TCM Prescription: Qiang Shen Wine



Prescription Description
Prescription IDTCMF4962
Pinyin NameQiang Shen Jiu
Chinese Name强身酒
English NameQiang Shen Wine
Function Description解㑊
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH2185 Acanthopanax gracilistylus 五加皮 TCMH2185
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 15.3609
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, MPO, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 15.3609
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, MPO, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 15.3609
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MPO, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 15.3609
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.9058
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.9058
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.5482
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.3695
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.1784
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.037
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FLT3, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 10.8846
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 10.5249
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TRPV1 10.4867
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.4265
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.2524
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC, TERT, TRPV1 10.1408
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.0363
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 9.7485
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.69656
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.53416
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE, PTGS2, SLC6A4 9.46747
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE, PTGS2, SLC6A4 9.46747
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SMAD3, TRPV1 9.46747
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 9.45302
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.44912
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.41988
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 9.41988
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TEK, TRPV1 9.41988
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 9.38503
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SMAD3, SRC, TRPV1 9.31529
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, GRM1, HSPA1A, HTR6, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.21863
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, GRM1, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.08433
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.94785
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.86774
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.86774
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.86774
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, KCNH2, KDR, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 8.54475
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, IDO1, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 8.48469
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.45777
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, DRD5, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1 8.36735
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 8.29472
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A, TRPV1 8.26864
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1 8.21997
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.18964
[BP] GO:0015872 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 8.16394
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.16394
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.16394
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 8.03232
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, IDO1, MPO, PRKCE, PTGS2, RORC, SLC6A4, SRC, TYR 7.97728
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.82756
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, PRKCD, PRKCE, SLC6A4, SRC 7.80955
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 7.73949
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.72479
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HSPA1A, MMP2, MPO, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 7.58522
[BP] GO:0051937 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.5429
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.5181
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 7.49479
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.38729
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.34629
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 7.33653
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, IDO1, MPO, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 7.28318
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.27271
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM2, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8 7.16529
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.16529
[BP] GO:0007187 None ADORA1, ADRA2A, CHRM2, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8, HTR6 7.15153
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 7.14633
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.14361
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.14361
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.13385
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.08891
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.08891
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 7.06102
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 7.06061
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC, TERT 7.04749
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.94539
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.94075
[BP] GO:0007268 None CHRM2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PRKCG, SLC1A1, SLC6A2 6.94075
[BP] GO:0098916 None CHRM2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PRKCG, SLC1A1, SLC6A2 6.94075
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 6.94075
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 6.92574
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 6.90057
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 6.90057
[BP] GO:0099536 None CHRM2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PRKCG, SLC1A1, SLC6A2 6.83185
[BP] GO:0099537 None CHRM2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PRKCG, SLC1A1, SLC6A2 6.83185
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.83185
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, HSD11B1, HSD17B1, HSD17B2 6.83185
[BP] GO:0007188 None ADORA1, ADRA2A, CHRM2, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8 6.83185
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CHRM2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HSPA1A, IDO1, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.83185
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.82158
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.7528
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TRPV1 6.73726
[BP] GO:0015844 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.71545
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, KCNH2, MMP12, PRKCD, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TERT, TRPV1 6.62636
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 6.6207
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.61674
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.58354
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT 6.58354
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.55564
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 6.54916
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 6.51825
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD11B1, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 6.50131
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 6.47608
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.45446
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.4494
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 6.41519
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 6.38706
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, IDO1, MPO 6.30516
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.26679
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.26679
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, DRD1, DRD5, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TRPV1 6.23191
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KCNH2, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 6.22488
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC6A2, SLC6A4, TRPV1 6.21675
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.21339
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, PRKCG, RORC, SLC6A4, SRC, TOP2A 6.19703
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 6.19116
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, GPR35, KCNH2, MMP9, PRKCE, PTGS2 6.17303
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 6.15024
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.11658
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.06244
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, IDO1, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 6.06146
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, IDO1, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 6.0512
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM2, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PRKCG, PTGS2, SLC1A1, SLC6A2, TEK, TRPV1 6.05113
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.04225
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.02414
[BP] GO:0015893 None CA2, DRD1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 6.00333
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.99617
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, IDO1, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 5.97882
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.96501
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 5.93507
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 5.91303
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.89876
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.81001
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, PRKCA, PRKCE, SLC6A4, SRC, TERT 5.80385
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.77467
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 5.70701
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.70701
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, KDR, PRKCE, SRC, TRPV1 5.69037
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.67181
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2, SLC6A4 5.67181
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, CHRM2, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, KCNH2, PRKCA, PTGS2, SLC1A1, SMAD3, TRPV1 5.66654
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 5.61736
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 5.5301
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.52702
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.52671
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 5.50151
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.46283
[BP] GO:0007610 None BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, IDO1, INSR, PPARA, PRKCE, PRKCG, PTGS2, SLC6A4, TRPV1 5.4459
[BP] GO:0023052 None ADORA1, CHRM2, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, KCNH2, PRKCG, SLC1A1, SLC6A2, TEK 5.41694
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CES1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 5.41352
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 5.40204
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.40197
[BP] GO:0055065 metal ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.40197
[BP] GO:0001775 cell activation ADRA2A, ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, MPO, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 5.39907
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.39156
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.38252
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRM1, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.36141
[BP] GO:0007267 None ADORA1, CHRM2, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PRKCG, SLC1A1, SLC6A2, TEK 5.35773
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, MPO, PRKCD, PTGS1, PTGS2, SRC 5.35657
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, DRD2, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 5.26057
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5, PTGS2, SLC6A4 5.25226
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, DRD5, ESRRB, GRM3, GRM8, INSR, PPARA, PRKCA 5.23446
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, PRKCA 5.21596
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, BCL2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.2005
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.19784
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.17063
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.16314
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.16198
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 5.13016
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 5.12841
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, DRD5, ESRRB, GRM3, GRM8, INSR, PPARA, PRKCA 5.12507
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.11761
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.07807
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.07128
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, DRD2, EGFR, FLT3, GRM1, INSR, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 5.00831
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.00788
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.99159
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.97429
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA, PRKCA 4.97429
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA, PRKCA 4.93375
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.92632
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PRKCA 4.91217
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.89354
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, DRD5, GRM3, PRKCA 4.8596
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 4.83224
[BP] GO:0003018 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, PTGS2, SLC6A4, SRC, TEK 4.83224
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, GRM5, KCNH2, MMP9, PRKCD, PRKCE, PTGS2, SLC6A4 4.82821
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.82059
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PRKCA 4.81392
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 4.72988
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.72279
[BP] GO:0030814 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, PRKCA 4.71538
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PRKCA 4.70954
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.67919
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.6668
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PRKCA 4.66542
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PRKCA 4.66542
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, INSR, PRKCG, PTGS2, SLC6A4 4.66329
[BP] GO:0030802 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, PRKCA 4.64747
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.63326
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PRKCA 4.62053
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, IDO1, PPARA, PTGS1, PTGS2 4.60874
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, PRKCE, PTGS2 4.59857
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 4.59632
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9, PRKCE 4.56689
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.55532
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.55224
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 4.55224
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, PRKCD, PRKCE 4.53201
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA, PRKCB, PRKCD 4.51551
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.50508
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 4.49231
[BP] GO:0015696 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.49231
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, PIK3CB, PTGS2 4.49231
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.49231
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.46942
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.46942
[BP] GO:0007200 None ADRA2A, CHRM2, DRD1, DRD2, DRD5, ESR1, GRM5 4.45094
[BP] GO:1900371 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, PRKCA 4.41485
[BP] GO:0030808 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, PRKCA 4.39079
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 4.37407
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.35947
[BP] GO:0007611 None DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, INSR, PRKCG, PTGS2, SLC6A4 4.35354
[BP] GO:0015874 None SLC22A1, SLC22A2, SLC6A2 4.32806
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.32806
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.32528
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 4.31332
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 4.29175
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.29066
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 4.27245
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 4.26776
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, GRM3, PRKCA 4.25565
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2, PRKCE 4.25565
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9, PRKCE 4.25187
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.24575
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.24442
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.23881
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.21206
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 4.20598
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.1882
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TERT, TOP2A 4.17792
[BP] GO:0031279 None ADRA2A, DRD2, DRD3, DRD5, GRM3, PRKCA 4.17686
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CB, SRC, XDH 4.15257
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PRKCG, RORC, TOP2A 4.14915
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, PRKCA 4.1486
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.1459
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, GRM3, PRKCA 4.1459
[BP] GO:0051339 None ADRA2A, DRD2, DRD3, DRD5, GRM3, PRKCA 4.1459
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MMP12, PRKCE, SLC6A4, SRC, TRPV1 4.1459
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, DRD2, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 4.14323
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, INSR, KCNH2, PIK3CA, PRKCG, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 4.14174
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.14162
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.13926
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 4.13812
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA, TERT 4.11663
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 4.10915
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9, PRKCE 4.10915
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.09809
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.09809
[BP] GO:0006855 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.08004
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR, MPO 4.05902
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, GRM3, PRKCA 4.04173
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.02094
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, PPARA, PTGS1, PTGS2, SMAD3 4.02094
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3, PRKCE 3.98453
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, PRKCG, SMAD3 3.98432
[BP] GO:0042391 None ADORA1, BCL2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 3.96575
[BP] GO:0003013 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, PTGS2, SLC6A4, SRC, TEK 3.96472
[BP] GO:0001504 None SLC1A1, SLC22A3, SLC6A2, SLC6A4 3.93076
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.93061
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 3.92232
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.91766
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.9086
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.9086
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.87542
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3, SLC6A4 3.83248
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, TYR 3.82396
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 3.82023
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TOP2A 3.80553
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 3.79369
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.79197
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.77982
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.77982
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.77678
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.76023
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.73943
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 3.73655
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.73557
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, GPR35, MMP9, PRKCE 3.71669
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.68839
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.68529
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, PIK3CA, TRPV1 3.6797
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.65557
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.63588
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, TYR 3.62748
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, PRKCD, SMAD3, TEK 3.62279
[BP] GO:0050730 None ADORA1, ADRA2A, EGFR, FLT3, GRM5, PRKCD, PRKCE, PTPN1, SRC 3.58882
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, CA2, CHRM2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, INSR, PIK3CA, PIK3CB, SRC 3.58804
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.58804
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 3.55901
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.55901
[BP] GO:0097746 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, PTGS2, SLC6A4 3.55767
[BP] GO:0035296 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, PTGS2, SLC6A4 3.55767
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.5357
[BP] GO:0051172 None ADRA2A, APEX1, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.53041
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.52283
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 3.51699
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, GPR35, MMP9, PRKCE 3.49403
[BP] GO:0032409 None ADRA2A, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCD, PRKCE 3.44337
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GLO1, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.43552
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.43552
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, DRD2, DRD3, EGFR, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.40736
[BP] GO:0050880 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, PTGS2, SLC6A4 3.39515
[BP] GO:0035150 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, PTGS2, SLC6A4 3.37578
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.37122
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.37122
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.36887
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD5, PRKCE, PRKCG 3.36076
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.34474
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.34474
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 3.33939
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.33657
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2, TERT 3.32989
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.32957
[BP] GO:0010676 None ESRRB, INSR, PPARA, PRKCE, SRC 3.32957
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, GRM5, INSR, PTGS2 3.32619
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, MMP12, PRKCA, PRKCE, SLC6A4, SRC, TRPV1 3.31876
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SLC6A4, SRC 3.30085
[BP] GO:0043279 None DRD2, DRD3, DRD5, PRKCE, PRKCG, TRPV1 3.28939
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, ESRRB, HSD17B2, IDO1, INSR, MMP2, MMP9, PTGS2, SLC6A4, SRC, TOP2A 3.28865
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.27865
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, IDO1, PRKCG, SLC6A2 3.25756
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.24684
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR 3.24034
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 3.21681
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 3.19756
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.1956
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, PRKCE, SRC, TRPV1 3.18286
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 3.18286
[BP] GO:0072347 None DRD2, DRD3, DRD5, PRKCE, PRKCG 3.15564
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.15564
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR, PRKCE, PRKCG 3.14762
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.14495
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, GPR35, HSPA1A, KCNH2, MMP9, PRKCB, PRKCE, PTGS2 3.13277
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 3.11886
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 3.11132
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT 3.08991
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 3.07743
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, PRKCE, TERT 3.06564
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, MMP12, PRKCA, PRKCE, SLC6A4, SRC 3.05955
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.05845
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.05845
[BP] GO:0045936 None ADRA2A, DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 3.05533
[BP] GO:0010563 None ADRA2A, DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 3.04863
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.02688
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.02688
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.02688
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 3.02469
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.02303
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, APEX1, BCL2, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.02258
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.01993
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, PRKCD, SMAD3, TEK 3.0172
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, IDO1, KDR, MET, PRKCA, PTGS2, SMAD3 3.0172
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 3.01278
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.99241
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 2.99222
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, GPR35, KCNH2, PRKCE, PTGS2 2.98219
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 2.97536
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 2.97536
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.97184
[BP] GO:0050877 None ADORA1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, INSR, PRKCG, PTGS2, SLC6A4, TRPV1, TYR 2.96883
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.95758
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, PRKCE, SMAD3, TRPV1 2.9567
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, CHRM2, DRD2, EGFR, KCNH2, PTGS2, SLC1A1 2.9567
[BP] GO:0034762 None ADRA2A, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, GRM5, KCNH2, MMP9, PRKCE 2.93955
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.92945
[BP] GO:0043278 None DRD2, DRD3, PRKCE, PRKCG 2.92945
[BP] GO:0014072 None DRD2, DRD3, PRKCE, PRKCG 2.92945
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.92193
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, DRD2, GPR35, PTGS2 2.91779
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 2.90455
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.89292
[BP] GO:0046960 None DRD1, DRD5 2.88613
[BP] GO:0035408 None PRKCA, PRKCB 2.88613
[BP] GO:0009115 None AOX1, XDH 2.88613
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.88608
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.86268
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.84395
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, EGFR, HCAR2, MMP12, PRKCA, PRKCE, SRC 2.84171
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.84171
[BP] GO:0022898 None ADRA2A, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCE 2.83978
[BP] GO:0045913 None ESRRB, INSR, PPARA, PRKCE, SRC 2.8385
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.8385
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.83845
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.83125
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 2.81963
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2C19, CYP2D6, MPO 2.8147
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.8147
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 2.8147
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.8147
[BP] GO:0070201 None ACHE, ADRA2A, BCL2, DRD2, DRD3, EGFR, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.81356
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MPO, PRKCD, PTGS2, TERT 2.81038
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PRKCD, SMAD3, TEK 2.79603
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, IDO1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.79221
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, MPO, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.77574
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, KDR 2.76179
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.76162
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.75036
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.75036
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.75036
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.75036
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 2.7388
[BP] GO:0007189 None ADRA2A, DRD1, DRD2, DRD3, DRD5 2.7388
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.7388
[BP] GO:0007190 None ADORA3, DRD1, DRD5, PRKCA 2.71664
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 2.71664
[BP] GO:0010675 None ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.68636
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, MPO, PIK3CA, PIM1, SLC6A4, SMAD3 2.68542
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.68439
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 2.6743
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.6743
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 2.66902
[BP] GO:0007626 None DRD1, DRD2, DRD3, GRM1, GRM5, IDO1, PRKCE 2.66664
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66154
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.66154
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3 2.63958
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.63895
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.63895
[BP] GO:0097756 None ADORA1, DRD5, PTGS2, SLC6A4 2.63895
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 2.62914
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.61448
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.60448
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.59183
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.57439
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.57038
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, PPARA, PRKCA, RORC, SMAD3, SRC, TERT, TRPV1 2.55437
[BP] GO:0015850 None DRD1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 2.55317
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 2.54993
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, PRKCE, SRC 2.54763
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 2.53849
[BP] GO:0046683 response to organophosphorus APEX1, PTGS2, SLC6A4, TEK, TRPV1, TYR 2.53849
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.53812
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT, XDH 2.5287
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.52647
[BP] GO:0060341 regulation of cellular localization ADRA2A, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, GRIK5, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 2.52004
[BP] GO:0051223 None ACHE, ADRA2A, DRD2, DRD3, EGFR, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.51152
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.51141
[BP] GO:0043086 negative regulation of catalytic activity ADRA2A, CSNK2A1, DRD2, DRD3, DRD5, DUSP3, FABP4, GRM3, IGF1R, MMP9, PRKCA, PRKCD, PTGS2, PTPN1, SRC 2.51141
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.50881
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PRKCD 2.50881
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.50881
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.50881
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.50881
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.50881
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50881
[BP] GO:0070920 None EGFR, ESR1, TERT 2.50881
[BP] GO:0006836 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 2.4982
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.4982
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.4982
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.4982
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, SLC6A4, TRPV1, TYR 2.49698
[BP] GO:0099566 None GRM1, GRM5 2.49555
[BP] GO:0046110 None AOX1, XDH 2.49555
[BP] GO:0060160 None DRD2, DRD3 2.49555
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49555
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.49555
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC 2.49383
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CYP19A1, DRD2, EGFR, HCAR2, PRKCA, PRKCE 2.48322
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.47484
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 2.46609
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC, SLC6A4 2.45963
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.45404
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.45404
[BP] GO:0050708 None ACHE, ADRA2A, DRD2, DRD3, EGFR, HCAR2, MMP12, PRKCA, PRKCE, SRC 2.44873
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.44785
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, EGFR, ESR1, FLT3, INSR, PRKCD, PRKCE, SRC 2.44339
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.44003
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, IDO1, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.42428
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, DRD2, EGFR, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.42428
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, SLC22A2, SLC6A4 2.40521
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, MPO, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.38421
[BP] GO:0050776 regulation of immune response BCL2, DRD2, DUSP3, ESR1, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.37665
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 2.37531
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 2.37531
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 2.3731
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, PRKCE 2.35479
[BP] GO:0061041 regulation of wound healing ADRA2A, F3, PRKCA, PRKCD, PRKCE, SMAD3 2.35479
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, SLC6A4 2.35055
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.35055
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.347
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PRKCE, TERT 2.33884
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, MMP12, PRKCE, SLC6A4, SRC 2.33562
[BP] GO:0019933 None ADRA2A, DRD1, DRD2, DRD3, DRD5 2.33145
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GRM5, IGF1R, INSR, PRKCD, SRC 2.32877
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, IDO1, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT 2.32809
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.31762
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31762
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK 2.31762
[BP] GO:0014074 response to purine-containing compound APEX1, PTGS2, SLC6A4, TEK, TRPV1, TYR 2.3166
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.31555
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.30411
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.29796
[BP] GO:0006810 None ACHE, ADORA1, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, MPO, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TRPV1, XDH 2.29722
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.28842
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 2.27678
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC 2.27678
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.2599
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.2599
[BP] GO:1904062 None ADRA2A, DRD1, DRD2, DRD3, GPR35, KCNH2, MMP9, PRKCE 2.2599
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, DRD3, EGFR, IDO1, MMP12, MPO, PRKCD, PTGS2, SLC6A4, SMAD3, SRC, TRPV1, TYR 2.2599
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, MMP9, MPO, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 2.24416
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.24416
[BP] GO:1901374 None SLC22A1, SLC22A2 2.24416
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.24416
[BP] GO:0006145 None AOX1, XDH 2.24416
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24416
[BP] GO:0090066 None ADORA1, ADRA2A, DRD1, DRD5, EGFR, PRKCD, PRKCE, PTGS2, SLC6A4 2.24416
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 2.21598
[BP] GO:2000026 regulation of multicellular organismal development AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, IDO1, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.21122
[BP] GO:0048167 None ADORA1, DRD1, DRD2, DRD5, GRM5, PTGS2 2.2112
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, KCNH2 2.20958
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.20958
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.20958
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.20958
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 2.19988
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH 2.19523
[BP] GO:0032412 None ADRA2A, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCE 2.18697
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.18662
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.17867
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.17867
[BP] GO:0045765 regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 2.17863
[BP] GO:0019935 None ADRA2A, DRD1, DRD2, DRD3, DRD5 2.17521
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.16059
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.15924
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.15924
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.15924
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.15924
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.15924
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15924
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.15924
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.15924
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 2.15901
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.15602
[BP] GO:0051924 regulation of calcium ion transport ADRA2A, BCL2, DRD1, DRD2, GPR35, PRKCE, PTGS2 2.15047
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.1431
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.13998
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.12879
[BP] GO:0071456 cellular response to hypoxia BCL2, PRKCE, PTGS2, SRC, TERT 2.10783
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.10783
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.10783
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.10783
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.10783
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.10338
[BP] GO:0007613 None DRD1, DRD2, INSR, PTGS2, SLC6A4 2.09159
[BP] GO:0051222 positive regulation of protein transport ACHE, DRD2, EGFR, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.07544
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.07432
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, MMP12, PRKCE, SRC 2.06227
[BP] GO:0051894 None KDR, SMAD3, TEK 2.06227
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, DRD2, HSPA1A, IDO1, MMP12, PTGS2, SMAD3, SRC 2.06227
[BP] GO:0031331 positive regulation of cellular catabolic process ADRA2A, ESRRB, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PTPN1 2.06227
[BP] GO:0021853 None DRD1, DRD2 2.06227
[BP] GO:0010641 None F3, SRC 2.06227
[BP] GO:0046618 None SLC47A1, SLC47A2 2.06227
[BP] GO:1904936 None DRD1, DRD2 2.06227
[BP] GO:0042321 None ADORA1, DRD2 2.06227
[BP] GO:0090325 None DRD2, DRD3 2.06227
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.05775
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.05595
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CES1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.0558
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.05201
[BP] GO:1903034 regulation of response to wounding ADRA2A, F3, PRKCA, PRKCD, PRKCE, SMAD3 2.04566
[BP] GO:0043270 None ADORA1, ADRA2A, DRD1, DRD2, KCNH2, PRKCD, SLC6A4 2.03618
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, APEX1, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GRM3, GRM8, HSPA1A, IGF1R, INSR, MET, MMP12, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 2.02527
[BP] GO:0050927 None F3, KDR, SMAD3 2.01553
[BP] GO:0002684 positive regulation of immune system process AXL, BCL2, CA2, HCAR2, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SRC 2.00344
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 10.6572
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, CHRM2, DRD1, DRD2, DRD5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TEK, TRPV1 8.45777
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, CHRM2, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TEK, TRPV1 8.16394
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, AXL, CA2, CA4, CA9, CHRM2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, INSR, KCNH2, KDR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SRC, TEK, TRPV1 7.57947
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TEK, TRPV1 7.33021
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 7.20186
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TEK, TRPV1, TYR 5.61736
[CC] GO:0044456 None ACHE, ADORA1, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SLC6A4, SRC, TRPV1 4.16788
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GRIK5, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.77678
[CC] GO:0097060 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 3.68291
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CHRM2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR6, PIK3CA, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.64621
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 3.50904
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM2, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR6, PIK3CA, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.49914
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, SLC22A1, TEK 3.38556
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 3.21505
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 3.21505
[CC] GO:0097458 None ADORA1, CA2, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IDO1, INSR, PRKCG, PTGS1, PTGS2, SLC22A2, SLC6A2, SLC6A4, SRC, TRPV1 3.10726
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.00044
[CC] GO:0043005 None ADORA1, CA2, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC 2.97005
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, KCNH2, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR 2.72987
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC, TRPV1 2.66983
[CC] GO:0043235 receptor complex ADRA2A, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.60774
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KCNH2, KDR, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TOP2A, TRPV1, TYR, XDH 2.55188
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA9, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.45556
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.41769
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM2, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.2492
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM2, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.2492
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, EGFR, FLT3, GRIA2, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.23343
[CC] GO:0045121 membrane raft EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.21081
[CC] GO:0098857 membrane microdomain EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.19523
[CC] GO:0098793 None ADORA1, CHRM2, DRD2, GRIK5, SLC22A2, SLC6A4 2.06227
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TYR, XDH 13.4538
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 11.5482
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK, TRPV1 11.3573
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC6A4, SRC, TEK, TOP2A, TRPV1 10.8297
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 10.2919
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK, TRPV1 10.0969
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK, TRPV1 9.74541
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TOP2A, TYR, XDH 9.59201
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.41988
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 9.31529
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR6 8.20904
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 8.06471
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD11B1, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 7.89175
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 7.82756
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK, TRPV1 7.72228
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK, TRPV1 7.72228
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.58649
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, IDO1, MPO, PTGS1, PTGS2, SRC 7.57603
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, IDO1, MPO, PTGS1, PTGS2, SRC 7.27271
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.18851
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 7.09336
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.96428
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.73395
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.60403
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.51239
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.14263
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD17B1, IDO1, MPO, NQO2, PTGS1, PTGS2, SRC, XDH 6.04533
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.02992
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.87251
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.67181
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT 5.66654
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.66654
[MF] GO:0015238 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 5.3478
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.26522
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3, DRD5 5.19784
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 4.92632
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.90727
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.8596
[MF] GO:0005333 None SLC22A1, SLC22A2, SLC6A2 4.84109
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 4.83224
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, XDH 4.72378
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.66542
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.66542
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.66329
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, GRIK5, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC22A1, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 4.53574
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.50255
[MF] GO:0008519 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.37738
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.36403
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.32806
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.29066
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.24913
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 4.22796
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 4.1967
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.11086
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.07984
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ALDH2, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.06646
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5, SLC6A4 3.77678
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HSPA1A, KCNH2, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TOP2A 3.75512
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.74587
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.64509
[MF] GO:0000166 nucleotide binding ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 3.61628
[MF] GO:1901265 nucleoside phosphate binding ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 3.61346
[MF] GO:1901618 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 3.60291
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.59696
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.55767
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, DRD2, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.52432
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.43607
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.40989
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.32619
[MF] GO:0005326 None SLC1A1, SLC22A1, SLC22A2, SLC6A2, SLC6A4 3.25756
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 3.19707
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.1956
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.1956
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.9458
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 2.91779
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.88613
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.88613
[MF] GO:0035403 None PRKCA, PRKCB 2.88613
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.84171
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6 2.83978
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.83845
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, DRD2, EGFR, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.77987
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.74773
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.65242
[MF] GO:0008324 None GRIA2, GRIA4, GRIK5, KCNH2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, TRPV1 2.63989
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F3, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.63989
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.58318
[MF] GO:0004930 None ADORA1, ADORA3, ADRA2A, CHRM2, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6 2.57551
[MF] GO:1901363 heterocyclic compound binding ADORA1, ALDH2, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.5319
[MF] GO:0015307 None SLC47A1, SLC47A2 2.49555
[MF] GO:1901375 None SLC22A1, SLC22A2 2.49555
[MF] GO:0005330 None SLC6A2, SLC6A4 2.49555
[MF] GO:0005277 None SLC22A1, SLC22A2 2.49555
[MF] GO:0099583 None GRM1, GRM5 2.49555
[MF] GO:0008513 None SLC22A1, SLC22A2 2.49555
[MF] GO:0004699 None PRKCD, PRKCE 2.49555
[MF] GO:0047374 None CES1, CES2 2.49555
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.44785
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.39024
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.39024
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.34166
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.31762
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.31762
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.3166
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.29147
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.28537
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.2599
[MF] GO:0001588 None DRD1, DRD5 2.24416
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24416
[MF] GO:0004971 None GRIA2, GRIA4 2.24416
[MF] GO:0032795 None ADORA1, ADRA2A 2.24416
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.1431
[MF] GO:0008227 None ADRA2A, CHRM2, DRD2, HTR6 2.10338
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.08841
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.06227
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, PPARA, RORC, TRPV1 2.06227
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06227
[MF] GO:0043559 insulin binding IGF1R, INSR 2.06227


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, GPR35, GRIK5, TRPV1, GRM1, ADRA2A, GRM3, HTR6, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, DRD5, GRIA4 12.0634
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 9.7537
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.7537
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 9.7537
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 9.2497
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 8.9208
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, KDR, TEK, DRD2, MET 8.7688
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 9.8359
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 8.5157
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, HTR6, PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA, DRD5, GRIA4 8.0499
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, HTR6, PRKCB, CYP2D6, ALOX5, PRKCA, PTGS2, CYP2C19, PTGS1, SLC6A4 8.1982
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, BCL2, MET 7.5712
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 7.5712
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.8626
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, PRKCA, DRD1, DRD2, GRM1, EGFR 7.9073
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 7.4935
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 7.3017
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 7.0852
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3017
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 6.6623
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.9263
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, HTR6, GRM5, PRKCB, PRKCA, DRD1, GRM1, EGFR, DRD5 6.5931
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, PRKCA, DRD1, DRD2, DRD3, DRD5, GRIA4 6.7115
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.8526
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 6.4847
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, PTGS2, GRM1, GRIA4 6.4359
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.3742
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PRKCA, PIK3CB, GRM1, EGFR 6.4116
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 6.1842
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 6.2324
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.7637
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, INSR, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 5.1164
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 5.7178
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.5438
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 5.1051
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1, CES1 4.6889
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 5.6194
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.9314
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 6.4737
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.9314
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, PRKCA, DRD1, GRIA4 5.1989
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 5.4629
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 5.2266
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.6242
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.4359
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.517
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.5157
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, PIK3CB, ADRA2A 4.0314
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 4.7433
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.4934
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.0006
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9834
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA, DRD1 3.4621
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.3876
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.0408
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.1298
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.942
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9205
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.2591
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.2965
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.331
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.0006
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 2.9834
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.7747
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.8989
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1964
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2049
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2157
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.7027
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.7027
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.25
Phagosome_Homo sapiens_hsa04145 MPO 0.25
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.5164
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2859
Axon guidance_Homo sapiens_hsa04360 MET 0.2998
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3072
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.6966
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0034
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.3556
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.368
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.311
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5827
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3861
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5627
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5627
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.1281
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4046
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6914
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.2493
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4019
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4182
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4199
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4033
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 0.9101
Peroxisome_Homo sapiens_hsa04146 XDH 0.4199
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.4532
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB, EGFR 2.0392
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7326
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7615
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1563
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.5054
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.298
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.7047
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.1538
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.432
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.1724
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.1881
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4385
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.4305
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.5164
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8548
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.1329
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.8362
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.2781
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8655
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.4765
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.0419
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4701
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.5965
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.0239
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.761
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.9961
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.6286
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 2.9965
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.919
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.8928
Shigellosis_Homo sapiens_hsa05131 SRC 0.4917
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4949
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2043
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9654
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.0823
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4833
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1, CYP2C19 2.9462
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.5904
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9462
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, CYP2C19, PTGS1 3.0823
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5484
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5484
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5627
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.1178
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5635
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.7607
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.5683
Malaria_Homo sapiens_hsa05144 MET 0.5733
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1 1.136
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.8072
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.136
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.4908
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.4338
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 1.9743
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.9743
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.0365
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1916
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0566
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6091
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.9961
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.071
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0365
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.1724
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.311
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6931
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA, IDO1 3.9646
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3739
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7331
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7739
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7138
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4193
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.4639
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7331
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.751
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.4458
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7802
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7404
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5645
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7739
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7739
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.5645
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8097
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.7027
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7823
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6641
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7354
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.8072
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9813
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0172
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3502
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1308


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)