TCM Prescription: Qu Feng Su He Pills



Prescription Description
Prescription IDTCMF5069
Pinyin NameQu Feng Su He Wan
Chinese Name驱风苏合丸
English NameQu Feng Su He Pills
Function Description产后血晕, 中风, 腹痛, 类霍乱
IndicationsAbdominal pain disorder, Severe vomiting and diarrhoea disorder, Cholera, Stroke
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
SD92 [Severe vomiting and diarrhoea disorder (TM1), 霍乱 (TM1) ];
1A00 [Cholera, 霍乱 ];
8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationIntestine, Stomach, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2040 Liquidambar orientalis 苏合香 TCMH2040 GBVL2408-11, GBVL2411-11
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1741 Myristica fragrans 肉豆蔻 TCMH1741 GENG137-13, GBVH1657-11
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH158 Piper longum 荜茇 TCMH158 ITSAJ4247-14
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH2693 Fructus gleditsiae abnormalis 猪牙皂 TCMH2693
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT48 SCN5A Sodium channel protein type V alpha subunit Ion channel Q14524
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1312 Enterococcus durans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, INSR, KDR, MET, MIF, NR1H4, PPARA, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 15.2878
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.3688
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.3534
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 12.3534
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, ALPL, APEX1, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR1H4, NR3C1, PPARA, RORC, SRC, TEK, TYR 11.7312
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 11.3228
[BP] GO:0010033 response to organic substance ADRA2A, ADRB2, AKR1B1, ALPL, APEX1, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 11.3203
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.2953
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 11.1647
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 11.0536
[BP] GO:0042221 response to chemical ABCG2, ADRA2A, ADRB2, AKR1B1, ALPL, APEX1, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 11.0402
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 10.9417
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, NR1H4 10.8489
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AXL, BCL2, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 10.8462
[BP] GO:0009719 response to endogenous stimulus ADRA2A, ADRB2, AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, HSD11B2, IGF1R, INSR, MMP2, NR1H4, NR3C1, PPARA, SMAD3, SRC, TEK 10.7834
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, PGR, PIM1, PPARA, RORC, SRC, THRA, THRB 10.7056
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, MIF, NR1H4, PPARA, TBXAS1 10.1935
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NR1H4, NUAK1, PTPN1, SRC, TEK, XDH 9.82947
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 9.82947
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, GPER1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2C, NR1H4 9.78038
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 9.24964
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 9.18006
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, FABP3, FUT7, GBA2, GLO1, HMGCR, HSD17B3, HSPA1A, HTR2C, MIF, NR1H4, PIM1, PPARA, TBXAS1, TYR, XDH 9.17138
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, GPER1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, XDH 9.0435
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 9.03468
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.95618
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.95618
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, MIF, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 8.9148
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, MIF, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 8.9148
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 8.83253
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD11B2, HSD17B2, NR1H4, NR3C1, RORC, SRC, TYR 8.79145
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 8.77952
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD11B2, INSR, NR3C1, PPARA, SRC, TEK 8.69091
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GPER1, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, HTR2C, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS2, TOP1, TYR 8.6699
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.5622
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 8.54194
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 8.40503
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB2, APEX1, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, GPER1, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, THRA 8.40503
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 8.25801
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ADRB2, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 8.1336
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, ADRB2, AKR1B1, ALPL, APEX1, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, NR3C1, RORC, SMAD3, SRC 8.1136
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ADRB2, AR, EGFR, ERBB2, FLT3, GPER1, GRM1, HMGCR, HTR2C, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 8.02949
[BP] GO:0071310 cellular response to organic substance ADRA2A, ADRB2, AKR1B1, ALPL, APEX1, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR1H4, NR3C1, RORC, SMAD3, SRC 8.01693
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 7.98895
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2 7.75179
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, GPER1, HMGCR, HTR2C, KDR, MIF, NR1H4, SRC, TNKS, TNKS2 7.67729
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRA2A, ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, INSR, MET, NR1H4, SMAD3, SRC 7.67729
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 7.65231
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.61957
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, PPARA, SMAD3, SRC, TEK, THRA, TYR 7.59813
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 7.51015
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, ADRB2, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR1H4, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, TOP1, TOP2A, TYR 7.50653
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ADRB2, AR, DUSP3, EGFR, ERBB2, FLT3, GPER1, GRM1, HMGCR, HTR2C, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 7.30112
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, HSD11B2, NR3C1, RORC, SRC, TEK, TYR 7.22347
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, GPER1, HMGCR, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 7.22347
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 7.15454
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 7.11712
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.09064
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 7.07149
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 7.06666
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 6.98997
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PIM1, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TNKS2, XDH 6.85285
[BP] GO:0051716 cellular response to stimulus ADRA2A, ADRB2, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR1H4, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 6.76465
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 6.74141
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 6.72603
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.68677
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 6.67486
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK 6.67486
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.57202
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 6.53985
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.50091
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, TBXAS1, TYR, XDH 6.46039
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 6.29989
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 6.28032
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 6.28002
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, APEX1, AR, AXL, CDK6, CYP1B1, EGFR, ESR1, GPER1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR1H4, NR3C1, RORC, SRC 6.26456
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS2, TOP2A, TYR 6.25642
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 6.19142
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.18762
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 6.13615
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 6.12944
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK 6.12004
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 6.11653
[BP] GO:0048878 chemical homeostasis ABCG2, ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, INSR, MET, NR1H4, SMAD3 6.10082
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 5.93605
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 5.85694
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 5.85694
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.84315
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, GPER1, HMGCR, HTR2C, NR1H4, PPARA, RORC, SRC, TEK, THRA 5.8364
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, EGFR, GPER1, HMGCR, SRC, TEK 5.7358
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.73134
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, ADRB2, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 5.72345
[BP] GO:0007188 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, GPER1, GRM1, GRM3, GRM5, GRM8 5.71949
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ADRB2, AR, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.7182
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, ADRB2, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 5.68379
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, ADRB2, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 5.60864
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, CACNA1C, EGFR, GPER1, GPR35, GRM1, HTR2C, SLC1A1, SMAD3, THRA, THRB 5.59188
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.57533
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, GPER1, INSR, MET, SRC, TEK, XDH 5.55879
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.50008
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, XDH 5.50008
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ADRA2C, ADRB2, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GPER1, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, HTR2C, INSR, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, THRA 5.49815
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, ADRB2, AKR1B1, APEX1, AR, EGFR, ERBB2, ESR1, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, NR3C1, SMAD3, SRC 5.49346
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.48533
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, GPER1, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.45837
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.42778
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, ADRB2, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HTR2C, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 5.33186
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC 5.3133
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, MIF, PPARA, TBXAS1 5.3129
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 5.14677
[BP] GO:0007187 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, GPER1, GRM1, GRM3, GRM5, GRM8 5.13482
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 5.12521
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 5.0962
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.08809
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, HTR2C, KDR, NR3C1, SRC, TOP1 5.06355
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.03087
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.99502
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.98998
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, HMGCR, HTR2C, MIF, SRC, TNKS, TNKS2 4.98738
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, ADRB2, AURKB, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC, TEK, TNKS 4.98676
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.95632
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 4.95632
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, GPER1, HMGCR, HSPA1A, KDR, MET, MIF, MMP12, MMP9, NR1H4, PIM1, SLC1A1, SMAD3, SRC, TEK 4.92793
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.9139
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.9139
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, NR1H4, SRC, TEK 4.88432
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, ADRB2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC, TEK 4.87877
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 4.87435
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process ADRB2, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 4.85808
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 4.8476
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, INSR, MET, SRC, TEK 4.82382
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, ADRB2, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK, TNKS 4.81855
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, GPER1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.76079
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, EGFR, GPER1, HMGCR, SRC, TEK 4.75939
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.75939
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, ADRB2, AKR1B1, ALPL, AOX1, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.68704
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, ADRB2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC 4.67376
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.67044
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 4.64835
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.62544
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AR, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, XDH 4.62362
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB2, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, XDH 4.62261
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRA2C, ADRB2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK 4.62261
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, ADRB2, AR, BCL2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 4.57942
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, ERBB2, GPER1, HMGCR, HTR2C, KDR, MIF, PTPN1, SRC, TEK 4.57242
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, GPER1, HSD11B2, NR3C1, SRC 4.52896
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, CA2, CACNA1C, EGFR, ERBB2, GPER1, HMGCR, HTR2C, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 4.52191
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSD11B2, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, THRA, TYR 4.48845
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, GBA2, HMGCR, HSD17B3, NR1H4, TYR 4.47395
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.47014
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, EGFR, GPER1, HMGCR 4.45778
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, EGFR, GPER1, HMGCR 4.45778
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, XDH 4.44082
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PGR, PPARA, RORC, SRC, TOP1, TOP2A 4.44082
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, APEX1, FABP3, GPER1, GRM5, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK 4.43473
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, NR3C1, RORC, SRC 4.4145
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.3687
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, ADRB2, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, INSR, MIF, PTPN1, SRC 4.33498
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 4.31648
[BP] GO:0050801 ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPER1, GPR35, GRM1, GRM5, HTR2C, NR1H4, SMAD3 4.29883
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, EGFR, GPER1, HMGCR 4.27429
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, APEX1, EGFR, FABP3, FLT3, GPER1, GRM5, HSD11B2, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK, TYR 4.2647
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, EGFR, GPER1, HMGCR 4.25323
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.23846
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, ADRB2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC 4.23846
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, INSR, MMP2, MMP9, PGR, SRC, THRA, THRB, TOP2A 4.23846
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, GPER1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, NR1H4, PTPN1, SRC, XDH 4.21036
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.16027
[BP] GO:0051254 None ADRB2, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TOP2A 4.15246
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.15133
[BP] GO:0007154 None ADORA1, ADRA2C, ADRB1, ADRB2, AR, AXL, BCL2, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PGR, SLC1A1, TEK 4.15115
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, TYR 4.1441
[BP] GO:0050793 regulation of developmental process ADRA2C, ADRB1, ADRB2, AR, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, GPER1, HMGCR, HTR2C, INSR, KDR, MIF, NR1H4, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, TNKS2, XDH 4.13878
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, ADRB2, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC, TNKS 4.13529
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, EGFR, GPER1, HMGCR, HTR2C, MIF, MMP12, NR1H4, SRC 4.1017
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KDR, MET, NR1H4, SRC, TEK, TNKS, TOP1, TOP2A 4.0963
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, TOP1, XDH 4.09243
[BP] GO:0023052 None ADORA1, ADRA2C, ADRB1, ADRB2, AR, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PGR, SLC1A1, TEK 4.09056
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, EGFR, ERBB2, GPER1, MMP9 4.03953
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.01199
[BP] GO:0007267 None ADORA1, ADRA2C, ADRB1, ADRB2, AR, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PGR, SLC1A1, TEK 3.98459
[BP] GO:0045893 None ADRB2, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TOP2A 3.98097
[BP] GO:1903508 None ADRB2, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TOP2A 3.98097
[BP] GO:1902680 None ADRB2, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TOP2A 3.97747
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, ADRA2C, CACNA1C, CYP19A1, EGFR, GPER1, HMGCR, HTR2C, NR1H4 3.89855
[BP] GO:0045934 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2 3.89257
[BP] GO:0042391 None ADORA1, ADRB2, BCL2, CACNA1C, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.89257
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, PTPN1, SRC 3.89257
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, GPER1, MMP9 3.89257
[BP] GO:0050678 None AR, CDK6, EGFR, ERBB2, F3, KDR, MMP12, PGR, SMAD3, TEK, XDH 3.88835
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, APEX1, EGFR, FABP3, FLT3, GPER1, GRM5, HSD11B2, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK, TYR 3.87305
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ADRB2, ALPL, AR, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MIF, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A 3.87144
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, NR1H4, PPARA, TBXAS1 3.86756
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, GPER1, HTR2C, KDR, SRC 3.83966
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AR, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.82755
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GPER1, HSD11B2, NR3C1, SRC 3.82755
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 3.82755
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.82755
[BP] GO:0051172 None ADRA2A, APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.82534
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, HSD17B3 3.82534
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, GPER1, MMP9 3.79551
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.79093
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, TOP1, XDH 3.7556
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, NR1H4, SRC, TEK 3.72396
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, NR1H4, PPARA, SLC1A1 3.72396
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.69485
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK, THRA 3.68615
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GPER1, NR1H4, PPARA, SMAD3, TEK 3.66497
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, ADRB2, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, PTPN1, SRC 3.66497
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, NR3C1, SRC 3.66497
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, CACNA1C, EGFR, SLC1A1, THRA, THRB 3.63558
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, EGFR, ESR1, FLT3, GPER1, NR1H4, NR3C1, RORC, SRC 3.60952
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 3.60302
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 3.60302
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, CYP19A1, EGFR, GPER1, GRIK5, HMGCR, HTR2C, MIF, MMP12, NR1H4, SRC 3.59223
[BP] GO:0071880 None ADRA2A, ADRA2C, ADRB1, ADRB2 3.57484
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, ADRB1, ADRB2, APEX1, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 3.55998
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, PGR, SRC 3.55856
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GPER1, MMP12, NR1H4, PPARA, SMAD3, TEK 3.54719
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, GPER1, HMGCR, KDR, MET, MIF, MMP12, NR1H4, PPARA, SMAD3, TEK 3.52707
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 3.51577
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, GRM5, MIF, PTPN1, SRC 3.51577
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, TBXAS1 3.51092
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.50021
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2C, NR1H4, PPARA, SRC, TEK 3.49836
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, ADRA2C, ADRB1, ADRB2, CACNA1C, EGFR, GPER1, GRM5, KDR 3.46196
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 3.45483
[BP] GO:0010638 positive regulation of organelle organization ADRB2, AURKB, BCL2, GPER1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.44369
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.43413
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.43378
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.43378
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 3.42245
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, THRA, TYR 3.37026
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, EGFR, GPER1, MMP9 3.32343
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, BCL2, CACNA1C, EGFR, ERBB2, GPER1, HMGCR, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 3.27751
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.27751
[BP] GO:0071875 None ADRA2A, ADRA2C, ADRB1, ADRB2 3.27751
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MIF 3.2679
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, AR, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, GPER1, HMGCR, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 3.25634
[BP] GO:0098771 inorganic ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 3.25355
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, CYP19A1, EGFR, GPER1, GRIK5, HMGCR, HTR2C, MIF, MMP12, NR1H4, SRC 3.25355
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 3.2371
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, APEX1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, SRC 3.23353
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.20878
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.18896
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.18845
[BP] GO:0055082 cellular chemical homeostasis ABCG2, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, NR1H4, SMAD3 3.18075
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 3.16407
[BP] GO:0051094 positive regulation of developmental process ADRA2C, ADRB2, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, GPER1, HMGCR, HTR2C, INSR, KDR, NR1H4, PIM1, SMAD3, SRC, TEK, THRA 3.16394
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.16351
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade EGFR, GPER1, HMGCR, HTR2C, KDR, MIF, SRC, TEK 3.15067
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A 3.14551
[BP] GO:0003008 None ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, BCL2, CYP1B1, EGFR, GPER1, GRM1, GRM5, GRM8, HMGCR, HSD11B2, INSR, SRC, TEK, THRA, THRB, TYR 3.11487
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 3.11046
[BP] GO:0071073 None FABP3, HTR2C, NR1H4 3.10096
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GBA2, GLO1, MIF, NR1H4, PIM1, PPARA, TBXAS1, TYR 3.08871
[BP] GO:0090276 None ADRA2A, ADRA2C, CACNA1C, EGFR, GPER1, HMGCR, HTR2C, NR1H4 3.08533
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, AR, AURKB, AXL, BCL2, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.08533
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.07509
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, ADRB2, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, GPER1, INSR, MIF, MMP12, NR1H4, SMAD3, SRC 3.07272
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GBA2, GLO1, MIF, NR1H4, PIM1, PPARA, TBXAS1, TYR 3.06238
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.05562
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.0454
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, SRC 3.0454
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.0454
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, GPER1, INSR, NR3C1, SRC 3.02535
[BP] GO:0008217 None ADORA1, ADRB1, ADRB2, AR, HSD11B2, PPARA, SMAD3 3.02328
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, EGFR, ERBB2, GPER1, GRM5, IGF1R, INSR, KDR, MET, MIF, NUAK1, PTPN1, SRC, TEK 3.02194
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, APEX1, GPER1, GRM5, IGF1R, INSR, SRC 3.00913
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 3.00688
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, CACNA1C, EGFR, GPER1, HMGCR, MIF, MMP12, NR1H4, SRC 2.99341
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, CACNA1C, EGFR, ERBB2, GPER1, HMGCR, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.97561
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.97561
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.97561
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, APEX1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, SRC 2.96183
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, ADRB1, ADRB2, APEX1, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 2.95493
[BP] GO:0019725 cellular homeostasis ABCG2, APEX1, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, NR1H4, SMAD3 2.95493
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, GPER1, HMGCR, MIF, NR1H4, PPARA, SMAD3, TEK 2.95092
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, HSPA1A, MMP12, MMP2, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK 2.95092
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.94696
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.94582
[BP] GO:0045944 None ADRB2, AR, EGFR, ESR1, ESRRA, ESRRB, GPER1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, SMAD3, THRA, THRB, TNKS, TOP2A 2.94309
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.92152
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.92152
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, NR3C1, SRC 2.92152
[BP] GO:0044236 multicellular organism metabolic process ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9 2.88396
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.88396
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.86224
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.85702
[BP] GO:2000273 None ADORA1, ADRA2A, ADRA2C, ADRB2 2.8428
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.8428
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, EGFR, HSPA1A 2.84276
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, ADRB2, GPER1 2.83608
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 2.82589
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, HMGCR, HSD17B3, TYR 2.82571
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, ADRB2, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3, THRA 2.80702
[BP] GO:0010628 positive regulation of gene expression ADRB2, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TOP2A 2.80046
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.79933
[BP] GO:0008050 None THRA, THRB 2.799
[BP] GO:0009115 None AOX1, XDH 2.799
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, GPER1, NR1H4, TNKS, TNKS2 2.7963
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, GPER1, INSR, MIF, SRC 2.78465
[BP] GO:0055080 cation homeostasis ABCG2, BCL2, CA2, CA7, CACNA1C, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.77834
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 2.76113
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 2.76113
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.76113
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.76113
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 2.73704
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, NR1H4, PPARA, SLC1A1 2.73552
[BP] GO:0031644 None ADORA1, ADRA2C, GPR35, GRM1, HTR2C 2.70524
[BP] GO:1900542 None ADRA2A, ADRB1, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA 2.70091
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, ADRB1, ADRB2, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, GRM3, GRM8, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 2.66336
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.65871
[BP] GO:0007189 None ADRA2A, ADRA2C, ADRB1, ADRB2, GPER1 2.65274
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ADRB2, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.65274
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GBA2, GLO1, MIF, NR1H4, PIM1, PPARA, TBXAS1, TYR 2.64648
[BP] GO:0050679 None AR, EGFR, ERBB2, F3, KDR, MMP12, TEK 2.64344
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, NR1H4, PPARA, SMAD3, TEK 2.64117
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, GPER1, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TNKS, TOP2A 2.64117
[BP] GO:0006357 None ADRB2, AR, AURKB, CA9, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GLO1, GPER1, HSPA1A, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, THRB, TNKS, TOP2A 2.628
[BP] GO:0040008 regulation of growth ADRB1, ADRB2, AR, BCL2, CSNK2A1, EGFR, ERBB2, ESR2, HSPA1A, INSR, PIM1, SMAD3, TNKS2 2.62677
[BP] GO:0006140 None ADRA2A, ADRB1, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA 2.6242
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRB2, CA2, CA7, EGFR, GPER1 2.61132
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, RORC, SRC 2.61132
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRA2C, ADRB2, EGFR, GRM1, INSR, PTPN1, SRC 2.61132
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 2.60765
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.60708
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.59378
[BP] GO:0030003 cellular cation homeostasis ABCG2, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.59378
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, GPER1, HSD11B2, HSPA1A, HTR2C, MIF, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A 2.58432
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.57572
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.56008
[BP] GO:0006807 nitrogen compound metabolic process ABCG2, ACHE, ADRB2, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.5432
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.53582
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.53279
[BP] GO:0006873 cellular ion homeostasis ABCG2, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.50142
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, HMGCR, MMP2, MMP9 2.49071
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GPER1, GRIK5, INSR, SLC1A1, SMAD3 2.47238
[BP] GO:0002793 None ACHE, ADORA1, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.47238
[BP] GO:0060341 regulation of cellular localization ADRA2A, AR, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, GPER1, GRIK5, HMGCR, NR1H4, PTPN1, SMAD3, SRC, THRA 2.45963
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.4409
[BP] GO:0000122 None AR, AURKB, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, THRA, THRB 2.4409
[BP] GO:0045776 None ADORA1, ADRB1, ADRB2, PPARA 2.44
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.41783
[BP] GO:0071071 None FABP3, HTR2C, NR1H4 2.41314
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.41314
[BP] GO:0045986 None ADORA1, ADRA2C, ADRB2 2.41314
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, CACNA1C, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.40793
[BP] GO:0099566 None GRM1, GRM5 2.39578
[BP] GO:0060748 None AR, PGR 2.39578
[BP] GO:0046110 None AOX1, XDH 2.39578
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39578
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.39578
[BP] GO:0002520 None CACNA1C, SMAD3 2.39578
[BP] GO:0002025 None ADRB1, ADRB2 2.39578
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 2.37305
[BP] GO:1901360 None ABCG2, ACHE, AKR1B1, AKR1B10, AOX1, APEX1, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB, TOP1, TOP2A, TYR, XDH 2.36712
[BP] GO:0051128 regulation of cellular component organization ADRB2, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, GPER1, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, TOP2A 2.36626
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.36557
[BP] GO:0051098 regulation of binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TNKS 2.36557
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.35347
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.34894
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, ADRB2, BCL2, CA2, CA7, CACNA1C, GPER1, GPR35, GRM5, MIF, MMP9 2.34616
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1 2.33093
[BP] GO:0030154 cell differentiation ADRB1, ADRB2, ALPL, AR, AXL, BCL2, CDK6, CYP1A1, ERBB2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MMP2, MMP9, RORC, SMAD3, THRA, THRB, TOP2A 2.32166
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, XDH 2.28893
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.28428
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.2802
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, GPER1, HSPA1A, INSR, MIF, TNKS 2.27098
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.26888
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.26721
[BP] GO:0043434 None APEX1, FABP3, GPER1, HSD11B2, INSR, PPARA, SRC, TEK 2.2587
[BP] GO:0019933 None ADRA2A, ADRA2C, ADRB1, ADRB2, GPER1 2.24321
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.22038
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.21152
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.19165
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.18957
[BP] GO:0097755 None ADRB1, ADRB2, EGFR, GPER1 2.18957
[BP] GO:0055065 metal ion homeostasis ABCG2, BCL2, CACNA1C, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.16232
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.14616
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, ADRB2, AR, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, GPER1, HMGCR, INSR, KDR, NR1H4, PIM1, SMAD3, SRC, TEK, XDH 2.14402
[BP] GO:0035625 None ADRA2A, ADRA2C 2.14402
[BP] GO:0032811 None ADRA2A, ADRA2C 2.14402
[BP] GO:0070213 None TNKS, TNKS2 2.14402
[BP] GO:0006145 None AOX1, XDH 2.14402
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14402
[BP] GO:0050994 None ADORA1, ADRA2A, PPARA, THRA 2.14026
[BP] GO:1905475 None AR, BCL2, CSNK2A1, EGFR, ERBB2, GPER1 2.13977
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, TEK 2.13879
[BP] GO:1903507 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.12224
[BP] GO:0030817 None ADRA2A, ADRB1, GPER1, GRM3, GRM8 2.12041
[BP] GO:0019538 protein metabolic process ACHE, ADRB2, ALPL, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 2.11866
[BP] GO:1902679 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.1161
[BP] GO:0048146 positive regulation of fibroblast proliferation CDK6, EGFR, ESR1, MIF 2.11555
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.11555
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.0868
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.0868
[BP] GO:0019935 None ADRA2A, ADRA2C, ADRB1, ADRB2, GPER1 2.0868
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.0868
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, CACNA1C, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.07804
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GPER1, HSPA1A, MIF, MMP9, PTPN1, SMAD3, SRC 2.07804
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.07728
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.07397
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.07397
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.07397
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.07397
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.07397
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.06603
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.0556
[BP] GO:0090257 None ADORA1, ADRA2A, ADRA2C, ADRB2, CACNA1C, GPER1, SMAD3 2.04799
[BP] GO:0006937 None ADORA1, ADRA2A, ADRA2C, ADRB2, CACNA1C, GPER1 2.04203
[BP] GO:0044267 cellular protein metabolic process ADRB2, ALPL, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR1H4, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 2.02686
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.01347
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.01347
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.01228
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, ADRA2A, ADRB2, CA2, CA4, CA9, EGFR, ERBB2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 5.84032
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, ALOX5, ALPL, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR2C, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR 5.61263
[CC] GO:0043235 receptor complex ABCG2, ADRA2A, ADRB2, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, NR3C2, SMAD3 5.55879
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AXL, BACE1, CA4, F10, F3, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, TEK 5.2567
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AXL, BACE1, CA2, CA4, CA9, CACNA1C, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK 5.12521
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, ALPL, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, ESR1, F10, F3, FLT3, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 4.90664
[CC] GO:0044432 endoplasmic reticulum part BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FLT3, GBA2, GPER1, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2, PTPN1, TBXAS1 4.56715
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, GBA2, GPER1, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2, TBXAS1 4.43196
[CC] GO:0042734 None GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.05179
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR2C, IGF1R, INSR, KDR, MET, NR3C2, PTPN1, SLC1A1, SRC, TBXAS1, TEK, TYR 4.01199
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AXL, BACE1, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.00739
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, ADRA2C, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SMAD3, SRC, TBXAS1, THRA, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.71309
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, ERBB2, TEK 3.30415
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADORA1, ADRA2C, ADRB1, ADRB2, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SHBG, SLC1A1, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.16394
[CC] GO:0014069 None ADORA1, CACNA1C, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 3.13865
[CC] GO:0099572 None ADORA1, CACNA1C, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 3.13865
[CC] GO:0009330 None TOP1, TOP2A 2.799
[CC] GO:0043226 organelle ABCG2, ACHE, ADORA1, ADRA2C, ADRB1, ADRB2, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SHBG, SLC1A1, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.5432
[CC] GO:0044456 None ACHE, ADORA1, ADRA2C, CACNA1C, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.39578
[CC] GO:0044422 organelle part ABCG2, ADRB2, AKR1B1, ALOX5, AOX1, APEX1, AR, AURKB, BACE1, BCL2, CA4, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GBA2, GPER1, GRIA2, GRIA4, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, INSR, MIF, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR 2.32719
[CC] GO:0044454 None APEX1, AR, AURKB, CSNK2A1, ESR1, NR1H4, SMAD3, THRB, TNKS, TNKS2, TOP1 2.24321
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, GBA2, GPER1, GRIK5, HMGCR, HSD17B3, HSPA1A, KDR, PTPN1, XDH 2.20043
[CC] GO:0097060 None GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.17439
[CC] GO:0031233 None CA4, F10, F3 2.16034
[CC] GO:0005654 None AKR1B1, ALOX5, APEX1, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, MIF, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TNKS, TOP1, TOP2A 2.09926
[CC] GO:0044446 intracellular organelle part ABCG2, ADRB2, AKR1B1, ALOX5, AOX1, APEX1, AR, AURKB, BACE1, BCL2, CA4, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GBA2, GPER1, GRIA2, GRIA4, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, INSR, MIF, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR 2.05538
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, THRA, THRB, TNKS, TYR, XDH 19.9515
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 15.2878
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD11B2, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC, SHBG 14.6776
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 14.6776
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AXL, CDK6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 13.3237
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, PGR, PPARA, RORC, THRA, THRB 13.2349
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, PGR, PPARA, RORC, THRA, THRB 13.2349
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 13.1157
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 12.7485
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK, THRA, THRB 12.5872
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3, THRA, THRB, TNKS 11.7457
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.4023
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 9.86588
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, NR3C1, SHBG, THRA, THRB 9.24964
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, TBXAS1, TYR, XDH 7.93743
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 7.84713
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR2C, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 7.79062
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPER1, HSD11B2, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 7.71791
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.68765
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.59813
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.18282
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 7.1741
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 7.01422
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.90046
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, XDH 6.66552
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AXL, EGFR, ERBB2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, TEK 6.50864
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AXL, EGFR, ERBB2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, TEK 6.50864
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.39234
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, TYR 6.37342
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.22892
[MF] GO:0019899 enzyme binding ADRA2A, ADRB1, ADRB2, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PTPN1, SMAD3, SRC, TEK, THRB, TNKS2, TOP2A 6.12004
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC, TBXAS1 5.37111
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HMGCR, HSD11B2, HSD17B1, SRC, TBXAS1, XDH 5.21486
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.17409
[MF] GO:0051379 None ADRA2A, ADRA2C, ADRB1, ADRB2 5.12521
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 5.12521
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC, TBXAS1 5.12521
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, ERBB2, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1, TOP2A 5.06505
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR 4.9139
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AOX1, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SHBG, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, XDH 4.89534
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 4.77957
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, TYR 4.76079
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ADRB2, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, THRA 4.64835
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, ADRB2, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, THRA 4.5818
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.57385
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.50446
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.42633
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.36787
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.05179
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADRA2A, ADRA2C, ADRB2, AOX1, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PGR, SMAD3, TOP2A, TYR, XDH 4.01718
[MF] GO:0004935 None ADRA2A, ADRA2C, ADRB1, ADRB2 3.93208
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.89355
[MF] GO:0051380 None ADRA2A, ADRB1, ADRB2 3.89355
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PPARA, PTPN1, SMAD3 3.66497
[MF] GO:1901338 None ADRA2A, ADRA2C, ADRB1, ADRB2 3.57484
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.52154
[MF] GO:0004887 None NR1H4, THRA, THRB 3.43378
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR1H4, NUAK1, PIM1, SLC1A1, SRC, TEK, TOP1, TOP2A, XDH 3.27751
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, ADRB2, AOX1, AR, AXL, BCL2, DAO, EGFR, ERBB2, FLT3, HMGCR, SMAD3, TOP2A, TYR, XDH 3.18787
[MF] GO:0043565 None APEX1, AR, BCL2, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB, TOP1 3.16394
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.10096
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.09992
[MF] GO:0008227 None ADRA2A, ADRA2C, ADRB1, ADRB2, HTR2C 3.07272
[MF] GO:0001540 amyloid-beta binding ACHE, ADRB2, BACE1, GRIA2, INSR 2.97902
[MF] GO:1901363 heterocyclic compound binding ABCG2, ADORA1, AOX1, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, XDH 2.83692
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR2C 2.82589
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.799
[MF] GO:0003845 None HSD11B1, HSD11B2 2.799
[MF] GO:0008389 None CYP2A13, CYP2A6 2.799
[MF] GO:0003690 None APEX1, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.74842
[MF] GO:0003674 molecular_function ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SHBG, SLC1A1, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.66317
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 2.65918
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, SMAD3 2.59489
[MF] GO:0000981 None AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, THRB 2.57009
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRA2A, ADRA2C, ADRB1, AXL, BCL2, EGFR, ERBB2, SMAD3, TOP2A, TYR 2.45826
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 2.45826
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, NR1H4, PIM1, PPARA, SMAD3, SRC, THRA 2.4448
[MF] GO:0043168 anion binding ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR1H4, NUAK1, PIM1, SLC1A1, SRC, TEK, TOP1, TOP2A, XDH 2.39578
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.39578
[MF] GO:0004938 None ADRA2A, ADRA2C 2.39578
[MF] GO:0004939 None ADRB1, ADRB2 2.39578
[MF] GO:0099583 None GRM1, GRM5 2.39578
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.3782
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.37139
[MF] GO:0000166 nucleotide binding ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.35927
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.35729
[MF] GO:0000976 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.32601
[MF] GO:0031690 None ADRA2A, ADRA2C, ADRB1 2.28428
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.22038
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.22038
[MF] GO:0044212 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.17657
[MF] GO:0001067 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.17297
[MF] GO:1990837 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.14402
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.14402
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.14402
[MF] GO:0004971 None GRIA2, GRIA4 2.14402
[MF] GO:0032795 None ADORA1, ADRA2A 2.14402
[MF] GO:0005497 None AR, SHBG 2.14402
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.14402
[MF] GO:0005102 receptor binding ADORA1, ADRA2A, ADRA2C, ADRB1, AR, DAO, EGFR, ERBB2, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NR1H4, PTPN1, SMAD3, SRC 2.13198
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.07397
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1 2.01858
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.00412


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, THRB, THRA, GPR35, GRIK5, HTR2C, ADRB1, ADRB2, NR3C1, ADRA2C, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 12.1743
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 10.6868
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.1197
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2342
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.2342
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.2167
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 6.7378
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 5.8687
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, SMAD3, FLT3, MMP1, MMP2, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 4.8283
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.7321
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.8283
Metabolic pathways_Homo sapiens_hsa01100 HSD17B3, AKR1B1, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.8283
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4263
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C, ADRB2, ADRA2C, ADRA2A 4.5538
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, HTR2C, ADRB1, CACNA1C, ADRB2, GRM1, EGFR 4.3398
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, ADRB2, MET, EGFR, IGF1R, HSPA1A 4.1278
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2C, ADRB1, GRM1, EGFR 4.1998
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.7418
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, BCL2, TEK, EGFR, IGF1R 3.8761
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1, ADRB2 4.0327
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, ADRB1, CACNA1C, ADRB2, PPARA, GRIA4 3.2743
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.2506
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.7572
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.1799
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.2043
Prostate cancer_Homo sapiens_hsa05215 AR, ERBB2, BCL2, EGFR, IGF1R 3.2075
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.0081
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4, HMGCR, CYP3A4, ABCG2 3.6096
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 2.7222
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.0081
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.4214
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, ERBB2, EGFR 2.7222
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 2.4054
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.5669
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3465
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 2.7222
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C, ADRB2 2.7452
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 2.7201
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.6588
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 2.6949
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.3156
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.6949
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, THRA, SRC, ESR1 1.9314
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C, ADRB2 1.6511
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, CDC25B, HSPA1A 1.523
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.4167
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.8072
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.523
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7104
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8173
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 1.9547
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.4167
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 1.7786
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.439
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.8877
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.2999
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.3142
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.7688
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, HTR2C, CACNA1C 1.296
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.2432
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.2305
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.2212
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.2212
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.2212
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.1487
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.1906
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1162
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1317
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0373
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.0373
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1963
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2021
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2128
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.0373
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2019
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2128
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2463
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2695
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.28
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.8505
Axon guidance_Homo sapiens_hsa04360 MET 0.2937
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3087
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.4317
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.4462
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.3087
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5441
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3311
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, CACNA1C 0.5441
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.5936
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6386
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6386
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5242
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7029
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3467
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6313
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.658
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7109
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3536
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR, NR3C2 2.3703
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3536
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3536
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.363
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3623
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.3748
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3777
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.1906
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 0.9097
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2C 0.8368
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8554
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.388
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3766
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3757
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRB2 0.8752
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8554
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.3868
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8752
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.8791
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.8752
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.3948
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.8918
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 0.9893
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9431
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 0.9097
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.3892
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4052
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4067
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4178
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9382
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4317
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4178
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4317
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4438
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.095
Shigellosis_Homo sapiens_hsa05131 SRC 0.4462
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1331
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0601
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.0923
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.4881
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.1902
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1162
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.0923
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.502
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.2212
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.1946
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.2212
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.5315
Malaria_Homo sapiens_hsa05144 MET 0.536
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5441
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.3252
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5406
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5441
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.5574
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.523
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.5293
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.5911
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6313
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5911
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.4761
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4056
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6598
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7029
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6423
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6792
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7104
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.708
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6692
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7029
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.7886
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7683
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8554
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8428
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9052
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1807


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)