Prescription ID | TCMF5136 |
Pinyin Name | Suan Zao Ren Tang Jiang |
Chinese Name | 酸枣仁糖浆 |
English Name | Suan Zao Ren Syrup |
Function Description | 不寐, 心悸, 眩晕 |
Indications | Vertigo disorder, Insomnia disorder, Insomnia, Palpitations, Dizziness |
Disease ICD-11 Category |
SD22 [Vertigo disorder (TM1), 眩晕 (TM1)
]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MC81.2 [Palpitations, 心悸 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
Human Tissues Associated with Indication | Heart, Brain |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH2052 | Ziziphus jujuba var. spinosa | 酸枣仁 | TCMH2052 | ITSAM943-14 |
TCMH2624 | Anemarrhena asphodeloides | 知母 | TCMH2624 | GBVA3255-11, GBVU1201-13 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT186 | MAOB | Monoamine oxidase B | Oxidoreductase | P27338 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT209 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | Oxidoreductase | P80365 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT231 | GBA2 | Beta-glucosidase | Hydrolase | Q9HCG7 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT332 | AOC3 | Amine oxidase, copper containing | Oxidoreductase | Q16853 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT39 | PDE5A | Phosphodiesterase 5A | Hydrolase | O76074 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT637 | SIRT3 | NAD-dependent deacetylase sirtuin 3 | Hydrolase | Q9NTG7 |
TCMT638 | SIRT2 | NAD-dependent deacetylase sirtuin 2 | Hydrolase | Q8IXJ6 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1186 | Plasmodium yoelii yoelii |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1223 | Staphylococcus epidermidis |
TCMT1224 | Proteus mirabilis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1234 | Bacillus coagulans |
TCMT1235 | Clostridium sporogenes |
TCMT1236 | Mycobacterium bovis |
TCMT1237 | Mycobacterium kansasii |
TCMT1238 | Mycobacterium xenopi |
TCMT1239 | Mycobacterium marinum |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1321 | Staphylococcus hominis |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1457 | Leishmania major |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 8.63103 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 7.28551 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR | 7.04456 |
[BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA | 6.88233 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MAOB, MMP2, MMP9, PPARA, TYR | 6.52829 |
[BP] GO:0008152 | metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 6.52829 |
[BP] GO:0033993 | response to lipid | ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MAOB, TYR | 6.13234 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7 | 5.98769 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PDE5A, PPARA, TYR, XDH | 5.66564 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 5.26073 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.24573 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TYR, XDH | 5.16951 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.85897 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7 | 4.81097 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, MAOB, PPARA | 4.81097 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MAOB, MMP2, PPARA, TYR | 4.78512 |
[BP] GO:0065008 | regulation of biological quality | ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PPARA, TNKS, TNKS2, XDH | 4.69969 |
[BP] GO:0009056 | catabolic process | ACHE, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MAOB, MMP1, MMP2, MMP9, PDE5A, XDH | 4.57478 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.49531 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, MAOB, MMP1, MMP2, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 4.48898 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, MAOB, TYR | 4.45599 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MAOB, MMP2, MMP9, PPARA, TYR | 4.16358 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HCAR2, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, XDH | 4.05731 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, MAOB, MMP2, PPARA | 4.01029 |
[BP] GO:0048513 | animal organ development | ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, TYR | 3.95083 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.92411 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1, MAOB | 3.92411 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, MAOB, TYR | 3.82061 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.7551 |
[BP] GO:0050665 | hydrogen peroxide biosynthetic process | CYP1A1, CYP1A2, MAOB | 3.5824 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HCAR2, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, XDH | 3.51312 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MAOB, MMP9 | 3.48385 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 3.39253 |
[BP] GO:0044238 | primary metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 3.3437 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.30109 |
[BP] GO:0032502 | developmental process | ACHE, AKR1B1, ALPL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, MAOB, MMP2, MMP9, PPARA, TNKS2, TYR | 3.28675 |
[BP] GO:0048856 | anatomical structure development | ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, MAOB, MMP9, PPARA, TYR | 3.2123 |
[BP] GO:0022900 | electron transport chain | AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH | 3.21183 |
[BP] GO:0010647 | positive regulation of cell communication | AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, MMP9, PDE5A, PTPN1, TNKS, TNKS2, XDH | 3.18203 |
[BP] GO:0023056 | positive regulation of signaling | AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, MMP9, PDE5A, PTPN1, TNKS, TNKS2, XDH | 3.16588 |
[BP] GO:0016042 | lipid catabolic process | AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 | 3.09911 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 3.00262 |
[BP] GO:0072593 | reactive oxygen species metabolic process | BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB | 2.97183 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 2.96793 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA | 2.92024 |
[BP] GO:0009115 | None | AOX1, XDH | 2.83775 |
[BP] GO:1901575 | None | ACHE, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MAOB, PDE5A, XDH | 2.82398 |
[BP] GO:0010038 | response to metal ion | BCL2, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9 | 2.70193 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, PPARA | 2.66631 |
[BP] GO:0016137 | None | AKR1B1, AKR1B10, GBA2 | 2.62133 |
[BP] GO:0042127 | regulation of cell proliferation | AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, MMP2, MMP9, PDE5A, XDH | 2.59418 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA | 2.52488 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.42723 |
[BP] GO:0046110 | None | AOX1, XDH | 2.40986 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.40986 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.31967 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, MAOB | 2.25879 |
[BP] GO:0032501 | multicellular organismal process | AKR1B1, AKR1B10, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, MMP1, MMP2, MMP9, PDE5A, PPARA, TNKS2, TYR | 2.24294 |
[BP] GO:0044248 | cellular catabolic process | ACHE, AKR1B10, AOX1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, MAOB, PDE5A, XDH | 2.21637 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA | 2.17988 |
[BP] GO:0018958 | None | AKR1B1, BCL2, MAOB, TYR | 2.16249 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.16249 |
[BP] GO:0006145 | None | AOX1, XDH | 2.16249 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.16249 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA | 2.16249 |
[BP] GO:1901360 | None | ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PDE5A, PPARA, TYR, XDH | 2.15091 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9 | 2.10182 |
[BP] GO:0009755 | hormone-mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA | 2.08669 |
[BP] GO:0035265 | organ growth | BCL2, CYP19A1, ESR1 | 2.0383 |
[BP] GO:0042743 | hydrogen peroxide metabolic process | CYP1A1, CYP1A2, MAOB | 2.0383 |
[BP] GO:0044242 | None | AKR1B10, CYP1B1, FABP3, FABP4, GBA2 | 2.02634 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA | 2.00675 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FUT7, GBA2, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 2.00473 |
[CC] GO:0044444 | cytoplasmic part | ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, MMP2, MMP9, PDE5A, PTPN1, TNKS, TNKS2, TYR, XDH | 1.98688 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2 | 1.4885 |
[CC] GO:0044432 | endoplasmic reticulum part | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 | 1.15379 |
[CC] GO:0000242 | None | TNKS, TNKS2 | 0.97054 |
[CC] GO:0031233 | None | CA4, F3 | 0.97054 |
[MF] GO:0046914 | transition metal ion binding | AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TYR, XDH | 11.5728 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 8.45545 |
[MF] GO:0003824 | catalytic activity | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, MMP1, MMP2, MMP9, PDE5A, PTPN1, TNKS, TNKS2, TYR, XDH | 6.94918 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS | 6.48901 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TYR, XDH | 6.10771 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH | 5.98769 |
[MF] GO:0043167 | ion binding | ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 5.98769 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 5.47527 |
[MF] GO:0043169 | cation binding | ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 4.81097 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 4.81097 |
[MF] GO:0005496 | steroid binding | ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 | 4.51996 |
[MF] GO:0046872 | metal ion binding | ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PDE5A, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH | 4.42065 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, ESRRA, ESRRB, PPARA | 4.27232 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA | 4.27232 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH | 4.04389 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 3.96117 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA | 3.93961 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.86689 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 3.80592 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.7551 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.63391 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, MAOB, XDH | 3.3437 |
[MF] GO:0005506 | iron ion binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH | 3.22877 |
[MF] GO:0008289 | lipid binding | ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA | 3.12416 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 3.09877 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 3.01475 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 2.98781 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 2.96326 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.83775 |
[MF] GO:0003845 | None | HSD11B1, HSD11B2 | 2.83775 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 2.19614 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.16249 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 10.2948 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA14 | 10.2948 |
Metabolic pathways_Homo sapiens_hsa01100 | MAOB, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH | 6.1159 |
Tryptophan metabolism_Homo sapiens_hsa00380 | MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 | 6.1159 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 | 5.7734 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP1A2, CYP1A1, CYP1B1 | 3.5261 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.5564 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | MMP2, MMP9, ESR1, ESR2 | 3.2016 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP1A2, CYP1A1, CYP1B1 | 3.3844 |
Tyrosine metabolism_Homo sapiens_hsa00350 | MAOB, AOX1, TYR | 3.2016 |
Bladder cancer_Homo sapiens_hsa05219 | MMP1, MMP2, MMP9 | 3.0584 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | CDK6, BCL2, CYP1B1, MMP9, CDC25B | 2.4811 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, AOX1 | 2.4966 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | MAOB, CYP1A2, AOX1 | 2.4811 |
Pathways in cancer_Homo sapiens_hsa05200 | CDK6, MMP1, MMP2, BCL2, MMP9 | 1.997 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, F3 | 2.0556 |
Hepatitis B_Homo sapiens_hsa05161 | CDK6, BCL2, MMP9 | 1.7133 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | MMP2, MMP9, ESR1 | 1.3567 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | ESR1, ESR2 | 1.3367 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.467 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1 | 1.331 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, BCL2 | 1.0754 |
Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, BCL2 | 1.2391 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PPARA | 1.0759 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 1.1901 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9614 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.8474 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1177 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 1.0401 |
Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1 | 0.9698 |
Cell cycle_Homo sapiens_hsa04110 | CDK6, CDC25B | 1.0267 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, AOX1 | 0.8841 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.9278 |
Purine metabolism_Homo sapiens_hsa00230 | PDE5A, XDH | 0.8404 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2 | 0.7883 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, PPARA | 0.7905 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CDK6, BCL2 | 0.5938 |
Prostate cancer_Homo sapiens_hsa05215 | BCL2 | 0.5938 |
Glioma_Homo sapiens_hsa05214 | CDK6 | 0.637 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B | 0.5819 |
GnRH signaling pathway_Homo sapiens_hsa04912 | MMP2 | 0.5938 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.5588 |
Pancreatic cancer_Homo sapiens_hsa05212 | CDK6 | 0.637 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6 | 0.6334 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.581 |
Amphetamine addiction_Homo sapiens_hsa05031 | MAOB | 0.637 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.581 |
Melanoma_Homo sapiens_hsa05218 | CDK6 | 0.637 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5938 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | BCL2 | 0.5789 |
Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.5216 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6334 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | ESR1 | 0.5513 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5938 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | BCL2 | 0.5513 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.3647 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1 | 0.5216 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5844 |
Serotonergic synapse_Homo sapiens_hsa04726 | MAOB | 0.5572 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.5223 |
Colorectal cancer_Homo sapiens_hsa05210 | BCL2 | 0.643 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.637 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2 | 0.476 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1 | 0.5216 |
Dopaminergic synapse_Homo sapiens_hsa04728 | MAOB | 0.5289 |
Toxoplasmosis_Homo sapiens_hsa05145 | BCL2 | 0.5513 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5844 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | ESRRB | 0.5216 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4 | 0.6772 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.5081 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.5109 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | BCL2 | 0.5513 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6 | 0.6772 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.5216 |
Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6 | 0.4338 |
Alcoholism_Homo sapiens_hsa05034 | MAOB | 0.4666 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PDE5A | 0.476 |
Tuberculosis_Homo sapiens_hsa05152 | BCL2 | 0.4666 |
Focal adhesion_Homo sapiens_hsa04510 | BCL2 | 0.4347 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | MMP9 | 0.4666 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.4612 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.6002 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F3 | 0.6135 |
p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.637 |
Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.637 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7016 |
Cocaine addiction_Homo sapiens_hsa05030 | MAOB | 0.7009 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.7011 |
Arginine and proline metabolism_Homo sapiens_hsa00330 | MAOB | 0.7005 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.7003 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH | 0.7016 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.7442 |
Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA2 | 0.7016 |
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | MAOB | 0.7426 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.8303 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8122 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.8303 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8404 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.26 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8404 |
Histidine metabolism_Homo sapiens_hsa00340 | MAOB | 0.8579 |
Phenylalanine metabolism_Homo sapiens_hsa00360 | MAOB | 0.9698 |
Other glycan degradation_Homo sapiens_hsa00511 | GBA2 | 0.9574 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.0267 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.2919 |