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.18358
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DHFR, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.14871
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.10957
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.08198
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.08076
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0571
[MF] GO:0043546 None AOX1, XDH 2.0571
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.0571
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC 2.00276


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.7411
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 11.395
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7411
Metabolic pathways_Homo sapiens_hsa01100 AKR1C3, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 7.3479
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, IGF1R 6.2554
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.5682
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3886
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.3886
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3886
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8904
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.2133
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, IGF1R 3.5077
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0847
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, KIT, KDR, BCL2, MET, IGF1R 3.2466
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 3.2466
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.7503
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2466
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.5322
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.2917
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.2856
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.3657
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.367
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3189
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3, PTGS2 2.3168
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.2856
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.2425
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.046
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2917
Prostate cancer_Homo sapiens_hsa05215 GSK3B, BCL2, IGF1R 2.015
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 2.0445
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT, TYR 1.8962
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.7951
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.2638
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9735
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2 1.7951
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.7721
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.6304
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1 1.6312
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7617
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.7321
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.4816
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, ESRRB, IGF1R 1.5984
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2 1.2571
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1024
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.1755
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0318
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1542
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B 1.0324
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0321
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.07
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.3651
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1738
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.9905
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9974
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9974
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, BCL2 1.3957
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2561
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3405
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.9083
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.8983
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9594
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.8353
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9083
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4281
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3405
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.817
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6988
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7799
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.817
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.7545
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.2711
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2714
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3214
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.595
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3617
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3822
Purine metabolism_Homo sapiens_hsa00230 XDH 0.375
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.3412
Influenza A_Homo sapiens_hsa05164 GSK3B 0.375
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4305
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4178
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B 0.4141
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4129
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.424
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4454
Platelet activation_Homo sapiens_hsa04611 SRC 0.4602
Hepatitis C_Homo sapiens_hsa05160 GSK3B 0.4454
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4602
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4602
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4494
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5141
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5293
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.534
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5216
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5337
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5426
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5334
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.543
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5441
Gap junction_Homo sapiens_hsa04540 SRC 0.5441
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5436
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.595
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.595
Peroxisome_Homo sapiens_hsa04146 XDH 0.5588
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8684
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.595
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.595
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5738
Bile secretion_Homo sapiens_hsa04976 CA2 0.595
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6115
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6115
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6115
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5983
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6115
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6276
Shigellosis_Homo sapiens_hsa05131 SRC 0.6115
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7809
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6507
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8245
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6714
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6535
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7721
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6747
Malaria_Homo sapiens_hsa05144 MET 0.6813
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0445
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6887
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.678
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6851
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6887
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6887
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.745
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7794
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.3189
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.817
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8306
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8306
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8536
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8438
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9401
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9722
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1484
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3405


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)