TCM Prescription: Nei Xiao Luo Li Pills



Prescription Description
Prescription IDTCMF4845
Pinyin NameNei Xiao Luo Li Wan
Chinese Name内消瘰疬丸
English NameNei Xiao Luo Li Pills
Function Description瘰疬
IndicationsTuberculosis of intrathoracic lymph nodes
Disease ICD-11 Category 1B10.Z [Respiratory tuberculosis, without mention of bacteriological or histological confirmation, 呼吸道结核病，未提及细菌学或组织学证实 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH380 Halitum 大青盐 TCMH380
TCMH797 Sargassum 海藻 TCMH797
TCMH2596 Fritillaria verticillata 浙贝母 TCMH2596
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH626 Concha meretricis seu cyclinae 蛤壳 TCMH626
TCMH86 Ampelopsis japonica 白蔹 TCMH86 ITSAJ4449-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2342 Natrii sulfas exsiccatus 玄明粉 TCMH2342
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2764
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2764
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 11.5522
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 11.3861
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2987
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FDPS, FUT7, GBA2, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 10.8922
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4067
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 10.3737
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TYR 10.2234
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TYR 9.4053
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.08881
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 8.86614
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.58903
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TYR 8.54279
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.4637
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 8.06743
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, HCAR2, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 7.88596
[BP] GO:0007187 None ADORA1, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.83437
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 7.79496
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.76365
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.72957
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 7.55534
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 7.24379
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.00995
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 6.90113
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.82735
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PTGS2, SRC 6.82735
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR 6.7144
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 6.66936
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC 6.64081
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 6.63636
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 6.63636
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 6.53492
[BP] GO:0007193 None ADORA1, CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.28963
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 6.28618
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.11811
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.06348
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2, SRC 5.9607
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.87987
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 5.87476
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 5.8248
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.8126
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.73848
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 5.72874
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.68046
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 5.67639
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.62746
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 5.59901
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.4754
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.36332
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 5.26793
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.26793
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, SRC 5.26793
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.24707
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM2, CNR1, CNR2, ESR1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.19889
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.18909
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.17437
[BP] GO:0007188 None ADORA1, CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.17437
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.11887
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 5.08265
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PTGS2, SRC 5.02558
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.00818
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.93964
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 4.82545
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.81506
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.81506
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 4.73516
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 4.65272
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.62038
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.59899
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 4.50779
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.50779
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA, PTGS1, PTGS2, TBXAS1 4.4957
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.36959
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 4.36338
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.29028
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.28285
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.27299
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC 4.24952
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.23618
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 4.23395
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.18945
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 4.17826
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.08088
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.98701
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, XDH 3.95504
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.95504
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 3.93787
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 3.92974
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 3.91295
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.91274
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.91274
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.8896
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.79627
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TYR 3.79288
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.78128
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 3.77679
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.76755
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.75666
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.75666
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.73941
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.71917
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.71365
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.71325
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.70254
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.6695
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, XDH 3.65687
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.64041
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.62551
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, HTR1A, TYR 3.56533
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.41525
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.41525
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.41525
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.4062
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.36069
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.34402
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.34189
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.23835
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.23055
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.23055
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.22158
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.17665
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC 3.17265
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.17265
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, POLA1, SRC, TYR 3.17265
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.17265
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.17265
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.17265
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.17265
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.13306
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.11516
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, POLB, PPARA, PTGS2, SRC, TYR 3.08374
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.08067
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.08067
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.07302
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.03133
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.00895
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.9973
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.99262
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.99262
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.9778
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.97193
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.95163
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 2.91125
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.8967
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 2.86869
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.85012
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 2.85012
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTPN1, SRC, XDH 2.81448
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 2.81448
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.79558
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.78667
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.77518
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.76579
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RORC, SRC 2.74913
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.72846
[BP] GO:0007267 None ADORA1, CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.72846
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.72846
[BP] GO:0007208 None HTR2A, HTR2C 2.72846
[BP] GO:0009115 None AOX1, XDH 2.72846
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.69884
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HTR2B, MET, PIK3CA, PPARA 2.69884
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 2.69436
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.6922
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.66236
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.65951
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.62669
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.62478
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.60995
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.59775
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.57398
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.57398
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.56041
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, HTR1D, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.52308
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, HTR1B, KDR, PTGS2, SRC 2.50882
[BP] GO:0090066 None ADORA1, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.49523
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, PPARA, RORC, SRC 2.49066
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.47361
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.46449
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 2.444
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 2.44075
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.4217
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, ESRRB, HCAR2, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.41642
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.41642
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.41642
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.41642
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HCAR2, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.40195
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.38641
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.38208
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.36745
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.34533
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.34533
[BP] GO:0023052 None ADORA1, CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.34533
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.32591
[BP] GO:0046110 None AOX1, XDH 2.32588
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.32588
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.31722
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.30913
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.30004
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.29631
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.28576
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.28429
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.26633
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.25261
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 2.25087
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.24763
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB, PTGS2 2.24747
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.22814
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.22524
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SRC, TNKS2, XDH 2.20352
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.20352
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.20352
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.20272
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.17552
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.17552
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.15421
[BP] GO:0046890 None FABP3, FDPS, HTR2A, HTR2B, HTR2C, PTGS2 2.13937
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TYR 2.12244
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, HCAR2, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.12244
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.11311
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.11039
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.0864
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.08342
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 2.08342
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.08342
[BP] GO:0070213 None TNKS, TNKS2 2.08342
[BP] GO:0006145 None AOX1, XDH 2.08342
[BP] GO:0038171 None CNR1, CNR2 2.08342
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.08342
[BP] GO:0014827 None HTR1D, HTR2B 2.08342
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.08342
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.08342
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.07284
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.07284
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.07284
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.07284
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.07284
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, SRC 2.06555
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, PIK3CB, PTPN1, SRC 2.05243
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 2.04299
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.03508
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.03179
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.02745
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.02745
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.02745
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.02167
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.02027
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.02027
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.02027
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.02027
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.00689
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.006
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.91196
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR 4.26697
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.03783
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, GBA2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 3.8924
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TYR 3.88897
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, SRC 2.99955
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.40195
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 2.01005
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 17.0698
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.2962
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2764
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2764
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.2259
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.2259
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.8629
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 15.8629
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.5523
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FDPS, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TYR, XDH 12.5975
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.5608
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.5388
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3737
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.286
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F3, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 10.2136
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 9.49036
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.19991
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 8.70246
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, TNKS 8.54627
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.54279
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 8.33556
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 7.3895
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 7.26551
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 6.97201
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 6.89249
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 6.7015
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 6.7015
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FDPS, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TYR, XDH 6.64081
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.33978
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1, TYR 6.28618
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.04744
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.04744
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.61338
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 5.47483
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.98315
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.81506
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.81506
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.6837
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.52799
[MF] GO:0004930 None ADORA1, ADORA3, CHRM2, CNR1, CNR2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.40246
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.36959
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.65687
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, XDH 3.62284
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, XDH 3.37847
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.1611
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.04927
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.04499
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.04499
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.03133
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.85012
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.82255
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.81448
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.72846
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.72846
[MF] GO:0003845 None HSD11B1, HSD11B2 2.72846
[MF] GO:0008389 None CYP2A13, CYP2A6 2.72846
[MF] GO:0071886 None HTR2A, HTR2C 2.72846
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.61982
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.43545
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.32588
[MF] GO:0004949 None CNR1, CNR2 2.32588
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.12244
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.08342
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC 2.04567
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.02831
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.006


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 16.1871
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.477
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 11.6792
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.8557
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 8.8277
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.4912
Metabolic pathways_Homo sapiens_hsa01100 FDPS, ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.8345
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.5174
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.6254
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.5174
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.9469
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.9851
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.9851
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.0558
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.3781
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.4262
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.3781
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.2966
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 4.2838
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.0143
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.8063
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0048
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 3.7338
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9658
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.6936
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.2877
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.7338
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.2619
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.1201
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.1201
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.7857
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2877
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.1201
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7804
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8063
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6893
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.091
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.7783
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.6893
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1201
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5556
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8595
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.6923
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.4841
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3962
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.4019
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 2.2738
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0531
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3095
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.3095
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3095
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.1258
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.0854
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.9427
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 1.8645
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.783
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6419
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.5632
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.8374
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.0233
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1412
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7765
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.1258
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5246
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3551
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.1728
HTLV-I infection_Homo sapiens_hsa05166 POLB, FDPS, PIK3CA, PIK3CB 1.3555
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.2837
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1773
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.4978
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3963
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.4391
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1258
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.783
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4391
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.3994
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2593
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.283
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3536
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3407
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3337
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0854
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB 1.2058
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8401
Axon guidance_Homo sapiens_hsa04360 MET 0.3668
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.139
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3746
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6625
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6586
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4253
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8047
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4359
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4365
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8182
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8294
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.7905
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8604
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4487
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4478
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4609
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 0.9889
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4619
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9686
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9889
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9751
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4639
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.043
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4639
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9751
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.035
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9991
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 0.9889
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4629
Peroxisome_Homo sapiens_hsa04146 XDH 0.479
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.6718
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4939
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5168
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5148
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5261
Bile secretion_Homo sapiens_hsa04976 CA2 0.524
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5283
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2058
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5476
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2485
Shigellosis_Homo sapiens_hsa05131 SRC 0.5476
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2187
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5476
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5682
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2485
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3393
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4112
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3434
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6276
Malaria_Homo sapiens_hsa05144 MET 0.6398
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6494
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6445
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4608
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4978
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6494
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4904
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.783
DNA replication_Homo sapiens_hsa03030 POLA1 0.7416
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7916
Base excision repair_Homo sapiens_hsa03410 POLB 0.7731
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.678
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7997
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6603
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7474
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8077
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8374
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8013
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8294
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.971
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0482
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8948
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9706
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.043
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3536


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)