Prescription ID | TCMF4918 |
Pinyin Name | Qi Rong Pian |
Chinese Name | 杞蓉片 |
English Name | Qi Rong Tablets |
Function Description | 遗精, 阳萎, 早泄, 不寐, 健忘 |
Indications | Premature ejaculation disorder, Involuntary ejaculation disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Sexual dysfunction, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Heart, Brain, Kidney |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
TCMH1740 | Cistanche deserticola | 肉苁蓉 | TCMH1740 | ITSAM2511-14 |
TCMH2056 | Cynomorium songaricum | 锁阳 | TCMH2056 | ITSAO3649-14 |
TCMH1866 | Cnidium monnieri | 蛇床子 | TCMH1866 | ITSAL2575-14 |
TCMH1597 | Ligustrum lucidum | 女贞子 | TCMH1597 | ITSAM2109-14 |
TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
TCMH1133 | Rosa laevigata | 金樱子 | TCMH1133 | ITSAJ4477-14 |
TCMH2507 | Epimedium brevicornum | 淫羊藿 | TCMH2507 | AY362429 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT337 | XPO1 | Exportin-1 | Unclassified | O14980 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT637 | SIRT3 | NAD-dependent deacetylase sirtuin 3 | Hydrolase | Q9NTG7 |
TCMT638 | SIRT2 | NAD-dependent deacetylase sirtuin 2 | Hydrolase | Q8IXJ6 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Target ID | Target Name |
---|---|
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1212 | Verticillium dahliae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1243 | Aspergillus flavus |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1250 | Vesicular stomatitis virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1354 | Streptococcus mutans UA159 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1393 | Vibrio sp. |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 | 10.9561 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 9.63299 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 9.63299 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TRPV1, TYR | 8.8097 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HSPA1A, PIM1, PPARA, TYR, XDH | 8.75494 |
[BP] GO:0065008 | regulation of biological quality | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TRPV1, XDH | 8.56617 |
[BP] GO:0008152 | metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 8.45915 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 8.32337 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.99275 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH | 7.78371 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 | 7.6425 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 7.62203 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.58433 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.32745 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 7.08649 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TRPV1 | 7.08649 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TEK, TRPV1, TYR | 7.08649 |
[BP] GO:0010647 | positive regulation of cell communication | AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 7.04958 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA | 7.04149 |
[BP] GO:0023056 | positive regulation of signaling | AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 7.04149 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC | 6.8421 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 | 6.80572 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH | 6.70043 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 6.65079 |
[BP] GO:0032502 | developmental process | ACHE, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR | 6.54352 |
[BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.54352 |
[BP] GO:0032501 | multicellular organismal process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 6.48708 |
[BP] GO:0042127 | regulation of cell proliferation | AKR1B1, ALOX12, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH | 6.45954 |
[BP] GO:0010941 | regulation of cell death | AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 6.44402 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 6.42826 |
[BP] GO:0060548 | negative regulation of cell death | AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK | 6.40079 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 | 6.39203 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR | 6.39203 |
[BP] GO:0043067 | regulation of programmed cell death | AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 6.32121 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 6.30025 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.28581 |
[BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.18397 |
[BP] GO:0043069 | negative regulation of programmed cell death | AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK | 6.16891 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 6.15545 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.14256 |
[BP] GO:0048856 | anatomical structure development | ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR | 6.03243 |
[BP] GO:0044238 | primary metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 6.0129 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 | 6.0129 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 5.98464 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR | 5.83297 |
[BP] GO:1902531 | regulation of intracellular signal transduction | AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 5.73416 |
[BP] GO:0042981 | regulation of apoptotic process | AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 5.71878 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.68038 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 5.56469 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.55303 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH | 5.53723 |
[BP] GO:0043066 | negative regulation of apoptotic process | AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK | 5.51089 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.51089 |
[BP] GO:0032879 | regulation of localization | ACHE, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 | 5.41696 |
[BP] GO:0030335 | positive regulation of cell migration | ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 5.32568 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 5.30492 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR | 5.28393 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH | 5.22643 |
[BP] GO:2000147 | positive regulation of cell motility | ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 5.17754 |
[BP] GO:0051272 | positive regulation of cellular component movement | ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 5.0493 |
[BP] GO:0009967 | positive regulation of signal transduction | AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 5.01955 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 5.01955 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 4.93314 |
[BP] GO:0040017 | positive regulation of locomotion | ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 4.90668 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH | 4.89584 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 | 4.83315 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK | 4.82078 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 4.79161 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 4.73657 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR | 4.69911 |
[BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 4.69911 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, BCL2, CDC25B, CHRM1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK | 4.57591 |
[BP] GO:0040012 | regulation of locomotion | ALOX12, APP, BCL2, CHRM1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 4.54243 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.53284 |
[BP] GO:0030334 | regulation of cell migration | ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 4.48889 |
[BP] GO:0010646 | regulation of cell communication | ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH | 4.481 |
[BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.41164 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APP, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 | 4.40128 |
[BP] GO:0023051 | regulation of signaling | ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH | 4.37747 |
[BP] GO:0042592 | homeostatic process | AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TRPV1 | 4.36638 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK | 4.35264 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 | 4.26435 |
[BP] GO:2000145 | regulation of cell motility | ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 4.20538 |
[BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 4.14202 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 4.08212 |
[BP] GO:0009628 | response to abiotic stimulus | AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR | 3.95312 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.93514 |
[BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.91286 |
[BP] GO:0048584 | positive regulation of response to stimulus | AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 3.90631 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2 | 3.90397 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 | 3.8545 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.83745 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR | 3.82027 |
[BP] GO:0051270 | regulation of cellular component movement | ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 3.82027 |
[BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.82027 |
[BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.82027 |
[BP] GO:0010038 | response to metal ion | ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 3.81643 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 3.79787 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, HSPA1A | 3.77954 |
[BP] GO:0051049 | regulation of transport | ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 | 3.77801 |
[BP] GO:0072593 | reactive oxygen species metabolic process | ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR | 3.77801 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.76251 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.7265 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.7265 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ALOX12, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 | 3.7091 |
[BP] GO:0050896 | response to stimulus | ACHE, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 3.69823 |
[BP] GO:0071363 | cellular response to growth factor stimulus | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 3.69823 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH | 3.69823 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 3.6879 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 3.66727 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.632 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.632 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.61684 |
[BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.59487 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 | 3.56179 |
[BP] GO:0009611 | response to wounding | ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 | 3.56179 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 3.55945 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 3.55945 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC | 3.55945 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR | 3.53956 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH | 3.46046 |
[BP] GO:0019216 | regulation of lipid metabolic process | CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK | 3.44935 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK | 3.40102 |
[BP] GO:0080134 | regulation of response to stress | ALOX12, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 3.39891 |
[BP] GO:0043408 | regulation of MAPK cascade | ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH | 3.39248 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.37161 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 3.36483 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TYR | 3.36203 |
[BP] GO:0070848 | response to growth factor | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 3.3615 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.35514 |
[BP] GO:0009056 | catabolic process | ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH | 3.34093 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 | 3.33999 |
[BP] GO:1903725 | regulation of phospholipid metabolic process | CHRM5, FABP3, FLT3, SRC, TEK | 3.33037 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC, TRPV1 | 3.31361 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.31361 |
[BP] GO:0051130 | positive regulation of cellular component organization | ALOX15, APP, AURKB, AXL, BCL2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK | 3.2983 |
[BP] GO:0042325 | regulation of phosphorylation | ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH | 3.27579 |
[BP] GO:0010638 | positive regulation of organelle organization | ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 3.27579 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SRC | 3.25418 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, SRC, TEK, XDH | 3.17663 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ALOX15, APP, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH | 3.17511 |
[BP] GO:0001932 | regulation of protein phosphorylation | ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.11768 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, EGFR, FLT3, NR3C1, SRC | 3.08022 |
[BP] GO:0042738 | exogenous drug catabolic process | CYP1A2, CYP2A6, CYP3A4 | 3.07887 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 | 3.01308 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 2.99834 |
[BP] GO:0031399 | regulation of protein modification process | ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 2.98113 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.97972 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, INSR, SMAD3, TRPV1 | 2.97373 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.97373 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.97373 |
[BP] GO:0030155 | regulation of cell adhesion | ALOX12, ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK | 2.97205 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TYR | 2.96836 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 2.96689 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, SRC, TEK | 2.95675 |
[BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.95175 |
[BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.95175 |
[BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.95175 |
[BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, RORC, SMAD3, SRC, TRPV1 | 2.93219 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, INSR, SMAD3, TRPV1, XDH | 2.92865 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, EGFR, FLT3, NR3C1, SRC | 2.92538 |
[BP] GO:0051050 | positive regulation of transport | ACHE, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, SMAD3, SRC, TRPV1 | 2.92056 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.92056 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, EGFR, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 | 2.91779 |
[BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TYR | 2.91587 |
[BP] GO:0007165 | signal transduction | AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 | 2.89376 |
[BP] GO:0048732 | gland development | BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR | 2.86229 |
[BP] GO:0048583 | regulation of response to stimulus | AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 2.85238 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MMP9, PTPN1, SRC | 2.8386 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR | 2.8386 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC | 2.82615 |
[BP] GO:0042327 | positive regulation of phosphorylation | ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.82279 |
[BP] GO:0048585 | negative regulation of response to stimulus | ALOX12, ALOX15, BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 2.79581 |
[BP] GO:0051239 | regulation of multicellular organismal process | ALOX12, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1, XDH | 2.75982 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5 | 2.75982 |
[BP] GO:0009966 | regulation of signal transduction | AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH | 2.74382 |
[BP] GO:0044092 | negative regulation of molecular function | APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC | 2.74205 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.73639 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.73639 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.73639 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.73639 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 2.72001 |
[BP] GO:0001666 | response to hypoxia | BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK | 2.70989 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, KDR, SMAD3, SRC, TEK | 2.70255 |
[BP] GO:0032844 | regulation of homeostatic process | AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, SRC, TRPV1 | 2.69036 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 2.67411 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.6488 |
[BP] GO:1901654 | None | AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC | 2.6488 |
[BP] GO:0036293 | response to decreased oxygen levels | BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK | 2.63797 |
[BP] GO:0045787 | positive regulation of cell cycle | APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC | 2.62314 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.62206 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, AXL, BCL2, CYP1B1, SRC | 2.61751 |
[BP] GO:0016042 | lipid catabolic process | AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 2.61408 |
[BP] GO:0009987 | cellular process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 2.60175 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.59784 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.59784 |
[BP] GO:0065009 | regulation of molecular function | APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 2.57756 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.57075 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.57075 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | ALOX15, BCL2, KDR, SMAD3, SRC, TEK | 2.5434 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.52935 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.52497 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.52497 |
[BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC | 2.52115 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.51967 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC | 2.50495 |
[BP] GO:0007166 | cell surface receptor signaling pathway | APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 | 2.50183 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 | 2.46931 |
[BP] GO:0044267 | cellular protein metabolic process | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK | 2.46188 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH | 2.45463 |
[BP] GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ALOX15, APP, EGFR, KDR, SRC, TEK | 2.44971 |
[BP] GO:0070482 | response to oxygen levels | BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK | 2.44767 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC | 2.42594 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 2.42594 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, SRC, TEK | 2.39511 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, SRC, TEK | 2.36326 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.35402 |
[BP] GO:0050801 | ion homeostasis | APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, GPR35, SMAD3, TRPV1 | 2.34622 |
[BP] GO:2000021 | regulation of ion homeostasis | BCL2, CA2, CA7, KDR, SRC, TRPV1 | 2.33589 |
[BP] GO:0009893 | positive regulation of metabolic process | ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.32217 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.32217 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.3186 |
[BP] GO:0061900 | None | APP, EGFR, TRPV1 | 2.3186 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.3186 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ALOX15, APP, AURKB, BCL2, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.2914 |
[BP] GO:0032872 | regulation of stress-activated MAPK cascade | APP, DUSP3, EGFR, IGF1R, PTPN1, XDH | 2.27755 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 | 2.26973 |
[BP] GO:0070302 | regulation of stress-activated protein kinase signaling cascade | APP, DUSP3, EGFR, IGF1R, PTPN1, XDH | 2.26937 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, EGFR, SRC, TRPV1, TYR | 2.24451 |
[BP] GO:0019538 | protein metabolic process | ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK | 2.23097 |
[BP] GO:0031099 | regeneration | AXL, BCL2, CSNK2A1, EGFR, FLT3 | 2.23097 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.23097 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.23097 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC | 2.22279 |
[BP] GO:0006464 | cellular protein modification process | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK | 2.22156 |
[BP] GO:0036211 | protein modification process | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK | 2.22156 |
[BP] GO:0051726 | regulation of cell cycle | APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC | 2.22006 |
[BP] GO:0043549 | regulation of kinase activity | APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK | 2.21667 |
[BP] GO:0050790 | regulation of catalytic activity | APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH | 2.20671 |
[BP] GO:0051384 | response to glucocorticoid | ALPL, BCL2, EGFR, FLT3, NR3C1 | 2.19935 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 2.18484 |
[BP] GO:0051338 | regulation of transferase activity | APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK | 2.18419 |
[BP] GO:0043412 | macromolecule modification | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK | 2.17399 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, INSR, MMP2, MMP9, SRC | 2.17346 |
[BP] GO:0071383 | None | EGFR, FLT3, NR3C1, SRC | 2.16746 |
[BP] GO:0051128 | regulation of cellular component organization | ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK | 2.15675 |
[BP] GO:0046541 | None | CHRM1, CHRM3 | 2.15675 |
[BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.15675 |
[BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.15675 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APP, CDC25B, CYP1A1, DUSP3, INSR | 2.14737 |
[BP] GO:0007193 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.13569 |
[BP] GO:0031100 | animal organ regeneration | AXL, CSNK2A1, EGFR, FLT3 | 2.13569 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9 | 2.13569 |
[BP] GO:0042060 | None | ALOX15, EGFR, PPARA, SMAD3 | 2.11753 |
[BP] GO:0043405 | regulation of MAP kinase activity | DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC | 2.11678 |
[BP] GO:0031401 | positive regulation of protein modification process | ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.10623 |
[BP] GO:0046903 | None | ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSPA1A, MMP9, TRPV1, XDH | 2.1006 |
[BP] GO:0006950 | response to stress | ACHE, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 | 2.09548 |
[BP] GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | FLT3, SRC, TEK | 2.09548 |
[BP] GO:0042743 | hydrogen peroxide metabolic process | CYP1A1, CYP1A2, EGFR | 2.09548 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, SRC | 2.06898 |
[BP] GO:1901890 | None | KDR, SMAD3, TEK | 2.05859 |
[BP] GO:0071276 | cellular response to cadmium ion | CYP1A2, EGFR, MMP9 | 2.05859 |
[BP] GO:0006691 | None | ALOX12, ALOX15, ALOX5 | 2.05859 |
[BP] GO:1901655 | None | AKR1B1, EGFR, NR3C1, SRC | 2.0525 |
[BP] GO:0033273 | response to vitamin | ALPL, CYP1A1, EGFR, TYR | 2.0368 |
[BP] GO:1903426 | None | EGFR, INSR, SMAD3, TRPV1 | 2.0368 |
[BP] GO:1901888 | regulation of cell junction assembly | KDR, SMAD3, SRC, TEK | 2.0368 |
[BP] GO:0003018 | None | CHRM1, CHRM3, EGFR, SRC, TEK | 2.03305 |
[BP] GO:0048729 | tissue morphogenesis | BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC | 2.0296 |
[BP] GO:0051902 | negative regulation of mitochondrial depolarization | BCL2, SRC | 2.0296 |
[BP] GO:1990535 | None | APP, INSR | 2.0296 |
[BP] GO:0002933 | lipid hydroxylation | CYP1A1, CYP3A4 | 2.0296 |
[BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP3A4 | 2.0296 |
[BP] GO:2001242 | regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MMP9, PTPN1, SRC | 2.00623 |
[BP] GO:0009894 | regulation of catabolic process | BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 | 2.00408 |
[BP] GO:0090218 | positive regulation of lipid kinase activity | FLT3, SRC, TEK | 2.00316 |
[BP] GO:0006775 | fat-soluble vitamin metabolic process | CBR1, CYP1A1, CYP3A4 | 2.00316 |
[BP] GO:0010907 | None | INSR, PPARA, SRC | 2.00316 |
[BP] GO:0106027 | None | APP, IGF1R, INSR | 2.00316 |
[CC] GO:0016020 | membrane | ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, TYR | 3.3488 |
[CC] GO:0005886 | plasma membrane | ACHE, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 | 3.17917 |
[CC] GO:0044425 | membrane part | ACHE, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK, TRPV1, TYR | 2.88616 |
[CC] GO:0098590 | plasma membrane region | CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, INSR, MET, SRC, TEK, TRPV1 | 2.86229 |
[CC] GO:0045202 | None | ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR | 2.70255 |
[CC] GO:0016323 | basolateral plasma membrane | CA2, CA4, CA9, CHRM3, EGFR, TEK | 2.56775 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FLT3, HSD11B1, HSD17B2, PTPN1 | 2.34622 |
[CC] GO:0031226 | intrinsic component of plasma membrane | APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 | 2.34069 |
[CC] GO:0044459 | plasma membrane part | ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK, TRPV1 | 2.29614 |
[CC] GO:0030054 | cell junction | ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, HCAR2, HSPA1A, KDR, TEK, TRPV1 | 2.11443 |
[CC] GO:0044444 | cytoplasmic part | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NR3C1, PIM1, PTPN1, SMAD3, SRC, TRPV1, TYR, XDH | 2.1116 |
[CC] GO:0005887 | integral component of plasma membrane | APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 | 2.05063 |
[CC] GO:0097443 | sorting endosome | KDR, PTPN1 | 2.0296 |
[MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH | 13.9957 |
[MF] GO:0003824 | catalytic activity | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TYR, XDH | 11.6133 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 10.02 |
[MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 9.63299 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 8.46189 |
[MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH | 8.23027 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 | 8.03646 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH | 7.86886 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 7.60783 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 7.08649 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.90832 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.54352 |
[MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.54352 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR | 6.40974 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 5.7731 |
[MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH | 5.71878 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 5.63714 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.63714 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC | 5.56469 |
[MF] GO:0042562 | hormone binding | ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 | 5.47367 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC | 5.34977 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR | 5.00411 |
[MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH | 4.84706 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 | 4.72093 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 4.48494 |
[MF] GO:0038023 | signaling receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 | 4.31319 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3 | 4.26665 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH | 4.23722 |
[MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.22484 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.7091 |
[MF] GO:0004871 | signal transducer activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 | 3.69681 |
[MF] GO:0004872 | receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 | 3.66207 |
[MF] GO:0060089 | molecular transducer activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 | 3.4994 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.4994 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 | 3.46197 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.42586 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.42586 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.36784 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH | 3.35659 |
[MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.08313 |
[MF] GO:0099600 | transmembrane receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 | 2.98486 |
[MF] GO:0004888 | transmembrane signaling receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 | 2.98486 |
[MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.95175 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.95175 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 2.82814 |
[MF] GO:0019902 | phosphatase binding | BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 | 2.81622 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK | 2.73639 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.57075 |
[MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.57075 |
[MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.57075 |
[MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.52497 |
[MF] GO:0032403 | protein complex binding | ACHE, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC | 2.42594 |
[MF] GO:0005524 | ATP binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 | 2.32359 |
[MF] GO:0008289 | lipid binding | ALOX15, AXL, CYP3A4, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 | 2.32217 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.32217 |
[MF] GO:0051425 | None | APP, INSR | 2.32217 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.32217 |
[MF] GO:0019838 | growth factor binding | EGFR, IGF1R, INSR, KDR, TEK | 2.3068 |
[MF] GO:0032559 | adenyl ribonucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 | 2.23341 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX12, ALOX15, ALOX5 | 2.23097 |
[MF] GO:0030554 | adenyl nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 | 2.21667 |
[MF] GO:0043168 | anion binding | ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH | 2.19935 |
[MF] GO:0004435 | None | CHRM1, CHRM3, CHRM5 | 2.19775 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.19775 |
[MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX12, ALOX15, ALOX5 | 2.19775 |
[MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.15675 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.15675 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.12603 |
[MF] GO:0043548 | phosphatidylinositol 3-kinase binding | AXL, IGF1R, INSR | 2.12603 |
[MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK | 2.09548 |
[MF] GO:0004629 | None | CHRM1, CHRM3, CHRM5 | 2.09548 |
[MF] GO:0005158 | None | IGF1R, PTPN1, SRC | 2.05859 |
[MF] GO:0019899 | enzyme binding | APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, HSPA1A, MET, NR3C1, PPARA, PTPN1, SMAD3, SRC, TEK | 2.03573 |
[MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.0296 |
[MF] GO:0016788 | None | ACHE, ALPL, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 | 2.0296 |
[MF] GO:0004064 | arylesterase activity | CA1, CA2 | 2.0296 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 9.6838 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 11.237 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 9.3157 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 8.659 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.659 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 8.3728 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH | 6.2415 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, CHRM1, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R | 4.7918 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 5.4989 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 | 4.7683 |
Pathways in cancer_Homo sapiens_hsa05200 | SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R | 4.3644 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R | 4.3988 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, INSR, KDR, TEK, MET, EGFR, IGF1R | 4.355 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.833 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, EGFR, HSPA1A | 3.8529 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, CHRM3, CHRM1, GPR35, CHRM5, TRPV1, NR3C1 | 3.6966 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | INSR, BCL2, TEK, EGFR, IGF1R | 3.8239 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B | 3.5378 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, BCL2, MET, EGFR, IGF1R | 3.5378 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR | 3.4583 |
Ras signaling pathway_Homo sapiens_hsa04014 | INSR, KDR, TEK, MET, EGFR, IGF1R | 3.3528 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, ALOX15, ALOX12 | 3.5378 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, CHRM1, CHRM5, EGFR | 2.8748 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1, CYP3A4 | 3.4769 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1 | 2.8533 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.4127 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5, ALOX15, ALOX12 | 2.7113 |
Hepatitis B_Homo sapiens_hsa05161 | SMAD3, SRC, BCL2, MMP9 | 2.32 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, INSR, EGFR, IGF1R | 2.4443 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | INSR, IGF1R, HSPA1A | 2.3381 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.0581 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, CHRM1, PPARA | 1.9337 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET, EGFR | 2.3059 |
Melanoma_Homo sapiens_hsa05218 | MET, EGFR, IGF1R | 2.2688 |
Prostate cancer_Homo sapiens_hsa05215 | BCL2, EGFR, IGF1R | 2.0211 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 2.2996 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, EGFR | 2.0042 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC, ALOX12, TRPV1 | 1.9337 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2, CYP3A4 | 2.2931 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.8684 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, EGFR, CDC25B, HSPA1A | 1.6216 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, INSR, PPARA | 1.833 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, CYP3A4, XDH | 2.7176 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.573 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5, BCL2, HSPA1A | 1.7555 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2, HSPA1A | 1.2402 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.2574 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC, EGFR | 1.1718 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 1.1163 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | INSR, IGF1R | 1.1366 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, HSPA1A | 0.8989 |
AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.9574 |
Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2 | 1.2812 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA, EGFR | 0.9101 |
Glioma_Homo sapiens_hsa05214 | EGFR, IGF1R | 1.3648 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, INSR | 1.4401 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.3939 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, INSR | 0.8938 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 0.9838 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 1.1581 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, IGF1R | 0.8887 |
Cell cycle_Homo sapiens_hsa04110 | SMAD3, CDC25B | 0.9574 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1 | 0.8887 |
Gap junction_Homo sapiens_hsa04540 | SRC, EGFR | 1.1694 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.8938 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 1.1386 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | INSR, EGFR | 0.8834 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4338 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.2457 |
Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2 | 1.1263 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | INSR, PPARA | 0.869 |
Pancreatic cancer_Homo sapiens_hsa05212 | SMAD3, EGFR | 1.3598 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, PIM1 | 0.8456 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, BCL2 | 1.3884 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC, EGFR | 0.8456 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2, HSPA1A | 0.8111 |
Bile secretion_Homo sapiens_hsa04976 | CA2, CYP3A4 | 1.3075 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3 | 0.2524 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.4134 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.7878 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.3648 |
Viral carcinogenesis_Homo sapiens_hsa05203 | SRC | 0.3175 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3435 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3564 |
Influenza A_Homo sapiens_hsa05164 | HSPA1A | 0.3564 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.3432 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3653 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | INSR | 0.3653 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.3901 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.398 |
Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.4139 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.4257 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.4493 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | BCL2 | 0.4511 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | BCL2 | 0.4511 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.4413 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.472 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.4493 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC | 0.4511 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.4962 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | EGFR | 0.4962 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3 | 0.4889 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4962 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5079 |
Taste transduction_Homo sapiens_hsa04742 | CHRM3 | 0.5287 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.5287 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5287 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5287 |
Insulin secretion_Homo sapiens_hsa04911 | CHRM3 | 0.5287 |
Salivary secretion_Homo sapiens_hsa04970 | CHRM3 | 0.5287 |
Small cell lung cancer_Homo sapiens_hsa05222 | BCL2 | 0.5287 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5287 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5287 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | SMAD3 | 0.5653 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC | 0.5664 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5487 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5732 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.5919 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5936 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.6209 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | EGFR | 0.644 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.6467 |
Endometrial cancer_Homo sapiens_hsa05213 | EGFR | 0.6647 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.668 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6796 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | INSR | 0.6834 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9034 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.336 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.776 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.763 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.8579 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.7981 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.0706 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.869 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.7981 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8336 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8713 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8422 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.869 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.0694 |