TCM Prescription: Tui Zhang Yan Ointment



Prescription Description
Prescription IDTCMF5198
Pinyin NameTui Zhang Yan Gao
Chinese Name退障眼膏
English NameTui Zhang Yan Ointment
Function Description白内障, 角膜斑翳
IndicationsCataract, Macular keratitis
Disease ICD-11 Category 9B10 [Cataract, 白内障 ];
9A78.Z [Certain specified disorders of cornea, unspecified, 某些特指的角膜疾患,未特指的 ];
Human Tissues Associated with IndicationLiver, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH1535 Equisetum hiemale 木贼 TCMH1535
TCMH699 Eriocaulon buergerianum 谷精草 TCMH699
TCMH1878 Periostracum serpentis 蛇蜕 TCMH1878
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH797 Sargassum 海藻 TCMH797
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1487 Buddleja officinalis 密蒙花 TCMH1487 ITSAM868-14
TCMH73 Tribulus terrestris 白蒺藜 TCMH73 ITSAJ4258-14
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
TCMH1937 Concha haliotidis 石决明 TCMH1937
TCMH1226 Laminaria japonica 昆布 TCMH1226 AB022790
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8416
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9437
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FDPS, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.477
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 9.80443
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 9.7696
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, FDPS, NISCH, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 8.87923
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FDPS, FLT3, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, SRC, TYR, XDH 7.98527
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, PTGS1, PTGS2 7.79127
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, EPHX2, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MAOA, MET, NISCH, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, SRC, XDH 7.54931
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, PTGS1, PTGS2 7.25454
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, EPHX2, ERBB2, FABP3, FABP4, FDPS, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.17768
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2 7.12816
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 7.12816
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, PTGS1, PTGS2 7.05479
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC 6.58958
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 6.42572
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.32187
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CLK1, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 6.31932
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FDPS, FLT3, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, SRC, TYR, XDH 6.23058
[BP] GO:0016310 phosphorylation AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 6.05414
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.95353
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, PTGS1, PTGS2 5.93857
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, PTGS1, PTGS2 5.75967
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, SRC, XDH 5.73363
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 5.70756
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, FDPS, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, SRC, XDH 5.69268
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 5.69042
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 5.63859
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, SRC, XDH 5.63355
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, PPARA, PTGS1, PTGS2 5.57059
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PRKCA, SRC 5.5558
[BP] GO:0006793 phosphorus metabolic process ACHE, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, FDPS, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, SRC, XDH 5.35426
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, FDPS, HSD17B1, HSD17B2 5.25934
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, SRC 5.21583
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 5.18718
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CHRM1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, XDH 5.14592
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2, PRKCA 5.13534
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.12639
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, SRC 5.12636
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 5.09163
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, SRC, XDH 5.07824
[BP] GO:0010033 response to organic substance AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PRKCA, PTGS2, SRC, TYR 4.97994
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SRC 4.8845
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, CA2, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK3, EGFR, ERBB2, ESR1, FABP4, FLT3, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, SRC, TYR 4.84305
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, EPHX2, FABP3, FDPS, FLT3, HCAR2, PPARA, PTGS2, SRC 4.80149
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 4.79376
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 4.73757
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 4.7247
[BP] GO:0003018 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, PTGS2, SRC 4.70031
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 4.5871
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.56393
[BP] GO:0042221 response to chemical AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, SRC, TYR 4.53374
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, EPHX2, NQO2, PTGS1 4.42284
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 4.3664
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AXL, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 4.29954
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SRC 4.27222
[BP] GO:0038128 None EGFR, ERBB2, PIK3CA, PRKCA, SRC 4.23316
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.23208
[BP] GO:0097746 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, PTGS2 4.21117
[BP] GO:0035296 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, PTGS2 4.21117
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.1998
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2 4.10897
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CHRM1, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 4.08366
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CACNA1C, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DYRK2, EGFR, ERBB2, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PIK3CB, PPARA, PRKCA, PTGS2, SRC 4.08366
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, EGFR, ERBB2, ESR1, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 4.08366
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.08366
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 4.08366
[BP] GO:0050880 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, PTGS2 4.07002
[BP] GO:0035150 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, PTGS2 4.05601
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.03349
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, SRC, XDH 3.97083
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, SRC 3.9658
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, DYRK1B, DYRK2, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, SRC, XDH 3.94903
[BP] GO:0003013 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, PTGS2, SRC 3.93599
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, PTGS2 3.89146
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, AXL, CA12, CA2, CA7, CACNA1C, EGFR, EPHX2, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 3.86482
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 3.86276
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, PIK3CA, PIK3CB, SRC, XDH 3.86006
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC 3.85255
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, PPARA, PTGS1, PTGS2 3.82047
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 3.80709
[BP] GO:0008217 None ADORA1, ADRB1, EPHX2, NISCH, PPARA, PTGS1, PTGS2 3.78336
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, PIK3CA, PIK3CB, SRC 3.72866
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.68615
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.68615
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 3.64725
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.61501
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.61251
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.61251
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, ALOX5, AXL, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, EGFR, EPHX2, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 3.52251
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, HCAR2, PRKCA, PTGS2 3.52251
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.44465
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.42386
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 3.39144
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 3.33734
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EPHX2, FABP3, FABP4, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.31629
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 3.2942
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, SRC, TYR 3.23878
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, IGF1R, PIK3CA, PIK3CB 3.2239
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, CHRM1, DYRK2, EGFR, ERBB2, HCAR2, MMP12, PRKCA, PTGS2, SRC 3.2003
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 3.17566
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15762
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.14206
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.12056
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.01827
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.01827
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC, TYR 2.98182
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FDPS, FLT3, HASPIN, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, SRC, TYR, XDH 2.98126
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA 2.97226
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.97226
[BP] GO:0038127 None EGFR, ERBB2, PIK3CA, PRKCA, SRC 2.84867
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 2.84561
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.84413
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.83173
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.83173
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA 2.81578
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.77628
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.77135
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FDPS, FLT3, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, SRC, TYR, XDH 2.75879
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2 2.75458
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.74859
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CACNA1C, CHRM1, CYP19A1, DYRK2, EGFR, ERBB2, HCAR2, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, SRC 2.74859
[BP] GO:0090257 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, PRKCA, PTGS2 2.73706
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, CACNA1C, CYP1B1, DYRK2, EGFR, ERBB2, HASPIN, IGF1R, KDR, MET, NISCH, PIK3CA, PIK3CB, PRKCA, SRC 2.71806
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.6978
[BP] GO:0071310 cellular response to organic substance AKR1B1, AXL, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC 2.69055
[BP] GO:0007188 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 2.67034
[BP] GO:0006937 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, PTGS2 2.59742
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, CACNA1C, EGFR, EPHX2, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.59196
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.59192
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, CHRM5, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, SRC, XDH 2.59192
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59097
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, AXL, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ERBB2, ESR1, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SRC, XDH 2.5892
[BP] GO:0030258 lipid modification CYP1A1, EGFR, EPHX2, ERBB2, MET, PIK3CA, PIK3CB 2.5866
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.58633
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, CHRM5, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, SRC, XDH 2.56623
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, EGFR, ERBB2, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 2.56623
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, EGFR, ERBB2, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 2.56623
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FDPS, FLT3, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, SRC, TYR, XDH 2.56623
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.55604
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, FLT3, HASPIN, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, SRC, TYR, XDH 2.55399
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, PTGS1, PTGS2, SRC 2.54606
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.52966
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2 2.50784
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AXL, CA1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DYRK2, EGFR, ERBB2, ESR1, FLT3, HASPIN, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NISCH, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SRC 2.50784
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.48446
[BP] GO:0048731 system development ACHE, ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, DYRK1A, ERBB2, MMP9, PIK3CA, SRC 2.48446
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 2.48446
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 2.47934
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.46781
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.44605
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.44353
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44353
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DYRK1A, DYRK3, EGFR, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, PTGS2, SRC, XDH 2.4363
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS 2.4363
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, ERBB2, PPARA 2.41661
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, SRC 2.38445
[BP] GO:0046834 lipid phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.36874
[BP] GO:0007187 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 2.36874
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, SRC 2.35101
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.29921
[BP] GO:0019229 None CHRM1, CHRM3, EGFR, PTGS2 2.25449
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.25351
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, MET, PIK3CA 2.25351
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.25019
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.24332
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, SRC 2.24332
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.24097
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.24097
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, SRC, XDH 2.22175
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.21466
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20091
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, ERBB2, FLT3, KDR, PIK3CB, PRKCA, SRC, XDH 2.19326
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.19326
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.19326
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.19326
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.19326
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.17674
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, FDPS 2.1635
[BP] GO:1902532 negative regulation of intracellular signal transduction DYRK1A, DYRK3, ESR1, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.16065
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15981
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.15722
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD17B1, HSD17B2 2.15398
[BP] GO:0051223 None ACHE, CACNA1C, CHRM1, DYRK2, EGFR, ERBB2, HCAR2, MMP12, PRKCA, PTGS2, SRC 2.13921
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PRKCA, PTGS2 2.13598
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.12669
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, NISCH, PTGS2 2.12371
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, NISCH, PTGS2 2.12371
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.11758
[BP] GO:0006644 phospholipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, FDPS, MET, PIK3CA, PIK3CB 2.11535
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, EPHX2, MAOA 2.10961
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, EGFR, ERBB2, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, XDH 2.06061
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.04691
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.0096
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, AURKB, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, EPHX2, ERBB2, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, SRC, XDH 2.0096
[BP] GO:0046541 None CHRM1, CHRM3 2.0096
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, ERBB2 3.22495
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, MET, PTGS2, SRC 2.48446
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 2.48446
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FLT3, HCAR2, HSD17B2, IGF1R, KDR, MAOA, MET, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, SRC, TYR 1.91322
[CC] GO:0045202 None ACHE, CHRM1, CHRM2, CHRM3, CHRM5, EGFR 1.69922
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.0253
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, FDPS, FLT3, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, SRC, TYR, XDH 14.7968
[MF] GO:0043167 ion binding ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, EPHX2, ERBB2, ESR1, FABP3, FABP4, FDPS, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, SRC, TYR, XDH 14.1771
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, TYR, XDH 13.5143
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SRC 11.1297
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9437
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 9.91636
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.7696
[MF] GO:0004672 protein kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC 9.00544
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 8.66577
[MF] GO:0016301 kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 7.98953
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 6.88453
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.58958
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.32187
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.32187
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.25517
[MF] GO:0043169 cation binding ACHE, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, EPHX2, ESR1, FDPS, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PTGS1, PTGS2, TYR, XDH 6.23058
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.12128
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.95353
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA 5.95353
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 5.75967
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 5.75967
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.53631
[MF] GO:0046872 metal ion binding ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, EPHX2, ESR1, FDPS, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PTGS1, PTGS2, TYR, XDH 5.40296
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.35426
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.25934
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.88157
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, PIK3CA, PIM1, PRKCA 4.80037
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, XDH 4.67374
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.60462
[MF] GO:0005524 ATP binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.5871
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.55336
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.44351
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.407
[MF] GO:0000166 nucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, XDH 4.08366
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, XDH 4.08366
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.06614
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.98788
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, NQO2 3.97174
[MF] GO:0043168 anion binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, NISCH, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, XDH 3.86482
[MF] GO:0008227 None ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 3.54764
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 3.39167
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, SRC 3.32771
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.27312
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.26733
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.263
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 3.263
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 3.22996
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 3.22909
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 3.2243
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.2003
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.07869
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.06726
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.03429
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.90565
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 2.86834
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.81582
[MF] GO:0008389 None CYP2A13, CYP2A6 2.81582
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 2.6397
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET 2.57351
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET 2.57351
[MF] GO:0035173 histone kinase activity AURKB, HASPIN, PRKCA 2.5362
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 2.50784
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, SRC 2.45069
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, DYRK1A, EGFR, EPHX2, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NISCH, NQO2, PTGS2, TYR, XDH 2.44544
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.41883
[MF] GO:0016740 transferase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FDPS, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 2.25351
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 2.21024
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, SRC 2.09884
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.02666
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRB1, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, FDPS, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, SRC, XDH 2.00988


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.4851
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, ERBB2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 9.5092
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.5092
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, PRKCA, CACNA1C, PIK3CB 8.2524
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, ADRB1, PIK3CB, PTGS2, PTGS1 7.5882
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, ERBB2, PRKCA, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 6.6966
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, ERBB2, PRKCA, ADRB1, CACNA1C, EGFR 6.6874
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.8548
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, ADRB1, CACNA1C, PIK3CB, PPARA 6.3598
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, ERBB2, KDR, PRKCA, PIK3CB, MET, EGFR, IGF1R 6.3494
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR 6.2109
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 6.1222
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2109
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, ERBB2, PIK3CB, MET, EGFR 5.9066
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PRKCA, PIK3CB, MET, EGFR, IGF1R 5.2973
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 5.6761
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 5.2732
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, ERBB2, PRKCA, PIK3CB, EGFR 5.3348
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, ERBB2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, EGFR 5.2498
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PRKCA, CACNA1C, PIK3CB, PTGS2, EGFR 5.0858
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, KDR, PRKCA, PIK3CB, MET, EGFR, IGF1R 4.8468
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.4374
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, ERBB2, PRKCA, PIK3CB, EGFR, IGF1R 5.0262
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, PRKCA, CACNA1C, PTGS2, PTGS1 4.8468
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, ERBB2, PRKCA, PIK3CB, EGFR 5.0262
Glioma_Homo sapiens_hsa05214 PIK3CA, PRKCA, PIK3CB, EGFR, IGF1R 4.7703
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PRKCA, PIK3CB, MET, EGFR, IGF1R 4.1953
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MAOA, EPHX2, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 4.1585
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5955
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, ERBB2, PIK3CB, EGFR, IGF1R 4.1704
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, ADRB1, CACNA1C, PIK3CB 3.9796
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PRKCA, PIK3CB 3.9547
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA, CACNA1C, EGFR 4.1497
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.5508
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, ADRB1 3.7404
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PRKCA, PIK3CB, ESR1 3.6861
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.6861
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PRKCA, PIK3CB 3.6617
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PRKCA, PIK3CB, MMP9 3.3078
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 3.0915
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PRKCA, ADRB1, CACNA1C, PIK3CB 3.2982
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.7404
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, ERBB2, PIK3CB, EGFR 3.8817
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.4188
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, ERBB2, PIK3CB, EGFR 3.5474
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PRKCA, PIK3CB 2.9638
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.2491
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7894
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB, EGFR 2.9219
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6358
Gap junction_Homo sapiens_hsa04540 SRC, PRKCA, ADRB1, EGFR 3.1174
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.302
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, EGFR, IGF1R 2.5113
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.5113
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, EPHX2, PTGS2, PTGS1 3.6442
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4815
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB, EGFR 2.4238
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PRKCA, PIK3CB 2.1625
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1364
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3288
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3367
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3366
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4419
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3366
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.0366
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 2.0786
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3488
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.5089
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.9237
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0711
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6645
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA, CACNA1C 2.16
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7849
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.4059
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.7049
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, PRKCA, CACNA1C 1.7433
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 2.3131
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7049
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.1515
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 2.0366
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.8389
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6014
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.5536
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 2.0174
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA, ADRB1 2.1267
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA, CACNA1C 2.1349
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.6645
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.684
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.315
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA, CACNA1C, PTGS2 2.0105
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4238
Axon guidance_Homo sapiens_hsa04360 MET 0.4401
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 2.0509
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.4419
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4487
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, PRKCA, CACNA1C 2.4115
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3107
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4293
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3924
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CACNA1C, EGFR 1.1123
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5164
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, PIK3CB 1.1088
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.4059
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5361
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.9788
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 0.9809
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.9718
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5533
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0127
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2 2.394
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5561
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.0778
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1517
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5547
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA, CACNA1C 1.1088
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1627
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.1858
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1627
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA, CACNA1C 1.0778
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5753
Circadian entrainment_Homo sapiens_hsa04713 PRKCA, CACNA1C 1.2222
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.596
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.2484
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2351
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6155
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.2533
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C 1.3107
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6232
Bile secretion_Homo sapiens_hsa04976 CA2 0.6232
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.7627
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA, CACNA1C 1.317
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.6131
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.6232
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3924
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3924
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.3107
Shigellosis_Homo sapiens_hsa05131 SRC 0.6486
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4063
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PRKCA, PIK3CB 2.9978
Long-term potentiation_Homo sapiens_hsa04720 PRKCA, CACNA1C 1.4613
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6836
Legionellosis_Homo sapiens_hsa05134 CLK1 0.7082
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.7082
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.5305
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.5079
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.7321
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.7368
Malaria_Homo sapiens_hsa05144 MET 0.7418
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.7418
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.7049
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7228
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.7093
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.8176
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.8655
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9226
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9598
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8573
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8993
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9333
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.9147
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9598
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1915
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9923
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 1.0216
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.1123
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4374


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)