Prescription ID | TCMF493 |
Pinyin Name | Deng Zhan Sheng Mai Jiao Nang |
Chinese Name | 灯盏生脉胶囊 |
English Name | Deng Zhan Sheng Mai Capsule |
Function Description | 中风后遗症"中风后遗症, 症见痴呆, 健忘, 手足麻木症, 冠心病心绞痛, 缺血性心脑血管疾病, 高脂血症见上述证候者 |
Indications | Numbness disorder, Forgetfulness disorder, Dementia disorder, Stroke, Coronary heart disease, Angina pectoris, Hyperlipidemia |
Disease ICD-11 Category |
SC62 [Numbness disorder (TM1), 麻木 (TM1)
]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD86 [Dementia disorder (TM1), 痴呆 (TM1) ]; 8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ]; BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ]; BA40 [Angina pectoris, 心绞痛 ]; 5C80.Z [Hyperlipoproteinaemia, unspecified, 高脂蛋白血症,未特指的 ]; |
Human Tissues Associated with Indication | Brain, Heart |
Reference | Chinese pharmacopoeia (2015) |
Reference Book/link | ISBN 978-7-5067-7337-9 |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH440 | Erigeron breviscapus | 灯盏细辛 | TCMH440 | ITSAM3906-14 |
TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT283 | PTPRS | Receptor-type tyrosine-protein phosphatase S | Hydrolase | Q13332 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT508 | SYK | Tyrosine-protein kinase SYK | Kinase | P43405 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT848 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Kinase | O75460 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1189 | Pseudomonas fluorescens |
TCMT1208 | Escherichia coli K12 |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1250 | Vesicular stomatitis virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1292 | Japanese encephalitis virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1336 | Yellow fever virus |
TCMT1337 | Dengue virus type 4 |
TCMT1338 | Rift Valley fever virus |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 | 14.9113 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 9.45824 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 9.35948 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TRPV1, XDH | 8.42094 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 8.42094 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 8.36298 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 8.36298 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 7.91237 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 7.88907 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 7.6972 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 7.68319 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 7.52993 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 7.51145 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 7.50216 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 7.427 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH | 7.34191 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 7.06648 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 7.06259 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.80403 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.7825 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH | 6.68975 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.60612 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC | 6.59093 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 6.53706 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.53706 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 6.48756 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 | 6.41971 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 6.41971 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 6.39999 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, ALOX12, APP, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH | 6.16323 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TYR, XDH | 6.05005 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC | 5.63434 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 5.63434 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 5.45064 |
[BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, SRC, TYR | 5.41868 |
[BP] GO:0014070 | response to organic cyclic compound | APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1, TYR | 5.3886 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 5.33454 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 5.32449 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 | 5.24453 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, PTPRS, SRC, TYR | 5.20196 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 5.15048 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 5.05668 |
[BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 4.98764 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NQO2, PTGS1 | 4.94631 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 | 4.73929 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.73776 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.7145 |
[BP] GO:0046456 | icosanoid biosynthetic process | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 4.69773 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH | 4.69773 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 4.66276 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, XDH | 4.62463 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.60465 |
[BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 4.58616 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC | 4.56122 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, XDH | 4.5363 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.53305 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5, PTGS2 | 4.52998 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TRPV1, TYR | 4.45605 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TRPV1 | 4.45605 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 4.44693 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, SRC, TYR | 4.42678 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 4.42678 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR | 4.42678 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR | 4.2303 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 4.19695 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, SRC, TRPV1 | 4.1803 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 3.98809 |
[BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.97369 |
[BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.97369 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TRPV1, XDH | 3.86827 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TYR | 3.8674 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 3.85991 |
[BP] GO:0071407 | cellular response to organic cyclic compound | APP, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1 | 3.85766 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.85766 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.83444 |
[BP] GO:0009820 | alkaloid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.76441 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 | 3.7466 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 | 3.71548 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 3.71347 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.69015 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.67166 |
[BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 | 3.67097 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TRPV1, XDH | 3.64085 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 | 3.5966 |
[BP] GO:0006636 | unsaturated fatty acid biosynthetic process | ALOX12, ALOX15, PTGS1, PTGS2 | 3.57723 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.57721 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.55731 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 3.54814 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.53176 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.47416 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.47416 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, APP, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB, TRPV1 | 3.46184 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 3.4597 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.4597 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.4597 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, ALOX12, APP, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.4597 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.4597 |
[BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.38212 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 3.35687 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.35687 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.33679 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 3.33679 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ALOX15, APP, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.33115 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ALOX15, APP, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.2947 |
[BP] GO:0010038 | response to metal ion | ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 3.29185 |
[BP] GO:1901570 | None | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 3.2905 |
[BP] GO:0006954 | inflammatory response | ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 | 3.25363 |
[BP] GO:0044283 | None | AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 | 3.22763 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.21836 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 3.21836 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.17802 |
[BP] GO:0070989 | oxidative demethylation | CYP1A2, CYP2D6, CYP3A4 | 3.14351 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.1402 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC | 3.09408 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.06846 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, PTGS2, SRC, TRPV1 | 3.05871 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 | 3.05408 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 3.05408 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.05294 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.04096 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR | 3.03357 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.99051 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.96792 |
[BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.96792 |
[BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.96792 |
[BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.96792 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC | 2.96227 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.96052 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TRPV1 | 2.95179 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.91452 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, HCAR2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 | 2.90352 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.87286 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, ALOX12, CYP19A1, ESR1, FABP4, KDR, MET, MMP12, PPARA, PTGS2, PTPRS | 2.85204 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC | 2.83647 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, ALOX12, ALOX15, CYP19A1, ESR1, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH | 2.82269 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.82144 |
[BP] GO:0044236 | multicellular organism metabolic process | MMP1, MMP12, MMP2, MMP9, TRPV1 | 2.80022 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ALOX15, APP, FLT3, KDR, PIK3CB, PTPN1, SRC, XDH | 2.79995 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.78248 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.78117 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR | 2.77785 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.77785 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.76352 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.72648 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.71672 |
[BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, ESR1, HCAR2, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SRC | 2.7126 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, XDH | 2.70902 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, XDH | 2.70902 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.70902 |
[BP] GO:0046486 | glycerolipid metabolic process | ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB | 2.69509 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, FLT3, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.6708 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SRC, TRPV1 | 2.64465 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.63859 |
[BP] GO:0070988 | demethylation | CYP1A1, CYP1A2, CYP2D6, CYP3A4 | 2.59012 |
[BP] GO:0009822 | alkaloid catabolic process | CYP2D6, CYP3A4 | 2.59012 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.59012 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, PTGS2 | 2.58859 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, MET, MMP9, PPARA, SRC | 2.57441 |
[BP] GO:0030198 | extracellular matrix organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.56454 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC | 2.56274 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AURKB, CSNK2A1, CYP2D6, ESR1, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.56182 |
[BP] GO:0043062 | extracellular structure organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.56182 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, ALOX15, APP, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.557 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, CA2, CA7, KDR, SRC, TRPV1 | 2.55345 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.54385 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.54385 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC | 2.54385 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC, XDH | 2.52869 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ALOX15, APP, FLT3, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH | 2.51028 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ALOX15, APP, CDC25B, CSNK2A1, ESR1, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.49013 |
[BP] GO:0030335 | positive regulation of cell migration | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.47981 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.4719 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.46423 |
[BP] GO:0030100 | regulation of endocytosis | ALOX15, APP, AXL, PIK3CB, PTPN1, SRC | 2.45198 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.44227 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.38708 |
[BP] GO:2000147 | positive regulation of cell motility | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.3834 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 | 2.3834 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.35189 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.35189 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.35189 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC | 2.32281 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 2.31788 |
[BP] GO:0051272 | positive regulation of cellular component movement | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.31528 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.30447 |
[BP] GO:0044243 | multicellular organismal catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.29741 |
[BP] GO:0072330 | monocarboxylic acid biosynthetic process | ALOX12, ALOX15, CYP1A1, PTGS1, PTGS2 | 2.24429 |
[BP] GO:0030258 | lipid modification | ALOX12, CYP1A1, CYP3A4, MET, PIK3CA, PIK3CB | 2.23621 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, MMP2, MMP9, PTGS2 | 2.23595 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CYP1B1, ESR1, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TRPV1, XDH | 2.22799 |
[BP] GO:0040017 | positive regulation of locomotion | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.22355 |
[BP] GO:0008209 | androgen metabolic process | CYP19A1, CYP3A4, ESR1 | 2.22021 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TRPV1 | 2.21981 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 2.21898 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC | 2.2042 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, APP, AXL, CA2, CYP19A1, HCAR2, MMP12, PTGS2, SRC, TRPV1 | 2.19832 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ALOX15, APP, CDC25B, ESR1, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.19599 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ALOX12, APP, AXL, CA2, CYP1B1, HCAR2, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TRPV1 | 2.18933 |
[BP] GO:0022617 | extracellular matrix disassembly | MMP1, MMP12, MMP2, MMP9 | 2.18933 |
[BP] GO:0044248 | cellular catabolic process | ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, PIK3CB, SRC, XDH | 2.18754 |
[BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.17678 |
[BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.17678 |
[BP] GO:0032963 | collagen metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.15703 |
[BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 | 2.1458 |
[BP] GO:2000106 | regulation of leukocyte apoptotic process | AURKB, AXL, HCAR2, PIK3CB | 2.14121 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, ALOX15, APP, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.12578 |
[BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.12292 |
[BP] GO:0014065 | phosphatidylinositol 3-kinase signaling | IGF1R, PIK3CA, PIK3CB | 2.12265 |
[BP] GO:0006691 | None | ALOX12, ALOX15, ALOX5 | 2.12265 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, ESR1, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TYR, XDH | 2.11992 |
[BP] GO:0022900 | electron transport chain | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.10788 |
[BP] GO:0051047 | None | ACHE, ADORA1, CYP19A1, HCAR2, MMP12, SRC, TRPV1 | 2.09447 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 2.09447 |
[BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7 | 2.09039 |
[BP] GO:0006633 | None | ALOX12, ALOX15, PTGS1, PTGS2 | 2.08313 |
[BP] GO:0044259 | multicellular organismal macromolecule metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.08313 |
[BP] GO:0046394 | None | ALOX12, ALOX15, ALOX5, CYP1A1, PTGS1, PTGS2 | 2.08017 |
[BP] GO:0016053 | None | ALOX12, ALOX15, ALOX5, CYP1A1, PTGS1, PTGS2 | 2.07436 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.07436 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 2.04734 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 2.04734 |
[BP] GO:0033029 | regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.04607 |
[BP] GO:0002933 | lipid hydroxylation | CYP1A1, CYP3A4 | 2.04607 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, IGF1R, MMP2, PTGS2, SRC, TRPV1 | 2.02965 |
[BP] GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | CSNK2A1, MMP9, PTGS2, SRC | 2.02485 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 2.02412 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 3.38212 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR | 3.08001 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SRC, TRPV1 | 2.54385 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR | 2.36592 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 | 2.31346 |
[CC] GO:0097443 | sorting endosome | KDR, PTPN1 | 2.04607 |
[MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, TYR, XDH | 16.0258 |
[MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 11.7867 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TYR, XDH | 11.4949 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 10.5512 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 9.67681 |
[MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH | 7.52993 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 7.41204 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 7.10023 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 7.10023 |
[MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TRPV1, TYR, XDH | 6.87077 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 6.87077 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.8684 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR | 6.53706 |
[MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TRPV1, TYR, XDH | 6.51896 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.07304 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 5.85571 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TRPV1 | 5.77691 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1 | 5.65329 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 5.45064 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR | 5.42551 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.72932 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.71548 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.71548 |
[MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.68641 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.46814 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH | 3.38212 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2D6, CYP3A4 | 3.35687 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.30784 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, PIK3CA, PIK3CB | 3.24895 |
[MF] GO:0042562 | hormone binding | ACHE, HSD17B1, IGF1R, NQO2, NR3C1 | 3.17911 |
[MF] GO:0051213 | dioxygenase activity | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 3.07484 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.96792 |
[MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.96792 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.84943 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.80876 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.77785 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.77785 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC | 2.69648 |
[MF] GO:0008289 | lipid binding | ALOX15, AXL, CYP3A4, ESR1, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 | 2.67853 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 | 2.60607 |
[MF] GO:0050473 | arachidonate 15-lipoxygenase activity | ALOX15, PTGS2 | 2.59012 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.59012 |
[MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.59012 |
[MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.59012 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.57441 |
[MF] GO:0043168 | anion binding | ALOX15, APP, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TRPV1, XDH | 2.49357 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.35189 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.35189 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.25783 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC | 2.2042 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.18926 |
[MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.17678 |
[MF] GO:0036094 | small molecule binding | ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TRPV1, XDH | 2.1458 |
[MF] GO:0005158 | None | IGF1R, PTPN1, SRC | 2.12265 |
[MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.09039 |
[MF] GO:0005496 | steroid binding | CYP3A4, ESR1, HSD17B1, NR3C1 | 2.08313 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.05942 |
[MF] GO:0004064 | arylesterase activity | CA1, CA2 | 2.04607 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 10.1829 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 11.6743 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 9.8136 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R | 6.8499 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 | 6.5764 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 6.2691 |
Metabolic pathways_Homo sapiens_hsa01100 | ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH | 5.706 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 6.0185 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 | 5.3787 |
Pathways in cancer_Homo sapiens_hsa05200 | PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R | 4.8775 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 | 5.7716 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 5.0611 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 5.0611 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.7428 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 | 4.1977 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B | 3.8735 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.8589 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.7742 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.3513 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.8589 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET | 3.6415 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, IGF1R | 3.5815 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1 | 3.5761 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, PIM1, PIK3CB | 3.0852 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 3.1205 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.6112 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.4572 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA | 3.015 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.9987 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, PIK3CB, PPARA | 3.0007 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.8401 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.8768 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.908 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.908 |
Hepatitis B_Homo sapiens_hsa05161 | PIK3CA, SRC, PIK3CB, MMP9 | 2.6054 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.8925 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2 | 2.5394 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.4598 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.1972 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.3492 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, IGF1R | 2.5984 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, PIK3CB, IGF1R | 2.5984 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB | 2.2989 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.5892 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, PIK3CB, IGF1R | 2.2879 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 3.0767 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, PIK3CB, IGF1R | 2.2286 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, PIK3CB, PTGS2 | 2.3043 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, PIK3CA, PIK3CB | 2.064 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, PIK3CB, IGF1R | 2.1322 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, CYP3A4 | 2.5984 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.9024 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2, CYP3A4 | 2.5429 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, PIK3CB | 1.997 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, IGF1R | 1.9516 |
FoxO signaling pathway_Homo sapiens_hsa04068 | PIK3CA, PIK3CB, IGF1R | 1.8952 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | ADORA3, ADORA1, TRPV1, NR3C1 | 1.8502 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB | 1.8752 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA | 1.8952 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, PIK3CB | 1.8557 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.4372 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | PIK3CA, PIK3CB, IGF1R | 1.8502 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, PIK3CB, PPARA | 1.7948 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, PIM1, PIK3CB | 1.7533 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.5929 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, PIK3CB | 1.5382 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.5264 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | PIK3CA, SRC, PIK3CB | 1.4825 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2952 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.4046 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3942 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.404 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4173 |
HTLV-I infection_Homo sapiens_hsa05166 | PIK3CA, PIK3CB | 0.7106 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.2912 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4728 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.5151 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.5151 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.5096 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, PIK3CB | 1.1198 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB | 0.9678 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 1.1211 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 1.1393 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 1.0856 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PIK3CA, PIK3CB | 1.1024 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 1.1524 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, PIK3CB | 1.2222 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5847 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5847 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.3111 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.3961 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB | 1.336 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5943 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.3881 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PTGS2 | 0.5847 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5938 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | PIK3CA, PIK3CB | 1.3218 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.3393 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.6073 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.3218 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.608 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.3509 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.6096 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.6096 |
Gap junction_Homo sapiens_hsa04540 | SRC | 0.6096 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.6089 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PTGS2 | 1.3881 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.6214 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.6641 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.5553 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6625 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | PIK3CA, PIK3CB | 1.5553 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.5929 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.677 |
Pancreatic cancer_Homo sapiens_hsa05212 | PIK3CA, PIK3CB | 1.6014 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.5678 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.6692 |
Bile secretion_Homo sapiens_hsa04976 | CA2, CYP3A4 | 1.5678 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.7049 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.5929 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.7025 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.7228 |
Colorectal cancer_Homo sapiens_hsa05210 | PIK3CA, PIK3CB | 1.6474 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB | 1.7151 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.6774 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB | 1.7652 |
Malaria_Homo sapiens_hsa05144 | MET | 0.8008 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.93 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.8502 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, PIK3CB | 1.8204 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.8136 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP3A4, XDH | 1.8502 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 2.1096 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 2.064 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.9838 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.9307 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.2982 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 1.0309 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.42 |